Trisulfide Research Articles

Degradation Urushiol Coating Composition Crosslinked by Diallyl Trisulfide

Urushiol (UR) was a kind of natural paint with a long history and excellent performance. Its high price restricts its development. For the sake of the sustainable development of UR, we prepared a new urushiol based coating composition which is of degradation. To be more specific, we develop a blend by diallyl trisulfide (TS) and urushiol, in which a free radical copolymerization process would take place to form a coating composition under UV irradiation. In this work, FT-IR was used to prove the reaction proces; the reversibly cross-linking properties and the rheological properties were also been proved; the basic mechanisms active in microstructure and the associated surface energy was elucidated; mechanical analysis and showed the mechanical property of coating composition. It was found that a copolymer formed by copolymerization of diallyl trisulfide and urushiol. The introduction of trisulfide bonds assists in achieving the reversibly cross-linking under extreme alkalinity (pH > 8). various trisulfide densities brought about different microstructures on the modified urushiol. The surface energy of coating composition had been enhanced after UV-curing and its increase was related to the phase inversion (represented by microstructure). What was more, the existence of flexible segments offered the coating composition with excellent flexibility (2 mm) and rheological properties (15 MPa.S), while the hardness of coating dropped to 2H.

Improvements in the Performance of a Visible-NIR Photodetector Using Horizontally Aligned TiS3 Nanoribbons.

We report the fabrication and characterization of visible and near-infrared-resistive photodetector using horizontally aligned titanium tri sulfide (TiS3) nanoribbons. The fabrication process employed micro-electromechanical system, photolithography and dielectrophoretic (DEP) methods. The interdigitated electrodes (IDE) fingers were fabricated using photolithography and thin-film metallization techniques onto the Si/SiO2 substrate, and then TiS3 nanoribbons were horizontally aligned in between IDE using DEP. The fabricated device was first characterized in absence of light and then, the photodetector-based characteristics were obtained by illuminating it with fiber-coupled laser beam. These characteristics were optimized by varying wavelength and power density of the laser beam. The present photodetector shows a maximum responsivity of 5.22 × 102 A/W, quantum efficiency of 6.08 × 102, and detectivity of 1.69 × 109 Jones. The switching times, i.e., response and recovery times were found to be 1.53 and 0.74 s, respectively, with 1064 nm wavelength and 3.4 mW/mm2 power density of the laser beam. Also, the effect of O2 adsorption on nanoribbons has been studied and it is found that adsorbed O2 acts as electron acceptor and decreases the conductivity of the photodetector. Experimentally, it is found that the photoresponse of the horizontally aligned TiS3 nanoribbons is better than that of a randomly oriented TiS3 nanoribbon-based photodetector. Finally, the performance of the present photodetector was compared to that of the previous ones that were found to outperform the reported ones. The additional advantages of the photodetector include excellent stability and portability from which it may be concluded that TiS3 nanoribbons can be a promising candidate for application in nanoscale electronic and optoelectronic devices.

