Turmeric Curcumin Research Articles

Harnessing the Power of Curcumin: Evaluating Its Efficacy as an Antileishmanial Agent in the Fight Against Leishmaniasis

Over 100 countries are impacted by the dangerous parasite disease leishmaniasis, which is categorized as a neglected tropical disease (NTD). Protozoan parasites use sandflies and other vectors to spread the disease. Herbal compounds like turmeric curcumin have demonstrated promise in the treatment of parasitic illnesses despite their limited bioavailability and water solubility. From small, self-healing skin lesions to serious intestinal infections, leishmaniasis can cause a wide range of illnesses in humans. Since there isn’t a gold standard test for one type, mucocutaneous leishmaniasis (MCL), it can be difficult to diagnose. Treatments for MCL can be quite harmful, which emphasizes how crucial a correct diagnosis. This study aims to assess the diagnostic performance of PCR (polymerase chain reaction) for MCL and to compare the findings with the authors’ most recent clinical research findings.

Mint species (Mentha longifolia and Mentha spicata L) growth, essential oil generation and chemical components are impacted by turmeric curcumin applications

Mint essential oil has several applications in pharmacy and food industries. As mint species multiplied, active chemicals evolved, resulting in changes in their biological effects. Mint growth in Egypt’s sandy soils is hampered by abiotic stress. Phenols like turmeric curcumin reduce abiotic stress which plant suffers. Finding active chemicals in various aromatic plant species to substitute synthetic ones is an enticing approach to developing a new pharmaceutical regimen; these plants need to be studied to locate active components. Therefore, this study aimed to reduce the potential negative effects of abiotic stress in sand soil on horsemint (Mentha longifolia) and spearmint (Mentha spicata L) by applying turmeric curcumin (as organic elicitor), to assess if growing them in the new reclamation zones is a viable option in order to obtain essential oil naturally. Both species received 0, 30, 60, 90, and 120 mg L−1 turmeric curcumin. Horsemint exposed to 30 mg L−1 turmeric curcumin produced the maximum values of plant length (93 cm), fresh herb (114.73 g plant−1) and dry herb (33.81 g plant−1); spearmint × 30 mg L−1 turmeric curcumin resulted in the greatest amounts of chlorophyll a, chlorophyll b and carotenoids with values of 5.38, 1.83 and 1.45 mg g−1, respectively. The maximum values of eucalyptol (65.44%), camphor (23.81%), carvone (65.95%) and limonene (15.9%) were recorded under 90 mg L−1 turmeric curcumin. Horsemint plants subjected to 60 mg L−1 turmeric curcumin gave the highest essential oil yield (1.52 g plant−1), sesquiterpenes (31.4%), soluble sugars (102.19 mg g−1), free amino acids (8.73 mg g−1), phenols (3.71 mg g−1), flavonoids (5.28 mg g−1), free radical's inhibition (64.35%), protein (17.09%) and nitrogen (1.27 g plant−1); spearmint × 60 mg L−1 turmeric curcumin resulted in the greatest values of monoterpenes (98.76%), nitrogen (2.74%), phosphorous (0.54% or 0.17 g plant−1) and potassium (0.56% or 0.18 g plant−1). Control × spearmint gave the maximum value of sodium (0.17% or 0.04 g plant−1). To mitigate the detrimental effects of stress-related factors on sandy soil, turmeric curcumin can be applied to mint species; additionally, it could broaden the sources of natural products. On the other hand, this work provides as a guide for choosing mint species for usage in industries connected to essential oils based on pertinent components.

Testing the Feasibility and Dietary Impact of Macaroni Fortified with Green Tea and Turmeric Curcumin Extract in Diabetic Rats.

