Profile Of Tuberculosis Research Articles

Profile of Tuberculosis in Children in Taman District, Sidoarjo Regency, Indonesia

Highlight: Pediatric tuberculosis patients profile using the medical records was determined.The most pediatric tuberculosis patients under five years have pulmonary tuberculosis.Pediatric tuberculosis patients received BCG immunization had a contact with adult tuberculosis patients histories. Abstract:The prevalence of tuberculosis (TB) in Indonesia is 391 per 100,000 population with the number of deaths around 110,000 cases in 2016. This study is descriptive research that aims to determine the profile of pediatric TB patients using the medical records at Taman public health center the period 2016-2019 with a total sampling technique. The sample in this study were 31 pediatric patients aged 0-14 years with a history of TB. Pediatric TB patients aged >5 years (58.1%) and who aged ≤5 years (41.9%). Pediatric TB patients had pulmonary tuberculosis (83.9%) and those who had extrapulmonary tuberculosis (16.1%). Pediatric TB patients aged ≤5 years had good nutritional status (32%) and who had poor nutritional status (27.2%). Meanwhile, pediatric TB patients aged >5 years had poor nutritional status (22.7%) and who had good nutritional status (18.1%). Pediatric TB patients who had a history of contact with adult TB patients (86.7%) and who did not have a history of contact with adult TB patients (13.3%). Pediatric TB patients who had received BCG immunization (86.2%) and who had not received BCG immunization (13.8%). This study concludes that most pediatric TB patients are >5 years old, almost all pediatric TB patients have pulmonary tuberculosis. Pediatric TB patients aged ≤5 years are more likely to have good nutrition. Meanwhile, there were more pediatric TB patients aged >5 years who had poor nutritional status. Almost all pediatric TB patients had a history of contact with adult TB patients and had received BCG immunization.

Profile of Tuberculosis in Children and Adolescent at Dr. Soetomo General Hospital Surabaya

Introduction: Tuberculosis is one of ten leading causes of death worldwide, including Indonesia. Indonesia is one of seven countries that causes 64% deaths due to tuberculosis. Tuberculosis is caused by Mycobacterium tuberculosis through droplet nuclei in the air. It can occur to any group age, including children and adolescent, if there is a contact history of people with tuberculosis infection. In 2016, one million children had tuberculosis and around 250,000 children died because of tuberculosis. This study aimed to know the profile of tuberculosis in children and adolescent at Dr. Soetomo General Hospital Surabaya.Methods: This was a descriptive study using retrospective approach. Sample of this study was collected from electronic medical record provided by Dr. Soetomo General Hospital Surabaya using statistic formula of single sample for estimated population proportions of children and adolescent with tuberculosis from 2013-2017, with total samples of 149 people.Results: There were 149 samples of children and adolescent patients with tuberculosis. Most of the children were mostly 0-4 years old and 57% were female. 84% of the children had been immunized with BCG and classified as moderate, and 35% were under nutritional status. This study showed that 67% of the children in household contacts of adult tuberculosis patients also had tuberculosis. The most frequent symptoms of tuberculosis in children and adolescent were fever (72%) and cough (80%).Conclusion: Tuberculosis in children and adolescent is more likely to occur in children than adolescent, especially children within group age of 0-4 years old. The number of pulmonary tuberculosis in children and adolescent are higher than extrapulmonary tuberculosis.

Profile of Tuberculosis in Children and Adolescent at Dr. Soetomo General Hospital Surabaya

