Trochlear Ridge Research Articles

Reconceptualization of Trochlear Dysplasia in Patients With Recurrent Patellar Dislocation Using 3-Dimensional Models.

Common classification schemes, measurements, and surgical planning for trochlear dysplasia are predicated on 2-dimensional imaging views. To investigate patellofemoral joint osseous anatomy using 3-dimensional (3D) printed models to describe osseous anatomic trochlear variations in patients with recurrent patellar dislocation. Cross-sectional study; Level of evidence, 3. Computed tomography scans were obtained from 20 patients with recurrent patellar dislocation and 10 healthy control knees, and 3D prints generated from these computed tomography scans were studied with respect to mediolateral positioning of the proximal trochlear groove and groove obliquity as well as changes in the appearance, height, and orientation of the medial and lateral trochlear ridges. Each trochlea was centered with respect to a vertical line perpendicular to the distal femoral condyles and through the central intercondylar notch roof, with the 3D models resting on their posterior femoral condyles. A novel 3D measurement method was devised to assess groove obliquity, termed the entry point-transition point (EP-TP) angle. The EP was defined as the midpoint of the flattened region of the proximal trochlea where the lateral and medial ridges of the proximal trochlea meet, and the TP was the point along the trochlear groove at which the groove shape changes from an oblique orientation proximally to one more vertical distally. Measurements were obtained by 3 reviewers, and reliability analyses were performed. With the dysplastic knees arranged according to flattening of the trochleas, increased obliquity of the trochlear grooves was observed, as reflected by increased EP-TP angles as well as more lateral patellar EPs into the proximal trochleas of these recurrent patellar dislocation knees when compared with the control knees. The degree of trochlear dysplasia (according to the Dejour classification and trochlear flatness in the frontal and axial planes) was associated with diminished prominence of the lateral trochlear convexity, increasingly lateralized proximal trochlear EPs, increased trochlear groove obliquity, lateral trochlear curvature, and progressive medial ridge deformity. The 3D reproductions enabled unique conceptualization of trochlear deformity associated with recurrent patellar dislocation.

Evaluation of a co-culture of rapidly isolated chondrocytes and stem cells seeded on tri-layered collagen-based scaffolds in a caprine osteochondral defect model

Cartilage has poor regenerative capacity and thus damage to the joint surfaces presents a major clinical challenge. Recent research has focussed on the development of tissue-engineered and cell-based approaches for the treatment of cartilage and osteochondral injuries, with current clinically available cell-based approaches including autologous chondrocyte implantation and matrix-assisted autologous chondrocyte implantation. However, these approaches have significant disadvantages due to the requirement for a two-stage surgical procedure and an in vitro chondrocyte expansion phase which increases logistical challenges, hospital times and costs. In this study, we hypothesized that seeding biomimetic tri-layered scaffolds, with proven regenerative potential, with chondrocyte/infrapatellar fat pad stromal cell co-cultures would improve their regenerative capacity compared to scaffolds implanted cell-free. Rapid cell isolation techniques, without the requirement for long term in vitro culture, were utilised to achieve co-cultures of chondrocytes and stromal cells and thus overcome the limitations of existing cell-based techniques. Cell-free and cell-seeded scaffolds were implanted in osteochondral defects, created within the femoral condyle and trochlear ridge, in a translational large animal goat model. While analysis showed trends towards delayed subchondral bone healing in the cell-seeded scaffold group, by the 12 month timepoint the cell-free and cell-seeded groups yield cartilage and bone tissue with comparable quality and quantity. The results of the study reinforce the potential of the biomimetic tri-layered scaffold to repair joint defects but failed to demonstrate a clear benefit from the addition of the CC/FPMSC co-culture to this scaffold. Taking into consideration the additional cost and complexity associated with the cell-seeded scaffold approach, this study demonstrates that the treatment of osteochondral defects using cell-free tri-layered scaffolds may represent a more prudent clinical approach.

Computed tomographic measurements of the femoral trochlea in dogs with and without medial patellar luxation.

