Turret Speed Research Articles

Robust design space of compression parameters for initial and reprocessed granules

The design of experiments has been widely used for product and process development based on Quality by design (QbD) approach to achieve quality product. Sources of variability are identified and controlled during manufacturing. However, uncertainty due to uncontrollable variables in the process leads to quality issues and the need for reprocessing in some cases. This study proposes a systematic approach to determine the robust design space for process parameters embraced with the variation of initial and reprocessed materials to ensure that the tablet will meet the specification. The Taguchi L36 experiment design is applied to determine suitable tableting parameters for different granules to ensure physical specifications. Four types of calcium carbonate granules were produced with different moisture contents (ZM) and manufacturing conditions (ZT). Additionally, three critical parameters of tablet compression process—filling volume (XV), compression force (XF), and turret speed (XS)—each encompassing three levels, were selected as input variables. The responses were derived from the product specification, namely weight (YW), tensile strength (YTS), and disintegration time (YDT). The experiment results were embedded into two models: the single independence response model (SRM) and the multiple dependent response model (MRM). After a confirmation experiment using predicted parameters, a comparison of their %MAPE (mean average percentage error) revealed that MRM has lower accuracy in terms of YTS but dominates SRM in terms of the region of design space. This finding relates to the effect of data transformation capturing non-linear relationships between these factors and responses. The design space derived from the models allows manufacturers to adjust critical process parameters for getting desired specification tablets and also provides a framework for continuous improvement by enhancing their original design space and providing a rigorous reprocessing plan.

Regulation on microstructure and mechanical properties of SiC particles reinforced AZ31 magnesium matrix composites fabricated by synchronous feeding of powder and wire in wire-arc directed energy deposition

Ceramic particles reinforced magnesium matrix composites (CMMCs) have attracted widespread attention and investigation due to their excellent comprehensive performances. However, limited research on additive manufacturing of CMMCs has been performed. In this work, the SiC/AZ31 composites were fabricated by wire-arc directed energy deposition (WA-DED) based on the synchronous feeding strategy of powder and wire. The defects, SiC particle distribution, microstructure and mechanical properties of the prepared WA-DED SiC/AZ31 composites were studied. The results indicated that SiC particles with the content range of 0.3–1.7 wt% have been successfully added into the single-channel monolayer AZ31 matrix by adjusting the turret speed (TS) and the argon gas flow rate (AGFR) flowing through the powder feeder. The mathematical model is established to predict the introduced SiC particle content by correlating the relationship between SiC particle content and process parameters (TS and AGFR) of the powder feeder. The transformation from columnar to equiaxed grains occurs after adding SiC particles, more precipitated phases are formed after introducing more SiC particles. Compared to the AZ31 matrix, the WA-DED SiC/AZ31 composites exhibit the highest yield strength of 92.8 MPa and tensile strength of 213.3 MPa on the premise of almost no loss of elongation, and the maximum improvement efficiency of tensile strength reaches 56%, which is mainly ascribed to refinement strengthening, while thermal mismatch strengthening, Orowan strengthening and load-bearing strengthening play a booster action.

Particle-level insights into the powder flow behavior of the Fette 1200i tablet press feed frame using the discrete element method (DEM)

This study employs the DEM to simulate powder flow in the Fette-1200i tablet press three-chambered feed-frame system under varying operating conditions. It examines the influence of operational speeds on parameters like residence time, particle travel distance, shear work, paddle torque, tablet weight, and API concentration. Utilizing continuous spatial surface maps, the research comprehensively analyzes powder flow behavior. Results indicate that particle residence time increases with paddle speed but decreases with turret speed. Similar trends are observed for particle travel distance and shear work. Larger particle residence time can lead to overlubrication. The torque of the paddles is related to the volume of material in each chamber, with the distributing chamber having the largest volume. Tablet weight rises with paddle speed but drops with turret speed. The smallest particle (API) tends to collect near the paddle hub due to limited centrifugal force and on the chamber floor due to percolation. However, the tablet's API content eventually stabilizes at the target concentration.

