ABSTRACT We numerically examine the thermal performance of a round tubular heat exchanger featuring a combination of three passive techniques for heat-transfer enhancement: (i) center-cleared twisted-tape inserts, (ii) tube corrugations, and (iii) nanofluids. We consider three geometric tape parameters – the central-clearance width (C), the tape width (W), and the 180° tape pitch (H) – across a range of Reynolds numbers (500 ≤ Re ≤ 1250). For both water and a representative nanofluid (Al2O3-water), increasing W or decreasing C or H is found to increase the heat transfer coefficient at all Re. Switching from water to one of four water-based nanofluids − Al2O3-water, CuO-water, Cu-water, and TiO2-water – is found to improve the heat transfer rate sufficiently to overcome any associated rises in pressure drop, resulting in thermal efficiencies higher than those of water. The highest thermal efficiency coefficient (η = 1.157) occurs with the Cu-water nanofluid at the smallest Re (500), whereas the lowest thermal efficiency coefficient (η = 1.115) occurs with the CuO-water nanofluid at the largest Re (1250). Across the entire Re range, increasing the volume concentration of Al2O3 nanoparticles (from ϕ = 2 to 5%) is found to increase the coefficients of heat transfer and thermal efficiency. This study provides new insight into how the heat transfer capabilities of a tubular heat exchanger can be enhanced by combining center-cleared twisted-tape inserts, tube corrugations and nanofluids.