Protective effect of diallyl trisulfide on acute lung injury in rats

Objective Observing the protective effect of diallyl trisulfide (DATS) on acute lung injury induced by cecal ligation and puncture (CLP). Methods The animal model of acute lung injury was induced by CLP. The 30 male SD rats were fasted 16 h before surgery, then was anesthetized by intraperitoneal injection of 10% chloral hydrate (4 ml/kg). Then all rats were randomly divided into 3 groups (n=10), sham group (group Ⅰ), CLP+normal saline (NS) group (groupⅡ) and CLP+DATS group (group Ⅲ). Rats in groupⅠ and group Ⅱ were injected with saline 10 ml/kg through caudal vein, but group Ⅲ were injected with DATS 10 mg/kg. The arterial cannulation was used in carotid artery of the rat to measure the blood gas after the surgery at 0 h (T0), 6 h (T6) and 12 h (T12). All male SD rats were subcutaneously injected with normal saline 0.05 ml/g. Subsequently, the male SD rats were sacrificed at 12 h after operation by the blooding and collected samples of lung tissue. The lung tissue wet/dry weight ratio (W/D), myeloperoxidase (MPO) activity, malondialdehyde (MDA), superoxide dismutase (SOD) and nitric oxide (NO) levels, expression of nuclear factor-κB(NF-κB) P65 and IκB-α in the cytoplasm of lung tissue, expression of NF-κB P65 in the nucleus of lung tissue were measured. Pathological changes of lung tissue was observed under light microscope. Another 30 male SD rats were grouped randomly and received the same experiment methods. The survival rate at 24 h was observed. Results Compared with group Ⅰ, the arterial partial pressure of oxygen (PaO2) and activity of SOD were significantly decreased (P<0.05), but the arterial partial pressure of carbon dioxide (PaCO2), lung tissue W/D, activity of MPO, concentration of MDA and NO in the group Ⅱ and group Ⅲ at T6 and T12 were significantly increased (P<0.05). Inflammatory reaction was significantly increased under light microscope in the group Ⅱ. The expression of cytoplasmic NF-κB P65 and IκB-α was decreased (P<0.05), but the expression of nucleus NF-κB P65 was increased in the group Ⅱ(P<0.05). The survival rate of the group Ⅱ in 24 h was lower than the rate in group Ⅰ (P<0.05). Compared with group Ⅱ, the arterial PaO2 and activity of SOD was increased (P<0.05), but the arterial PaCO2, lung tissue W/D, activity of MPO, concentration of MDA and NO were decreased in the group Ⅲ at T6 and T12(P<0.05). Inflammatory reaction was significantly decreased under light microscope in group Ⅲ. The expression of cytoplasmic NF-κB P65 and IκB-α were increased (P<0.05), but the expression of nucleus NF-κB P65 were decreased in group Ⅲ (P<0.05). The survival rate of the group Ⅲ in 24 h was improved (P<0.05). Conclusions DATS has a protective effect on acute lung injury in SD rats. Key words: Diallyl trisulfide; Cecum; Perforation of intestine; Acute lung injury

FABRICATION AND INVESTIGATION OF STRUCTURAL, OPTICAL AND DIELECTRICAL PROPERTIES OF BISMUTH TRISULFIDE (Bi2S3) THIN FILM

Bismuth trisulfide (Bi2S3) in thin films was prepared by spray pyrolysis method at temperature of 280°c. The films were of orthorhombic crystal structure, and direct optical gap of 1.61eV. Tangent of dielectric losses, AC conductivity, dielectric constant and electric modulus were investigated versus the frequency (5Hz-13MHz) and the temperature (293-333°K). The single electric relaxation time is of order of nano-second and DC conductivity from 0.29 to 3.22 (Ω.cm)-1, were indicated from electrical analysis. The observed behavior was described in term of a multi-hopping process. The dependence of ‘σAC’ and ‘S’ with temperature, were interpreted by the model (CBH). The density of the localized states N(Ef) is of order of 1020 cm-3.Ω-1, the maximum barrier height WM of order of 0.1eV, and the activation energy (Ea ≈0.12eV ) were calculated for these materials.

Therapeutic discrepancy of diallyl trisulfide and diallyl disulfide in part may be attributed to the resonance-stabilization of allylic cations and trisulfide anions

Accumulating pharmacological evidence has revealed that diallyl trisulfide (DATS) is uniquely active and its therapeutic effect prevails over diallyl disulfide (DADS). The cited reasons involve the bond dissociation energy, interconversion, lipophilicity, and polarizability of DATS. We hypothesize that the resonance-stabilized DATS could provide some unique chemical species, which are not likely to form from DADS. GC/MS analysis showed the formation of nine ionic species in DATS, and seven ionic species in DADS. The two ions uniquely formed from DATS are allyl trisulfide (ATS) and trisulfide (TS) anions. The high resonance energy of allylic cation, 37 kcal mol−1, facilitates the formation of allylic cation and TS anion from DATS. Consequently, the anions ATS and TS uniquely produced by DATS are likely critically important in the molecular bioactivity of DATS and probably function by enhancing the thiolation of glutathione and proteins producing microfilament oxidation and microtubule dysfunction.

Dially trisulfide enhancing killing effects of herpes simplex virus thymidine kinase / ganciclovir system against prostate cancer cells

