Fluid–Structure Interaction (FSI) is an important phenomenon in many fields. In this study, the Moving Particle Simulation (MPS) along with Finite Element Method (FEM) are coupled together. MPS-FEM coupled method is used as the numerical simulators to estimate the effects for structures by the fluid pressure of the tsunami. This simulator consists of two solvers: fluid analysis and structure analysis. The fluid analysis is based on MPS and the structural part is analyzed by using FEM. In this paper, for verification of the MPS-FEM coupled method, the problem of hydrostatic pressure on a structure is calculated. The results are compared with the theoretical values and the results obtained by the original FEM analysis. We confirmed that the MPS-FEM coupling method can achieve adequate accuracy. Furthermore, the MPS-FEM coupled simulation for the turbine building of Fukushima Dai-ichi Nuclear Power Station Unit 1 has been done.