Core-based laboratory experiments were performed on water- and chemically-treated-oil-wet Berea sandstone long-core samples to investigate the disproportionate permeability reduction (DPR) potential of a low-molecular weight associative polymer. The impact of single- and two-phase DPR treatments were considered at 60 °C. In the experiments conducted, real-time electrical resistivity measurements were obtained during the coreflood tests to serve as (a) a valuable tool for fluids saturation monitoring and (b) improved core fluids saturation evaluation in flooded porous media. Results from DPR treatments in water-wet cores showed high initial oil residual resistance factors, RRFo (≈20), followed by relatively long clean-up times; stabilized RRFo was achieved at relatively high PVs of oil injection (≈25). For the range of the post-treatment pressure gradients applied in the laboratory experiment, no DPR effects were observed for the water-wet core samples. However, the different shear-dependent behavior for the oil and water phases in the treated zone suggests that a positive DPR effect is possible at extrapolated low post-treatment applied pressure gradients; this could also be translated as higher clean-up times. For the two-phase DPR treatments in water-wet cores, RRFo can be significantly reduced to approximately 8, while RRFw stabilized at the relatively high value of 40. However, the required significantly long clean-up period during oil flow through the treated zone may question the efficiency of the achieved DPR effect. For the two-phase DPR treatment in oil-wet cores, stabilized RRFo were achieved at considerably lower injected oil PVs, i.e., shorter post-treatment clean-up periods were required. In addition, distinguishably smaller RRFo values were achieved for the oil-wet cores compared to the water-wet ones with a substantial separation from the achieved RRFw values (i.e., faster attainment of low values ranging between 6 and 4 for 15 to 40 injected PVs clean-up duration). These results indicate greater potential for effective positive DPR treatment for oil-wet medium treated through two-phase injection methods. Multi-rate tests conducted during polymer injection showed that the mobility reduction (resistance factor, RF) during DPR treatments, for both single- and two-phase methods, are shear dependent. In addition, post-treatment water and oil injection (production) showed different behavior regarding permeability reduction (RRF). In both core wettability cases, water flow experienced a noticeable power-law dependency to the applied differential pressure. On the other hand, the oil flow behavior in the two wettability cases was different; slightly shear-thinning for the water-wet cases and weakly shear-thickening for the oil-wet cores. In both cases the shear dependency of oil flow was much less pronounced than that of the water flow. Finally, the production water cut can be decreased to a noticeable amount using associative polymer DPR treatments. However, one must note that the water cut reduction (economic gain) is associated with a reduced total (oil) production rate (time loss); therefore, implementation of an associative polymer DPR treatment should be considered carefully.