Objective To investigate the killing effect of herpes simplex virus thymidine kinase /ganciclovir (HSV-TK/GCV) system combined with diallyl trisulfide (DATS) on prostate cancer cell line PC-3 and the mechanism.Methods TK gene was transfected into PC-3 cells with lipofectamine. Cell viability was determined using methyl thiazol tetrazolium (MTT) assay. Apoptosis was assessed by flow cytometry. Protein levels of apoptosis regulating proteins were detected by using Western blotting. The activity of Caspase-3 was measured using a colorimetric assay.Results GCV or DATS alone could inhibit the proliferation of PC-3/TK cells. In GCV + DATS group,the cell viability was decreased to ( 35.0 ± 2.8) ％as compared with that in 5 μmol/L GCV group [ (68.0 ± 1.8) ％ ] and 15 μmol/L DATS group [ (63.9 ±5.9) ％ ], suggesting the synergic effects of GCV and DATS. Apoptosis rate in GCV + DATS group was higher than in GCV alone group and DATS alone group. The combined use of GCV + DATS could significantly reduce the expression of B lymphocytes/leukemia-2 (bcl-2) and bcl-xL,promote the release of cytochrome c and the cleavage of Caspase-9,and enhance the activity of Caspase-3.Conclusion The combination of HSV-TK/GCV system with DATS can inhibit the proliferation of prostate cancer cells synergically through inducing apoptosis,which may be correlated with the down-regulation of bcl-2 and bcl-xL,the release of cvtochrome c, the cleavage of Caspase-9 and the activation of Caspase-3. Key words: Prostate cancer; Diallyl trisulfide; Gene therapy

ChemInform Abstract: Bis(diethylthiophosphoryl) Trisulfide.

C 8 H 20 P 2 S 5 cristallise dans P2 1 /c avec a = 11,998, b = 12,678 et c = 12,181 A, β = 115,96 °, Z = 4; affinement jusqu'a R = 0,044. Les groupes thiophosphoryl sont en conformation trans et la geometrie autour des liaisons S-S est similaire a la geometrie attendue pour les sulfuranes.

Inhibitory effects of diallyl trisulfide on the growth of hepatocellular carcinoma in rats after orthotopic liver transplantation

Objective To study the effect of diallyl trisulfide (DATS) on the growth of hepato-cellular carcinoma(HCC)after orthotopie liver transplantation(OLTx)in rats. Methods Twenty-four rats bearing subcutaneous xenograft HCC after OLTx were randomly divided into 3 groups: the control group,the DATS group Ⅰ(DATS 1 mg/kg every day) and DATS group Ⅱ(DATS 5 mg/kg every day). The effects of DATS on the growth of the tumor were evaluated after 2 weeks,including the tumor size and weight. Fluorescent quantitation ploymerase chain reaction was used to detect the expression of vascular en-dothelial growth factor (VEGF) mRNA and matrix metalloproteinase 2(MMP-2)mRNA. The effects of DATS on the liver and kidney in rats were assayed by biochemical methods. Results DATS inhibited the growth of HCC in rats after OLTx. Tumor size : the control group(0. 78±0.25)cm3, DATS group Ⅰ (0.42±0.17) cm3 ,and DATS group Ⅱ (0.38±0.21)cm3 (P 0.05 ). Conclusion DATS can inhibit the growth of HCC in rats af-ter OLTx without side effects in vivo by suppressing the expression of VEGF mRNA and MMP-2 mRNA inHCC. Key words: Diallyl trisulfide; Carcinoma,hepatocellular; Vascular endothelial growth factor; Matrix metalloproteinase

Reaction of ?-diiodotetraphosphorus trisulfide with dialkyldisulfides

Reaction of ?-diiodotetraphosphorus trisulfide with dialkyldisulfides

Bis(diethylthiophosphoryl) trisulfide

C 8 H 20 P 2 S 5 cristallise dans P2 1 /c avec a = 11,998, b = 12,678 et c = 12,181 A, β = 115,96 °, Z = 4; affinement jusqu'a R = 0,044. Les groupes thiophosphoryl sont en conformation trans et la geometrie autour des liaisons S-S est similaire a la geometrie attendue pour les sulfuranes.

Structure of the occupationally disordered crystal of diphosphorus diarsenic trisulfide

P 2 As 2 S 3 cristallise dans le systeme orthorhombique, groupe Pnma et sa structure est affinee jusqu'a R=0,028. La structure est isomorphe de β-As 4 S 3 et contient des molecules type cage P 2 As 2 S 3 avec un moriori de symetrie et les atomes P et As desordonnes sur les positions aux sommets et de base

Correction. Perfluoro-n-propyl Disulfide and Perfluoro-n-propyl Trisulfide

Correction. Perfluoro-n-propyl Disulfide and Perfluoro-n-propyl Trisulfide

The Oxidation of Indium Trisulfide

The Oxidation of Indium Trisulfide

New Compounds. Hexadecyl Trisulfide and Hexadecyl Tetrasulfide

New Compounds. Hexadecyl Trisulfide and Hexadecyl Tetrasulfide