Macaroni is a commercially available Italian food product that is popular among consumers around the world. The supplementation of green tea extract (GTE) and turmeric curcumin extract (TCE) in macaroni may serve as promising and beneficial bioactive ingredients. We aimed to produce functional macaroni, assess the degree of consumer satisfaction and study the antidiabetic activity in diabetic rats. In this study, macaroni was fortified with GTE, TCE and a mixture of GTE and TCE ratio of 1:1, w/w (GTE/TCE). The resulting products were then analyzed in terms of their chemical compositions, while the degree of consumer satisfaction was monitored and the hypoglycemic and hypolipidemic effects in streptozotocin (STZ)-rats were investigated. GTE/TCE-M exhibited the strongest antioxidant activity (p < 0.05), while phenolics were most abundant in GTE-M. The overall preference for GTE-M, TCE-M and GTE/TCE-M were within ranges of 4.7-5.1, 5.9-6.7 and 6.2-8.2, respectively, in the nine-point hedonic scale. Consumption of these three preparations of macaroni (30 and 300 mg/kg each) neither decreased nor exacerbated increasing blood glucose levels in diabetic rats, while GTE-M (30 mg/kg) tended to lower increased serum triglyceride and cholesterol levels. In conclusion, GTE/TCE-M containing high amounts of bioactive EGCG and curcumin exerted the strongest degree of antioxidant activity and received the highest level of acceptance. Importantly, consumption of GTE-M tentatively ameliorated serum lipid abnormalities in diabetic STZ-induced rats by inhibiting lipase digestion and lipid absorption. Herein, we are proposing that GTE-fortified macaroni is a functional food that can mitigate certain metabolic syndromes.

Riboflavin (Vitamin B2), Turmeric (Curcumin) Photosensitizers Mediated Photodynamic Therapy, and Er, Cr: YSGG on Microleakage of Class V Cavities Restored by Resin-Modified Glass-Ionomer Cement

Purpose: The present study aimed to assess the effect of RF and CP intervened PDT and Er, Cr: YSGG laser on microleakage in class V RMGIC restorations in permanent teeth. Materials and Methods: In-vitro eighty standardized class V cavities (4×4×2) were prepared in extracted permanent molars based on ICDAS II (International Caries Detection and Assessment System II) caries severity code 0. All samples were arbitrarily alienated into four groups: Group 1, PDT mediated riboflavin photosensitizer (RF) [concentration of 150 μg/mL]; Group 2, PDT with curcumin photosensitizer (CP) [concentration of 100 μg/mL]; Group 3, Er, Cr: YSGG laser application; Group 4, control group: rinsed and dried dentin. Cavities were restored with conventional RMGIC. The specimens were immersed in 0.5% Fuchsine solution for 24 hrs. and sectioned. Microleakage scores were assessed under a microscope. Intergroup and intragroup comparisons were made at enamel and cementum margin respectively. Data were analyzed by non-parametric Kruskal-Wallis test and Wilcoxon tests at the level of significance deemed p &lt; 0.05. Results: Riboflavin and curcuminmediated PDT would produce a superior reduction (95% viz 90%) of microleakage as compared to Er, Cr: YSGG laser (85%), and no control groups. Cu-PDT observed the highest amount of microleakage with the least amount of microleakage in the control group. Conclusion: Riboflavin and curcumin photosensitizers mediated PDT and Er, Cr: YSGG laser has the potential to be utilized in class V cavities before RMGIC restorations at enamel margins without adversely affecting the marginal integrity.

Comparative studies of antibacterial activity of Ocimum Sanctum and curcuma longa leaf extracts against E. coli and Staphylococcus Aureus

Due to their traditional therapeutic use, Ocimum Sanctum (Tulsi) and Curcuma Longa (Turmeric) have been subjected to numerous antibacterial tests. To compare the antibacterial effects of tulsi (Ocimum sanctum) as well as Curcuma Longa (Turmeric) against Gram-positive (Staphylococcus aureus) as well as Gram-negative (Escherichia coli) bacteria. The method of agar well diffusion was used. In addition, different phytochemical tests were carried out. Aside from the froth test, tannin tests; Sterol tests showed positive. All of the results are presented in the form of a graph and various tables. When turmeric was used, it exhibited a 22 mm Zone of Inhibition (ZOI) in E. coli and a 17 mm ZOI in Staphylococcus aureus. When tulsi was applied, however, roughly 20mm of ZOI was found in both E. coli and Staphylococcus aureus. At six different concentrations, the diameter of ZOI was measured, methanol extract of both the Turmeric and tulsi, including 0.2 g/ml, 0.3 g/ml, 0.4 g/ml, 0.5 g/ml, 0.6 g/ml, and 0.7 g/ml.In conclusion, Tulsi leaf extract and Turmeric curcumin extract were collected to perform various antibacterial activities. The agar well diffusion method was used in this study. The bactericidal activity of different concentrations of extracts varied significantly.

