Triple-phase CT Research Articles

A Challenging Diagnosis - Large Leiomyomas on Rudimentary Uterus in Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome

A 40-year-old woman diagnosed with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome at 16 years of age presented with a large abdominal mass protruding to the right subcostal margin, equivalent to 30 weeks gestation. She didn’t have comorbidities of hypertension or diabetes. The vitals were normal with BMI 30. She was asymptomatic except for occasional vague abdominal discomfort. Further imaging studies were conducted to assess the extent and nature of the findings. Pelvic and transvaginal ultrasound demonstrated the presence of multiple large fibroids extending beyond the level of the umbilicus. This was corroborated by pelvic MRI, which further confirmed the massively enlarged multi-fibroid uterus. Additionally, intravenous contrast-enhanced imaging revealed large bilateral ovarian collaterals and prominent blood vessels extending to the broad ligament. Triple-phase CT angiogram of the abdomen/pelvis with pre-contrast revealed an 8mm aneurysm on the anterior aspect of the abdominal aorta and unusual vascular anatomy, raising the possibility of an atypical or neoplastic process in the right iliac fossa. In view of these findings, an opinion by an Oncologist was sought, who suspected the possible presence of an abnormal nidus of vessels and a fluid attenuation area in the right iliac fossa. Additionally, the Risk of Ovarian Malignancy Algorithm (ROMA) test was performed, revealing a slightly elevated value. To reach the final diagnosis, the decision for the exploratory laparotomy was undertaken. Intraoperative findings revealed the presence of a rudimentary uterus with normal ovaries (Figure 1 and Figure 2), as well as the presence of bilateral broad fibroids (Figure 3). The broad ligament areas around the uterus were occupied with large circumscribed masses, identified as fibroids. The right-side fibroid measuring 17 x 15cm (Figure 4) and the left-side fibroid measuring 10 x 10cm (Figure 5) were excised, respectively, while preserving the left ovary and rudimentary uterus. Peritoneal fluid samples were obtained to ascertain the nature of malignancy. No evidence of infiltration or adhesions was detected. Postoperatively, the patient experienced no complications. Histological examination of the masses growing from bilateral uterine remnants confirmed the presence of leiomyomas, with no glandular epithelium identified. Peritoneal fluid analysis revealed the absence of malignant cells.

EGS P24 Management of oesophageal denture impaction and complications - a case series

Abstract Background Dentures are sometimes inadvertently ingested and can impact in the oesophagus. This can lead to complications such as mediastinitis, perforation and major vascular fistulae. In 1914, Chiari coined ‘aorto-oesophageal syndrome’ following foreign body ingestion. Usually diagnosed post-mortem, he described a triad of chest pain, haematemesis and cardiac arrest resulting from perforation and aortic fistula. Modern dentures are radiolucent, have complex configurations and commonly impact in the oesophagus at the level of the aortic arch. Early specialist intervention by experienced oesophago-gastric (OG) surgeons is crucial to the prognosis. We present our personal experience of managing oesophageal denture impaction and complications. Methods A retrospective review of electronic health records of the authors’ case series of patients with a diagnosis of oesophageal denture impaction over a 13-year period from 01/01/2010 to 31/12/2022 was performed. The inclusion criteria was adult patients with a clinical diagnosis of oesophageal denture/dental bridge impaction. Pathology and complications from impaction and mode of intervention was reviewed. Other outcome measures evaluated were treatment complications, length of stay and 90-day mortality. Results Seven patients (6 males) with median age 54 were reviewed. Dentures were impacted at or above the aortic arch in 6 patients. Attempted retrieval with ENT rigid scope in 3 caused migration of denture causing perforation. Attempted retrieval with flexible gastroscope was successful in 3 but led to opening up of a fistula in one. Five patients underwent surgical intervention (results summarised in tables 1 and 2). 90-day mortality was 0%. The median length of stay in the surgical intervention group was 30 days. Two patients who had aorto-oesophageal fistulae required additional input by cardiac surgery and vascular radiology teams. Conclusions This is a report of the authors’ experience of managing oesophageal denture impaction and it’s sequelae. A favourable 0% 90-day mortality rate despite complex presentations including aorto-oesophageal fistulae has been described. For patients presenting with haematemesis or prolonged history of denture impaction a triple phase CT scan should be performed prior to intervention. The variable complex configuration of dentures complicates their impaction or attempts at extraction. Attempts at extraction with a rigid endoscope can lead to oesophageal perforation. Successful management of these complex cases requires an effective multidisciplinary approach in a specialist OG surgery centre.