Effect of process parameters and formulation properties on the lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements

The use of in-line near-infrared (NIR) measurements for tablet potency monitoring and diversion was studied. First, the optimal sample size for in-line NIR measurements inside the feed chute and the dosing and filling chamber of the tablet press feed frame was determined to allow proper comparison between these different measurement positions. Because of the considerably longer measurement time needed to obtain the same sample size inside the feed chute compared to the feed frame, the possibility of powder segregation inside the feed chute and the additional powder mixing inside the feed frame, the latter is preferred over the feed chute for in-line blend potency monitoring. Next, a design of experiments (DoE) was performed to evaluate the effect of paddle speed, turret speed, overfill level and formulation properties upon the lead-lag and the time it takes before the powder blend that is expelled at the dosing station is measured by the NIR inside the dosing chamber. Lead-lag is defined as the difference in time and API concentration between the measured in-line NIR response inside the filling chamber of the feed frame and the off-line NIR tablet response. Paddle speed and turret speed were the only compression parameters affecting lead-lag. Lead-lag decreased with increasing paddle speed for the first formulation. For the second formulation, lead-lag decreased with decreasing paddle speed and/or increasing turret speed. Formulation properties did not have an effect on the lead-lag. The in-line NIR response inside the dosing chamber of the feed frame was found to be closely following the tablet NIR response. Therefore, the dosing chamber could be used as an additional in-line NIR position for tablet potency monitoring and diversion. It can provide an extra layer of confidence about the final tablet quality. To demonstrate this potential benefit of simultaneous in-line NIR measurements inside the filling and dosing chamber of the feed frame, a tableting experiment was performed where a surrogate API spike was introduced into the product stream to mimic a potential process disturbance. The in-line NIR measurements inside the filling chamber allow diverting tablets in-time when the blend potency crosses the predefined control limits. And because the NIR response inside the dosing chamber closely follows the tablet NIR response, tablet diversion can discontinue when the blend potency inside the dosing chamber is again within the control limits. This could increase the yield of the tableting process by avoiding a longer than needed wash-out period and rejecting tablets that meet the release limits.

At-line porosity sensing for non-destructive disintegration testing in immediate release tablets

Fully automated at-line terahertz time-domain spectroscopy in transmission mode is used to measure tablet porosity for thousands of immediate release tablets. The measurements are rapid and non-destructive. Both laboratory prepared tablets and commercial samples are studied. Multiple measurements on individual tablets quantify the random errors in the terahertz results. These show that the measurements of refractive index are precise, with the standard deviation on a single tablet being about 0.002, with variation between measurements being due to small errors in thickness measurement and from the resolution of the instrument. Six batches of 1000 tablets each were directly compressed using a rotary press. The tabletting turret speed (10 and 30 rpm) and compaction pressure (50, 100 and 200 MPa) were varied between the batches. As expected, the tablets compacted at the highest pressure have far lower porosity than those compacted at the lowest pressure. The turret rotation speed also has a significant effect on porosity. This variation in process parameters resulted in batches of tablets with an average porosity between 5.5 and 26.5%. Within each batch, there is a distribution of porosity values, the standard deviation of which is in the range 1.1 to 1.9%. Destructive measurements of disintegration time were performed in order to develop a predictive model correlating disintegration time and tablet porosity. Testing of the model suggested it was reasonable though there may be some small systematic errors in disintegration time measurement. The terahertz measurements further showed that there are changes in tablet properties after storage for nine months in ambient conditions.

저 관성을 가지는 공작기계의 터렛 서보 시스템에서 과도상태의 진동억제를 위한 댐핑 보상기법

In general, rotor inertia has an inversely proportional relationship with proportional gain and bandwidth in a turret speed control system of machine tools; thus, this system has a disadvantage, such as weak disturbance caused by a decrease in the damping ratio and an increase in bandwidth due to low rotor inertia. This paper proposes a damping compensator that is resistance to disturbances in order to improve the above problems. The proposed damping compensator reduces the residual vibration induced in the transient state by using a digital high-pass filter. The experimental results showed that the overshoot was reduced by about 5.5% in the speed response and by about 20% in the torque response in the no-load condition. Under the load condition of 4.8 N.m, the torque response showed that the undershoot was reduced by about 26%.

