This paper aims at presenting the integration of different creativity enhancement tools, from C-K theory and TRIZ, in medical device design. After the description of the current development process, the paper focuses on the application of C-K mapping and TRIZ tools in a case study concerning the improvement of knee implants for total knee replacement - TKR - surgery. The analysis of this case study highlights that the synergy between TRIZ and C-K theory is possible. As a result, C-K theory represents a good way for structuring design reasoning mostly in the conceptual phases of product innovation and development and it may be also used to explore market information, while TRIZ is suitable for formulating and refining the design problem in a structured way.