To determine cutoff values in small (SB) and medium/large (MLB) breed dogs with and without medial patellar luxation (MPL) for identifying abnormal femoral trochlea morphology. Original research. A total of 80 computed tomographic (CT) scans from client-owned dogs METHODS: Four groups of 20 dogs were created: (1) control SB, (2) control MLB, (3) MPL-SB, and (4) MPL-MLB. Two authors measured the femoral trochlear groove angle (FTGA), femoral trochlear angle (FTA), and femoral trochlear ridge inclination angle (FTRIA) in two points with CT. ANOVA and ROC-analysis were tested to the control and MPL groups to assess sensitivity, specificity, and cutoff values. Statistical significance was set to p < .05. Intraclass correlation coefficients evaluated the inter-rater agreement. FTGA (± SD) in control SB (128.8° ± 4.7°) and control MLB (119.2° ± 5.6°), was smaller (p < .0001) than in MPL-SB (139.4° ± 4.4°) and MPL-MLB (133.7° ± 5.1°). FTA and FTRIA were decreased (p=.12, p=.23) in MPL-SB (2.1° ± 6.8; -0.3° ± 3.3°) and MPL-MLB (3.8° ± 5.6°; 1.7° ± 4.5°) compared to control SB (0.2° ±4.1; -0.1° ± 2.6°) and control MLB (5.3° ± 2.8°; 3.1° ± 1.3°). Cutoff values for FTGA, FTA, and FTRIA were > 134°, < -5.9°, < -2 ° (SB), and > 128.3°, < -0.4°, < -0.4° (MLB). Sensitivity, specificity, and inter-rater agreement were superior for FTGA than FTA and FTRIA. Dogs without MPL had a deeper femoral trochlear groove than MPL dogs. SB had a shallower groove than MLB. The measurement of FTA and FTRIA was not reliable. A FTGA <134° (SB) and < 128° (MLB) may be considered as a cutoff for trochleoplasty decision-making.

When treating medial patellar luxation in dogs is a block trochleoplasty superior over a wedge trochleoplasty?

PICO question&#x0D; As part of the surgical correction for medial patellar luxation in dogs, which procedure results in a better outcome for the patient: block or wedge recession trochleoplasty?&#x0D; &#x0D; Clinical bottom line&#x0D; Category of research question&#x0D; Treatment&#x0D; The number and type of study designs reviewed&#x0D; Three studies satisfied the inclusion criteria for answering the PICO; one cadaver study, one retrospective observational study and one clinical case series&#x0D; Strength of evidence&#x0D; Weak&#x0D; Outcomes reported&#x0D; Postoperative complications including reluxation rates.&#x0D; Ex vivo: Trochlear groove depth, patella articular contact, percentage of recessed trochlear surface area, resistance to medial patella luxation&#x0D; Conclusion&#x0D; There is only weak evidence to support block recession trochleoplasty over wedge recession trochleoplasty as part of the surgical correction for medial patella luxation in dogs. Both procedures are associated with a good clinical outcome. There are some proposed benefits to trochlear block recession made from an ex vivo study comparing the two procedures. These include an increased patellar volume under the trochlear ridges when the stifle is extended. The articular contact and recessed trochlear surface area were also increased in the trochlear block recession group when compared to trochlear wedge recession. However, the clinical relevance of these perceived benefits remains unproven. In practice, and until prospective randomised controlled trials are carried out, veterinary surgeon preference and previous experience remain relevant factors in choosing which procedure to perform&#x0D; &#x0D; How to apply this evidence in practice&#x0D; The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.&#x0D; Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.&#x0D; &#x0D;

Lateral Patellar Luxations following Bilateral Hip Joint Replacement in a Dog

AbstractA 2-year-old male neutered crossbreed was presented with a 7-month history of left pelvic limb lameness. Following a diagnosis of bilateral hip dysplasia, staged hybrid total hip replacements (THR) were performed 16 months apart. An ipsilateral grade II lateral patellar luxation (LPL) developed within 24 hours after each THR. Both LPLs were successfully treated by block recession sulcoplasty. Subjective gait analysis showed an abnormal pelvic limb gait following each THR. Clinical examination detected a grade II LPL on each operated limb. Computed tomography of both pelvic limbs revealed mild trochlear sulcus hypoplasia but no other skeletal abnormalities. Trochlear block recession sulcoplasty was performed 10 and 4 weeks respectively after THR. Long-term follow-up 12 months after the last surgery found minimal (0–1/10) lameness, no pain on clinical examination in both PLs and an overall low client-based metrology instrument mobility score of 2 (Liverpool Osteoarthritis in Dogs). This case report documents that in predisposed dogs, with hypoplastic trochlear ridges, LPL can occur secondary to THR and can be successfully managed by standard techniques to address the luxation. Furthermore, despite anecdotal verbal reports of medial patellar luxation occurring secondary to THR in dogs, this is the first published report of the management of any patellar luxation subsequent to THR.