Serum alpha-fetoprotein level (> 10,000 U/mL) is a marker of hepatocellular carcinoma: A case study

Hepatocellular Carcinoma (HCC) development in young adults is strongly multifactorial. Important risk factors for the same are smoking, alcohol abuse and hepatitis C virus (HCV) infection at an early age. However, suspecting HCC is enigmatic at early age in which biochemical marker may aid in identifying such patients. In this article, we describe an unusual case of a 27-years-old male who presented with complaints of vague right upper abdominal fullness, non-bilious, non-projectile vomiting, loss of appetite, and significant weight loss for the past 2 months. On examination, there was firm, non-tender hepatomegaly. Patient had normal liver enzymes with very high alpha-fetoprotein (AFP) level (> 10,000 U/mL). Ultrasoundabdomen suggested hetero-echoic lesion in liver along with chronic kidney disease (CKD) changes. The triple phase CT of the abdomen showed a liver mass with arterial enhancement and delayed washout suggestive of HCC. Chronic HCV infection was confirmed with high RNA titres (> 50,000 IU/mL). Patient was diagnosed as HCC at an early stage, which allowed for timely initiation of treatment. This early age onset of HCC in a young adult may be due to multiple factors such as HCV infection, alcoholism, cirrhosis, and CKD. This single case study confirms that alcohol-induced liver injury increases the risk of developing early age HCC in persons infected with HCV and complicated with CKD. And AFP measurement helps inearly identification of HCC, especially at such high level > 10,000 U/mL.

MDCT evaluation of Dorsal Pancreatic Artery and Intrapancreatic arcade anatomy.

The purpose of the study was to analyze the anatomy and variations in the origin of the dorsal pancreatic artery, greater pancreatic artery and to study the various types of arterial arcades supplying the pancreas on multidetector CT (MDCT). A retrospective analysis of 747 MDCT scans was performed in patients who underwent triple phase or dual phase CT abdomen between December 2020 and October 2022. Variations in origin of Dorsal pancreatic artery (DPA), greater pancreatic artery (GPA), uncinate process branch were studied. Intrapancreatic arcade anatomy was classified according to Roman Ramos et al. into 4 types-small arcades (type I), small and large arcades (type II), large arcades (type III) and straight branches (type IV). The DPA was visualized in 65.3% (n = 488) of cases. The most common origin was from the splenic artery in 58.2% (n = 284) cases. The mean calibre of DPA was 2.05mm (1.0-4.8mm). The uncinate branch was seen in 21.7% (n = 106) with an average diameter of 1.3mm. The greater pancreatic artery was seen in 57.3% (n = 428) predominantly seen arising from the splenic artery. The most common arcade anatomy was of Type II in 52.1% (n = 63) cases. Pancreatic arterial variations are not very uncommon in daily practice. Knowledge of these variations before pancreatic surgery and endovascular intervention procedure is important for surgeons and interventional radiologist.

