To reveal the seismic dynamic response of the pile-supported tunnel group in the soil-rock mixture deep backfill region, a three-dimensional finite element model was established based on the engineering conditions of the subway section and three tunnels with close access lines. Subsequently, the seismic dynamic response of the tunnel lining structure was studied. The results show that: Under the action of seismic, the soil-rock mixture stratum presents nonlinear characteristics with shear failure and plastic deformation. In addition, the acceleration and earth pressure of the soil-rock mixture stratum is in a “saturated” state; The seismic dynamic response of the three tunnels influences each other. The bending moments in the X and Y directions of the tunnel lining cross-section are distributed in “X” and inverted “V” shapes, respectively. Meanwhile, the tensile stress and shear stress are distributed in an “X” shape; Under the action of seismic, the main failure form of tunnel lining is tension shear failure, and the most vulnerable position is the left and right arch foot, followed by the left and right arch shoulder; The bending moment of the pile body changes nonlinearly in the height direction. The most significant bending moment value appears at the top 1/5 of the pile length and the junction of different strata. Furthermore, the most significant horizontal displacement of the lining structure occurs at the tunnel vault.