Introduction: Tuberculosis is one of ten leading causes of death worldwide, including Indonesia. Indonesia is one of seven countries that causes 64% deaths due to tuberculosis. Tuberculosis is caused by Mycobacterium tuberculosis through droplet nuclei in the air. It can occur to any group age, including children and adolescent, if there is a contact history of people with tuberculosis infection. In 2016, one million children had tuberculosis and around 250,000 children died because of tuberculosis. This study aimed to know the profile of tuberculosis in children and adolescent at Dr. Soetomo General Hospital Surabaya.Methods: This was a descriptive study using retrospective approach. Sample of this study was collected from electronic medical record provided by Dr. Soetomo General Hospital Surabaya using statistic formula of single sample for estimated population proportions of children and adolescent with tuberculosis from 2013-2017, with total samples of 149 people.Results: There were 149 samples of children and adolescent patients with tuberculosis. Most of the children were mostly 0-4 years old and 57% were female. 84% of the children had been immunized with BCG and classified as moderate, and 35% were under nutritional status. This study showed that 67% of the children in household contacts of adult tuberculosis patients also had tuberculosis. The most frequent symptoms of tuberculosis in children and adolescent were fever (72%) and cough (80%).Conclusion: Tuberculosis in children and adolescent is more likely to occur in children than adolescent, especially children within group age of 0-4 years old. The number of pulmonary tuberculosis in children and adolescent are higher than extrapulmonary tuberculosis.

Level of Mycobacteria in Pre-Treatment Sputum and Susceptibility of M. tuberculosis Strains Isolated from Patients with non-Multidrug-Resistant Pulmonary Tuberculosis AFB (+) and Factors Influencing MGIT Results after the First 8 Weeks of Anti-Tuberculosi

Vietnam is among 30 high TB ​​burden countries even though the Vietnam National TB Program has made great efforts to detect and treat tuberculosis. Objectives: Assessment of Mycobacterial level in sputum before treatment, and susceptibility to the first line anti-TB drugs of M. tuberculosis strains isolated from TB patients with AFB (+) and non-multidrug-resistant. Moreover, factors influencing MGIT outcome after the first 8 weeks of first-line anti-TB drugs therapy in patients with pulmonary tuberculosis was also analysed. Methodology: An observational, analytical study was performed in 128 patients with non-multidrug-resistant pulmonary tuberculosis AFB (+) for evaluating the level of Mycobacteria in sputum before treatment by smear microscopy method; the susceptibility of M. tuberculosis isolated from sputum of the patient was analysed by Lowenstein - Jensen method. Factors affecting positive MGIT results after 2 months of treatment were determined by multivariate logistics regression. Results: The patients had AFB 3+ were 28% in new cases and 24,5% retreatment patients. The rate of M. tuberculosis strains was susceptible to the first line anti-TB drugs in new cases was higher than retreatment patients. The percentage of any anti-TB drug resistance in retreatment tuberculosis was 59,6%, higher than that of new case TB (23,6%). There was high rate of M. tuberculosis strains resistant to Streptomycin and Isoniazid (12,5% and 16,8% for new cases; 42,3% and 36,5% for retreatment cases, respectively). Large radiographic chest lesions and high AFB levels in pre-treatment sputum were factors associated with a positive MGIT result after the first 8 weeks of treatment. Conclusion: Most of TB patients had high level of Mycobacteria in sputum samples collected before treatment. The percentage of M. tuberculosis strains isolated from sputum of pulmonary non MDR-TB patients had any anti-TB drug resistance were high. High Mycobacteria level in pre-treatment sputum and radiographic chest lesions related to positive MGIT result after the first 8 weeks of treatment.
 Keywords
 Pulmonary tuberculosis, first-line anti-TB drugs, anti-TB drug resistance, susceptibility, M. tuberculosis.
 References
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Social profile of tuberculosis in urban area