Hepatoid adenocarcinoma masquerading as adrenocortical carcinoma in an elderly male

Background: Hepatoid adenocarcinoma is a malignant lesion arising from an anatomic site other than the liver with histological features similar to hepatocellular carcinoma. Hepatoid adenocarcinoma has been reported from various anatomical sites, but adrenal hepatoid adenocarcinomas are extremely rare.Case Description: A 70-year-old male with well-controlled hypertension presented with chronic abdominal pain and was found to have a large left-sided supra renal mass. The lesion showed radiological features suggestive of malignancy with local invasion. There was biochemical evidence of primary aldosteronism and a non-suppressed overnight dexamethasone suppression test. He underwent open left-sided adrenalectomy: histologically the tumour demonstrated features typical of a hepatoid carcinoma with bile production and immunohistochemical staining for Hep Par-1 and CD10 demonstrating a hepatic canalicular pattern. Adrenocortical-specific immunohistochemical markers (Inhibin and melan A) and neuroendocrine markers (synaptophysin and chromogranin) were negative. He did not have clinical or biochemical evidence of cirrhosis, Hepatitis B or C infection. Triple-phase CT scanning of the abdomen before resection of the adrenal lesion and five months following surgery did not show any significant lesion in the liver suggestive of primary hepatocellular carcinoma, except an 8 mm non enhancing benign-appearing cystic lesion.Conclusion: Most hepatoid adenocarcinomas originate from the gastro-intestinal tract. We present a patient with hepatoid adenocarcinoma masquerading as adrenocortical carcinoma due to misleading imaging and biochemical evidence. Very little is known about their pathogenesis, especially those with an atypical site of origin such as the adrenal gland.

Confirmed and presumed canine insulinomas and their presumed metastases are most conspicuous in the late arterial phase in a triple arterial phase CT protocol.

Arterial enhancement is the commonly described characteristic of canine insulinomas in contrast-enhanced computed tomography (CECT). However, this finding is also reported as inconsistent. The main aim of this single-center retrospective observational study was to describe the contrast enhancement (CE) pattern of canine presumed and confirmed insulinomas and presumed metastases in three consecutive (early, mid, and late) arterial phases. Included dogs had a medical-record-based clinical or cytological/histopathological diagnosis of insulinoma and quadruple-phase CECT.The arterial phases were identified according to published literature. The arterial enhancement of confirmed and presumed lesions was assessed using a visual grading score. Twelve dogs with a total of 17 pancreatic nodules were analyzed. Three dogs had multiple pancreatic nodules and nine had solitary findings. Four insulinomas were histopathologically confirmed. Late arterial phase (LAP) images demonstrated the largest number of pancreatic nodules reaching the highest enhancement scores (n=13, 76%). All analyzed dogs had CT evidence of arterially enhancing nodules in the liver (n=12), seven in the hepatic, splenic, or colic lymph nodes, and three in the spleen. Three out of five sampled livers and three lymph nodes were metastatic. All sampled spleens were benign. Avid arterial enhancement was the most dominant feature of canine presumed and confirmed insulinomas and presumed metastases in quadruple-phase CECT. The highest enhancement scores were observed primarily in LAP, followed by MAP. Authors, therefore, recommend including LAP in the standard CT protocol for dogs with suspected pancreatic insulinomas.

Sarcopenia as a Predictive Factor for Recurrence of Hepatocellular Carcinoma Following Radiofrequency Ablation.

Sarcopenia is a skeletal muscle mass deficiency and a potential prognostic factor for the recurrence of hepatocellular carcinoma (HCC). To determine whether sarcopenia correlates with the recurrence rate of HCC after curative radiofrequency ablation (RFA) in early and very early HCC. We retrospectively reviewed 669 HCC patients who underwent their first curative RFA at Siriraj hospital from 2011 to 2020. Fifty-six patients who were diagnosed with HCC by triple-phase CT scan and had complete response on follow-up CT were included. All patients underwent skeletal muscle index (SMI) assessment at level L3 vertebra and sarcopenia was defined by the cut-off values of 52.4 cm2/m2 for men and 38.5 cm2/m2 for women. We compared patients with and without sarcopenia. Time to recurrence was evaluated by the Kaplan-Meier method. Univariate and multivariate Cox regression analysis was performed. Sarcopenia was present in 37 of 56 patients (66.1%). There was no significant difference between groups except body mass index (BMI) (P<0.001) and serum alanine aminotransferase (ALT) (P=0.035). There was a promising result indicating the difference of time to recurrence between each group (P=0.046) and potential association of sarcopenia with HCC recurrence (HR=2.06; P=0.052). The Child-Pugh score and tumor number were independent risk factors for HCC recurrence (HR=2.04; P=0.005 and HR=2.68; P=0.017, respectively). Sarcopenia is a potential prognostic factor for recurrence of HCC in Thai patients who underwent RFA. A larger study is required to properly confirm this association.

