Aiming at the problem of low efficiency of the JP80D turbocharger rotor system, an optimization analysis of the turbocharger impeller was carried out. Since the second-order critical speed of the rotor system will produce resonance hazards within the system’s operating speed range, the second-order speed needs to be optimized away from the working speed. Therefore, this paper adopts the methods of finite element analysis and Campbell diagram analysis. The three parameters of impeller’s long and short blade combination, blade thickness and blade forward inclination angle are optimized by single-variable progressive optimization method, and then the compressor is simulated by finite element. Finally, by comparing the distribution of the internal flow field characteristics of the compressor, the optimal structural parameter scheme is obtained. By optimizing the impeller to make the second-order speed far away from the working speed, the internal flow field is in an excellent working state. It greatly improves the unbalanced performance of the rotor system, and avoids the problem of low efficiency due to basic excitation and unbalance.