ObjectiveTo report an uncommon case of a patient with an isolated deep-seated brain tuberculoma. MethodsCase illustration and discussion on the pathogenesis and current clinical and surgical management of this condition. ResultsGross total resection was achieved through a left frontal craniotomy and a trans-sulcal approach using a tubular retractor system for access. The patient presented with an isolated brain lesion without any primary foci in the lung parenchyma or any other organ. Antifimic treatment began as soon as the diagnosis was confirmed by PCR. ConclusionsTB continues to be a public health burden in developing countries and is still considered among the most lethal infectious diseases in the world. The main objective of minimally invasive surgery of deep-seated lesions is to reduce damage caused by prolonged brain retraction required to access these lesions. Tubular retractors could be advantageous for tumor resection in deep regions.