A curious case of confusion

A curious case of confusion

Association between serum midkine levels and tumor size in Indonesian hepatocellular carcinoma patients: a cross-sectional study.

Background: The incidence of liver cancer is increased worldwide with 75%-85% diagnosed as hepatocellular carcinoma (HCC). Current practice has low sensitivity limitations to diagnose the early stages of HCC, thus urging the need for a biomarker with higher sensitivity to detect HCC, specifically in the early stage. This study aimed to determine the association between midkine levels and progressiveness of hepatocellular carcinoma (HCC), according to tumor size, Barcelona Clinic Liver Cancer (BCLC), and presence of portal venous thrombosis. Methods: This cross-sectional study involved 100 patients in Adam Malik General Hospital diagnosed with HCC, collected with a consecutive sampling method, whose diagnoses were confirmed by findings of hypervascular on arterial phase imaging and portal vein or delayed phase washout triple-phase CT Scan. Samples are later categorized according to Barcelona Clinic Liver Cancer (BCLC) stages, tumor size, and presence of portal venous thrombosis. Blood samples were drawn to measure serum midkine using ELISA. Kruskal-Wallis and Mann-Whitney U tests were conducted to determine the difference of midkine levels based on tumor size, BCLC staging, and presence of portal venous thrombosis. Results: Serum midkine level shows a significant difference over tumor size (p=0.014), no significant difference found compared to BCLC stages and presence of portal venous thrombosis. Conclusion: Serum midkine levels are associated with the tumor size of HCC, thus helping physicians determine treatment plans.

The Role of USG and Triple Phase CT for Evaluation of Space Occupying Lesions Including Liver Hemangioma

Purpose: To know the role of USG and triple phase CT for evaluation of space occupying lesions including liver hemangioma and to compare the diagnostic capability of CT Triple Phase and USG. Method: This comparative study was conducted in SGT hospital. Data was collected of 25 patients for five months. Patients were taken &gt;18 and &lt; 75 years of age. Consent form was filled up by the patients and history was also taken. Diseases were diagnosed on both the modalities USG and CT and comparison was done after examine the patients. Result: Out of 25 patients, 18 (72%) were males and 7 (28%) were females. Maximum number of diseases were diagnosed on CT Triple phase, in 17(68%) patients and less number of diseases were diagnosed on ultrasound, in 8(32%) patients. Out of 17 patients who underwent for CT Triple phase, maximum number of patients had liver abscess 6(35.29%), multifocal hepatic lesion and hepatic granulomas were in 1(5.88%) patients. Out of 8 patients who underwent for ultrasound, maximum number of patients had liver abscess in 3(37.5%) patients and multifocal hepatic lesion was found in 1(12.5%) patients. Cystic lesion and hepatic granulomas were not seen on ultrasound. Conclusion: The sensitivity of liver triple phase was high as compare to the ultrasound which was mainly noticed in liver abscess. USG must be performed in all the patients with clinical suspected hepatic masses for initial detection and localization of lesion. Keywords: ultrasound, CT, liver, triple phase, lesion, hemangioma

A Biology-Driven Radiomics Model for Unresectable Intrahepatic Cholangiocarcinoma Treated with Radiotherapy

