To comprehensively and accurately simulate and predict the flow and heat transfer characteristics of the two-phase loop thermosyphon (TPLT), a two-fluid two-phase model was developed. A six-equation set was formulated to account for two-phase flow, encompassing mass equations, momentum equations, and energy equations. The interactions between the fluids in terms of mass, momentum, and energy were also taken into account. To obtain numerical solutions for the partial differential equations within a staggered mesh framework, we employed the 2nd-order Lax-Wendroff scheme to obtain the discrete linear system, complemented by the inclusion of a flux limiter. The Semi-Implicit Method for Pressure-Linked Equation (SIMPLE) algorithm was employed to address the solution of the linear equation system. Data from a small-scale TPLT test was used to assess the accuracy and reliability of both the physical models and the numerical method proposed in this study. Simulations were performed under two working conditions of the thermosyphon with filling ratio of 45 % and 64 %. The simulation results exhibited good agreement with the experimental data, demonstrating the accuracy of the model. Furthermore, the model is capable of providing information on the complex two-phase flow inside the TPLT that cannot be measured experimentally.