Two-hour Postprandial Blood Glucose Research Articles

Exploring application of WeChat for gestational diabetes mellitus management

Objective To researching the effect of gestational diabetes mellitus (GDM) prevention and control management by WeChat consultation on the Internet platform. Methods There were 586 pregnant women who performed prenatal care regularly and accepted glucose tolerance test for GDM at 24 to 28 weeks in our hospital during 2015 and 2016 as research objects. Determination of the observation group: in 2016, the 308 people who match the condition of the study during annual prenatal examination in line, in addition to routine guidance outside the clinic and joined the division to establish a dedicated WeChat group for a comprehensive health management consulting. Determination of the control group: in 2015, the 278 people who match the condition of the study during annual prenatal examination in line were treated as control groups. The two groups of observation indexes included the fasting blood glucose and two-hour postprandial blood glucose control in GDM pregnant women, the weight growth rate of the whole pregnancy, cesarean section rate, birth rate of newborns, neonatal referral rate and so on. Results The rate of fasting blood glucose and two-hour postprandial blood glucose control in the observation group was significantly better than that in the control group (t= 2.01- 3.11, all P<0.05). According to the pre-pregnancy physical index, the weight growth of the observation group was significantly better than the control group (t= 2.12- 3.76, all P< 0.05).The cesarean section rate, birth rate and neonatal referral rate were 21.10% (65/308) , 4.87% (15/308) , 7.14% (22/308) in the observation group, and 28.78% (80/278) , 10.07% (28/278) , 12.23% (34/278) in the control group, there were significant differences (U= 2.10- 2.42, all P<0.05). Conclusions Gestational diabetes prevention and control management in the Internet platform for WeChat consultation application effect is remarkable, which can effectively improve the maternal and child outcomes. In the protection of maternal and child health is of great significance. Key words: Wechat consulting; Gestational diabetes mellitus; Management

Effects of psychological intervention on glucose metabolism in patients with type 2 diabetes mellitus accompanying depression in community

Objective: To explore the effect of psychological intervention on glucose metabolism in patients with type 2 diabetes mellitus (T2DM) accompanying depression in community. Methods: Four hundred and ten cases of T2DM patients in the Community Health Service Center of Friendship Office (Baotou) were chosen as the research objects. The evaluation and analysis were made according to Zung self-rating depression scale (SDS), and 176 cases of T2DM patients with depression were found out in the community. 176 cases of T2DM patients with depression were divided into the experimental group and the control group by use of random number table, with 88 cases in each group. The control group was treated with conventional therapy, while the experimental group was given psychological intervention treatment on the basis of conventional therapy. After 3-month psychological intervention, fasting blood glucose (FPG), two-hour postprandial blood glucose (PG2h), glycosylated hemoglobin (HbA1c) and Zung self-rating Depression Scale (SDS) were measured in two groups. In two months after psychological intervention stopped, the follow-up was conducted to determine the levels of FPG, PG2h and HbA1c, and to assess the level of depression and quality of life. Statistical analysis was performed by use of SPSS 17.0 statistical software. Results: After 3-month psychological intervention, the levels of FPG, PG2h and HbA1c in the experimental group were significantly lower than those in the control group, the depression index was significantly lower than that in the control group as well, the difference was statistically significant ( p &lt; .01). In two months after psychological intervention stopped, glucose metabolism indicators in the experimental group were significantly lower than those in the control group; the depression index was dramatically lower than that in the control group, the difference was of statistical significance ( p &lt; .01). Conclusions: Psychological intervention can effectively improve the depression symptoms and glucose metabolism indicators in T2DM patients with depression in community, but it needs a long-term persistence.

A Mixed-Methods Study on Acceptability, Tolerability, and Substitution of Brown Rice for White Rice to Lower Blood Glucose Levels among Nigerian Adults.

