True Partners Research Articles

P2.02-01 ALKFusion and the Unmet Need of Patient-Centric Research

Approximately four (4) to seven (7) percent of non-small cell lung cancer (NSCLC) is driven by the ALK transfusion. In the United States, approximately 11,000 people are diagnosed with ALK-positive NSCLC every year. There are an array of treatment options for the ALK-positive patient, and these options have improved overall survival rates in this subset of NSCLC patients. Currently, there are five FDA approved tyrosine kinase inhibitors (TKIs) that treat ALK-positive NSCLC: crizotinib, ceritinib, alectinib, brigatinib and lorlatinib. There are other drugs and drug combinations that are currently in clinical trials. Invariably, patients develop acquired resistance to each of these drugs, but the mechanisms of resistance can vary. Better understanding these mechanisms of resistance will provide invaluable information and improve survival outcomes. The development of new drugs, drug combinations, and innovative treatments will significantly impact the survival rate for ALK-positive lung cancer. ALKFusion was conceived by a group of seven lung cancer patient advocates with over 30 years of combined patient focused advocacy experience in the lung cancer community. A primary goal of the ALKFusion group is to improve survival for people with ALK-positive NSCLC by accelerating research. Patient collaboration with key shareholders in the lung cancer arena is critical. Further, patients must be educated about their disease in order to make the best treatment decisions. Often, patients lack access to doctors who specialize in ALK-positive lung cancer, as it is a rare subset of NSCLC, so there is a particular need for patients themselves to have the educational resources to discuss with their doctor. As a patient-centric organization, ALKFusion is committed to accelerating research to improve the outcomes for ALK-positive lung cancer patients. ALKFusion’s vision is twofold; to initiate and support patient-centric research with a focus on collaboration and disease management, and to provide tools to patients so that they can truly be a partner in their care decisions. As patients, the members of ALKFusion are on the frontline of this disease. To aid it in achieving this goal, the group has engaged with a wide range of researchers, clinicians, other lung cancer organizations, and the pharmaceutical industry, with the aim of advancing cutting-edge research and in the treatment of those living with ALK-positive NSCLC. Further, ALKFusion publishes a monthly newsletter titled The ALKFusion Reporter, which provides summaries and links to every recent scientific publication relating to ALK-positive lung cancer. ALKFusion is a crucial component of the "patient-first" movement that has been gaining momentum in several oncogene communities. It is a rapidly growing group of educated patient advocates who endeavour to be true partners with the medical community in order to accelerate research for ALK-positive lung cancer.

Informed Consent-The Process Model.

Informed consent is a widely accepted necessity for those of us practicing implant dentistry. How the consent is obtained and the degree of detail it contains is highly variable. It is well established by the courts that it is a common legal requirement for providers to obtain legitimate and well-informed consent before initiating treatment.1 Simply obtaining a signed authorization for surgery or prosthetic restoration is a limited view of this vital component of treatment. Patients should have a conscious participation in the treatment decision-making process. Lidz et al2 called the simple signature signing an “event model” that is now outdated. A “process model” should replace the event model. The process model focuses on efforts that promote the patient's active participation in making a shared treatment decision. If the process model is used, the patient takes ownership of the treatment decisions.The suggested elements of the process model should include:Options discussed should include:When these aspects of a thorough, informed consent are used there is evidence that the patient freely has made an educated decision and the clinician has treated the patient as a true partner in the decision-making.3 Patients must take ownership of their decisions and not leave open the option for them to state later: “I had no idea what I was getting” or “I would have never done this had I been told this could happen.” Treatment decisions must be a signed mutual agreement.Patients and clinicians can expect to have success with dental implants. Success rates are quite high, however complications or complete failure can occur. The patient should know the potential risks and the chance of their occurrence.In a systematic review regarding the survival and complication rates of implant-supported fixed dental prosthesis Pjetursson et al4 estimated an implant survival rate of 95.6% after 5 years and 93.1% after 10 years.Adler et al5 recently examined the survival and complication rates in a long-term 9- to 15-year retrospective follow-up study regarding dental implant treatments. The findings revealed the implant survival rate up to 15 years was 82.6% (SE 4.1%). The occurrence of biological complications was 52% and technical complications occurred at a rate of 32% at some point in time. At least one complication was experienced by 65% of patients. When patients presented with a history of stage II-IV periodontitis, they were more likely to experience an implant fixture loss (P = .008). A history of smoking was a significant predictor of future peri-implantitis (P = .006).5Complications include but are not limited to: (i) immediate postsurgical pain, (ii) infection (at any point), (iii) inflammation, (iv) edema, (v) bleeding, and (vi) other unforeseen issues.Discussing the possible occurrence and frequency of complications prior to the commencement of treatment demonstrates an openness and honesty by the clinician. If a patient is forewarned of possible risks and the procedure is preformed without complication, then “all-the-better” the practitioner appears to be in the patient's eyes. However, if a patient is not told of the risks and a complication does occur, the patient thinks the clinician may have done something wrong; when in reality the clinician did nothing wrong. Unfortunately, it is human nature to try and place blame on others, and no clinician wants to be made the “scapegoat.”It is also important to identify patients preoperatively who may be at a higher risk of treatment complications. Is there a complex medical history that includes systemic illnesses or medications that can interfere with postoperative healing? Are there anatomical considerations that preclude the ideal surgical or prosthetic outcome? What is the patient's age? Does the patient have realistic cosmetic expectations? These issues are better addressed preoperatively.Surgical and prosthetic clinicians should have a complete, sincere, and open discussion with all patients. This takes time and the financial reward for this time must be incorporated into the treatment fee. Establishing a “process model” for informed consent for you and your patients will establish a lasting mutual trust.