Background. Tuberculosis is an infectious socially significant disease. Apart from individual traits of the disease pathology, drug sensitivity and the availability of effective medicine and prevention, an important factor of its control is the patient’s social status. Social patient profiling in various locations across the country is vital for developing and deploying a high-quality and feasible tuberculosis care programme.Objectives. Social profiling of tuberculosis in St. Petersburg as an example of large urban area. Methods. We developed a questionnaire to assess 40 social parameters of a patient with tuberculosis. The study sample was representative and surveyed 666 (63.4%) and 704 (65.7%) patients with primary diagnosis in 2017 and 2018, respectively.Results. The survey showed almost no impact of external migration on tuberculosis epidemiology in St. Petersburg. Internal migrants counted 76 (11.4%) in 2017 and 96 (13.4%) in 2018, thus suggesting the majority of primary tuberculosis patients being permanent residents of St. Petersburg. The contribution of individuals with no fixed abode to the incidence rate was also insignificant, 2.4% and 1.9%. Most patients were unemployed people of working age, 236 (35.4%) in 2017, 261 (37.1%) in 2018. Incidence among students as a younger population was lowest, 2.1% and 2.8%. Smokers accounted for half of total patients, 370 (55.6%) and 368 (52.3%). One in five patients carried HIV infection, with half of them not receiving antiretroviral therapy. Patients with unfinished secondary education and residing in collective dwellings were significantly more frequent, whilst the proportion of persons with high income decreased. Over half of the patients had no family at primary diagnosis, and over a third had never been married.Conclusion. The social profile of primary tuberculosis in an urban area is as follows: single man, near 40 years old, permanent resident, unemployed, working-age, smoker, resides in private abode, has secondary or secondary vocational education, low to average income.

Epidemiological profile of tuberculosis in the city of Sinop, Mato Grosso, from 2012 to 2018

Tuberculosis is an important global health problem associated with low levels of education and income. This study aims to describe the epidemiological profile of notified cases of tuberculosis in the municipality of Sinop, Mato Grosso, between 2012 and 2018. This is a descriptive study using secondary data from the Brazilian Notification Disease Information (SINAN NET). In the municipality of Sinop, between 2012 and 2018, there were 162 reports of tuberculosis, 80.86% of new cases, 4.32% of relapses, 4.93% of re-entry after treatment abandonment. Regarding age, the most affected was between 20 and 34 years (36% of cases); 23% of individuals completed elementary school only; 65% are male and 9% are coinfected with HIV. It was noticed that the epidemiological profile of tuberculosis cases in Sinop, are in line with the reality presented worldwide, and it is necessary to reinforce the health care of the population, seeking to walk together with the other international organizations that aim to eliminate this disease.

Epidemiologia da tuberculose no nordeste do Brasil, 2015 – 2019

Objetivo: avaliar o perfil epidemiológico da tuberculose na Região Nordeste nos últimos 5 anos. Metodologia: trata-se de um estudo epidemiológico descritivo, retrospectivo e quantitativo dos casos confirmados de tuberculose na Região Nordeste do Brasil no período de 2015 a 2019. Resultados: nos últimos 5 anos foram notificados 117.638 casos de tuberculose no Nordeste. Ao analisar o perfil dos indivíduos com tuberculose, constatou-se que 68% são do sexo masculino, com faixa etária de 20 a 39 anos, equivalendo a 43% dos casos, seguida dos indivíduos de 40 a 59 anos que representam 32%. A forma clínica de tuberculose mais prevalente no período foi a pulmonar (86%) dos casos. Possuem Aids 9.550 (14%), 10.269 (16%) são portadores de diabetes, 22.019 (34%) são tabagistas e 23.237 (6%) fazem uso de álcool. Conclusão: a tuberculose permanece como uma doença da atualidade ainda distante da erradicação na região Nordeste. Os aspectos epidemiológicos evidenciados pela pesquisa, revelam a necessidade de planejamento dos serviços de saúde quanto a capacitação dos profissionais para combater a tuberculose.

Sulfonamide-containing copper(II) metallonucleases: Correlations with in vitro antimycobacterial and antiproliferative activities