Effects of Interval Training Intensity and Curcumin on expression of Endothelial Progenitor Cells mRNA and C Reactive Protein in Elderly Rats Heart.

Endothelial progenitor cells (EPCs) play a role in preventing endothelial dysfunction and increasing the angiogenesis process. Regular training increases these cells. Turmeric Curcumin has anti-inflammatory and anti-atherosclerotic properties. 49 Wistar rats were randomly assigned to control (C), Saline (S), curcumin (cur), moderate interval training (MIT), high interval training (HIT), MIT+curAndHIT+cur. The training groups trained 8 weeks,3 sessions per week and 40 minutes each session at 28 and 34 m / min. 48 hours after the last training, The gene expression of the CD34 and KDR was measured by Real-time PCR and CRP usesthe ELISA method. CD34 and KDR mRNA in cur, MIT and HIT groups showed a significant increase compared to C and Sgroups.The highest levels of CD34 and KDR mRNA were observed in HIT+curgroup. While the increase of CD3 mRNA in HIT group was greater than the cur and MIT groups(P = 0.0001). KDR showed a significant increase in MIT and HIT groups compared to C, S, cur and MIT+cur groups. Serum CRP means significantly decreased in all experimental groups compared to C and S groups. The rate of increase in EPCs mRNA in response to aerobic training is dependent on training intensity. HIT training is likely to be more effective in the repair and development of coronary arteries. These findings can be useful for cell therapy and improve cardiovascular regeneration after injury and myocardial disor-der, especially in elderly conditions.

ADDING DIFFERENT LEVELS OF TURMERIC POWDER AND CURCUMIN IN THE DIET ON SOME SERUM BIOCHEMICAL OF BROILER REARED UNDER NORMAL AND HEAT STRESS CONDITIONS

This study was carried out to elucidate the effect of supplementing different levels of turmeric powder and curcumin on serum lipid profile, protein, thyroid hormones (T3 and T4), ALT, AST enzymes, uric acid, creatine kinase and glucose. Seven-hundred and fifty chicks Ross 308, received from a local hatchery. Chicks divided into two groups, normal and heat stressed conditions, with 5 treatments and 3 replicates in which 25 chicks for each. The dietary treatments composed of basal diet (control), 50 g curcumin/ton, 75 g curcumin/ton, 1.65 kg turmeric powder/ton and 2.5 kg turmeric powder/ton. Results showed that adding turmeric powder and curcumin had significant effects (P&lt;0.05) on serum lipid profile, protein profile, T3, T4, ALT enzyme, creatine kinase, uric acid and glucose. Concerning the rearing condition, which had a significant effect (P&lt;0.05) on the serum cholesterol, LDL, total protein, albumin, T3 hormone, ALT, AST enzymes, creatine kinase, uric acid and glucose.

Complementary and alternative medicine (CAM) in Turkish cutaneous melanoma patients: A prospective study from tertiary cancer center.

Only a few studies assessed the prevalence and the predictors of complementary and alternative medicine (CAM) use specifically in melanoma patients. The aim of this study was to assess the extent of CAM use in Turkish melanoma patients. To assess the extent of CAM use and to compare sociodemographic and clinical characteristics between users and non-users in melanoma patients. One hundred melanoma patients who were seen in outpatient clinics were included in a survey using questionnaire on CAM use. Twenty-seven patients used at least one type of CAM, the majority of which were herbs (73%). Turmeric (curcumin) was the most popular herb that was used alone or in conjunction with various other herbs (41%). Living in rural areas was significantly associated with CAM use (p = 0.02). The most common reason for CAM use was intent to cure of the disease (52%). The primary source of information about CAM was a close friend or a family contact (44%). CAMs were generally used together with conventional anticancer treatment modalities (64%) and they were ingested on a regular base (72%). CAMs could easily be acquired at regular herbal stores (88%). The patients experienced almost no adverse effects with CAM use; and most cases (71%) had confidence in CAM. About half of the patients consulted with their physicians about CAM use. Minority, nearly one fourth of the melanoma cases used at least one type of CAM, the majority of which were herbs and turmeric (curcumin) was the most popular agent.

