With three convenient samples (n = 1,087) and one sample representative for the German population in terms of age and gender (n = 210), we replicate research by Zlatev (2019) showing that perceived benevolence-based and perceived integrity-based trustworthiness increase with a target’s level of caring about a social issue. We show that these results generalize to various issues ranging from environmental issues (i.e., installation of wind turbines in the North Sea) to issues related to the COVID-19 pandemic (i.e., online teaching to prevent the spread of the virus). Furthermore, we provide initial behavioral evidence for this effect by showing that transfers in a trust game increase with a target’s caring about a social issue. All results are robust for age, gender, and social issue. To provide best estimates for the effect of a target’s level of caring on perceived trustworthiness, we report results of three mini meta-analyses including our findings as well as the findings of the original research. Policy implications are discussed.