Patellar Groove Replacement in a Cat

AbstractThe aim of this study was to report patellar groove replacement in a 6-year-old domestic short hair cat with chronic unilateral pelvic limb lameness and severe femoro-patellar osteoarthritis due to medial patellar luxation. This study is a case report. Computed tomographic scan of the affected limb revealed marked periarticular osteophytosis, medial trochlear ridge erosion, marked flattening of femoral trochlea, ectopic pseudo-trochlear groove, and medial patellar luxation. Femoral trochlear ostectomy with patellar groove replacement, release of the medial fibrocartilage, partial parasagittal patellectomy, and lateral tibial tuberosity were performed. Clinical review and radiographs performed 53 days post-surgery revealed no complications and substantial decrease in lameness. Thirteen months postoperatively the cat scored 2/72 on the Feline Musculoskeletal Pain Index questionnaire by the owner, indicating good mobility, minimal discomfort, and good quality of life. As far as the authors are aware, this is the first report of the use of patellar groove replacement in the management of feline medial patellar luxation. Patellar groove replacement, in combination with adjunctive procedures, resulted in a substantial improvement in lameness in this cat with chronic medial patellar luxation and severe femoro-patellar osteoarthritis.

Paper 50: Isolated Medial Patellofemoral Ligament Reconstruction for Recurrent Patellar Instability Regardless of Tibial Tubercle - Trochlear Groove Distance and Patellar Height: Minimum 5-Year Outcomes

Objectives:It remains unclear which subset of patients with recurrent patellofemoral instability would benefit from a concomitant bony realignment procedure in addition to a medial patellofemoral ligament (MPFL) reconstruction. The purpose of this study is to provide midterm results on previously reported patient reported outcomes (PRO), return to sport (RTS) and imaging measurements collected for patients who underwent an isolated MPFL reconstruction as part of an ongoing prospective trial. This includes minimum 5-year outcomes data on a cohort of 55 patients as well as 2-year outcomes data on an expanded cohort of 121 patients.Methods:Patients with recurrent patellar instability who did not meet exclusion criteria were prospectively enrolled in an institutional registry beginning in March 2014. Exclusion criteria included patients with a prior history of a patellar stabilization procedure, an off-loadable (inferior/lateral) Outerbridge Grade IV chondral defect, obligatory dislocators (patients who require patellar dislocation in order to achieve full knee extension) or patients with a “Jumping J” sign and patients who reported anterior knee pain as more than 50% of their chief complaint.All patients who were not excluded by the above criteria underwent primary, unilateral, isolated MPFL reconstruction regardless of their bony anatomy (tibial tubercle - trochlear groove (TT-TG), trochlear morphology, trochlear depth, or patellar height) for treatment of recurrent patellar instability. Patient data including PROs, episodes of recurrent instability or dislocation, and ability to return to sport (RTS) was obtained annually. Radiographic MRI measurements including TT-TG, Caton-Deschamps Index (CDI), Patellar Trochlear Index (PTI), Trochlear Depth Index (TDI), Patellar Tendon to Lateral Trochlear Ridge (PT-LTR) and Tibial Tubercle to Lateral Trochlear Ridge (TT-LTR) were obtained at baseline.Results:138 patients (72% female; mean age 20.1 ± 6.1 years) underwent isolated MPFL reconstruction between March 2014 and December 2019. 55 patients reached the ≥5-year postoperative time point, of which 40 (72%) completed follow-up PROs. 121 patients reached the ≥2-year postoperative time point, of which 89 (74%) completed follow-up PROs.99% (n=136) of patients at 2 years and 96% (n=132) of patients at ≥ 5 years had no self-reported post-operative patellofemoral instability: 6 patients (4%) reported recurrent instability at a mean of 3.0 ± 0.7 years postoperatively. Activities during which failure occurred included jumping on a trampoline, dancing, and playing lacrosse.Preoperatively, 100 (72%) patients participated in sports or physical activity, of which 87 reported return to sport (87%). All patients that returned to sport did so within 24 months postoperatively with a mean RTS of 9.3 months. KOOS-Qol, Pedi-Fabs, IKDC, KOOS-PS and Kujala PROS are reported in Table 1.The mean TT-TG was 15.1 ± 4.9 mm (1.90 to 27.2 mm), mean CDI was 1.14 ± 0.16 (0.72 to 1.65), mean PTI was 46.9 ± 15.1% (13 to 100%) and mean trochlear depth was 2.5 ± 1.2 mm (-1.55 to 5.15 mm). Trochlear dysplasia, defined as a TDI < 3 mm, was present in 77 (56%) of patients. The mean measure of extensor mechanism containment, TT-LTR, was -8.4 ± 5.7 mm (-24.0 to 3.20 mm) and the rate of TT-LTR within 1 mm, found to be predictive of recurrent instability, was 8% (n=11). The mean PT-LTR, a measurement of lateral patellar tracking, was 5.7 ± 6.2 mm (-5.70 to 21.1 mm).The six patients who experienced recurrent instability after an isolated MPFL reconstruction had a mean CDI of 1.19 and a mean TT-TG of 18.75. Individual imaging data for these six patients can be seen in Table 2.Conclusions:Midterm outcomes for patients who underwent isolated MPFL reconstruction (within strict exclusion criteria parameters) are shown to be favorable and maintained at 5 years. Additionally, the outcomes for the expanded cohort of patients with a minimum of 2-year follow up supports the previously published results. Most athletes were able to return to sport. Completion of this study enrollment with long term follow up will allow for more robust assessment of long-term outcomes and incidence of recurrent instability after isolated MPFL reconstruction. The ultimate goal of this work is the creation of a predictive model utilizing the bony and clinical characteristics of those patients who sustain recurrent instability in order to better predict who might benefit from additional bony realignment procedures at the time of their index procedure.Table 1.Patient Reported Outcomes at Baseline, 2 years and ≥ 5 yearsTable 2.Radiographic Measurements for Patients with Recurrent Patellar Instability after Isolated MPFL Reconstruction