Design and Test of Soil–Fertilizer Collision Mixing and Mulching Device for Manure Deep Application Machine

Aiming at the problems of low uniformity and utilization rate in the traditional deep application method of orchard manure, a soil–fertilizer collision mixing and mulching device was designed. The ditching mechanism, the structure of the soil divider, and the fertilizer delivery auger were analyzed and designed. Furthermore, with the rotational speed of the cutter and auger and the deflection angle of the soil divider as factors, as well as the uniformity of soil–fertilizer mixing and mulching as evaluation indexes, the discrete element simulation tests were conducted. The simulation results showed that when the turret speed, the stirrer speed and the soil separator deflection angle were 140 r/min, 146 r/min and 22°, the mixing uniformity and mulching uniformity were the highest, which was 88.35% and 96.86%, respectively. Based on the optimal parameters, the field test was conducted, and the soil–fertilizer mixing uniformity was 87.02%, with a relative error of 1.33% compared with the simulation test results. The relative error of 94.37% of mulch uniformity is 2.49%, which indicates that the simulation optimization results are reliable and the mixing performance of the device is good and can meet the requirements of soil–fertilizer mixing operation. The results of this study can provide an important reference for the design of the soil and fertilizer mixing machine.

Particle Scale Insights into a KG-Pharma RoTab Tablet Press Feed-Frame System Using the Discrete Element Method (DEM) Modeling

In the pharmaceutical industry, tablets are a common dosage form. As part of the manufacturing process, powder in a tablet press passes through a feeding system called the feed-frame before reaching the die cavity. Under different manufacturing conditions (e.g., paddle speed, turret speed), issues such as segregation of powder blend components, over lubrication, and drug particle attrition often occur in the tablet press feed-frame, which affect the final drug product quality. Therefore, developing a particle-scale understanding of powder behavior in a feed-frame is essential. This paper used the discrete element method (DEM) to study powder flow in the feed-frame of a kg-pharma RoTab tablet press. Simulation results show that an increase in paddle speed has less effect on tablet mass than turret speed and that an increase in turret speed reduces tablet mass and increases variability in the tablet mass. The effect of paddle speed and turret speed on the API content in the tablet is small, but large paddle speeds exacerbate the segregation of powder blend components in the feed frame, increase particle traveled distance, particle shear work, and torque on the paddle wheel, thereby increasing particle over lubrication and attrition. However, the increase in paddle speed reduces the mean residence time of drug particles and prevents over lubrication at low turret speeds. Increasing the turret speed reduces tablet mass, particle shear work, paddle torque, and mean residence time. Although increasing turret speed can effectively prevent particle attrition and over lubrication, short residence times are not conducive to mixing excipients and API components, leading to higher tablet mass variability. This study not only gives us a particle-level insight into the process but can also be used to inform and optimize the design of experimental studies.

Modeling gravity filling of dies on a rotary tablet press

For tableting on rotary presses, die filling is the quality dominating process step as the tablet weight and its variation is influenced. Therefore, a deeper understanding of this process is necessary. In this study, the filled powder weight was investigated for various parameter combinations on a rotary tablet press in lab-scale. Based on the obtained data for four materials, which differ in density and flow properties, a process-property model was developed to describe the volume flow into the dies. The flow can be transferred either into the final tablet weight or into the minimal paddle speed to fill the dies completely at a set turret speed, which supports process development. Finally, model parameters were correlated with the materials bulk density and permeability. Therefore, this models enables the prediction of the die filling process only based on geometrical data of the rotary press and measureable material properties, for the first time. • Investigation of the gravity filling process on a rotary tablet press in lab-scale. • Developed model to describe gravity filling process. • Correlation of model parameters with powder properties like permeability and bulk density. • Prediction of the minimal paddle speed to fill dies completely for a set turret speed by using the model. • Very good agreement between predicted and experimentally determined minimal paddle speed for all investigated materials.

QbD Consideration for Developing a Double-Layered Tablet into a Single-Layered Tablet with Telmisartan and Amlodipine.

The aim of this study was to develop a single-layered version of commercially available Twynstar® (Telmisartan + Amlodipine) double-layered tablets to improve the dosing convenience. A quality-by-design approach was applied to develop the single-layered version. To evaluate the range and cause of risks for a single-layered tablet in the formulation design research, we used the tools of the risk assessment, initial risk assessment of preliminary hazard analysis and main risk assessment of failure mode and effect analysis to determine the parameters affecting formulation, drug dissolution, and impurities. The critical material attributes were the stabilizer and disintegrant, and the critical process parameters were the wet granulation and tableting process. The optimal range of the design space was determined using the central composite design in the wet granulation and tablet compression processes. The stabilizer, kneading time, and disintegrant of the wet granulation were identified as X values affecting Y values. The compression force and turret speed in the tablet compression were identified as X values affecting Y values. After deciding on the design space with the deduced Y values, the single-layered tablets were formulated, and their dissolution patterns were compared with that of the double-layered tablet. The selected quality-by-design (QbD) approach single-layered tablet formulated using design space were found to be bioequivalent to the Twynstar® double-layered tablets. Hence, the development of single-layered tablets with two API using the QbD approach could improve the medication compliance of patients and could be used as a platform to overcome time-consuming and excessive costs and the technical and commercial limitations related to various multi-layered tablets.

