We present an application of the residual-based variational multiscale turbulence modeling (RBVMS) methodology to the computation of turbulent Taylor–Couette flow at high Reynolds number. We show that the RBVMS formulation globally conserves angular momentum, a feature that is felt to be important for flows dominated by rotation, and that is not shared by standard stabilized formulations of fluid flow. Weak imposition of Dirichlet boundary conditions is employed to enhance the accuracy of the RBVMS framework in the presence of thin turbulent boundary layers near solid walls. Calculation of conservative boundary forces and torques is also presented for the case of weakly enforced boundary conditions. NURBS-based isogeometric analysis is employed for the spatial discretization, and mesh refinement is performed to assess the convergence characteristics of the proposed methodology. Numerical tests show that very accurate results are obtained on relatively coarse grids. To the best of the authors’ knowledge, this paper is the first to report large eddy simulation computations of this challenging test case.