Tumor Texture Research Articles

9058 Analysis of tumor texture on a pre-treatment CT scan predicts treatment outcome in NSCLC patients

9058 Analysis of tumor texture on a pre-treatment CT scan predicts treatment outcome in NSCLC patients

Relative indications for radiosurgery and microsurgery for acoustic schwannoma.

The physical and biological principles underlying the use of radiosurgery for the treatment of vestibular schwannomas of up to 2.5 cm in diameter are reviewed together with the historical controversies that have surrounded its introduction. The results in terms of mortality, quality of life, preservation of facial movement and hearing, incidence of shunt-dependent hydrocephalus, cancer neogenesis and brain stem damage are compared in the Marseilles series of 600 microsurgical procedures and 830 Gamma knife procedures and with the peer-reviewed literature. The key principles of a steep profile to radiation exposure at the tumour margin, careful topographical planning of the radiation against the tumour shape to minimise the radiation dose to the cranial nerves and brain stem, early tumour swelling, tumour texture and national history of the tumour are analysed. Protocols for the management of unilateral schwannoma, Type II neurofibromatosis (both the Wishart and the Gardner types) and residual/recurrent tumours are presented. In summary, the growth of nearly 97% of vestibular schwannomas (up to 2.5 cm) is arrested by the Gamma knife, the facial nerve is preserved in almost all cases and hearing may be preserved at its pre-operative level in nearly 70% of cases without the complications of microsurgery.

Computerunterstützte Ultraschall-B-Bild-Texturanalyse experimenteller Lebertumoren

Primary liver cancer has been induced experimentally in female Wistar rats by diaminoazobenzene intoxication or subcapsular liver implantation of Novikoff cell suspensions. The ultrasonic B-scan image of these malignant tumours are described via statistical texture parameters in respect of image brightness, microtexture and macrotexture. A discrimination of the tumour texture profiles is possible with an accuracy of about 80%. There are correlations between ultrasonic image parameters and histomorphological tissue components but there is no specific link between the histological tumour-type and these B-scan data.

Medical pattern recognition pitfalls in a clinical setting: renal cell carcinoma survival prediction.

Three studies to predict renal cell carcinoma patient survival from tumor textures found in digitized early venous phase arteriograms were successful individually. However, when the three methods were compared, they were not consistent and no single method was clinically useful. The first study predicted 5 yr survival of 37 patients with 87% accuracy. The second study added 29 patients to the data base; the poor survival of the 21 patients who died within 5 yr of diagnosis was predicted with 80.9% accuracy. When 27 of these cases were redigitized with a laser scanner, average survival prediction accuracy was 78%. In these studies, digitization hardware, radiographic technique, normalization methods, window selection, and contrast medium distribution all contributed to differences in the statistics separating poor from good patient survival.

The ultrasound image texture of liver tumors

The ultrasound image texture of liver tumors

Studies in variation associated with the measurement of solid tumors

The existing system for solid tumor evaluation is criticized and revised criteria are proposed. The foundation for this analysis is a tumor stimulation experiment to determine the distribution associated with measurement of solid tumors. This tumor simulation experiment was conducted among 26 oncologists in order to assess the errors associated with the measurement of solid tumors by means of palpation. Tumor size, shape, and texture were included as study factors. Tumor texture did not appear to affect measurement outcome. Overall, the statistical law governing tumor area measurement is best described as a log-normal distribution. Under this assumption, the sufficient statistic for the evaluation of tumor response or progression is simply the ratio of the tumor areas at each evaluation. The data generalize to permit the construction of statistical power curves for the probability of declaring response or progression, based upon the theoretic tumor/area ratios. Response and progression criteria are related in logarithmic proportion, i.e., a 50% decrease for response corresponds to a 100% increase for progression. The use of more sensitive progression criteria (a 25% increase in solid tumor area), in light of the nature of tumor measurement error, can lead to premature rejection of any therapy that stabilizes or reduces disease. Furthermore, the use of specified cutoffs for progression and response introduce a significant error into clinical evaluations of solid tumors.

Stromal aspects of breast carcinoma

In invasive breast carcinoma, there are wide variations in the ratio of neoplastic cells to stoma and in the relative proportions of the various stromal elements such as connective tissue, elastic tissue, blood vessels and inflammatory cells. The inter-relations between these stromal components and the neoplastic cells impart diagnostic features, determine the texture of the mammary tumors and influence their pattern of growth. In the present report some aspects of the stromal reaction are presented; in particular, ultrastructural features of the stroma are correlated with gross traits of breast carcinoma. Electron microscopic study of a series of human scirrhous carcinoma of the breast revealed a stromal population of mesenchymal cells with features of myofibroblasts. These cells displayed prominent rough endoplasmic reticulum, well-developed Golgi zones, and longitudinal bundles of microfilaments with dense bodies. The nuclei frequently had irregular contours with indentations of the nuclear membrane. Part of the cell surface was, at times, covered by a layer of fibrillar material resembling basal lamina. Intercellular junctions were observed between myofibroblasts. It is proposed that myofibroblasts may play a role in the retraction phenomena observed in scirrhous carcinoma such as dimpling of the skin. Elastosis, an increase of elastic tissue, a common occurrence in scirrhous carcinoma, could also contribute to the retraction process.