Tropical cyclones (TCs) predictions are crucial and of significant scientific and socio-economic interest. To improve the TC's simulation, this study aimed to use the Weather Research and Forecasting (WRF) model to assimilate satellite radiances and surface and upper-air conventional observations cyclically at the intervals of 6 h. The predictive skill of WRF with 4D variational (4DVar) and 3D variational (3DVar) data assimilation (DA) systems are investigated to examine the added value of 4DVar considering four cyclones namely Vardah, Titli, Bulbul, and Yaas over the North Indian Ocean (NIO). Each analysis was subjected to a short-range free forecast, and the estimates obtained from the 4DVar DA showed more realistic TC characteristics in terms of structure, intensity, rainfall, and track. The simulation of mean sea-level pressure and maximum sustained wind has demonstrated significant improvements in the 4DVar run for all the cases. Furthermore, the vector displacement error in cyclone Vardah was reduced by 54%–57% in the 4DVar simulation, whereas this improvement was found to be 9%–18% in the case of Titli. More or less similar results were found for Bulbul and Yaas also. Simulation of rainfall also showed marked improvement from the 4DVar scheme. Thus, the performance of the WRF model integrated with the 4DVar DA method enhanced the simulations of TC intensity, tracks, and structures over the NIO.