Determination and understanding of lead-lag between in-line NIR tablet press feed frame and off-line NIR tablet measurements

The influence of different tableting process parameters on lead-lag was studied by collecting in-line near-infrared (NIR) spectra in the filling chamber of the tablet press feed frame and off-line NIR tablet data. Lead-lag is defined as the difference in time and API concentration between the measured in-line feed frame NIR response and the off-line NIR tablet data. Lead-lag results from the product formulation blend undergoing additional mixing after passing the NIR probe inside the feed frame, before being filled into the dies of the tablet press. A design of experiments (DoE) was performed to evaluate the effect of the tableting process factors paddle speed, turret speed, overfill level, paddle speed ratio and feed frame type upon lead-lag. Paddle speed and turret speed were identified as the only tableting parameters affecting lead-lag. Lead-lag decreased with increasing paddle speed or turret speed and became negligible at high paddle speed and high turret speed. Overfill level, paddle speed ratio and feed frame type did not affect lead-lag, suggesting that the amount and the trajectory of the recirculating powder in the feed frame did not significantly vary and hence influence the lead-lag within the examined process factor ranges. Finally, a methodology was developed using the in-line feed frame NIR measurements for the continuous monitoring and control of blend potency and tablet content uniformity. Tablet diversion should start when the in-line feed frame monitored blend potency exceeds the predefined control limits and can discontinue when this blend potency is again within the control limits for a duration equal to the lead-lag time. A combination of continuous blend potency monitoring inside the feed frame and in-process tablet weight control allows real-time tablet content uniformity assurance. Although the findings of this study are restricted to the specific equipment, tableting parameter ranges and product formulation used, the suggested approach for lead-lag determination and continuous tablet content uniformity monitoring can be applied to any rotary tablet press and product formulation.

Real-Time Monitoring of Powder Mass Flowrates for Plant-Wide Control of a Continuous Direct Compaction Tablet Manufacturing Process

While measurement and monitoring of powder/particulate mass flow rate are not essential to the execution of traditional batch pharmaceutical tablet manufacturing, in continuous operation, it is an important additional critical process parameter. It has a key role both in establishing that the process is in a state of control, and as a controlled variable in process control system design. In current continuous tableting line operations, the pharmaceutical community relies on loss-in-weight feeders to monitor and understand upstream powder flow dynamics. However, due to the absence of established sensing technologies for measuring particulate flow rates, the downstream flow of the feeders is monitored and controlled using various indirect strategies. For example, the hopper level of the tablet press is maintained as a controlled process output by adjusting the turret speed of the tablet press, which indirectly controlling the flow rate. This gap in monitoring and control of the critical process flow motivates our investigation of a novel PAT tool, a capacitance-based sensor (ECVT), and its effective integration into the plant-wide control of a direct compaction process. First, the results of stand-alone experimental studies are reported, which confirm that the ECVT sensor can provide real-time measurements of mass flow rate with measurement error within -1.8 ~ 3.3% and with RMSE of 0.1 kg/h over the range of flow rates from 2 to 10 kg/h. The key caveat is that the powder flowability has to be good enough to avoid powder fouling on the transfer line walls. Next, simulation case studies are carried out using a dynamic flowsheet model of a continuous direct compression line implemented in Matlab/Simulink to demonstrate the potential structural and performance advantages in plant-wide process control enabled by mass flow sensing. Finally, experimental studies are performed on a direct compaction pilot plant in which the ECVT sensor is located at the exit of the blender, to confirm that the powder flow can be monitored instantaneously and controlled effectively at the specified setpoint within a plant-wide feedback controller system.

Flow behaviour of pharmaceutical powders during rotary die filling with a paddle feeder.

