Tumor Vascular Bed Research Articles

Influence of noradrenaline on local tumour blood flow

The local blood flow in a transplantable rat sarcoma and in normal rat muscle and subcutaneous tissue was studied by local 133Xe clearance technique. Noradrenaline, mixed and injected with the isotope, reduced significantly the local blood flow in both tumour and normal tissues. This suggests that the tumour vascular bed, opposite to what has earlier mostly been stated on the basis of lack of adrenergic innervation, might be directly influenced by vasoactive drugs.