Dispute Resolution of Shariah Economy in Murahabah Financing Contract in Sahabat Mitra Sejati Cooperatives

Sharia resolution in the murabahah financing contract at the Mitra Sejati Cooperative indirectly in the process of resolving the dispute still refers to Law No. 21 of 2008 concerning Sharia Banking. While the Fatwa of the National Syari'ah Council Number 07 / DSN-MUI / IV / 2000 explained that the resolution of murabahah financing disputes was in the Syari'ah Arbitration Board. According to Article 55 of Law No. 21 of 2008 concerning Sharia Banking, that sharia dispute resolution can be carried out by the Court within the religious court environment and can also be resolved by referring to the contents of the contract. In fact, murabahah financing contracts carried out by true partner cooperatives do not explicitly appoint which judicial institutions to solve them. Sharia dispute resolution in the murabahah financing contract must be settled in the Religious Court but the fact is resolved in non-litigation in the form of a public auction. When viewed from the theoretical concept of legal certainty, this does not reflect the firmness in the rule of law because the resolution through non KPKNL parate litigation does not yet have binding legal force. where the results of the auction cannot automatically have disputed objects. With respect to murabahah financing agreements in true partner cooperatives, legal defects can be declared because there is no firmness and there is no accuracy of the contract maker when a dispute occurs where the contract maker does not confirm which institution is appointed and agreed when a dispute occurs.

Report from the Medical Library Association's InSight Initiative Summit 2: Meeting the Evolving Information Needs of Library Stakeholders.

At the Medical Library Association’s InSight Initiative Summit 2, held September 27–28, 2018, academic and hospital librarians joined with publishing industry partners to develop a deeper shared understanding of technology- and social interaction–driven changes in how health sciences researchers and clinicians discover and consume information in their fields. Through a mixture of keynote talks, a panel discussion with health care professionals, and small-group problem-solving exercises, the summit program invited participants to collaboratively develop strategies for helping users recognize the value of curated or peer-reviewed content obtained through institutional access channels. Themes of the summit included the existence of different user modes of information discovery and access, user reliance on professional societies and Twitter as information sources, the extent to which smartphones are used to find medical information, the importance of inducing disorienting dilemmas in library users that cause them to recognize librarians as true partners in information seeking and research, the dangers of depending on non-curated information, and the need for publishers and librarians to work together to ease barriers to access and enrich the user experience.

Disconnect: Contradictions and Disagreements in Faculty Perspectives of Information Literacy

ABSTRACTBroward College, an early adopter of Guided Pathways, has made efforts to incorporate information literacy throughout the curriculum by embedding librarians in pathways and through General Education learning outcomes. However, although college administrators and faculty acknowledge that the integration of information literacy instruction throughout the curriculum is crucial to student success, librarians have struggled to become true teaching partners. A survey was administered to discipline faculty to determine attitudes, perceptions, and a self-assessment of information literacy. This study includes a nuanced analysis of discipline faculty responses and reveals conflicting attitudes and behaviors related to information literacy instruction.