Whole-grain products such as brown rice have been associated with lower risk of metabolic disorders including diabetes. We examined the acceptability and tolerability of substituting brown rice for white rice and the feasibility of introducing brown rice into the diet through a long-term trial to lower the risk of type 2 diabetes. Fifty-one adults residing in Abuja, Nigeria, participated in this study. Using purposeful sampling for focus group discussions (FGDs), participants were enrolled based on their age (19-25 vs. 40-60 years) and body mass index (BMI) (normal weight vs. overweight/obese). Participants tasted four meals with different constitution of brown and white rice (25:75%, 50:50%, 75:25%, and 100% brown rice). Twelve FGDs were conducted, six before and six after the food tasting. Two-hour postprandial blood glucose was measured after consumption of each rice meal. The mean age of the participants was 39 (±14) years, their mean BMI was 25.6 (±5.2) and about half of them were male. Most of the participants (61%) reported that rice was their main source of carbohydrate and 67% consumed rice at least five times/week. Before the food tasting, participants considered white polished rice superior to brown rice with regard to quality, taste, and nutritional value. After the food tasting, most of the participants (49%) indicated a preference for the 100% brown rice, 19% preferred the 25% brown rice, 18% preferred the 50% brown rice, and 7% preferred the 75% brown rice meals. Factors that may affect the acceptability of brown rice include its appearance, longer cooking time, cost, limited availability, and poor appreciation of its nutritional value. In general, 2-h postprandial glucose levels were lower, after consumption of meals with higher proportion of brown rice. This study provides valuable insight into the acceptability of brown rice as a substitute for white rice in Nigeria. If confirmed in larger studies, these results highlight the importance of increasing awareness on the nutritional value of brown rice and support the rationale for conducting a large-scale intervention trial to examine the effect of brown rice consumption on blood sugar levels among Nigerians.

Diabetes among Māori women with self-reported past gestational diabetes mellitus in a New Zealand Māori community.

Gestational diabetes mellitus (GDM) is a risk factor for subsequent development of type 2 diabetes mellitus (T2DM). We have investigated the extent of this risk among Māori women without known diabetes. We recruited 2786Māori women aged 28-86years between 2004 and 2006, without diagnosed diabetes from the Waikato and Southern Lakes regions, via media, community and general practitioner channels, and invited them for an oral glucose tolerance test (OGTT). Fifty (1.8%) women reported previous GDM (pGDM). The prevalence decreased significantly with age (P=0.009). Women aged <50years with pGDM had higher body mass index (35.6±6.7 vs 32.4±7.7kg/m2 , P<0.01), waist circumference (105.3±18.8 vs 96.9±16.6cm, P<0.01), fasting blood glucose (5.5±1.0 vs 5.1±0.8mmol/L, P≤0.01), two-hour post-prandial blood glucose (6.6±3.0 vs 5.6±2.1mmol/L, P<0.01) and HbA1c (6.0±0.8 vs 5.8±0.6%, P<0.05) than women without pGDM. PGDM was a significant risk factor for undiagnosed diabetes (odds ratio 4.0; (5% confidence interval 1.67-9.71). Undiagnosed diabetes was significantly more prevalent among women with than without pGDM aged <40years (20.0% vs 1.5%). Self-reported past GDM was a significant risk factor for undiagnosed diabetes in this Māori population, particularly among women aged <40years, highlighting the importance of targeting this group for more intensive screening.

Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes.

Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes.

Self-Care Behaviors of Mothers with Gestational Diabetes Treated with Insulin Based on the Theory of Planned Behavior

Background & aim: The prevalence of gestational diabetes during pregnancy is one of the major maternal and fetal complications. Self-care behavior could be an effective method to control gestational diabetes induced by pregnancy. The theory of planned behavior (TPB) is one of the popular conceptual frameworks for the study of human action and the prediction and understanding of particular behaviors, including self-care behavior. With this background in mind, this study was performed to evaluate the predictive factors for self-care behaviors based on TPB in patients with gestational diabetes treated with insulin.Methods:This descriptive and analytical study was performed on 60 women with gestational diabetes treated with insulin referring to diabetes clinic of Ommolbanin Hospital in Mashhad, Iran in 2014. The samples were randomly selected and evaluated based on a researcher-made questionnaire of awareness, gestational diabetes self-care behaviors, the variables of the theory of planned behavior theory (TPB) (attitude, subjective norm, perceived behavioral control, and behavioral intention), and fasting blood glucose and two-hour postprandial blood glucose tests. Data analysis was performed in SPSS V.16 using descriptive and inferential statistics (correlation, multiple regression analysis, ANOVA, Kruskal-Wallis, and independent t-tests).Results: A direct relationship was observed between intention and perceived behavioral control indices and self-care behaviors. Moreover, attitude affected self-care behaviors through both intention and perceived behavioral control. With regard to total effects of the variables, perceived behavioral control was the second predictive factor for self-care after behavioral intention.Conclusion: TPB emphasizes on behavioral intention and perceived behavioral control, which could be used as a framework to design educational interventions for promotion of gestational diabetes self-care behaviors in mothers.

