The increased use of TiO2 nanoparticles in manufacturing and commercial products has led to environmental contamination and health issues. This study aimed to apply tubular ceramic membrane fabricated using low-cost clays (kaolin, quartz) along with hydroxypropyl methylcellulose binder for the separation of TiO2 nanoparticles from water. The prepared tubular ceramic membrane exhibited excellent water permeability (1.4945 × 10−7 m3/m2s kPa) with an average pore size of 0.178 μm and porosity of 40 %. Cross flow microfiltration experiments using TiO2 nanoparticles suspension were performed by varying the applied pressure (138–414 kPa), cross flow velocity (2.41 × 10−3 - 5.63 × 10−3 m/s), pH (4–11) and feed concentration (0.05–1 wt%). The permeate flux increased linearly with an increase in the pressure as well as cross flow velocity with a maximum permeate flux of 4.24 × 10−5 m3/m2s at 414 kPa, whereas a reduction in permeate flux was observed with increasing feed concentration of TiO2. The membrane displayed 100 % separation efficiency at all the investigated pressures. Furthermore, the membrane fouling mechanism during the microfiltration process was analyzed using resistance-in-series model. Results demonstrated that filtration resistance (Rf) and total resistance (Rt) decreased with increasing cross flow velocity from 2.41 × 10−3 m/s to 5.63 × 10−3 m/s, whereas filtration resistance remained constant at high pressures. The estimated membrane cost is 253 USD/m2 based on raw materials, energy consumption, manpower and equipment cost. These promising results elucidated the suitability of tubular ceramic membrane towards the removal of TiO2 from wastewater.