Hypoglycemic and antioxidant effects of five commercial turmeric ( Curcuma longa ) supplements

We evaluate the hypoglycemic and antioxidant effects of five commercial turmeric (Curcuma longa) supplements: (1) bulk samples, (2) turmeric root from India, (3) curcuma turmeric Pronat® , (4) turmeric & black pepper Swanson® , and (5) C3 complex® turmeric curcumin. Glucose diffusion and enzymatic starch digestion assays, using α-amylase and α-glucosidase, were performed. The antioxidant activity of turmeric supplements was measured through lipid peroxidation inhibition and the scavenging radical assay. A starch dose of 102mg/Kg of body weight (equivalent to 1g/day in humans) was used to perform the oral starch tolerance test (OSTT) in Wistar male rats. All turmeric supplements decreased glucose diffusion and α-glucosidase enzyme activity, and inhibited lipid peroxidation. The rats that received bulk samples and CT showed significantly lower glucose levels than rats receiving acarbose and those of negative control group. Our results show that biological activities of turmeric supplements vary according to the commercial presentation. PRACTICAL APPLICATIONS: The study results suggest that the hypoglycemic and antioxidant effects of five commercial turmeric supplements vary among them. The information provided would be useful to physicians and individuals using these supplements.

Extraction, Characterization, and Usage of Turmeric Curcumin for Color Coating of Metronidazole Tablets

Curcumin is a chemical compound produced by Curcuma longa plants that is widely used as a coloring agent and a dietary supplement and has some therapeutic activity. Our aim is to evaluate the use of curcumin as color coating material for metronidazole tablets. Curcumin was extracted at higher yields from three different samples of turmeric plants. The extract obtained was characterized by Infrared Red Spectroscopy (IR), Thin Layer Chromatography (TLC) and ash content and melting point (MP). The curcumin produced has an MP content ranging from 182 ° C to 184 ° C and an ash content ranging from 1.5 to 3.17 %. Curcumin material was used as a colorful agent for the coating of metronidazole tablet pills using spray coating technology. Experimental results have shown that curcumin-coated metronidazole tablets exhibit strong color stability even at higher temperatures, and that the taste of bitterness in metronidazole pills has been reduced or has disappeared entirely.

Effect of heat and microwave treatments on phenolic compounds and fatty acids of turmeric (Curcuma longa L.) and saffron (Crocus sativus L.)

Abstract Turmeric and saffron are spices with fatty acids and phenolic compounds that exert several human health benefits. Nonetheless, their bioavailability may be reduced by cooking that involves high temperatures. Thus, our aim was to evaluate the effects of domestic heat treatments with respect to untreated controls on these molecules assessed by spectrophotometry and gas chromatography: microwaving, boiling under pressure and boiling without it (compared by ANOVA, p &lt; 0.05). All treatments reduced phenolic compounds in saffron, whereas only microwaving decreased them in turmeric. Turmeric curcumin was reduced by microwaving and boiling under pressure. Turmeric and saffron showed a different fatty acid profile, which was differentially affected depending on the treatment. In conclusion, although the functional and nutritional quality of these spices can be affected, turmeric is more resistant to heat than saffron and shows a better lipid profile with high unsaturated fatty acids even after treated. Also, boiling preserved potential health-promoting phenolic compounds and some unsaturated fatty acids. Although a risk of bioactive compound loss exists, the correct cooking method can reduced it.

Preliminary Study of Various Intervals and Administration of Feed Enriched with Turmeric and Garlic on the Growth Performance of Catfish

As a food ingredient, turmeric curcumin increases appetite and increases the effectiveness of digestive organs function, while garlic increases fish growth. The combination of the two ingredients is believed to increase growth and survival rate of catfish. This study aimed to determine growth performance, Food Conversion Ratio (FCR) and Survival Rate (SR) of catfish seeds in high density fish farming based on biofloc, and supplemented with turmeric and garlic for feed. The research methodology was a complete randomized design, and treated with T1: turmeric and garlic given once a week; T2: turmeric and garlic were given twice a week, and T3: turmeric and garlic were given three times a week. Fish weight was recorded every week, then data were analyzed for fish growth using regression. The study was conducted in 4 weeks. The results showed that the best weight growth performance was obtained at T1 with the regression equation YT1 = −1.07 + 17.92. This equation provides predictions that fish harvesting can be carried out within 6 weeks, with the average weight of fish measured at 100 grams and FCR = 0.91 ± 0.016 and SR = 88.45 ± 8.89%.