Effects of laser acupoint irradiation on blood glucose and glycosylated hemoglobin in type 2 diabetes mellitus

To investigate the effects of semiconductor laser acupoint irradiation on blood glucose, glycosylated hemoglobin and physical fitness in type 2 diabetes mellitus, 44 cases of type 2 diabetic patients were randomly divided into a control group and a treatment group. All patients in both groups were given a drug treatment. The Hegu, Quchi and Zusanli acupoints of patients in the treatment group were then irradiated daily for 15 d with a 10 MW semiconductor laser. Before and after treatment, patients in both groups underwent a variety of tests and measurements: a two-hour postprandial blood glucose test; a glycosylated hemoglobin test and body mass index (BMI), waist-to-hip ratio (WHR) and body fat percentage (BFP) measurements. The data detected after treatment greatly decreased in the treatment group and was significantly different from that in the control group. It is shown that the acupoint irradiation with a semiconductor laser can improve two-hour postprandial blood glucose, glycosylated hemoglobin and some physical fitness measurements in type 2 diabetes mellitus patients.

Dietary intake, food pattern, and abnormal blood glucose status of middle-aged adults: a cross-sectional community-based study in Myanmar

BackgroundLifestyle changes, particularly dietary intake, had resulted in increasing trends of type-2 diabetes mellitus worldwide. However, dietary intake is diverse across country contexts. This study aimed to compare the dietary intake, food patterns, and blood glucose among middle-aged adults living in urban and suburban areas in Mandalay city, Myanmar, and explore their relationships.MethodsA cross-sectional community-based study was conducted during June–November 2014. Adults aged 35–64 were randomly selected and requested to record all food they ate in a 4-day diary. Fasting and 2-hour postprandial blood glucose values were measured over two consecutive days. Dietary intakes were calculated in terms of energy, macronutrients, glycemic index, and glycemic load, and food patterns were identified by factor analysis. The relationships between food pattern, dietary intake, and blood glucose were assessed.ResultsOf 440 participants, dietary intake between urban and suburban residents was significantly different. Six food patterns were identified. There was no difference in fasting and 2-hour postprandial blood glucose between urban and suburban residents, but a strong correlation between fasting blood glucose and 2-hour postprandial blood glucose was found (correlation coefficient=0.8). Identification of abnormal blood glucose status using original fasting and converted 2-hour postprandial values showed substantial agreement (prevalence-adjusted bias-adjusted Kappa= 0.8). Relationships between food patterns and blood glucose or abnormal blood glucose status were not found.ConclusionFood patterns were associated with dietary intake, not with abnormal blood glucose status. Two-hour postprandial blood glucose was highly correlated with fasting blood glucose and may be used for identifying abnormal blood glucose status.

Stick it to me

Stick it to me

Influence of Dihydromyricetin on Lowering Blood Glucose Concentration and Reducing Early Kidney Damage in Imparied Glucose Tolerance Rats

Diabetic nephropathy (DN) is a common complication of diabetes and it is related to irreversible kidney damages and chronic renal failure. Impaired glucose tolerance (IGT) is an early stage in the development of diabetes and DN. Early detection of IGT and treatment of its associated early kidney damage can effectively prevent the development of DN. In this paper, the influence of dihydromyricetin (DHM) on lowering blood glucose concentration and reducing early kidney damage in IGT rats was studied. Animal model of IGT rats was built by two week intragastric injection of D-galactose and treated with eight weeks of intragastric injection of DHM at two dose levels. The concentrations of fasting blood glucose (FBG), two-hour postprandial blood glucose (2hBG), insulin levels, contents of microalbuminuia (mAlb) and blood urea nitrogen (BUN), and activities of lactate dehydrogenase (LDH) in kidney were analysed and compared with those in control groups. Experimental results indicated that DHM treatment can significantly lower the levels of two-hour postprandial blood glucose and insulin, decrease the content of mAlb and the activities of LDH in kidney, but does not influence the level of BUN. The study suggested that DHM can effectively improve the states of IGT rats and provide a protective effect against early kidney damage.