The bis-(1,10-phenanthroline)copper(I) complex, [Cu(I)(phen)2]+, was the first copper-based artificial nuclease reported in the literature. The biological and ligand-like properties of sulfonamides make them good candidates for fine-tuning the reactivity of the [Cu(phen)2] motif with biomolecules. In this context, we developed three novel copper(II) complexes containing the sulfonamides sulfameter (smtrH) and sulfadimethoxine (sdmxH) and (N^N)-bidentate ligands (2,2′-biyridine or 1,10-phenantroline). The compounds were characterized by chemical and spectroscopic techniques and single-crystal X-ray crystallography. When targeting plasmid DNA, the phen-containing compounds [Cu(smtr−)2(phen)] (1) and [Cu(sdmx−)2(phen)] (2) demonstrated nuclease activity even in the absence of reducing agents. Addition of ascorbic acid resulted in a complete cleavage of DNA by 1 and 2 at concentrations higher than 10 μM. Experiments designed to evaluate the copper intermediates involved in the nuclease effect after reaction with ascorbic acid identified at least the [Cu(I)(N^N)2]+, [Cu(I)(sulfa)(N^N)]+ and [Cu(I)(sulfa)2]+ species. The compounds interact with DNA via groove binding and intercalation as verified by fluorescence spectroscopy, circular dichroism (CD) and molecular docking. The magnitude and preferred mode of binding are dependent on the nature of both N^N ligand and the sulfonamide. The potent nuclease activity of compounds 1 and 2 are well correlated with their antiproliferative and anti-M. tuberculosis profiles. The results presented here demonstrated the potential for further development of copper(II)-sulfonamide-(N^N) complexes as multipurpose metallodrugs.

A study on co-morbidities and treatment outcome based on updated definitions among tuberculosis patients registered at a tuberculosis unit, Bangalore

Background: Tuberculosis remains one of the world‘s deadliest communicable diseases and a major public health problem and is a most common opportunistic infection in people living with HIV. The treatment outcome of Tuberculosis is influenced by numerous factors of which presence of co-morbidities is one of the factors. The present study was done with following objectives, to assess the proportion of co-morbidities and treatment outcome of the Tuberculosis cases registered for DOTS treatment at the Tuberculosis unit.Methods: A Descriptive study was conducted at a Tuberculosis Unit in Bangalore with 80 subjects selected by purposive sampling satisfying inclusion & exclusion criteria. Data was collected using a pretested semi structured proforma administered to all the study subjects by trained investigators. Data regarding socio demographic profile, profile of tuberculosis, medical co-morbidities which the subjects were suffering were collected and these patients were followed up till their treatment completion and outcome of treatment was given based on new WHO definitions.Results: The present study showed that, 38 (47.50%) of the study subjects had one or the other comorbidities with chronic obstructive pulmonary disease being the most common 18(22.5%) followed by Diabetes 13(16.25%). On determining the treatment outcome of the study subjects the overall treatment success rate was 86.25% which included the cured and treatment completed subjects. However there was no statistically significant (p = 0.614) association between treatment success and presence of comorbidity.Conclusions: The cure rate among the tuberculosis patients, following DOTS therapy was found to be slightly less than the RNTCP standards.

Profile of Tuberculosis in Paediatric patients

Introduction: Tuberculosis (TB) is very important cause of infection related deaths worldwide and has been declared by WHO as a global health emergency. Around half million children fall ill with TB each year. Due to non-specific signs and symptoms TB in children may be overlooked. Aims and objectives: 1) To study the occurrence of TB in pediatric patients at tertiary care hospital KVG Medical College, Sullia, Karnataka. 2) To study the occurrence of TB in patients with and without BCG scar. 3) To study the occurrence of smear positive cases in pediatric age group. 4) To study the type of TB in pediatric patients. Material and methods: Specimens like sputum, bronchial lavage, lymph node aspirate, gastric lavage, CSF were collected depending on the site of disease. Specimens were stained by ZN staining method. Culture was done on LJ media. Tuberculin test was also done. Chest X rays of the patients were done presenting with pulmonary signs and symptoms. Result: In our study, 102 (0.98%) were positive. Age group of 5-9 years was the most commonly affected. Males (57.84%) were more affected than females (42.16%). BCG scar was found only in 20.59% cases. Smear positivity was seen in 22.89% cases. Extrapulmonary manifestations were more compared to pulmonary manifestations. Conclusion: As smear examination is negative in most of the patients, culture of Mycobacterium tuberculosis is important. This age group present with non-specific signs and symptoms and hence tuberculosis should always be considered as one of the differential diagnosis.

Profile of tuberculosis and its response to anti-TB drugs among tuberculosis patients treated under the TB control programme at Felege-Hiwot Referral Hospital, Ethiopia.