The US Food and Drug Administration Centers for Regulatory Science and Innovation: Current Activities and Future Promise to Accelerate Innovations.

The US Food and Drug Administration Centers for Regulatory Science and Innovation: Current Activities and Future Promise to Accelerate Innovations.

Théodore Simon (1873-1961). The career of a psychiatrist involved in the professionalization of psychiatric nurses

Well-known for having created the famous Metric Scale of Intelligence along with the psychologist Alfred Binet (1857-1911), what is less known is that Théodore Simon (1873-1961) was also a major actor of the professionalization of psychiatric nurses in France. From his engaged textbook published in 1911 to his journal, explicitly titled ?L'Infirmier Psychiatrique,? which he created in 1953 via the specialized school he founded and directed between 1946 and 1957 at the Maison Blanche hospital in Neuilly-sur-Marne, Simon worked throughout his career for the acknowledgment and the training of those he considered as true partners. This is what we want to demonstrate in this paper, which redraws the forgotten career history of this militant psychiatrist in order to shine a light on his commitment to the professionalization of psychiatric nurses.

Engineering a Foundation for Partnership to Improve Medication Safety during Care Transitions.

There are major gaps and barriers for patients and caregivers after hospital discharge to achieve safe medication use. Patients and caregivers are often not ready to take on the responsibility for medication management when transitioned from inpatient care. Current approaches tend to focus on adding isolated strategies. A system thinking can enable a fundamental transformation to redesign professionals' interactions with patients and caregivers with an explicit goal to develop patients and caregivers into true partners, with targeted roles, skills, attitude, knowledge, and tool support. We must recognize the fact that medication safety during care transition and, more so, at patient homes is the property of a "work system", in which the patient and caregivers are at the center, with collaboration with health professionals. Innovative ideas are needed to engineer work system components by systematically examining professionals' interactions with patients and caregivers, such as those during hospital stays and transitions (e.g., follow-up phone calls, community pharmacist consults, and home visits). Based on human factors principles, we describe a set of recommendations on engineering partnership with patients and their caregivers at different stages of a care episode, to enable productive interactions among work systems that are distributed and are often limited in their ability to exchange information and co-align their interests.

Interprofessional Practice and Education in Clinical Learning Environments: Frontlines Perspective

This Invited Commentary is written by coauthors working to implement and study new models of interprofessional practice and education in clinical learning environments. There are many definitions and models of collaborative care, but the essential element is a spirit of collaboration and shared learning among health professionals, patients, and family members. This work is challenging, yet the benefits are striking. Patients and family members feel seen, heard, and understood. Health care professionals are able to contribute and feel appreciated in satisfying ways. Learners feel included. Care interactions are richer and less hierarchical, and human dimensions are more central. A crucial insight is that collaborative care requires psychological safety, so that people feel safe to speak up, ask questions, and make suggestions. The most important transformation is actively engaging patients and families as true partners in care creation. A leveling occurs between patients, family members, and health professionals, resulting from closer connections, deeper understandings, and greater mutual appreciation. Leadership happens at all levels in collaborative care, requiring team-level capabilities that can be learned and modeled, including patience, curiosity, and sharing power. These abilities grow as teams work and learn together, and can be intentionally advanced by reconfiguring organizational structures and care routines to support collective team reflection. Collaborative care requires awareness and deliberate practice both individually and as a team together. Respectful work is required, and setbacks should be considered normal at first. Once people have experienced the benefits of collaborative care, most "never want to go back."

Person-centred pain management for the patient with acute abdominal pain: An ethnography informed by the Fundamentals of Care framework.

To explore and describe the impact of the organizational culture on and the patient-practitioner patterns of actions that contributes to or detract from successful pain management for the patient with acute abdominal pain (AAP) across the acute care pathway. Although pain management is a recognized human right, unmanaged pain continues to cause suffering and prolong hospital care. Unanswered questions about how to successfully manage pain relate to both organizational culture and individual practitioners' performance. Focused ethnography, applying the Developmental Research Sequence and the Fundamentals of Care framework. Participant observation and informal interviews (92hr) were performed at one emergency department (ED) and two surgical wards at a University Hospital during April-November 2015. Data include 261 interactions between patients, aged ≥18years seeking care for AAP at the ED and admitted to a surgical ward (N=31; aged 20-90years; 14 men, 17 women; 9 with communicative disabilities) and healthcare practitioners (N=198). The observations revealed an organizational culture with considerable impact on how well pain was managed. Well-managed pain presupposed the patient and practitioners to connect in a holistic pain management including a trustful relationship, communication to share knowledge and individualized analgesics. Person-centred pain management requires an organization where patients and practitioners share their knowledge of pain and pain management as true partners. Leaders and practitioners should make small behavioural changes to enable the crucial positive experience of pain management.