Analysis of the effect of metabolic parameters on the self-efficacy in patients with diabetes mellitus

Objective To investigate the effect of metabolic parameters on the self-efficacy in patients with diabetes mellitus.Methods 175 diabetes mellitus patients were recruited by random sampling method.Demographic data and metabolic parameters were obtained and the scales of self-efficacy of diabetes patients were evaluated by secd6.We further analyzed the effect of metabolic parameters on the selfeffficacy in diabetes mellitus patients.Results Two-hour postprandial blood glucose had negative correlation with self-efficacy among 10 metabolic parameters in diabetes mellitus patients.Conclusions Twohour post-prandial hyperglycemia affects the scale of self-effcacy.So we should strengthen the management of two-hour postprandial hyperglycemia to increase the self-efficacy in diabetes mellitus patients. Key words: Diabetes mellitus; Self-efficacy; Metabolic parameters

A Multinational, Observational Study to Investigate the Efficacy, Safety and Tolerability of Acarbose as Add-On or Monotherapy in a Range of Patients: The GlucoVIP Study

The burden of type 2 diabetes mellitus is growing rapidly, particularly in the Asia-Pacific region. The aim of this international, large-scale, observational study was to investigate the efficacy and tolerability of the antidiabetic agent acarbose as add-on or monotherapy in a range of patients with type 2 diabetes, including those with cardiovascular morbidities. The majority of practices were included from high-burden regions (predominantly those in the Asia-Pacific region). This was an observational study conducted in 15 countries/regions. Adults with pre-treated or untreated type 2 diabetes prescribed acarbose as add-on or monotherapy were eligible. Two-hour postprandial blood glucose (2-h PPG), glycosylated haemoglobin (HbA1c) and fasting blood glucose (FBG) were measured over a 3-month observation period. A total of 15,034 patients were valid for the efficacy analysis and 15,661 for the safety analysis (mean age was 57.6 years and 92.6 % of patients were Asian). Mean (SD) 2-h PPG decreased by -71.9 (62.3) mg/dL, to 170.2 (46.5) mg/dL at final visit (after 12.8 [4.1] weeks). Mean HbA1c decreased by -1.1 % (1.3) to 7.2 % (1.1) and mean FBG decreased by -33.0 (43.3) mg/dL to 124.8 (30.5) mg/dL. Acarbose was effective regardless of the presence of cardiovascular co-morbidities or diabetic complications. The efficacy of acarbose was rated 'very good' or 'good' in 85.5 % of patients, and tolerability as 'very good' or 'good' in 84.9 % of patients. Drug-related adverse events, mainly gastrointestinal, were reported in 490/15,661 patients (3.13 %). The results of this observational study support the notion that acarbose is effective, safe and well tolerated in a large cohort of Asian patients with type 2 diabetes.

Efficacy and safety of acarbose chewable tablet in patients with type 2 diabetes: a multicentre, randomized, double‐blinded, double‐dummy positive controlled trial

To evaluate the effect and safety of HbA1c and glycemic control of acarbose chewable tablets in patients with type 2 diabetic. A multicentre, randomized, double-blinded, double-dummy, positive controlled clinical trial was conducted. Two hundred thirty-four Chinese patients with type 2 diabetic were enrolled in eight clinical centres, who were divided randomly into the acarbose chewable tablet group (experimental group, n = 116) and the acarbose treatment group (control group, n = 118). Two hundred seven patients (88.5%) took part in the 12-week trial. At the beginning and end of the clinical trial, HbA1c and blood glucose as well as safety indexes were measured. After the treatment, the level of finger two-hour postprandial blood glucose (PPBG) was decreased 4.15 mmol/L (26.82%) and 3.54 mmol/L (22.77%), respectively, in the experiment group and the control group. The levels of venous two-hour PPBG in the experiment group and the control group were decreased 4.04 mmol/L (25.38%) and 2.75 mmol/L (17.26%), respectively, with the means of HbA1c lowering 11.67% and 12.44%, respectively. Fasting blood glucose (FBG) also was reduced significantly in both groups. Patients in both groups showed obvious weight reduction (P < 0.0001). There were no significant differences in the incidence of adverse events between the two groups. In summary, acarbose chewable tablets have a definite curative effect in treating type 2 diabetic patients as HbA1c and blood glucose levels decreased significantly after the 12-week treatment.

Effect of Obesity on Parameters of Ovarian Reserve in Premenopausal Women

ObjectiveTo study the relationship between obesity and serum and ultrasound markers of ovarian reserve in premenopausal women. MethodsWe performed a cross-sectional comparative study of two age-matched groups of premenopausal participants (early transition phase): 50 participants (“non-obese”) had a BMI<30kg/m2, and the other 50 participants (“obese”) had a BMI of 30 to 35kg/m2. The obese women had a mean age of 46.2years and the non-obese women had a mean age of 46.1years. Blood samples were collected from all participants, anthropometric measurements were calculated, and transvaginal ultrasonography was performed to measure the antral follicle count (AFC) and ovarian volume during the early follicular phase. The blood samples were assayed for antimüllerian hormone (AMH), follicle-stimulating hormone (FSH), fasting blood glucose (FBG) and two-hour postprandial blood glucose (2h PP). ResultsThere was no significant difference between the two groups in mean age, levels of serum AMH, serum FSH, FBG, 2hr PP, or AFC. Ovarian volume was significantly lower in obese women (3.7±0.8mL) than in non-obese women (6.6±0.4mL) (P=0.03). There was no significant correlation between BMI and serum AMH, serum FSH, FBS, or 2hr PP. ConclusionObesity has no association with levels of serum FSH, AMH, blood glucose, or AFC indicating that obesity is unlikely to affect ovarian reserve in the perimenopausal age group.