Differential Protein Expression of the Marginal Transitional Zone in Foals with Osteochondrosis

The marginal transitional zone is peripherally located within the diarthrodial joint, and represents the interface of articular cartilage, periosteum, and the fibrous joint capsule. The purpose of this study is to characterize the protein expression of matrix and molecular regulators in the marginal transitional zone of foals having osteochondrosis (OC) compared to normal foals. Several families of proteins with known roles in cartilage and bone development are investigated, including matrix molecules, Wnt signaling, apoptotic factors and paracrine cell signaling molecules. Our results demonstrate differential protein expression in the marginal transitional zone from the lateral femoral trochlear ridge of foals affected by osteochondrosis. Alterations in protein expression of OC-affected foals mainly involve components of extracellular matrix homeostasis and canonical Wnt signaling. Matrix expression of collagen type IIB and lubricin are decreased and matrix metalloproteinase-3 expression is increased in OC-affected marginal transitional zone samples. Canonical Wnt signaling is inhibited in OC-affected marginal transitional zone samples, based on increased Dickkopf-1 and decreased β-catenin protein expression. Most apoptotic and paracrine signaling proteins are not altered in OC-affected marginal transitional zone samples.

Disorders of the sustentaculum tali and the medial trochlear ridge of the talus in horses: Novel findings and surgical management of five cases

AbstractThe sustentaculum tali (ST) is located at the medial aspect of the tarsus and is considered a rare anatomic location for diseases. This retrospective case series describes the management of five horses with septic and non‐septic ST injuries. All horses were treated surgically with tenovaginoscopy, ST fragment and exostosis removal. In two cases, lameness was caused by an exostosis involving the ST and the plantar aspect of the medial trochlear ridge (MTR). There are no reports of exostosis involving ST and MTR causing lameness. In four horses, the long‐term outcome was considered good and the horses were able to return to the previous level; one horse developed a recurrence of ST and MTR exostosis leading to recurrence of lameness. Curettage of the ST and MTR exostosis, removal of fragments and tarsal sheath adhesions play a pivotal role in increasing prognosis and long‐term outcome. Poor prognosis is correlated with exostosis recurrence.

Computed tomography assisted diagnosis and treatment of a comminuted fracture of the plantar aspect of the medial trochlear ridge and the proximal tubercle of the talus in a foal

SummaryIsolated fractures of the proximal tubercle of the talus and the medial trochlear ridge of the talus have been reported in the equine literature. A comminuted, intra‐articular fracture of the plantar medial trochlear ridge and proximal tubercle of the talus has not been previously reported. The current case report describes this unique comminuted fracture in a 6‐week‐old Thoroughbred foal with acute onset lameness. The diagnosis was achieved by a combination of radiography, ultrasonography and computed tomography (CT) followed by CT arthrography. Surgical removal of the fracture fragments was recommended; the intra‐articular fracture fragments were removed under arthroscopic visualisation of the plantar pouch of the tarsocrural joint; due to ligamentous attachments and partial extra‐articular nature, the fracture fragment of the proximal tubercle of the talus was removed via an arthrotomy extension of the medial arthroscopy portal. On follow‐up examination 12 months post‐operatively, the yearling showed no clinical evidence of lameness or radiographic evidence of secondary degenerative joint disease.

Location-Specific Study of Young Rabbit Femoral Cartilage by Quantitative µMRI and Polarized Light Microscopy.