Dendeng of cured duck meat in curcumin extract with added STPP, reviewed from chemical quality

The duck meat used in this study is duck meat obtained from unproductive female ducks having low tenderness and high-fat content. Curing with turmeric curcumin extract and adding STPP are ways to reduce fat and increase tenderness. Minced meat is one of the processed meat products traditionally made from ground meat plus palm sugar and other spices. Dendeng is popular in the community and is popular with young people as side dishes. The purpose of this study was to determine the chemical quality of “Dendeng” duck meat curing in the curcumin extract and the addition of STPP. The design used was a completely randomized design with a factorial pattern of 3x2, factor A (Sodium Tripolyphosphate 0%, 0.1%, and 0.2%), and factor B (Curing duck meat with curcumin 0.3 and 0.4%). The Variables observed were water content, fat content, and WHC. The data obtained were analyzed by analysis of variance (ANOVA), if there were significant differences between treatments then proceed with a real difference test of Duncan’s Multiple Range Test (DMRT). The results showed that there was an effect of adding Sodium Tripolyphosphate to WHC “Dendeng” duck meat. While the fat and water content are not affected by the addition of Sodium Tripolyphosphat, curcumin extract, and its interactions. It can be concluded that the curing with turmeric curcumin extract can be used up to 0.4% and the addition of 0.2% Sodium Tripolyphosphate is the best in terms of chemical quality.

In Vitro Anticlastogenic and Antioxidant properties of extracted and Pure form of Curcumin against Mitomycin C in Human Peripheral Leukocytes

Objectives: Turmeric is native to India and is widely used in Indian cuisine. Curcumin, the active principle of turmeric used primarily as a coloring agent in food, drug and cosmetics. The medicinal properties of curcumin are well known in ancient Indian Ayurvedic Medicine. Mitomycin C (MMC) is an antineoplastic agent used to fight a number of different cancers including cancer of the stomach, colon, rectum, pancreas, breast, lung, uterus, cervix, bladder, head, neck, eye and esophagus. It is a potent DNA cross-linker. But it has severe side effect, the prolonged use of the drug may result in permanent bone marrow damage and other various types of secondary tumors in normal cells. The present study was conducted to examine the anticlastogenic action of extracted curcumin from dry turmeric and pure curcumin against the MMC-induced chromosomal aberrations. For this purpose, in the present study, clastogenic parameter like chromosomal aberration test was conducted in peripheral human leukocytes. Methods: The antioxidant property of both extracted and pure curcumin was also evaluated by phosphomolybdenum method. Results: Our results demonstrated that, extracted as well as pure Curcumin, a strong antioxidant phyto-molecule is effective in counteracting the clastogenicity in human leukocyte in vitro. Conclusion: These results suggest that the use of turmeric in diet may be an effective protection against the health crisis generated by harmful agents.

Introducing curcumin biosynthesis in Arabidopsis enhances lignocellulosic biomass processing.

Lignin is the main cause of lignocellulosic biomass recalcitrance to industrial enzymatic hydrolysis. By partially replacing the traditional lignin monomers by alternative ones, lignin extractability can be enhanced. To design a lignin that is easier to degrade under alkaline conditions, curcumin (diferuloylmethane) was produced in the model plant Arabidopsis thaliana via simultaneous expression of the turmeric (Curcuma longa) genes DIKETIDE-CoA SYNTHASE (DCS) and CURCUMIN SYNTHASE 2 (CURS2). The transgenic plants produced a plethora of curcumin- and phenylpentanoid-derived compounds with no negative impact on growth. Catalytic hydrogenolysis gave evidence that both curcumin and phenylpentanoids were incorporated into the lignifying cell wall, thereby significantly increasing saccharification efficiency after alkaline pretreatment of the transgenic lines by 14-24% as compared with the wild type. These results demonstrate that non-native monomers can be synthesized and incorporated into the lignin polymer in plants to enhance their biomass processing efficiency.