Efficacy and Safety of AIR Inhaled Insulin Compared to Insulin Lispro in Patients with Type 1 Diabetes Mellitus in a 6-Month, Randomized, Noninferiority Trial

Patients with type 1 diabetes may prefer features of AIR inhaled insulin (developed by Alkermes, Inc. [Cambridge, MA] and Eli Lilly and Company [Indianapolis, IN]; AIR is a registered trademark of Alkermes, Inc.) over insulin injection, but the two methods need to be compared for efficacy and safety. This multicenter, 6-month, parallel-group, noninferiority trial had 500 patients with type 1 diabetes randomized to morning doses of basal insulin glargine plus either preprandial injectable insulin lispro or preprandial AIR insulin. We hypothesized that AIR insulin is noninferior (upper bound of the 95% confidence interval < or = 0.4%) to insulin lispro for change-from-baseline hemoglobin A1C (A1C). Baseline A1C was 7.95 +/- 0.08% for both groups. At end point, A1C was lower with insulin lispro than with AIR insulin by 0.27% (95% confidence interval 0.11, 0.43; P< 0.001). Noninferiority of AIR insulin to insulin lispro was not demonstrated, but similar percentages of patients in each group achieved A1C <7.0% (P = 0.448). Overall daily blood glucose was similar between groups at baseline (P = 0.879) and end point (P = 0.161). Two-hour postprandial blood glucose change from baseline was significantly (P < 0.001) higher with AIR insulin (20.77 +/- 4.33 mg/dL at 3 months and 15.85 +/- 3.08 mg/dL at end point) than with insulin lispro (3.29 +/- 4.14 mg/dL at 3 months and 1.67 +/- 2.91 mg/dL at end point). Overall hypoglycemia was similar between treatment groups (P = 0.355). The AIR insulin group had greater decrease in diffusing capacity of the lung for carbon monoxide at end point (P = 0.020) and greater incidence of cough (P = 0.024) and dyspnea (P = 0.030). Body weight decreased in the AIR insulin group and increased in the insulin lispro group. Insulin lispro provided lower A1C than AIR insulin, but the difference may not be clinically relevant.

Effect of the diabetes outpatient intensive management programme on glycaemic control for type 2 diabetic patients

The purpose of this study was to examine the effect of the diabetes outpatient intensive management programme (DOIMP) on glycaemic control over a 12 week follow-up period for type 2 diabetic patients in Korea. Diabetic complications can be prevented if the glycaemic status of diabetes patients is maintained within a nearly normal range. Patient education is critical in controlling blood glucose levels of patients with diabetes within the optimal range. DOIMP was composed of multidisciplinary education, complication monitoring and telephone counselling. Twenty-five patients in the intervention group participated in the DOIMP and 24 patients in the control group were briefed on the conventional description of diabetes mellitus by diabetes education nurses. Patients in the intervention group had a mean decrease of 2.3%, which those in the control group having a mean decrease 0.4% in glycosylated haemoglobin (HbA(1)c). There was no difference between the two groups in the change in fasting blood glucose (FBG) and two-hour postprandial blood glucose (2-h PBG). The proportion of the patients with HbA(1)c <7% was higher in the intervention group than in the control group at the post-test compare with the pretest. DOIMP can reduce HbA(1)c in type 2 diabetes patients. These findings indicated that DOIMP could be effective in glycaemic control in type 2 diabetes patients.

