The tangential injection flow commingled with the mainstream could be abstracted as mixing layer, and profound importance is attached to aero-optical reduction for film-cooling target-seeking vehicles in engineering application. Leveraging the in-house code based on explicit fifth-order Weighted Compact Nonlinear Scheme and ray-tracing method, the supersonic mixing layer is numerically simulated to investigate the effect of inflow disturbance on large-scale structure growth and aero-optical reduction. The vortex growth would be stimulated somewhere when the frequency of inflow perturbation added is close to the local characteristic most unstable value. Based on such cognition, different techniques of super-harmonic and sub-harmonic disturbance are employed for effective aero-optical suppression schemes in the following research. The sub-harmonic one without phase shift shows such ability in the whole turbulent region, and additional perturbation of white noise is also promising for better control consequence.