Metabolic treatment of syndrome linked with Parkinson's disease and hypothalamus pituitary gonadal hormones by turmeric curcumin in Bisphenol-A induced neuro-testicular dysfunction of wistar rat

The metabolic shift in cholinesterase activity and inhibitor of hypothalamus pituitary gonadal hormones were hypothesized as resultant effect of Parkinson's disease (PD) which is clinically characterized by a movement disorder. This study therefore examined the effect of turmeric curcumin (CUR) on index of PD, acetylcholine esterase activity and disorder of hypothalamus pituitary gonadal hormone (HPGH) in Bisphenol-A induced injury using animal model. Forty adult male albino rats were randomly distributed into five (n = 8) groups. Group I: vehicle control (olive oil 0.5 ml), Group II was given 50 mg/kg of BPA only, Group III was given 50 mg/kg BPA + 50 mg/kg curcumin, Group IV was given 50 mg/kg BPA + 100 mg/kg curcumin and Group V was administered 50 mg/kg of curcumin only for 14 days. The study examined the effect of curcumin on acetylcholineesterase (AChE) activity, nitric oxide radical (NO•) production, HPGH (LH, FSH and testosterone), MDA level, antioxidant enzymes (SOD and CAT), in BPA induced male rat. Sperm parameters were similarly examined. The animals induced with BPA exhibited impairment to striatum, leydig cells and sertoli cells by depleting LH, FSH, testosterone and spermatozoa with reduced AChE activity and significant (p < 0.05) alteration in cerebral enzymatic antioxidants. Locomotive activity was impeded followed by the increase of brain NO• level (marker of pro-inflammation). Therapeutically, CUR promoted hypothalamus–pituitary–testicular hormones via modulation of AChE and locomotive activities, reduction of intracellular NO• level, prevention of striatum-endocrine injury as well as oxidative damage. Hence, CUR abolished HPGH dysfunction linked with PD mediated by BPA in rat.

Sifat Fisik dan Komposisi Kimia Nugget Daging Itik Afkir Curing dalam Ekstrak Kurkumin Kunyit

This study aims were to determine the physical properties and chemical compositions of nuggets made from cured- duck meat in turmeric curcumin extract. The duck meat was cured in 0.3%turmeric curcumin for 10 minutes, and then it was processed into nuggets. The duck-meat nuggets were made with variation on original nugget, nugget with added of carrots and broccoli. This research was conducted to compare descriptively between nugget of duck-meat, nugget of duck-meat plus carrot and nugget of duck-meat plus broccoli. The data obtained were analyzed by descriptive analysis. The observation found that duck-meat nugget with the addition of carrots and broccoli has a brighter color than the duck-meat only. Medium texture plus broccoli was harder than the duck-meat and the added carrots. Based on the results of the study, it can be concluded that the nugget of duck-meat with the addition of carrots and broccoli will enrich the chemical composition, with relatively similar physical properties.

Metal oxide curcumin incorporated polymer patches for wound healing

Sodium alginate and Poly vinyl alcohol (PVA) based scaffolds are very well used for wound healing purpose. Sodium alginate is a natural polymer which is used for many biomedical applications. PVA is a biocompatible polymer used in many biomedical applications. Incorporation of Titanium dioxide (TiO2) nanoparticles in the scaffold increases the wound healing property of the scaffold. TiO2 nanoparticles are biocompatible. They enhance the wound healing activity by photo catalytic property. Curcumin is used for the treatment of inflammation. It is the main active compound of turmeric Curcumin is used for treatment of wound and inflammation. It had antimicrobial and antioxidant property.

