The FSI-mixed convection heat transfer in a lid–driven vented cavity is studied in the present work. The heat source is set partially on the base of the cavity; the left flexible wall is cold, while the remaining walls are adiabatic. The top wall of the cavity moves in different cases depending on its movement; stationary wall (case 0), moving to the left (case I) and moving to the right (case II). The arbitrary Lagrangian-Eulerian formulation and finite element method are utilized to solve the governing equations. A two-dimensional incompressible laminar flow with an unsteady-state condition is used in the present model. The effects of relevant factors like the Richardson number 0.01≤ Ri ≤ 100 and the ratio of the velocities of moving top wall to that of the air entering the cavity, which is governed by Reynolds numbers ratio 1 ≤ Rer ≤ 4 have been studied. The outcomes demonstrate the feasibility of using a flexible wall and a special movement of the top wall. The percentage increase of the Nusselt number due to the flexible wall alone is about 4.5% while when the top wall moving to the left (case I), the augmentation rises to 28%.