Twice‐daily pre‐mixed insulin rather than basal insulin therapy alone results in better overall glycaemic control in patients with Type 2 diabetes

To compare the glycaemic control of an insulin lispro mixture (25% insulin lispro and 75% NPL) twice daily in combination with metformin to that of once-daily insulin glargine plus metformin in patients with Type 2 diabetes inadequately controlled with intermediate insulin, or insulin plus oral agent(s) combination therapy. Ninety-seven patients were randomized in a multicentre, open-label, 32-week crossover study. Primary variables evaluated: haemoglobin A1c (A1c), 2-h post-prandial blood glucose (BG), hypoglycaemia rate (episodes/patient/30 days), incidence (% patients experiencing > or = 1 episode) of overall and nocturnal hypoglycaemia. At endpoint, A1c was lower with the insulin lispro mixture plus metformin compared with glargine plus metformin (7.54% +/- 0.87% vs. 8.14% +/- 1.03%, P < 0.001). Change in A1c from baseline to endpoint was greater with the insulin lispro mixture plus metformin (-1.00% vs. -0.42%; P < 0.001). Two-hour post-prandial BG was lower after morning, midday, and evening meals (P < 0.001) during treatment with the insulin lispro mixture plus metformin. The fasting BG values were lower with glargine plus metformin (P = 0.007). Despite lower BG at 03.00 hours (P < 0.01), patients treated with the insulin lispro mixture plus metformin had a lower rate of nocturnal hypoglycaemia (0.14 +/- 0.49 vs. 0.34 +/- 0.85 episodes/patient/30 days; P = 0.002), although the overall hypoglycaemia rate was not different between treatments (0.61 +/- 1.41 vs. 0.44 +/- 1.07 episodes/patient/30 days; P = 0.477). In patients with Type 2 diabetes and inadequate glucose control while on insulin or insulin and oral agent(s) combination therapy, treatment with a twice-daily insulin lispro mixture plus metformin, which targets both post-prandial and pre-meal BG, provided clinically significant improvements in A1c, significantly reduced post-prandial BG after each meal, and reduced nocturnal hypoglycaemia as compared with once-daily glargine plus metformin, a treatment that targets fasting BG.

Will pulmonary insulin delivery help improve type 1 and type 2 diabetes care?

Will pulmonary insulin delivery help improve type 1 and type 2 diabetes care?

The Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance in the Population of Riyadh

This study was conducted in Riyadh to determine the prevalence of diabetes mellitus and impaired glucose tolerance. Blood samples (3981) were collected from Saudi male and female adults (2402) and children (1579) during a household screening program conducted over a period of two years from September 1991 to September 1993. Fasting blood samples were collected and each individual was given an oral glucose load. Two-hour postprandial blood glucose was estimated and the World Health Organization (WHO) criteria were used to diagnose diabetes and impaired glucose tolerance. The diabetic patients were further grouped into noninsulin-dependent diabetes mellitus (NIDDM) and insulin-dependent diabetes mellitus (IDDM) depending on the age of onset and mode of treatment. The overall prevalence of diabetes mellitus (IDDM and NIDDM) was 4.76% in males and 4.10% in the females in the two-to 70-year age group. Ten individuals of the 3981 were suffering from IDDM, giving an incidence of two to three per 1000. When the children <14 years were removed, the prevalence increased to 8.235% and 6.476% in the males and females respectively, while in the >30 year old group, the prevalence increased to 16.0% and 12.34% in the males and females. Further significant increase in NIDDM and impaired glucose tolerance (IGT) was observed with age (P<0.05). NIDDM was more frequent in males while IGT was more frequent in females. This paper presents the results of screening in Riyadh and stresses the need for diabetes mellitus awareness programs in the Saudi population.

Body weight and coronary disease risk: patterns of risk factor change associated with long-term weight change. The Normative Aging Study.

Previous studies have suggested that excess body weight increases coronary disease risk by modification of the levels of other risk factors and in addition may contribute to overall risk independently. Few studies, however, have systematically characterized long-term change in risk factors with specific changes in overall weight while they have controlled for the effects of multiple potential confounders. Also, very little information is available on the differential impact of weight change on risk factor changes with advancing age. The present investigation used 15 years of longitudinal data collected on 1,396 men participating in the Veterans Administration Normative Aging Study in Boston, Massachusetts. Multiple regression analysis was used to predict change in each of eight putative coronary disease risk factors from change in weight and the interaction between weight change and age. These included blood pressure, serum cholesterol, triglycerides, fasting and two-hour postprandial blood glucose, uric acid, and forced vital capacity of the lungs. After controlling for initial levels of the risk factor, weight, age, and smoking status, change in weight remained a significant predictor of long-term change in each of the risk factors studied. In addition, the interaction between weight change and age was significant for fasting glucose, uric acid, and forced vital capacity, indicating that the effect of weight gain on uric acid and forced vital capacity was greater in younger men whereas the effect of weight gain on fasting glucose was greater in older men.