ObjectiveMicroscopic magnetic resonance imaging (µMRI) and polarized light microscopy (PLM) are used to characterize the structural variations at different anatomical locations of femoral cartilage in young rabbits (12-14 weeks old).DesignFour intact knees were imaged by µMRI at 86 µm resolution. Three small cartilage-bone specimens were harvested from each of 2 femoral medial condyles and imaged by quantitative µMRI (T2 anisotropy) at 9.75 µm resolution (N = 6). These specimens, as well as the other 2 intact femoral condyles, were used for histology and imaged by quantitative PLM (retardation and angle) at 0.25 µm to 4 µm resolutions.ResultsQuantitative MRI relaxation data and PLM fibril data revealed collaboratively distinct topographical variations in both cartilage thickness and its collagen organization in the juvenile joint. Cartilage characteristics from the central location have a 3-zone arcade-like fibril structure and a distinct magic angle effect, commonly seen in mature articular cartilage, while cartilage at the anterior location lacks these characteristics. Overall, the lowest retardation values and isotropic T2 values have been found in the distal femur (trochlear ridge), with predominant parallel fibers with respect to the articular surface. Central cartilage is the thickest (~550 µm), approximately twice as thick as the anterior and posterior locations.ConclusionDistinctly different characteristics of tissue properties were found in cartilage at different topographical locations on femoral condyle in rabbits. Knowledge of location-specific structural differences in the collagen network over the joint surface can improve the understanding of local mechanobiology and provide insights to tissue engineering and degradation repairs.

Patellar dislocation is associated with increased tibial but not femoral rotational asymmetry.

Patellar dislocation is associated with a range of anatomical abnormalities affecting the trochlea, extensor mechanism and the tibia. The relationship between patellofemoral instability and rotational abnormalities of the posterior condyles, trochlear groove and proximal tibia has not been adequately determined. This study aimed to identify the frequency and severity of anatomical risk factors to determine their relative contribution to patellofemoral instability. A retrospective morphological study was undertaken comparing multiple anatomical measurements with magnetic resonance imaging of 50 patients with patellofemoral instability to an age- and gender-matched Control group (n = 50). Several techniques were assessed measuring both femoral and tibial axial asymmetry. A new measurement, tibial rotational asymmetry, comparing a line between the midpoints of the collateral ligaments to the axis between the patellar tendon and posterior cruciate ligament, was assessed for its association with patellofemoral instability. Compared to the controls, the patellofemoral instability group demonstrated a significant difference in tibial rotational asymmetry, with a mean of 2.9° (SD 3.2°) externally rotated vs -1.6° (SD 2.2°) in the control group. Significant differences were also demonstrated regarding the sulcus angle, tibial tubercle-trochlear groove distance, tibial tubercle-posterior cruciate ligament distance, patellar size and the Insall-Salvati ratio. There were no differences between groups regarding the lengths of the posterior condyles, the heights of the trochlear ridges or lateralisation of the trochlear groove. Further analysis of the patellofemoral instability group revealed a subgroup of males with normal anatomy (7/50) and a subgroup of females with isolated patella alta (7/50). Patellofemoral instability is associated with tibial rotational asymmetry due to lateralisation of the tibial tubercle. It is also associated with patella alta and reduced trochlear groove depth. The femoral axial shape is otherwise unchanged. III.

Technical Considerations for an Anteromedializing Tibial Tubercle Osteotomy

Background: Tibial tubercle osteotomy and distal realignment allows for adjustment to the patellofemoral articulation in order to improve patellar tracking and redistribute patellar contract pressures. Indications: A healthy, active 39-year-old woman status post right knee tibial tubercle osteotomy presented with &gt;2 years of patellar instability symptoms in the left knee. Imaging revealed a tibial tubercle to trochlear groove (TT-TG) distance of 21 mm and patellar tendon lateral trochlear ridge (PT-LTR) distance of 14 mm. Technique Description: After knee arthroscopy is performed, an open incision is made along the inferomedial patellar tendon. Two pilot holes are created before a sagittal saw is used to make the tibial tubercle osteotomy, before completing it with an osteotome. Anteromedialization and/or distalization of the osteotomy is performed relative to templated values in order to improve patellar articulation. After correction, 3 bicortical screws are placed to achieve stable fixation. Results: There were no immediate complications following surgery. Surgical management led to improvement of the patient’s patellofemoral pain, which allowed return to prior baseline level of function. Discussion/Conclusion: The preferred technique for an anteromedialzing tibial tubercle osteotomy is presented. An anteromedializing tibial tubercle osteotomy is an effective surgical option for patients with evidence of patellar maltracking or central or lateral patellar chondromalacia whom have failed conservative management. This case demonstrates the efficacy of an anteromedializing tibial tubercle osteotomy to provide pain relief by improving patellar tracking and offloading patellar contact pressures on areas of prominent chondral wear.

