On the 10th of September 2013, after a brave 3-year struggle against a serious illness, Professor Dr Yves Vanrenterghem, a towering figure of kidney transplantation medicine, passed away, aged 65 years. Yves peacefully departed at his home in Leuven, Belgium. Yves Vanrenterghem was a true pioneer in transplantation medicine. His tremendous contributions to the clinical development of novel immunosuppressive therapies in renal allograft transplantation have helped to optimize patient management and improve transplantation outcomes worldwide. Yves, born in Brugge, started his medical career in 1973 when he obtained his MD at the Catholic University Leuven (KUL), Belgium. Five years later, he finished his training as renal physician at the University Hospitals Leuven and became a staff member of the Department of Nephrology in that same institution. Although the first successful renal transplantation in the Leuven hospitals was performed on the 4th of November 1963, Yves’ early career was already characterized by his visionary ideas about the importance of developing adequate immunosuppressive therapy to maintain long-term graft acceptance, about the value of careful registration of transplantation-related outcome parameters and the development of a clinically applicable electronic medical file. In 1988, he was appointed full professor at the KUL and became head of the Nephrology department 4 years later. His interests in (novel) immunosuppressive therapy positioned Prof. Vanrenterghem increasingly in a leading role in the planning and execution of numerous landmark clinical studies, culminating in more than 80 clinical trial publications including “The Thomas Study,” “The 310-Study,” “The enabling Study,” “The Caesar Study,” “The Symphony Study,” and the pivotal Belatacept studies, to just name a few. With more than 350 scientific papers in peer-reviewed journals, Prof. Vanrenterghem was a key opinion leader in clinical transplantation medicine. Yves presented the results of these studies around the world at international meetings in a manner that not so many people are able to do: clear, critical, focused, and straightforward directed at clinical relevance. For many among us, he was a great tutor and mentor in this respect. Yves has served on many editorial boards during his career, like for example, Transplantation, Transplantation Proceedings, American Journal of Transplantation, American Journal of Kidney Diseases, Transplant International, Nephrology, Dialysis and Transplantation, and Zeitschrift für Transplantationsmedizin and was author of numerous book chapters. Education and teaching were among his most valuable dedications. In 1996, he was appointed chairman of the Eurotransplant International Foundation, an office he fulfilled for almost a decade with strong leadership and vision. As a sign of gratitude for this outstanding performance in his role as chairman of Eurotransplant, he received an honorary order (“Leopoldsorde”) from King Albert II of Belgium and remained honorary chair of Eurotransplant. Prof. Vanrenterghem understood already very early in his clinical career that to optimize patient care after successful transplantation, a strict clinical follow-up was essential, and the continuous sharing of information between the transplant center and the treating nephrologists was of the utmost importance. To establish an effective clinical follow-up program, Yves developed a completely electronic medical transplantation file, which could be shared real time between the transplant unit and more than 20 different referring hospitals in Belgium via a computer-linked data system; this was in 1990! Today, the use of electronic medical files is becoming daily practice; in 1990, this was unheard of. This same electronic database allowed for generating yearly reports on important transplantation-related outcomes that formed the basis for continuous improvements in patient care.FIGURE 1: Prof. Vanrenterghem giving a lecture in the University of Leuven.Yves’s role in European kidney transplantation medicine would be sufficient to assure his place in history. However, he really was a citizen of the world. In 2006, Yves was elected European Councilor of The Transplantation Society (TTS) where he served for 4 years and was intensively involved in the society’s actions against transplant tourism and the Declaration of Istanbul. In 2012, he received the TTS-Novartis Award for outstanding contribution to evidence-based medicine in transplantation. Yves was a world-renowned scientist and a dedicated physician. During his busy career, he never ceased to participate in clinical practice, and his warm and empathic contact with his patients has touched the hearts of many. He was a great teller of stories and truly enjoyed the niceties of life in the company of his family, friends, and colleagues. We will miss Yves, together with many colleagues and friends around the world. He was an exemplary medical professional, a great scientist, and a mentor for many. He helped and encouraged others, invariably making them feel special. Although he is no longer with us, his influence will be felt for decades.