Abstract B56: Potential biomarkers for personalized oncology radiation in uterine cervical cancer

Abstract Uterine cervical cancer (UCC) is one of the most prevalent malignant neoplasms in the world. UCC develops beyond the stage in situ and is frequently treated by a combination of intracavitary radiation therapy and external beam radiation therapy; 30-40% of patients with similar prognosis factors do not respond equally to a comparable standard treatment. Therefore, the study and identification of prognostic biomarkers, which indicate the probable course of the disease in an untreated individual, and predictive biomarkers, which allow identification of subpopulations of patients most likely to respond to a given therapy, would be extremely useful in the selection of patients for the development of innovative and effective therapies for locally advanced, metastatic, and refractory uterine cervical cancer. Within work that we have been developing, we reported that gene expression of IGF1R is a strong predictive marker for lack of response to radiotherapy (p=0.018, 95% CI (1.7-41.2)), and patients HPV16 (+) have 28.6 times higher risk of failure treatment; consequently, with the present study, we proposed to determine whether expression of IGF-IR, GAPDH, HIF-1 alpha, Survivin, GLUT1, CAIX, HKII, and clinic-pathologic parameters can be used as prognostic and predictive biomarkers and as possible molecular targets for individualized treatment. Patients and Methods: This prospective cohort study included 149 patients with squamous cell carcinomas of the uterine cervix in FIGO stages IIB (n= 53) and IIIB (n=96). Of the 149 patients, 61 were treated with radiotherapy and 88 with concurrent radio-chemotherapy. Expression of the proteins CAIX, GLUT-1, HIF1α, HKII, IGF-IRα, IGF-IRβ, and Survivin was determined by immunohistochemistry in biopsies taken before treatment. Results: An overexpression was found for GAPDH (100%), followed by Survivin (87%), IGF-IRα (76.5%), IGF-IRβ (74.5%), HIF1α (74.1%), and IGF-IRα and IGF-IRβ (73%); strong expression was observed with low frequency for GLUT-1 (31.1%), CAIX (16.2%), and HKII (10.6%). Hgb level was significantly correlated with treatment response (p=0.01). With a median follow-up of 2.1 years, OS was decreased for patients overexpressing IGF-1R β (p=0.04). The OS of the subgroup of patients with anemia (Hgb &amp;lt; 11 g/dL) and concomitantly overexpressing IGF-1R and GLUT-1 was significantly decreased compared to the opposite control group (p=0.015). Conclusions: The expression of GLUT-1, IGF-1R, and Hgb (≤ 11 g/dl) is associated with poor prognosis, and thus appear to be interesting biomarkers of radiation resistance. In order to contribute to appropriate therapeutic management as a personalized neoadjuvant treatment, a prospective phase II study should be designed in the near future to evaluate the effect of turmeric (curcumin) as an inhibitor of IGF-1Rβ and GLUT1. Note: This abstract was not presented at the conference. Citation Format: Pablo Moreno-Acosta, Schyrly Carrillo, Oscar Gamboa, Alfredo Romero-Rojas, Jinneth Acosta, Diana Mayorga, Mónica Molano, Martha Cotes, Nicolas Magne. Potential biomarkers for personalized oncology radiation in uterine cervical cancer [abstract]. In: Proceedings of the AACR International Conference held in cooperation with the Latin American Cooperative Oncology Group (LACOG) on Translational Cancer Medicine; May 4-6, 2017; São Paulo, Brazil. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(1_Suppl):Abstract nr B56.

The effect of curcumin on epilepsy: an experimental review

Nearly 70 million people worldwide suffer from epilepsy. Despite administration of routine antiepileptic drugs (AEDs), nearly 30% of seizures are resistant to treatment called drug resistant epilepsy (DRE). Since the epilepsy treatment may result in consequences of multi-drugs administration or sometimes invasive surgical methods in DRE, herbal treatment can be a good alternative choice due to its easy accessibility, lower cost and fewer side effects. Although turmeric has been one of a very commonly used dietary spices and traditional herbal remedies, its derivation as a newly introduced medicine-curcumin has not been used to a large extent. In this literature, we have reviewed the available trial researches, which studied specifically antiepileptic effect of curcumin. We searched databases of Science direct, PubMed and Google Scholar (2008 to 2016) with key words of turmeric, curcumin, Diferuloylmethane, Epilepsy, and Seizure to find the related references. The major extract of turmeric curcumin has found to have antiepileptic effect according to recent surveys. It not only has no critical adverse effect, but also can protect patients from other AEDs severe side effects. It also makes it possible to gradually decrease the dose of AEDs in long-term combination therapy.