RELIABILITY OF NOVEL ULTRASOUND MEASUREMENT FOR DETERMINING PATELLA POSITION

Background:Patellar dislocations are common among youth athletes. A detailed understanding of patellofemoral anatomy is critical to determine patient prognosis and guide treatment and decision making. Recent literature suggests that measures of patella position relative to the trochlear groove may help identify individuals at risk of repetitive dislocations. While these measures were described using MRI, it is plausible that ultrasound imaging can be utilized to provide similar information in a more cost-effective and time-efficient manner.Purpose:To determine intra and inter-rater reliability of two newly described ultrasound-based measures of patella positioning within two novice examiners.Methods:Subjects were seated with the limb supported in full knee extension and neutral rotation. (Figure 1a) The examiners independently gathered all images and were blinded to each other’s measures for the duration of the study. The transducer was positioned transversely, on the anterior aspect of the knee such that the lateral trochlear ridge, center of trochlear groove, and proximal portion of the patellar tendon were all visible in cross-section. (Figure 1b) Two linear measures were obtained, representing the distance from midpoint of the patellar tendon to a) the center of trochlear groove (MPT-CTG) and b) the lateral trochlear ridge (MPT-LTR). Reliability was assessed using intraclass correlation coefficients (ICC). The average of two measures were used for data analysis. There was a minimum of 1 week between assessments for those subjects with repeated testing.Results:A total of 11 subjects (mean age 15.3) without history of knee pathology were included. There were no significant differences (p>0.05) in either measurement between limbs with MPT-CTG and MPT-LTR values (mean±sd) as follows: MPT-CTG right 8.4mm ± 3.0, left 8.4mm ± 3.3; MPT-LTR right 12.2mm ± 2.7, left 11.6mm ± 2.3. For reliability analysis, each knee served as a discrete variable, yielding a total of 22 data points for evaluation. Inter-rater reliability (n=22) was moderate to good for both measures, with ICC values of 0.724 and 0.814 for MPT-CTG and MPT-LTR, respectively. Intra-rater reliability (n=10) was good to excellent with ICC values of 0.913 and 0.794 for MPT-CTG and MPT-LTR, respectively. (Table 1)Conclusions:This new measure of patella positioning demonstrated moderate to excellent reliability and may be a practical, cost-effective alternative to MRI. While it is encouraging that the subjects in this sample demonstrated no side-to-side differences in either measure, future research should focus on establishing criterion validity and reliability amongst individuals with patellar instability.Figure 1.

Microfracture Augmentation With Trypsin Pretreatment and Growth Factor–Functionalized Self-assembling Peptide Hydrogel Scaffold in an Equine Model

Background: Microfracture augmentation can be a cost-effective single-step alternative to current cartilage repair techniques. Trypsin pretreatment combined with a growth factor–functionalized self-assembling KLD hydrogel (“functionalized hydrogel”) has been shown to improve overall cartilage repair and integration to surrounding tissue in small animal models of osteochondral defects. Hypothesis: Microfracture combined with trypsin treatment and a functionalized hydrogel will improve reparative tissue quality and integration as compared with microfracture alone in an equine model. Study Design: Controlled laboratory study. Methods: Bilateral cartilage defects (15-mm diameter) were created on the medial trochlear ridge of the femoropatellar joints in 8 adult horses (16 defects total). One defect was randomly selected to receive the treatment, and the contralateral defect served as the control (microfracture only). Treatment consisted of 2-minute trypsin pretreatment of the surrounding cartilage, subchondral bone microfracture, and functionalized hydrogel premixed with growth factors (platelet-derived growth factor and heparin-binding insulin-like growth factor 1). After surgery, all horses were subjected to standardized controlled exercise on a high-speed treadmill. Clinical evaluation was conducted monthly, and radiographic examinations were performed at 2, 16, 24, 32, 40, and 52 weeks after defect creation. After 12 months, all animals were euthanized. Magnetic resonance imaging, arthroscopy, gross pathologic evaluation of the joint, histology, immunohistochemistry, and biomechanical analyses were performed. Generalized linear mixed models (with horse as random effect) were utilized to assess outcome parameters. When P values were <.05, pairwise comparisons were made using least squares means. Results: Improved functional outcome parameters were observed for the treatment group, even though mildly increased joint effusion and subchondral bone sclerosis were noted on imaging. Microscopically, treatment resulted in improvement of several histologic parameters and overall quality of repaired tissue. Proteoglycan content based on safranin O–fast green staining was also significantly higher in the treated defects. Conclusion: Trypsin treatment combined with functionalized hydrogel resulted in improved microfracture augmentation. Clinical Relevance: Therapeutic strategies for microfracture augmentation, such as those presented in this study, can be cost-effective ways to improve cartilage healing outcomes, especially in more active patients.

