Coccidiosis is regarded as the parasitic disease that has the greatest economic impact on poultry production specially in the case of broilers chickens. Chemotherapy for coccidiosis is very costly, for example, In the UK, it is estimated that coccidiosis costs the poultry industry in excess of £40 million annually. If the control of the coccidian parasite could be made more economical, these savings could be passed on to the consumer. In addition there are some concerns about the side effects of drug residues in poultry products in common preventive procedure with coccidiostatic agents, thus the use of plant products that function by mechanisms other than those of chemotherapeutics, with the additional advantage of a natural origin will be considerable. Antioxidant compounds could hold promise for the control of Eimeria infections due to the association of coccidial infection with lipid peroxidation of the intestinal mucosa. In a study Four plan t extracts with antioxidant activity were screened for their anticoccidial activity in vivo with toltrazuril as the positive control. Combretum woodii (160 mg/kg) proved to be extremely toxic to the birds, while treatment with Tulbaghia violacea (35 mg/kg), Vitis vinifera (75 mg/kg) and Artemisia afra (150 mg/kg) resulted in feed conversion ratios similar to toltrazuril, and higher than the untreated control. All the plant extracts showed adequate antioxidant activity, with toltrazuril being more effective than the plant extracts. T. violacea also significantly decreased the oocyst production in the birds. From this study we conclude that antioxidant-rich plant extracts have potential benefits in treating coccidial infections.