According to the new European policies aimed at the replacement of highly-pollutant greenhouse gases refrigerants, the scientific community has focused on new synthetic environmentally friendly substances to be employed in vapor compression cycles for the refrigeration and the air conditioning fields.On this regard, R450A is a new blend made up of R134a (42%) and R1234ze (58%), having a GWP equal to 604, and therefore represents an attractive solution as pure R134a substitute. In this paper, new flow boiling heat transfer and pressure drop data of R450A collected at the refrigeration lab of Federico II University of Naples are presented. The data refer to a horizontal stainless-steel tube having an internal diameter of 6.0 mm. The effects of mass flux (from 150 to 400 kg m−2s−1), heat flux (from 10 to 20 kW m−2) and saturation temperature (from 30 to 50 °C) are presented and discussed, together with the assessment of the most quoted two-phase heat transfer and pressure drop prediction methods.