Tubular Apocrine Adenoma Research Articles

Syringocystadenoma Papilliferum of the Back Combined with a Tubular Apocrine Adenoma

Syringocystadenoma papilliferum (SCAP) and tubular apocrine adenoma (TAA) are rare benign sweat gland tumors. SCAP and TAA may have a histopathologic overlap, but few cases of a SCAP combined with a TAA have been reported. Herein we describe an unusual case of a SCAP co-existing with a TAA located on the back of a 12-year-old girl.

Syringocystadenoma Papilliferum in Co-existence with Tubular Apocrine Adenoma on the Calf

Syringocystadenoma papilliferum (SCAP) occurs singly or in association with other tumors. Although it is rare, the association of tubular apocrine adenoma (TAA) with SCAP in the background of nevus sebaceous (NS) on the scalp is well documented. However, the co-existence of these two tumors without background of NS has not been reported on the extremities. We report a case of SCAP associated with TAA on the calf without pre-existing NS in an adult.

Tubular apocrine adenoma of the nose

Auteur(s) : Tsuyoshi MITSUISHI tmitsu@nms.ac.jp, Seiji KAWANA Department of Dermatology, Nippon Medical School, 1-1-5 Sendagi, Bunkyou-ku, Tokyo, 113-8603, Japan A 61-year-old female was referred to our hospital for evaluation of a 6-month history of a solitary nodule on the nose. She did not have any notable medical history. On clinical examination, a hard, elastic, reddish nodule with a rough surface, 7 × 6 mm in diameter, was observed on the nose (figure 1A). The nodule was surgically [...]

Tubular Apocrine Adenoma: Presentation in the Vaginal Introitus of an Eight‐Year‐Old

Tubular apocrine adenoma is a very rare hamartomatous lesion that to our knowledge has never been described in the anogenital region in the pediatric population. A brief report of a tubular apocrine adenoma in the vaginal introitus of an 8-year-old.

A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus

Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor. TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in a nevus sebaceus (NS). Herein, we report on a 40-year-old Korean woman with TAA associated with SCAP that developed in a NS located on the scalp.

Naevus sebaceus on the female breast accompanied with a tubular apocrine adenoma and a syringocystadenoma papilliferum

Conflicts of interest: none declared. Sir, Tubular apocrine adenoma (TAA) is a very rare sweat gland tumour, first described in 1972.1 It was proposed as an independent clinical entity consisting of a benign appendage tumour of apocrine origin often associated with naevus sebaceus (NS).2 It is commonly located on the face and scalp. We report an unusual case of NS on the breast, which was accompanied with a TAA and a syringocystadenoma papilliferum (SCAP). A 77‐year‐old Japanese woman presented with several cutaneous lesions on her left breast. Physical examination revealed the lesions to consist of light‐brown, slightly elevated, linearly arranged plaques, an ulcerated intracutaneous nodule, and a red pedunculated nodule. The light‐brown plaques had been present since birth. In the plaques, there were small bean‐sized papules and fingertip‐sized, slightly elevated macules, forming a 10 × 4 cm, gently curved lesion as a whole at the upper lateral side of the left breast (Fig. 1, shown by dotted line with thin arrows). Then, 5 months prior to her visit, an asymptomatic, 10‐mm diameter, intracutaneous nodule with central ulceration (Fig. 1, arrow), and a red, 25‐mm diameter, pedunculated nodule resembling a raspberry (Fig. 1, arrowhead) appeared.

Mohs micrographic surgery for tubular apocrine adenoma

Mohs micrographic surgery for tubular apocrine adenoma

An unusual hamartoma of the folliculosebaceous‐apocrine unit: a case report

Hamartoma is a neoplasm-like lesion composed of an abnormal mixture of tissues native to the area. We report on an unusual example of a hamartomatous lesion that showed an abnormal mixture of elements of the folliculosebaceous-apocrine unit and arrector pili muscle. A 13-year-old female presented with two nodules situated 2 cm apart on the lower leg that were present since birth. The patient reported some enlargement and slight pain of the otherwise asymptomatic lesions during 2 years, before they were surgically removed. The patient obviously had no skin problems afterwards; her 12-year follow-up was significant for leucopenia and nephrolithiasis. The biopsies from both lesions looked identical. Each lesion was biphasic, i.e. composed of a predominant mesenchymal component and epithelial elements. The mesenchymal part resembled a leiomyoma, or in minor areas, the constituting cells had a myofibroblastic appearance. Encased within the mesenchymal component were large infundibulocystic structures and plentiful grouped and scattered roundish solid epithelial nodules, duct-like, glandular, and tubular elements. Some of the epithelial structures were reminiscent of those seen in tubular apocrine adenoma; others resembled syringomatous elements. We interpreted this unusual lesion as a hamartoma of the folliculosebaceous-apocrine unit.