Rotary tabletting presses are widely used to produce tablets in the pharmaceutical industry. In the tabletting process using a rotary press, rotary die filling is one of critical process steps, as powder behaviour during die filling dictates the quality of final products, such as dosage and weight variations. It is hence of importance to understand powder flow behaviour during rotary die filling. The purpose of this study is to identify the critical process parameters and material attributes that determine the die filling performance. For this purpose, a model rotary die filling system with a paddle feeder was constructed to mimic the powder feeding process in a typical rotary press. Using this model system, the effects of powder properties, turret speed and paddle speed on die filling behaviour were investigated. Three grades of microcrystalline cellulose powders were considered. It was found that the turret speed has a more pivotal role in controlling the die filling performance than the paddle speed. In addition, it is demonstrated that powder flowability has a great impact on the fill weight variation, and a higher weight variation is induced for the powders with poorer flowability.

A novel approach to avoid capping and/or lamination by application of external lower punch vibration.

Capping as well as lamination are two common problems, which affect the resulting product quality of the tablet. Usually, capping and lamination occur during or after tablet manufacturing, and may therefore influence follow-up processes such as the coating. In this context, there is an urgent need for approaches to overcome the occurrences of capping and lamination. In the present study, a novel lower punch vibration technique was used to decrease the capping or lamination tendency of different powder formulations. Different microcrystalline cellulose types, as well as an API (acetaminophen), were selected as model powders. The powders were investigated regarding their powder flow, density, particle morphology, and surface area. Moreover, the manufactured tablets were characterized regarding their tablet weight, tensile strength, and capping or lamination indices. It was shown that the capping or lamination tendency was strongly affected by the physical powder properties, the formulation composition, and the adjusted turret speed. In addition, the application of externally applied lower punch vibration led to a pronounced decrease of the capping or lamination tendency and improved mechanical stability of the manufactured tablets.

Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press

In the current study, the ability to use in-line NIR inside the feed frame of a tablet press to monitor the residence time distribution inside the tablet press was investigated. Pulse-response experiments were performed. In-line measurements inside the feed frame were compared to measurements on the actual produced tablets and the influence of different tableting parameters on the concentration profiles were studied. Turret speed had a major influence on the concentration profiles and RTD parameters. The in-line and off-line concentration profiles did not align with each other as spiking material was still detected in the tablets when no spiking material was observed in the powder blend by the in-line measuring method. The cause of this mismatch between the in-line and off-line curves was the in-line measuring position. By adjusting the position of the NIR probe to the bottom of the feed frame instead of at the top of the feed frame, a perfect alignment between in-line and off-line concentration curves was acquired. In-line measurements at the bottom of the feed frame could, if optimisation to avoid probe fouling is possible, be ideal for real-time measurement and control of the blend concentration during tableting. When probe fouling cannot be avoided, the correlation between the in-line measured concentration at the top of the feed frame and the concentration of the produced tablets should be investigated and modelled to enable real-time measurement and control based on in-line measurements.

Inline monitoring of the powder filling level within a rotary tablet press feed frame

The filling level within feed frames and the uniformity of the powder supply by feed frames for die filling have not been monitored so far during tableting processes. This study was intended to investigate if the powder filling level inside a rotary tablet press feed frame is affected by the feed frames' paddle wheel speed and/or by the turret speed. Furthermore, it was examined whether the filling level affects the resulting tablet masses while filling the respective dies. Two tableting excipients one with poor flowability and one with excellent flowability were selected as model powders.For inline analysis within the feed frame, a laser triangulator was used, which at a particular position scans the powder surface level within the filling chamber of the feed frame and, combined with the recognition of the angle position of the paddle wheel by a rotary encoder, calculates the filling level and the uniformity of the powder supply by an in-house written software.Results show that the turret speed, the paddle wheel speed and the powder characteristics may all affect the filling level within the filling chamber. The presented method is suitable for inline monitoring of the filling level in the filling chamber of the feed frame and the homogeneity of the powder supply for die filling during tableting. Moreover, a decrease of the filling level during tableting and/or a sudden refill effect of the filling chamber can be detected as well, which may occur under certain process settings at the end of the tablet production and may influence the tablet mass. The results also showed that initial deviations of the filling levels of the individual paddle wheel interspaces persisted until the end of the tableting runs, which might be one of the reasons for tablet mass deviations during production.