Continuous versus discrete data analysis for gait evaluation of horses with induced bilateral hindlimb lameness

BackgroundGait kinematics measured during equine gait analysis are typically evaluated by analysing (asymmetry‐based) discrete variables (eg, peak values) obtained from continuous kinematic signals (eg, timeseries of datapoints). However, when used for the assessment of complex cases of lameness, such as bilateral lameness, discrete variable analysis might overlook relevant functional adaptations.ObjectivesThe overall aim of this paper is to compare continuous and discrete data analysis techniques to evaluate kinematic gait adaptations to lameness.Study designMethod comparison.MethodsSixteen healthy Shetland ponies, enrolled in a research programme in which osteochondral defects were created on the medial trochlear ridges of both femurs, were used in this study. Kinematic data were collected at trot on a treadmill before and at 3 and 6 months after surgical intervention. Statistical parametric mapping and linear mixed models were used to compare kinematic variables between and within timepoints.ResultsBoth continuous and discrete data analyses identified changes in pelvis and forelimb kinematics. Discrete data analyses showed significant changes in hindlimb and back kinematics, where such differences were not found to be significant by continuous data analysis. In contrast, continuous data analysis provided additional information on the timing and duration of the differences found.Main limitationsA limited number of ponies were included.ConclusionsThe use of continuous data provides additional information regarding gait adaptations to bilateral lameness that is complementary to the analysis of discrete variables. The main advantage lies in the additional information regarding time dependence and duration of adaptations, which offers the opportunity to identify functional adaptations during all phases of the stride cycle, not just the events related to peak values.

Morphological Analysis of Bone Deformities of the Distal Femur in Toy Poodles with Medial Patellar Luxation.

The aim of this study was to evaluate the bone deformities of the distal femur of Toy Poodles with medial patellar luxation (MPL) using computed tomography. Computed tomography data from 37 stifles of Toy Poodles (16 normal, 10 grade 2 MPL and 11 grade 4 MPL) were analysed. For trochlear morphology, sulcus angle, medial or lateral trochlear inclination and trochlear angle were compared. For condylar morphology, distance between the apex of the medial or lateral trochlear ridge and the most caudal point of the medial or lateral femoral condyle (MC or LC), the length of the cranial/middle (anterior) part (MC(a) or LC(a')) and caudal (posterior) part (MC(p) or LC(p')) of distal femur and medial or lateral condyle width (MCW or LCW) were measured, and the ratios of medial-to-lateral condyles and anterior-posterior parts were compared. Sulcus angle was significantly higher, and medial trochlear inclination was significantly lower in grade 4 MPL group than other groups. Lateral trochlear inclination was not significantly different among 3 groups. Trochlear angles at proximal trochlear groove were significantly lower in grade 4 MPL group than other groups. MC/LC, MC(a)/LC(a'), MC(a)/MC(p), and LC(a')/LC(p') were significantly lower in grade 4 MPL group than other groups; however, there were no significant differences in MC(p)/LC(p') and MCW/LCW among three groups. Hypoplasia of the cranial and middle rather than caudal compartment of the distal femur was the primary morphological abnormality in Toy Poodles with grade 4 MPL.

Correlations Between Radial Head Diameters and Humeral Articular Dimensions: Bilateral MRI Morphometric Analysis on 39 Healthy Subjects

Choosing the correct size of head component in radial head arthroplasty is often challenging, particularly in comminuted fractures, deformities, and revision surgery. The main aim of this study was to investigate possible correlations between radial head diameters and the morphometric parameters of the articular distal humerus in order to find mathematical equations that may be used to infer radial head dimensions indirectly. We performed bilateral elbow magnetic resonance imaging on 39 healthy young subjects, comprising 19 women and 20 men, with a mean age of 28 years (range, 21-32 years). The following measurements, which included cartilage thickness, were calculated on the axial plane: maximum (Dmax) and minimum (Dmin) radial head diameters, capitellum width, capitellum to lateral trochlear ridge width (CAP-TROCHridge), humeral articular width (HUMwidth), capitellum radius of curvature, and lateral, medial, and total trochlear width. The anteroposterior diameters of the capitellum, trochlear sulci, and lateral and medial trochlear ridges were measured on the sagittal plane. CAP-TROCHridge and HUMwidth were found to be the parameters most strongly correlated with the radial head diameters. Four mathematical equations that allowed Dmax and Dmin to be calculated with an average residual error less than 1 mm, were obtained. The intraclass coefficient was greater than 0.95 for all the measurements. Radial head diameters can be accurately inferred from 2 humeral dimensions by magnetic resonance imaging. The HUMwidth, which is not influenced by cartilage thickness, may be useful for planning with preoperative imaging because it can also be calculated by computed tomography scan, whereas CAP-TROCHridge, which is influenced by cartilage thickness, might be useful for direct intraoperative measurement. Diagnostic III.