Tubular Adenoma of the Skin with Follicular and Sebaceous Differentiation

The main controversies regarding tubular apocrine adenoma and papillary eccrine adenoma are whether they are two distinct entities or are the very same tumor, and if so, which lineage of differentiation (apocrine versus eccrine) it pursues. We report two cases of tubular adenoma with follicular and, in one case, additionally, sebaceous differentiation. The features in both cases indicated apocrine differentiation of the tubular component. One patient was a 60-year-old woman with a 1-year history of a solitary nodule on the scalp. The other patient was a 48-year-old woman with a solitary nodule of unknown duration located on the back. In both patients, the tumors were surgically removed. The patients were alive and well 2.5 and 2 years after surgery, respectively. The histologic features that both cases had in common included the combination of a tubular adenoma, foci of follicular differentiation, and areas of immature squamous metaplasia. In case 1, follicular differentiation was seen in the form of strands of basaloid cells surrounded by a stroma resembling the embryonic perifollicular sheath. Some aggregates of basaloid cells were juxtaposed with small collections of plump fibroblasts, imparting a resemblance to rudimentary follicular germs associated with follicular papillae. Many minute lumens surrounded by more eosinophilic cells were seen within the strands. In case 2, follicular differentiation was seen as several infundibulocystic structures surrounded by isthmic epithelium housing scattered mature sebocytes. In addition, there were areas reminiscent of desmoplastic trichoepithelioma (columnar trichoblastoma). In both cases, the areas with immature squamous metaplasia were represented by solid nodules that were mostly devoid of lumens and a peripheral basal/myoepithelial cell layer. In conclusion, these two cases of cutaneous tubular adenoma with accompanying follicular and sebaceous differentiation give further support to the proposition that the majority of these neoplasms have apocrine differentiation. Rare cases occurring in the sites normally devoid of apocrine glands may represent the eccrine counterpart.

Tubular apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal

Tubular apocrine adenoma (TAA) is a very rare sweat gland tumour. Comprehensive review of the literature reveals that TAA in the external auditory canal (EAC) has not yet been reported. We report a case of TAA in the EAC, together with characteristic histopathological findings.

腋窩に生じたTubular Apocrine Adenomaの1例

腋窩に生じたTubular Apocrine Adenomaの1例

Adenoma tubular apocrino

We report the case of a 26-year-old man with an axillar tumour composed of tubules lined by two rows of cells showing decapitation secretion, which was diagnosed as tubular apocrine adenoma. We discuss on the nosology of this entity, particularly its controversial relationship with syringocystadenoma papilliferum and papillary eccrine adenoma.

Tubular Apocrine Adenoma in Association with Syringocystadenoma Papilliferum

Tubular apocrine adenoma is a very rare sweat gland tumor. In this report, a case of tubular apocrine adenoma in association with syringocystadenoma papilliferum on the scalp is presented. The stroma of the tubular apocrine adenoma consisted of numerous, young fibroblasts with mitotic activity. It was difficult to distinguish stromal cells and epithelial cells from each other in some areas. The characteristics and differences in histopathologic and immunohistochemical findings in these tumors are described.

A Case of Tubular Apocrine Adenoma

A Case of Tubular Apocrine Adenoma

A Case of Tubular Apocrine Adenoma

A Case of Tubular Apocrine Adenoma

Tubular Apocrine Adenoma with Eccrine and Apocrine Immunophenotypes or Papillary Tubular Adenoma?

A case of papillary tubular adenoma is reported. On microscopic examination the lesion, located on the scalp, showed a tubular-branching pattern, opening on the skin surface, and features of decapitation secretion. Immunohistochemical evidence of both eccrine and apocrine differentiation was found. This case, which on a clinicopathological basis alone could be classified as tubular apocrine adenoma, illustrates the difficulties in contrasting the latter to its eccrine counterpart (papillary eccrine adenoma) and suggests that the terms papillary tubular adenoma or tubulopapillary hidradenoma more accurately describe these lesions.

Ki-67 and p53 expression in cutaneous Bowen's disease: an immunohistochemical study of fixed-embedded tissue sections.

DF3(CA15-3) monoclonal antibody detects the 20 amino acid sequence of epithelial mucin. In normal cutaneous tissue DF3 antibody exhibits strong and constant positive reactivity with sebaceous and secretory segments of eccrine and apocrine sweat glands. All epidermal tumors are DF3 negative but poorly differentiated squamous cell carcinoma. Various adnexal tumors such as eccrine hidrocystoma, tubular apocrine adenoma, syringocystadenoma papilliferum, eccrine poroma, eccrine spiradenoma, clear cell hidradenoma, mixed cell tumor, eccrine porocarcinoma, extramammary Paget's disease and adenoid cystic carcinoma are DF3 positive, which indicates epithelial mucin production by these tumors.

Is Tubular Apocrine Adenoma a Distinct Clinical Entity?

A 75-year-old Japanese man developed a tubular apocrine adenoma (TAA) (tubulopapillary hidradenoma with apocrine differentiation, a rare skin tumor), within a long-standing organoid nevus on the parietal area of his scalp. Histologically, the tumor consisted of dilated ductlike areas with some atypism and apocrine glandlike areas surrounded by myoepithelial cells. The superficial part of the tumor was connected to the epidermis and showed some of the characteristics of syringocystadenoma papilliferum (SCAP). The close relationship between TAA, SCAP, and papillary eccrine adenoma (PEA) is discussed. According to 19 reported cases of TAA, SCAP might occur together with TAA when they are preceded by an organoid nevus, and they might represent a spectrum of disease. Although TAA and PEA may represent another spectrum (designated as tubulopapillary hidradenoma), the relationship to SCAP should be considered in understanding and diagnosing an intermediate case.

Papillary Eccrine Adenoma

A case of papillary eccrine adenoma of the thigh of a 63-year-old woman is reported. Histologically, the tumor was composed of cystic dilated and branching tubular structures with papillary projections into the lumen, surrounded by a fibrous stroma. In addition, in some areas it was composed almost exclusively of solid strands of epithelial cells. The tumoral eccrine differentiation was assessed by immunohistochemical studies. Problems of differential diagnosis with low-grade sweat gland carcinoma and with tubular apocrine adenoma are discussed.

An unusual presentation of a congenital benign apocrine hamartoma

A case of an unusual benign apocrine hamartoma was studied by light microscopic, immunohistochemical, and electron microscopic methods. This tumor clinically showed a linear configuration and was located on the midline chest of a pubescent male. Microscopic studies revealed features of both a tubular apocrine adenoma and a syringocystadenoma papilliferum.