AnnotaIntroduction. To prevent climate-dependent diseases, it is important to identify relationships in the system “Climate and weather - human vital activity”, which is especially important in present conditions of significant climate change. The purpose of the work is to probate the methodology of forecasting the adverse impact of extremely hot weather on human health in the South of the Russian Far East. Material and Methods. Analysis of the synoptic situations was made on the basis of meteorological data for one observation time to the 34 weather stations in the South of the Russian Far East for 2000-2012. Data on the general mortality rate (the entire population and separately for the age group of 65 years and older) in Khabarovsk for 2000-2012. To determine the characteristics of synoptic situations and their possible impact on the human body analysis of air masses and mortality was carried out. Results. The “mortality window” for the hot period of the year is revealed: it is shown that marine and continental tropical air masses are the most unfavorable for human health. It is shown that in the summer mortality in Khabarovsk increases by 12% when in the area of action of extremely hot and humid tropical marine air masses, by 11% - in the continental tropical air masses. Conclusion. The model of mortality forecast depending on weather conditions can be the basis for the development of the system for preventing the impact of extremely high temperatures on human health.ciya