2231 Research partnership, community commitment, and the people-to-people for Puerto Rico (#p2p4PUR) Movement: Researchers and citizens in solidarity

OBJECTIVES/SPECIFIC AIMS: Island communities face greater environmental risks creating challenges in their populations. A community and participatory qualitative research method aiming to understand community perspectives regarding the ecology and environmental risks of the island of Culebra was performed to develop a community-centered Information and Communications Technology (ICT) intervention (an app). The island of Culebra, a municipality from the archipelago of Puerto Rico is located 17 miles from the eastern coast of Puerto Rico’s main island. This ICT—termed mZAP (Zonas, Acción & Protección)—is part of a Translational Biomedical doctoral degree dissertation housed at the University of Rochester’s Clinical Translational Science Institute (CTSI) Informatics Core funded by an NIH Clinical Translational Science Award (CTSA). In September 2017, the island of Culebra faced 2 major category hurricanes 2 weeks apart. Hurricane Irma and Hurricane Maria devastated homes, schools, health clinics, and local businesses, disrupting an already-fragile ecological balance on the island. METHODS/STUDY POPULATION: These 2 storms catastrophically affected the archipelago of Puerto Rico. Culebra’s geographically isolated location, along with the inefficient response from authorities, exacerbated the stressors caused by these natural disasters, increasing the gap of social determinants of health, including the lack of potable water. Leveraging a community engagement partnership established before the hurricanes by the mZAP participatory research, which naturally halted once the hurricanes hit a new humanitarian objective formed to deliver aid. Along with another NIH funded RCMI Translational Research Network, or RTRN institution (University of Puerto Rico, Medical Science Campus) students and faculty, The Puerto Rico Testsite for Exploring Contamination Threats Program (PROTECT) an NIEHS Funded Grant, and the National Guard, a “people to people” approach was established to ascertain needs and an opportunity to meet those needs. A people-to-people approach brings humanitarian needs, identified directly by the community to the people who need it most; without intermediaries and bureaucratic delays that typically occur during catastrophes. RESULTS/ANTICIPATED RESULTS: The consumption of potable water in plastic bottles and subsequent accumulation of plastic material has proven to be collateral damage of a vulnerable water distribution system creating another environmental hazard on the island of Culebra. Therefore, this humanitarian partnership, worked to delivered community and family sized water filters, providing a safe environmental alternative to drinkable water for the island. The success of this approach, People to People for Puerto Rico (#p2p4PUR), demonstrated the power of genuine community engagement—arising from a previous clinical research partnership—and true established commitment with members of the community. DISCUSSION/SIGNIFICANCE OF IMPACT: Research partnerships can (and should, when needed) lead to humanitarian partnerships that extend beyond research objectives. Research may subsequently be adapted based on new realities associated with natural disasters and the altered nature of existing partnerships, allowing for a rapid response to communities need. Further, #p2p4PUR was not only able to channel a partnership humanitarian response but also created an opportunity to reflect on how the commitment between members of society and academia (researchers) can create beneficial bilateral relationships, always putting the community needs first. The resulting shared experience elevates community interest and engagement with researchers, and helps researchers see communities as true partners, rather than—simply—research subjects.

'A true partner around the table?' Perceptions of how to strengthen public health's contributions to the alcohol licensing process.

There are increased opportunities for public health practitioners (PHPs) in England to shape alcohol availability and reduce harms through a statutory role in licensing processes in local government. However, how public health can effectively influence alcohol licence decision-making is little understood. A mixed methods study was conducted to identify challenges faced by PHPs and mechanisms to strengthen their role. This involved a survey of practitioners across London local authorities (n = 18) and four focus group discussions with a range of licensing stakeholders (n = 36). Survey results indicated a varied picture of workload, capacity to respond to licence applications and levels of influence over decision-making among PHPs in London. Practitioners described a felt lack of status within the licence process, and difficulties using and communicating public health evidence effectively, without a health licensing objective. Strategies considered supportive included engaging with other responsible authorities and developing understanding and relationships over time. Against political and resource constraints at local and national government levels, pragmatic approaches for strengthening public health influence over alcohol licensing are required, including promoting relationships between stakeholders and offering opportunities for PHPs to share best practice about making effective contributions to licensing.