Predicting Risk of Recurrent Patellofemoral Instability With Measurements of Extensor Mechanism Containment

Background: Identifying risk factors for recurrent patellar dislocation after a primary dislocation may help guide initial treatment. Magnetic resonance imaging (MRI) measurements relating the alignment of the extensor mechanism to trochlear morphology have been shown to distinguish patients with dislocations from controls, but their usefulness in predicting the risk of a second dislocation is not known. Purpose: To identify the association of novel MRI measures of patellar containment with recurrent instability in pediatric patients presenting with a first-time patellar dislocation. Study Design: Cohort study (Prognosis); Level of evidence, 3. Methods: The study was conducted at a tertiary care children’s hospital (2005-2014) on patients (age, 8-19 years) with a first-time patellar dislocation. MRI measurements were made by 2 independent raters. Interobserver reliability was assessed for all measurements via an intraclass correlation coefficient (ICC). Only measurements with an ICC >0.8 were included. Univariable and multivariable logistic regression analyses were used to evaluate variables associated with recurrence. Results: A total of 165 patients with a median age of 14 years and a slight (57.6%) female predominance was identified. The median follow-up length of the whole cohort was 12.2 months (interquartile range, 1.6-37.1 months). Subsequent instability was documented in 98 patients (59.4%). MRI measurements with excellent correlation (ICC > 0.8) were the tibial tubercle to trochlear groove distance (TT-TG), the tangential axial width of the patella, the tangential axial trochlear width, the axial width of the patellar tendon beyond the lateral trochlear ridge (LTR), and the tibial tubercle to LTR distance. In univariate analysis, all mentioned MRI measurements had significant association with recurrent instability. However, after both backward and forward stepwise regression analyses, the tibial tubercle to LTR distance was the only independent predictor of recurrent instability (P = .003 in both). Patients with a tibial tubercle to LTR distance value greater than –1 mm had a significantly higher rate of recurrent patellar dislocation (72%). Conclusion: Of numerous axial view MRI parameters, only the tibial tubercle to LTR distance demonstrated a statistically significant association with recurrent patellar instability upon multivariable logistic regression analysis during short-term follow-up of a pediatric population presenting with initial lateral patellar dislocation. Interobserver correlation of the tibial tubercle to LTR distance was good (ICC > 0.8) and similar to that of TT-TG.

Lateral trochlear lengthening osteotomy

IntroductionThe purpose of this study was to describe the indications and technical aspects as well as evaluate the clinical and functional outcome of lengthening osteotomy of the lateral trochlear ridge in patients with patellofemoral pain and/or patella instability and presence of trochlear dysplasia Dejour type A or lack of Dejour type dysplasia and short lateral articular trochlea.Materials and methodsSix consecutive adult patients were treated with a lateral trochlear lengthening osteotomy. Five patients received a concomitant medial patellofemoral ligament reconstruction. Three patients had prior patella stabilization surgeries. Trochlea dysplasia (Dejour classification), Caton–Dechamps index, tibial tubercle trochlear groove (TT-TG) distance, patellar tilt and lateral condylar index were measured in preoperative MRIs. Clinical and functional evaluation included the Kujala Anterior Knee Pain Scale, the Lysholm Knee Score, the Tegner Activity Score, a subjective evaluation form and isokinetic muscle strength.ResultsFour patients had a Dejour type A dysplasia, two patients had no dysplasia. The mean (range) Caton-Dechamps index was 1.09 (0.95–1.16), TT-TG distance 10.9 mm (9.2–15.6 mm), patellar tilt 15° (4–32°) and lateral condylar index 82.0% (74–90%). One patient was lost to follow up, all others were followed for 2–5 years. All patients were satisfied with the clinical outcome. The Lysholm score increased from 55 (37–79) to 89 (76–100), the Tegner activity score from 3.6 (2–6) to 5.6 (5–7). The Kujala score postoperative was 90 (75–96). Some but not all patients had full strength recovery compared to the contralateral leg.ConclusionWe recommend measuring the lateral condylar index and considering the indication of a lateral trochlear lengthening osteotomy as an additional or isolated procedure in selected patients with trochlear dysplasia Dejour type A or lack of dysplasia and short lateral articular trochlea depending on the extent of the patellar instability.Level of evidenceLevel IV, Case Series.Trial registration numberNCT04378491, clinicaltrials.gov, May 7, 2020.