Separation of tuber proteins has been accomplished by disc electrophoresis. Soluble tuber proteins from twenty-six species of Solanum have been partially “resolved”. Comparisons of resulting protein patterns were made to detect possible differences between species. Differences, especially in major bands, suggest that the patterns may be species-specific. In some instances, interspecific hybrids appear to have a greater number of bands than either parental species. In addition, there is segregation in the hybrids for major bands present in either parental species. The possibility of using these results as another approach to taxonomic and genetic studies with Solanums is promising. The availability of a large number of tuber-bearing Solanum species, interspecific hybrids, and their derivatives representing different ploidy levels provides an excellent source of material for both genetic and taxonomic studies.