The Patient Experience: Informing Practice through Identification of Meaningful Communication from the Patient's Perspective.

(1) Background: There is limited empirical knowledge concerning aspects of healthcare that contribute to a good patient experience from the patient’s perspective and how patient feedback informs service development. (2) Aim: To examine the issues that influence the effectiveness of communication on patient satisfaction, experience and engagement, in an acute National Health Service (NHS) setting, through identification of the patient’s requirements and expectations. (3) Method: Data was gathered from a large teaching hospital using a Friends and Family Test (FFT) and a communication specific survey. Both surveys captured patient narrative to identify predominant influences to explain the quantitative responses. (4) Results: The key priorities for patients are involvement in their care and receiving the right amount of information to support this. However, the delivery of compassionate care was identified as having the most influence on the likelihood of patients to recommend an acute NHS Trust. (5) Conclusion: The findings support a broader understanding of the constituents of an all-encompassing patient experience from the patient’s perspective. (6) Implications: healthcare organizations need to focus their resources on how to improve patient/provider communication to support patients to be true partners in their care.

Hospital visiting policies – impacts on patients, families and staff: A review of the literature to inform decision making

Some healthcare organizations recommend adopting open visiting policies. These organisations are working towards the end goal of promoting the idea that patients and families can be true partners in care. An essential step in this culture shift involves openness to family presence and their engagement in the patient’s care. Among other things, their recommendations are based on data from studies that assessed the impacts of different types of visiting policies on patients, families and healthcare staff. In order to inform and guide an organizational reflection on possible changes to our hospital center’s visiting policies, our team undertook a systematic review that focussed on the advantages and disadvantages of open/flexible visiting policies, as perceived by patients, families and staff. Review articles and original articles were assessed and synthesized following a rigorous review process. Results of the reviewed studies suggest that flexible visiting policies lead to greater patient satisfaction with care and to positive impacts for both patients and families, and that these stakeholders have clear preferences for open/flexible policies. Nevertheless, policies including some guidelines to safeguard rest and sleep periods were deemed necessary by patients, rather than an unqualified open policy. Results also suggested that flexible visiting hours were not associated with an increased risk in hospital-acquired infections or septic complications in intensive care units (ICUs), where the majority of the reviewed studies were carried out. Authors recommended taking the specific context of care units into account when implementing new visiting policies, as needs may be different according to different health issues. Staff preferences over a model or the other were somewhat mixed. Some staff see the presence of families and visitors as an obstacle to the provision of care and a reason to fear increased workloads. In order to overcome this resistance, the importance of adequately preparing staff and supporting them throughout the policy change to ensure its success is highlighted.

Bidirectional Exchange in Global Health: Moving Toward True Global Health Partnership.

Although there has been rapid growth in global health educational experiences over the last two decades, the flow of learners remains overwhelmingly one directional; providers from high-resourced settings travel to limited-resourced environments to participate in clinical care, education, and/or research. Increasingly, there has been a call to promote parity in partnerships, including the development of bidirectional exchanges, where trainees from each institution travel to the partner's setting to learn from and teach each other. As global health educators and steering committee members of the Association of Pediatric Program Directors Global Health Pediatric Education Group, we endorse the belief that we must move away from merely sending learners to international partner sites and instead become true global health partners offering equitable educational experiences. In this article, we summarize the benefits, review common challenges, and highlight solutions to hosting and providing meaningful global health experiences for learners from limited-resourced partner institutions to academic health centers in the United States.