BackgroundTuberculosis (TB) is a global concern for both developing and developed countries. Currently it becomes more complex due to increasing levels of drug resistance and HIV co-infection. Delayed diagnosis and high case load are major factors contributing to continued transmission and failure to the treatment outcome. The study was conducted to determine the profile and treatment outcomes of TB patients at Felege-Hiwot Referral Hospital.MethodsWe analyzed the records of 1761 TB patients registered for treatment in Felege Hiwot Referral Hospital from July 2010 to June 2015. Data on patients’ socio-demographic characteristics, type of TB, HIV status and treatment outcome were analysed. Descriptive statistics and binary logistic regression models were used to present data. The odds ratio and the 95 % confidence intervals were calculated. A p-value of < 0.05 was considered statistical significant.ResultsThe proportion of smear positive, smear-negative and extra-pulmonary TB were 205 (11.6 %), 548 (31.1 %) and 1008 (57.2 %), respectively. The overall treatment success rate accounts 542(80.8 %) with unsuccessful treatment of 129(19.2 %). The treatment outcome varied by the years from 68.9 to 97.4 %. Among tuberculosis patients, 459(26.1 %) of them were HIV positive. Being HIV positive (AOR = 4.29, 95 % CI, 2.20–8.37 P = 0.001), retreatment (AOR = 5.32, 95 % CI, 1.92–14.3, P = 0.001), rural residency (AOR = 18.0, 95 % CI, 9.06–37.82, P = 0.001) and the age group of 15–24 years (AOR = 2.91, 95%CI, 1.00–8.45, P = 0.04) showed statistical significant association for poor treatment outcome.ConclusionsIn the studied region, the overall treatment success rate was still below the WHO target of success rate, 85 %. However, the trend of treatment success rate showed a promising increment. Patients at high risk of unsuccessful treatment outcome should be identified early and given additional follow-up, medical intervention and social support.

Profile of tuberculosis among the foreign-born population in Japan, 2007-2014.

The proportion of foreign-born people among the newly notified tuberculosis (TB) patients has been increasing in recent years and potentially poses a new challenge to TB control in Japan. In this report, we analysed the data from the Japan TB surveillance system between 2007 and 2014 to gain an overview of the trends and characteristics of foreign-born TB patients in Japan.We found that the proportion of foreign-born TB patients was especially high among the younger age groups – 44.1% among the 20–29 years age group in 2014. The largest groups of foreign-born patients were from China and the Philippines; however, the number of those from Nepal and Viet Nam was on the rise. Students comprised the second largest professional category group for TB after regular workers, and its proportion increased over the study period. Compared to Japan-born TB patients, foreign-born patients were more likely to be diagnosed through routine medical check-ups. Treatment successes and patients still on treatment were significantly lower among foreign-born patients than their Japan-born counterparts; and transferred-out and unknown outcomes were higher. Our results indicated that distinctive subgroups within the foreign-born population in Japan, especially students and regular workers, might have a higher risk of developing TB. Measures to ensure early diagnosis and treatment adherence should be adapted to such populations.

