Purpose. To evaluate the possibility of two-port surgical treatment of vitreomacular interface pathologies in standard surgical practice. Material and methods. The study included 24 patients (24 eyes) with macular pathology operated by the proposed two-port technique of vitrectomy 25G. The maximum corrected visual acuity before surgery was 0.2 ± 0.12. The minimum follow-up period after surgery is 1 month. Results. In all cases, it was possible to achieve anatomical restoration of the macular zone. The maximum corrected visual acuity after 1 month after surgery increased to an average of 0.6 ± 0.23. In all clinical cases, it was possible to successfully apply the two-port surgery technique. The need to return to traditional 3-port access was not required in any case. Conclusion. The proposed method for the surgical treatment of vitreomacular interface pathology through a two-port access is effective, technically simple and safe. Keywords: vitreomacular traction syndrome, macular hole, two-port vitrectomy 25G.
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