In this paper, we report a liquid-based tunable Cylindrical Dielectric Resonator Antenna (CDRA), whose resonance is varied by loading the cavity installed in the CDRA with different volumes of liquid. The tunability of the CDRA is investigated by loading the cavity with two different types of liquids, one with lower permittivity (i.e.) oil and the other with higher permittivity (i.e.) water. CDRA loaded with oil is found to be tunable over a small frequency range of 32MHz (5.76GHz to 5.728GHz), whereas the change in water volume in the cavity provides a wide tuning range of 452MHz (5.76GHz to 5.308GHz). Further, the antenna gain is found to be almost constant, around 5.1 dB, for oil-based CDRA. In a water-filled cavity, the gain is observed to reduce by 1dB as the volume is increased from 0 to 100%.