Abstract
Curcumin is a chemical compound produced by Curcuma longa plants that is widely used as a coloring agent and a dietary supplement and has some therapeutic activity. Our aim is to evaluate the use of curcumin as color coating material for metronidazole tablets. Curcumin was extracted at higher yields from three different samples of turmeric plants. The extract obtained was characterized by Infrared Red Spectroscopy (IR), Thin Layer Chromatography (TLC) and ash content and melting point (MP). The curcumin produced has an MP content ranging from 182 ° C to 184 ° C and an ash content ranging from 1.5 to 3.17 %. Curcumin material was used as a colorful agent for the coating of metronidazole tablet pills using spray coating technology. Experimental results have shown that curcumin-coated metronidazole tablets exhibit strong color stability even at higher temperatures, and that the taste of bitterness in metronidazole pills has been reduced or has disappeared entirely.
Highlights
Scientific research on color chemistry is needed to improve and maintain color stability
The extract obtained was characterized by Infrared Red Spectroscopy (IR), Thin Layer Chromatography (TLC) and ash content and melting point (MP)
Experimental results have shown that curcumin-coated metronidazole tablets exhibit strong color stability even at higher temperatures, and that the taste of bitterness in metronidazole pills has been reduced or has disappeared entirely
Summary
Scientific research on color chemistry is needed to improve and maintain color stability. Natural coloring additives are generally considered to be coloring additives derived from plant or animal sources by extraction or other physical processing[1,2]. Examples of natural colorants include carmine, annatto extract, grape skin extract, turmeric, saffron and beta-carotene, which are the major natural color additives used in food products. Synthetic coloring additives include chemically synthesized substances such as tartrazine, erythrosine and indigo carmine. Natural or vegetable colors are less in use because they are expensive or difficult to extract [1, 2]. Curcumin (synonyms: turmeric yellow, kurkum, INS No 100(i)) is an orange-yellow crystalline powder
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