20MnMoNb alloy steel is a structural steel for forgings with good mechanical properties, which is typically used in the manufacture of pressure vessel tube sheets. The mechanical properties of 20MnMoNb at different temperatures were systematically studied. It is shown that the 20MnMoNb material has the good high temperature resistance. With the increase of temperature, the yield strength and tensile strength of the material have little difference. The tensile strength is nearly 800MPa at high temperature, and the yield strength is about 643MPa, which could meet the complex working environment of the high pressure heaters. It is helpful to improve the accuracy of analytical design results and provide a data base for the revision of subsequent material standards.