HIV and Tuberculosis: the impact goes beyond those infected with HIV/AIDS

1 Medical officer, Department of Medicine, NMCH, Govt Medical College Kota, Rajasthan, India 2 Assistant Professor, Department of Medicine, NMCH, Govt Medical College Kota, Rajasthan, India 3 Professor, Department of Medicine, NMCH, Govt Medical College Kota, Rajasthan, India 4 Senior Professor, Department of Medicine, NMCH, Govt Medical College Kota, Rajasthan, India Corresponding Author Dr Sanjay Kumar Garg House no. 6, Suman Vihar, Bundi Road, Kunhari, Kota Rajasthan, India Pincode-324008 Emaildoctorsanjaygarg@yahoo.com, Mobile – +91 9414331357 Abstract Background & objectives: Tuberculosis is said to be one of the commonest opportunistic infection in patients with HIV/ AIDS. In this study the clinical profile of tuberculosis in patient with HIV infection /AIDS and to study the pulmonary and extra pulmonary tuberculosis involvement and clinical profile in HIV infection/AIDS subjects. Methods: HIV sero-positive patients with symptoms suggestive of pulmonary and extra pulmonary tuberculosis, attending the Outpatient Departments and indoor at Department of Medicine, Govt. Medical College, Kota. Results: fever (97.1%), weight loss (85.7%) cough (80%), pallor (68.5%) mouth ulcer (41.4%) and lymphadenopathy (33%). Incidence of both Pulmonary and extra pulmonary tuberculosis were almost same (45.71%).Among extra pulmonary tuberculosis, abdominal TB was (18.57%). Infiltrative lesions were (54.28%) on chest x-ray. Sputum positivity was seen only in 31.25% of patients. Mean CD4 counts was 133.95+141.89 cells/ μl. Most of the patients (78.57%) had CD4 counts 50 cells/μl. Conclusionmost common manifestation of TB in HIV infected patients were sputum negative pulmonary TB. A high proportion of cases with extra pulmonary TB were also found. There is an urgent need to strengthen the information, education and expand the ART services to meet the requirement of early testing and treatment initiation in patients co-infected with HIV-TB. KeywardsHIV/TB, AIDS, Tuberculosis, Extrapulmonary TB.

To Study Clinical Profile of Tuberculosis in Patients of Diabetes Mellitus

To Study Clinical Profile of Tuberculosis in Patients of Diabetes Mellitus

Profile of Tuberculosis Related Immune Reconstitution Syndrome in HIV Patients on Highly Active Anti-Retroviral Treatment: A Retrospective Study From South India

Profile of Tuberculosis Related Immune Reconstitution Syndrome in HIV Patients on Highly Active Anti-Retroviral Treatment: A Retrospective Study From South India

Clinical profile of tuberculosis in children up to 5 years of age

Introduction: Tuberculosis as a disease is of great public health problem in developing countries like India. Children contribute a significant proportion of disease burden and suffer from severe form of disease, but because of difficulty in establishing an accurate diagnosis, data of disease burden in pediatric population is lacking. This study is an attempt to assess clinical profile of tuberculosis in children upto 5 years of age. Method: present study was conducted at Kamla Raja Hospital & Gajra Raja Medical College Gwalior over a period of six months. 77 cases up to 5 years of age were selected from in-patient department, who were diagnosed to have tuberculosis. A detailed history of epidemiological factors including past history of infectious disease, history of contact contributing to disease state was recorded on predesigned Performa. Complete clinical examination and laboratory investigation was done to confirm the diagnosis. Result: approximately 70 % of study group was distributed in 2- 5 years of age group. Cases of CNS tuberculosis formed the main bulk to the study contributing 70.13% followed by intrathoracic (~16.88%), disseminated (6.49%), abdominal (5.19%) & lymphoid (1.29%) tuberculosis. Severe malnutrition, low socio economic status, illiteracy of parents were the important epidemiological factor affecting the disease status of child. Conclusion: childhood tuberculosis remained the neglected part in NTCP until RNTCP was introduced. Childhood cases have shown increasing trends with the advent of HIV infection. Prompt suspicion and early diagnosis can be an important step in controlling this epidemic.

Understanding the Profile of Tuberculosis and Human Immunodeficiency Virus Coinfection: Insights from Expanded HIV Surveillance at a Tuberculosis Facility in Durban, South Africa.

Background. Expanded HIV surveillance in TB patients forms part of the World Health Organization framework for strategic collaborative activity. Surveillance helps understand the epidemiology of the local dual epidemic and enables design of a tailored response to these challenges. Methods. We conducted an observational, cross-sectional study of anonymous unlinked HIV testing for 741 consecutive TB suspects attending an urban TB facility during a seven-week period in 2008. Results. A total of 512 patients were found to have TB. The mean age was 35.7 years, and 63% were male. The prevalence of HIV was 72.2% (95% CI: 68.2–75.9) in all TB cases, 69.8% (95% CI: 65.3–74.2) in pulmonary tuberculosis (PTB), 81.6% (95% CI: 72.9–90.3) in extrapulmonary disease, and 66.8% (95% CI: 60.7–72.9) in those without TB disease. HIV prevalence in TB patients was higher in females than males and in younger age groups (18–29 years). The sex ratio of PTB patients correlated with the sex ratio of the prevalence of HIV in the respective age groups (P < 0.05). Conclusion. The use of a rapid HIV test performed on sputum anonymously provides an opportunity for HIV surveillance in this high-burdened setting, which has the potential to lend valuable insight into the coepidemics.

