Tubular Carcinoma Of Breast Research Articles

Clinicopathologic hallmarks of mammary tubular carcinoma

Tubular carcinoma of the human breast is a rather uncommon neoplasm, which is characterized by particular histopathologic features and which seems to be either "scored down" (as grade I carcinoma) or overdiagnosed. Since this special variant of mammary cancer has been shown to respond more favorably to therapy than do common infiltrating carcinomas, its recognition as a genuine entity is important. Nineteen cases were studied and compared with the 110 tubular carcinomas reported in the literature. The basic clinicopathologic and histopathologic characteristics of true tubular carcinoma are discussed.

Patients' immune response to breast and lung carcinoma-associated Thomsen-Friedenreich (T) specificity.

We report here sensitive and specific measurement of immune responses of patients with certain kinds of carcinoma toward the physically and chemically well defined T antigen isolated from healthy human erythrocytes. Over 90% of adenocarcinoma tissues tested possess T-specific immunoreactive structures as determined with human antisera, in contrast to healthy tissues and benign lesions. Adenocarcinoma patients recognize the carcinoma-associated T antigen as foreign. Delayed-type skin hypersensitivity reaction to T antigen (DTHR-T) was positive in all 25 lung adenocarcinoma patients tested, in 88% of 101 patients with ductal, in 43% of 30 patients with lobular or tubular breast carcinoma and in 9/9 patients with adenocarcinoma of body cavities. Patients of all Stages reacted positively. All 7 patients with small cell lung carcinoma and 3/5 with malignant melanoma had a positive DTHR-T. None of 17 patients with malignant brain tumors, leukemia or Hodgkin's disease, sarcoma or thyroid carcinoma reacted. The DTHR-T was specific in that all 77 healthy persons and 48/49 with other diseases, including 23/24 with non-cancer lung disease were negative; one patient with organizing interstitial pneumonitis was positive. This points to a possible source of false positive reactions. 91% of 149 patients with histologically benign breast disease had a negative DTHR-T; the histology of some of the positive ones was reexamined, 2 proved to have carcinoma in situ.

Tubular carcinoma and sclerosing adenosis

Recent ultrastructural studies have shown that tubular carcinoma of the breast lacks basal lamina. This study was undertaken to determine the usefulness of light-microscopic examination of PAS staining for basal lamina in the differentiation of tubular carcinoma and sclerosing adenosis. Ten cases of tubular carcinoma show no basal lamina except for an occasional short segment. Ten cases of sclerosing adenosis show intact basal lamina except for short focal discontinuities. It is concluded that the lack of basal lamina in tubular carcinoma and its presence in sclerosing adenosis is a useful differential feature.

Delayed-type skin hypersensitivity reaction (DTH) to thomsen-friedenreich (T) antigen as diagnostic test for human breast adenocarcinoma

One intradermal (i.d.) injection of human erythrocyte T antigen in the upper outer arm contralateral to any breast lesion elicits a delayed tuberculin-type hypersensitivity reaction (DTH) in breast carcinoma patients. It is necessary to inject simultaneously but separately the same quantity of MN antigen (about 6--8 cm apart), from which the T Antigen has been prepared, since particularly patients with Stage I breast carcinoma (Internatl. nomenclature) and those with benign breast disease may significantly react to it. The extent of reaction to MN antigen must be subtracted from the reaction to T antigen before interpreting results. DTH response to T antigen was 85% accurate among 67 patients with ductal breast carcinoma of all Stages (including non-invasive), 95% accurate (5% so far falsely positive) among 95 patients with benign breast disease and it was 100% accurate (no false positives) among 36 "healthy" persons tested. Among 18 patients with the comparatively rare and less ominous lobular and tubular breast carcinomata, the DTH reaction was positive in 8 of 16 (50%) patients with lobular, and in none of 2 patients with tubular breast carcinoma.

Tubular carcinoma of the male breastReport of a case

Tubular carcinoma of the male breast is a rare neoplasm which may have a biological behavior comparable to its counterpart in females. A case of male tubular carcinoma treated by radical mastectomy and postoperative irradiation is reported. There was a metastasis to one axillary lymph node at the time of diagnosis. No associated areas of intraductal or infiltrating scirrhous carcinoma were found. Microscopic gynecomastia was present. The patient is alive and well 8 years postoperatively.