Effective implementation of the UNCRPD by Thailand State Party: challenges and potential remedies

BackgroundThe Thai government ratified the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) in 2008, and the first progress report by the State Party was issued in 2012. This study assesses and identifies gaps in the Government’s implementation of the Convention.MethodsUsing the Deming Plan-Do-Check-Act Cycle as an analytical framework for continuous quality improvement, we reviewed five documents which are: the 2012 State Party report; the list of issues by the Committee on the Rights of Persons with Disabilities; the 2015 replies to the list of issues by the Thai government; an alternative report produced by Civil Society Organizations (CSOs); and an alternative report produced by the National Human Rights Commission of Thailand. Content analysis is applied to generate the emerging gaps in implementation.ResultsThailand’s main advantage is the evolving legal frameworks operating in compliance with the convention, although further amendment is still needed, including effective law enforcement. Conflicting information between the Government’s and alternative reports reflects the shortcomings in the information system that intends to support rigorous monitoring and evaluation. Lacking of concrete measures and outcome indicators on certain articles reflects the State Party’s limited understanding of the concept of human rights and participatory approaches and insufficient institutional capacities for effective implementation.ConclusionsTo rectify these implementation gaps, a few actions are suggested. This includes amending the laws which violate the rights of persons with psychosocial disability; reforming governance where the monitoring bodies are truly independent from implementing agencies; strengthening cross-sectoral actions; and improving information systems which facilitate monitoring and evaluation where Disabled People’s Organizations and Civil Society Organizations are recognized as true equal partners. Implementation research can provide evidence for further effective implementation.

Le nouveau-né, un partenaire pour sa mère. Analyse du discours maternel

ObjectiveOver the course of the last decades, the content and prosodic characteristics of infant directed speech have been extensively studied. However, little research has focused on the content of mothers’ speech to newborn infants. In the present study, we wish to analyze the content of the mothers’ speech when they address their newborn infant, taking into account the newborn's behavioral state of alertness. In doing so, we wish to test the hypothesis that mothers consider their newborn as a true partner in the interaction. MethodsFifteen mothers and their healthy newborns were recorded in a face-to-face interaction when the newborns were 2 to 4 days old. The audio recordings were segmented and transcribed in order to extract and categorize the personal pronouns and the types of verbs the mother employed when addressing her newborn infant. The newborns’ behavioral states of alertness were also coded. ResultsTypes of verbs employed by the mothers changed according to the newborn's behavioral state. They employed verbs related to the physiological manifestations of the newborn, to volition or communication when the newborn was in a drowsy state, and verbs related to perception, emotion or cognition when the newborn was in a quiet alert state. The results also showed that the pronoun “you” was the most employed by mothers when addressing their newborn infant. Furthermore, the “you” pronoun was most employed with verbs relating to perception, communication, volition and emotion and less employed with verbs relating to the physiological manifestations of the newborn. ConclusionFrom the first days of life, mothers attune the content of their speech to the newborns’ behavioral sates. They seem to consider their newborn as a partner in the interaction, capable of sharing its intentions, emotions and desires with them.

In Memoriam: Joseph Kane (1957–2016)

This past July, I received a phone call from Jodi Kane with the awful news that her husband, Joe Kane, had passed away on 14 March. I was quite shocked by Jodi's news because Joe was recovering so well from a long-term illness when he attended the Miller Centennial.Joe was a son of the Midwest, a proud native of Wisconsin, a dedicated teacher, a true partner to his wife, Jodi. Most of us in the Miller Society knew Joe as, in the words of Christopher Bigsby, an “enthusiastic and effective researcher.” We always were amazed by Joe's ability to uncover lost manuscripts, documents, or bibliographical material related to Miller's life and career. For example, he discovered the lost reels to the film of Miller's playlet, The Reason Why. He was the most reliable fact-checker whose accurate information was irrefutable and, consequently, the bedrock for many scholarly articles and books. Joe's interview with the actor Eli Wallach remains one of the liveliest conversations published in The Arthur Miller Journal (vol. 3, no. 1).In recent years, Joe had been researching the radio plays that Miller wrote in the thirties and forties, and Joe had planned a book on this important period in Miller's career. We are searching for someone who can continue Joe's work. Chris Bigsby has reviewed some of Joe's extensive research and judges that the material would be valuable for graduate students or faculty with an interest in this area. We are also seeking a location to archive Joe's extensive files.Jodi Kane told me that Joe's involvement in The Arthur Miller Society was most definitely a high point in his life. She has provided the card from Joe's memorial service that contains a relevant quote from Miller and includes some photos from Joe's life—including his appearance on Who Wants to Be a Millionaire?Joe's passing forces us again to reconsider Charley's words in “Requiem” in Death of a Salesman. Joe is now “a man out there in the blue riding on a smile and a shoeshine.”