Assessment of material and process attributes' influence on tablet quality using a QbD and DEM combined approach

The combined approach of quality by design (QbD) framework and discrete element method (DEM) is applied to force feeding process within the tableting machine to assess the influence of potential critical process conditions (CPPs) and critical material attributes (CMAs) on tablet quality. The numerical model considers the three paddled force feeder of a FETTE 1200i tableting machine. The influence of the selected potential CPPs: turret speed and paddle wheels speed and CMAs: API dose strength, inter-particle cohesion, and particle-wall friction on the critical quality attributes (CQAs) tablet mass, tablet mass variation, and content uniformity are evaluated by using a fractional-factorial screening design. In addition to the CQAs, the DEM provides the opportunity to shed light on the powder flow phenomena within the force feeder thus an understanding on the impact of the paddle wheels on powder over-lubrication and particle attrition is provided. Such a combined approach of QbD and DEM helps in identifying the significance of selected CPPs and CMAs and thereby to generate the design space providing an optimal tablet quality.

The Effects of Feed Frame Parameters and Turret Speed on Mini-Tablet Compression

Die filling is a critical process step during tablet production as it defines the tablet weight. Achieving die fill consistency during production of mini-tablets, tablets with diameters ≤6 mm, is considerably more challenging. Although die filling in rotary presses had been studied in relation to the feed paddle design, paddle speed, and turret speed, it is unclear how these process variables could impact mini-tablet production and product properties. In this study, 1.8 and 3 mm mini-tablets were prepared using a rotary press with multiple-tip tooling using different process configurations. Mini-tablet weight variation within and across compaction cycles were determined using data from compression roller displacement and mini-tablet weight. Higher die fill densities were achieved with a flat feed wheel paddle and high paddle speed. This was attributed to better granule fluidization in the feed frame, which also increased the intercycle weight variation and reduced tensile strength. The turret speed did not impact mini-tablet properties significantly. Granule overlubrication in the feed frame potentially reduced mini-tablet tensile strength during compaction. The number of paddle passes in the die fill region was correlated to mini-tablet die fill performance. Findings from this study could provide better insights into the relationship between process variables and mini-tablet product quality.

Impact of blend properties on die filling during tableting

Based on characterization of a wide range of fillers and APIs, thirty divergent blends were composed and subsequently compressed on a rotary tablet press, varying paddle speed and turret speed. The tablet weight variability was determined of 20 grab samples consisting of each 20 tablets. Additionally, the bulk residence time, ejection force, pre-compression displacement, main compression force, die fill fraction and feed frame fill fraction were determined during each run. Multivariate data analysis was applied to investigate the relation between the process parameters, blend characteristics, product and process responses. Blends with metoprolol tartrate as API showed high ejection forces. This behavior could be linked to the high wall friction value of metoprolol tartrate. The main responses related to the die filling could be predicted via a PLS model based on blend characteristics. Tablet weight variability was highly correlated with the variability on pre-compression displacement and main compression force. A good predictive model for tablet weight variability was obtained taking the porosity, wall friction angle, flowability, density, compressibility and permeability into account. Additionally, turret speed and paddle speed were included in the calibration of the model. The applied approach can save resources (material, time) during early drug product development.

EVALUATION OF COMPRESSION PROCESS VARIABLES FOR MULTIUNIT PARTICULATE SYSTEM (MUPS) TABLET BY QbD APPROACH

Objective: The objective of the study was to evaluate and optimize compression process variables of Esomeprazole (Multiunit particulate system) MUPS tablet. Materials and methods: A three-factor, two-level, full factorial design was used to investigate the influence process variables Viz. Main compression force, Pre-compression force and Turret speed. Responses studied were Weight variation, Hardness, Thickness, Friability, Content uniformity, Drug release in 0.1N HCl at 120min and drug release in pH 6.5 simulated intestinal fluid at 15 min. Results and discussion: Main compression force and the Pre-compression force had a significant influence on hardness, thickness, drug release in 0.1N HCl at 120min and drug release in pH 6.5 SIF at 15min. Higher compression force leads to breakage of pellets during compression which showed impact drug release at acid stage. Turret speed had significant impact on final weight variation and content uniformity. The optimized process parameters Main compression force: 11.33 kP, Pre-compression force: 2.72 Kp and Turret speed: 23.56 rpm showed desired physical characteristics and drug release in 0.1N HCl which will result in lesser degradation of API at acid stage. Conclusion: It is concluded that Compression process variables in preparation of Esomeprazole MUPS were successfully evaluated using Design of Experiment approach. Keywords: process variables, Esomeprazole, Multiunit particulate system