Event Abstract Back to Event Synthesizing dynamic biomaterial matrices through the controlled incorporation of glycosaminoglycans Kristi S. Anseth1, 2 1 University of Colorado Boulder, Department of Chemical and Biological Engineering, United States 2 University of Colorado, Howard Hughes Medical Institute, United States The extracellular matrix is a dynamic environment that provides both chemical and mechanical cues to cells, and many of these matrix cues play important roles in wound healing, development, and even disease progression. The outcome often depends on both bidirectional signaling and dynamic adaptation of the cellular environment. This talk will provide several examples where glycosaminoglycans (GAGs) can be incorporated into biomaterial matrices to impart diverse and dynamic biophysical and biochemical properties. For example, reversible and irreversible crosslinking reactions allow for the synthesis of GAG-based hydrogels with tunable viscoelastic properties, material modulii, and degradability. From a biochemical perspective, sulfation patterns in GAGs are known to protect and control the release of many growth factors in the extracellular matrix. So this presentation will also review some of the recent advances in click chemistry and controlled polymerizations that are enabling the synthesis of biomacromolecular GAG-mimics, polymers with controlled sequences of saccharide functionalities to allow for the sequestration and local presentation of growth factors. Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: New Frontier Oral Topic: Biocompatibility of nanobiomaterials Citation: Anseth KS (2016). Synthesizing dynamic biomaterial matrices through the controlled incorporation of glycosaminoglycans. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.00245 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Kristi S Anseth Google Kristi S Anseth Google Scholar Kristi S Anseth PubMed Kristi S Anseth Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.