Abstract A31: Evaluating a diverse and cross community and academic partnership to promote colorectal cancer screening guidelines

Abstract Background A community and academic partnership is a powerful vehicle to translate lessons learned in research to a wider audience and bring about changes that can improve community health and eventually eliminate health disparities. Community-based participatory research (CBPR) is an approach to research that focuses on the development of a community-academic partnership. In CBPR, researchers work collaboratively with communities as true partners and use CBPR principles, such as co-learning and mutual benefit, to address identified public health concerns. Evaluating these partnerships and understanding the conditions and processes within CBPR that lead to achieving project goals, such as successful research implementation and outcomes, is important to move the science of CBPR forward. The purpose of this study was to evaluate a cross community and academic partnership that involved seven Asian communities (Cambodian, Chinese, Filipino, Korean, Laotian, South Asians and Vietnamese) that were different in culture, immigration history, and language. Method The parent project was designed to use a community-centered dissemination model to promote the adoption of colorectal cancer screening guidelines in Asian Americans (AA). The academic investigator has already established a good rapport with all partners prior to the project and has done projects with some of them in the past. Since community capacity building and sustainability are key values and outcomes of CBPR, an initial assessment of each partner's capacity and readiness was conducted during the first three months. Based on the findings, the research team conducted several training sessions throughout the 3-year project period to build capacity. In-person quarterly meetings were conduct to discuss project progress, solicit inputs for survey tools, disseminate findings and share lessons learned. The meeting sites were rotated among partners. A website was established to communicate project activities, findings and allow members to post comments. All partner leaderships were asked to participate in an one-on-one, in-depth interview at the end of the project to describe their experience of the partnership and the CBPR process. All interviews were tape-recorded and transcribed. All transcripts were coded and reviewed by three research members until consensus arrived on all themes. Results Overall project satisfaction rates were high, ranging from 8 to 10 out of a 10 scale (0=not at all satisfy and 10 = extremely satisfy). All partner leaderships reported that the project aligned with their priorities and values, although there were differences across organizations, from “including more specific education around specific diseases” to “getting some data for our work”. All leadership reported getting benefits from participating in the project. They also placed high value on the co-learning experience, from the academia and from other organizations. They also felt strongly about the collaboration, among partners and academia, and the attention they got as “mutually, equitably and well distributed”. Some organizations in their early development stage felt empowered by learning from more established organizations. Some saw the project as an opportunity to explore some other issues in their communities. All partners wanted to maintain the task force and to brainstorm issues that were relevant to Asian communities, even after the funding was ended. Conclusion A diverse and cross community partnership may sound complicated; however, with careful planning from the academic research team and mutual respect from all partners, it can enrich the CBPR process and generate greater outcomes. Citation Format: Karen Kim, Michael Quinn, Edwin Chandrasekar, Reena Patel, Helen Lam. Evaluating a diverse and cross community and academic partnership to promote colorectal cancer screening guidelines. [abstract]. In: Proceedings of the Ninth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2016 Sep 25-28; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2017;26(2 Suppl):Abstract nr A31.

Interaction Surfaces of Proteins Involved in Bacterial Chemotaxis with Rigid-Body Docking Decoys

To understand protein interaction mechanism, protein interaction interfaces are investigated using properties of protein interaction surfaces derived from sets of protein complex structures generated by rigid-body docking, referred as docking decoys. Because each docking decoys includes information of sets of possible interacting amino acid pairs we used profiles of protein interaction surfaces for improving the precision of protein-protein interaction (PPI) prediction in process of cluster analysis [Uchikoga & Hirokawa 2010 BMC Bioinfo.11:236]. By using profiles of protein interaction surfaces, we have developed methods for exploring docking search spaces in rigid-body docking process, Re-docking scheme [Uchikoga et al. 2013 PLoS ONE 8:e69365]. Protein interaction surfaces of whole decoys would contain clue for understanding protein interaction mechanisms. We then proposed a profile generated by assembling whole docking decoy interaction surfaces, referred as broad interaction surfaces (BIPs). And differences of BIPs between various protein pairs in a docking benchmark dataset were analyzed, indicating that BIPs are different between true and false protein interaction partners [Uchikoga et al. 2016 Biophys. Phisicobiol. 13:105-]. In this work, we apply the BIP method to PPI analysis involved in chemotaxis systems of several bacteria species. We then performed all-to-all docking analysis using a rigid-body docking software MEGADOCK for docking process. Cluster analysis could examine for differences between true interaction protein pairs and false pairs.