A study of epidemiology and clinical profile of tuberculosis in patients living with HIV-AIDS

Background: HIV-AIDS is associated with many opportunistic infections during the course of disease. One of the most important of them in India is tuberculosis (TB). Also tuberculosis is the one of the most common cause of morbidity and mortality in patients living with HIV-AIDS. Aims & Objectives: This study was carried out to know the epidemiology and clinical presentation of tuberculosis as an opportunistic infection in patients of HIV-AIDS. Materials and Methods: This study was carried out in GMERS medical college, Gandhinagar, Gujarat, India, which is attached with the district government hospital. 834 HIV-infected patients, who were visited ART center, general medicine OPD and Pulmonary medicine OPD between November 2012 and December 2013, were recruited in the study. All the patients were screened for presence of tuberculosis and structured performa was used to note down all the details of the patients. Results: Tuberculosis was most common opportunistic infection recorded and the prevalence rate was 22.19%. Tuberculosis involving the lymph nodes was the most common presentation of TB in patients of HIV-AIDS. Conclusion: Tuberculosis in HIV-AIDS patients is still an important and fairly common opportunistic infection. All HIV-AIDS patients needs to be screened for evidence of TB and all the patients with TB needs to be screened for HIV co-infection.

Epidemiological profile of tuberculosis in the city of Belo Horizonte (MG), from 2002 to 2008.

To assess the epidemiological profile of tuberculosis in Belo Horizonte, Minas Gerais State, from 2002 to 2008. For descriptive epidemiological study, the data were obtained from the municipal National Health Surveillance System, after obtaining approval from the Research Ethics Committee at the City Health Department. Incidence coefficient, average rates and stratified data analysis with significance level of p ≤ 0.05 were calculated. About 7.590 new tuberculosis cases were reported between 2002 and 2008. There was a slight reduction in the number of cases throughout the historical trend, with an average annual incidence rate of 46/100,000 inhabitants. The study also showed a male gender ratio of 1.84:1, a higher incidence coefficient in the age group between 40 and 59 years old (73/100,000) and a higher incidence of tuberculosis among people who only had primary education level. Pulmonary tuberculosis was the most prevalent form in every year of the study (p < 0,001). Among the cases reported with associated diseases, alcoholism was registered in 47.9% and AIDS in 34.5%. Between 2002 and 2008, there was an increasing trend of cases treated under Directly Observed Treatment, accounting for 29.5% in total. Cure percentage rate was below the expected result (67.3%) and non-adherence to treatment showed a high total percentage (17.9%). The results indicated that tuberculosis control actions need to be intensified with investments on professional training, systemic audits of the information system, improved integration between AIDS/tuberculosis programs and raising awareness of the disease with the goal of mobilizing the society.

A Comparative Study on the Body Composition of HIV/AIDS and Pulmonary Tuberculosis Co-infected and Only Pulmonary Tuberculosis Patients of Manipur

The present study deals with the comparative analysis of body composition of 200 (100 each) randomly selected Meitei male patients with confirmed HIV/AIDS and Pulmonary Tuberculosis co-infected, and only Pulmonary Tuberculosis patients, aged 20–40 years, collected from the JN Hospital Porompat, RIAC Centre of Khergao, Irilbung, Keirao, Kumbi, Lei-ingkhol TB hospital, DOTS centre of Nongmeibung, Bamon, Leikei, and Yaiskul. The findings of the present study show highly significant difference in all the seven anthropometric variables as evident from “t” value. Many such studies have furnished the clinical profile of Tuberculosis in HIV positive persons in USA and Africa; however, there is a paucity of such data from India. Hence, it is important to study their profile, as it would help in making an early diagnosis and treatment.