<h3>Purpose/Objective(s)</h3> For unresectable intrahepatic cholangiocarcinoma (ICC), we previously showed that pre-therapy CT volumetric enhancement (VE) associates with biological (e.g., degree of stromal infiltration and necrosis, genetic mutations, and infiltrating lymphocytes) and clinical outcomes. Further, we showed that a change in VE following radiotherapy (RT) is prognostic. Here, we integrated these baseline and post-treatment imaging features to appraise their joint prognostic value. <h3>Materials/Methods</h3> We retrospectively identified 112 patients (54% female, median age 63 years) who received definitive RT (78% photon, 22% proton; median biologically effective [BED₁₀] dose 86 Gy, interquartile range [IQR] 75-98 Gy) with triple phase CT imaging at diagnosis, prior to RT, and following RT. A technology company's multimodality tumor tracking software was used to quantify tumor VE ≥1 standard deviation of that of healthy parenchyma on each scan. Based on prior work, each patient was stratified into (1) low/high VE at baseline (cutpoint: 32% VE) and (2) VE-based response/non-response to RT (cutpoint: 26% decrease in VE). Overall survival (OS) and local failure-free survival (LFFS) following RT were assessed using the Kaplan-Meier method. Cox analyses were performed to include the 2 radiomic markers and traditional covariates of survival. Concordance indices (C-index) were used to evaluate model performance. <h3>Results</h3> At a median follow up of 74 months, 46% failed locally and 85% died. The 2-year OS and LFFS were 40% (95% confidence interval [CI], 30-49%) and 26% (CI, 18-34%), respectively. At baseline, median VE was 25% (IQR 14-45%); VE was categorized as low in 43% and high in 57%. Following RT, median change in VE was +3% (IQR -7% to +176%); change was categorized as non-response for 56% and response in 44%. On multivariable analysis for OS, Stage IV disease (hazard ratio [HR] 2.11, CI 1.35-3.31; <i>P</i>=0.001) was associated with poorer survival. High VE (HR 0.38, CI 0.24-0.59; <i>P</i><0.001) and VE-based response to RT (HR 0.19, CI 0.12-0.32; <i>P</i><0.001) were each independently associated with longer survival (C-index 0.77). For LFFS, Stage IV disease (HR 1.61, CI 1.03-2.52; <i>P</i>=0.036) was associated with shorter latency to local failure/death, while high VE (0.40, 95% CI 0.26-0.62; <i>P</i><0.001) and VE-based response to RT (HR 0.29, CI 0.18-0.46; <i>P</i><0.001) were associated with longer latency (C-index 0.74). Median OS stratified by cohort is shown in Table 1. <h3>Conclusion</h3> For ICC patients treated with definitive RT, VE measured on pre-therapy imaging and pre/post-RT imaging each independently had greater predictive value than conventional patient and disease factors. These metrics, with their biological and clinical associations, may help personalize therapeutic approaches for ICC. External model validation is warranted.

S1285 Association Between Distance to a Radiology Center and HCC Surveillance Among Patients With Cirrhosis in Florida

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of morbidity and mortality in patients with cirrhosis, and HCC survival is directly correlated with stage at diagnosis. Current guidelines recommend HCC surveillance with an abdominal ultrasound every 6 months, but unfortunately many patients do not meet this threshold.1 Our aim was to determine whether distance to a radiology center, measured in travel time, was associated with HCC surveillance rates. Methods: We included data on adult patients with cirrhosis within the OneFlorida Clinical Research Consortium from October 1, 2015- December 31, 2019. The primary outcome was a continuous measure of the percentage of time up to date with HCC surveillance (PTUDS) based on abdominal ultrasound (US), triple phase CT, and/or MRI with contrast. Travel time was calculated using ArcGIS geomodelling software as the estimated minimum travel time between the geographic centroid of patient’s zip code and the nearest American College of Radiology-accredited center for US, CT, and/or MRI. Linear regression models were fit with PTUDS as the outcome; all covariates with a p< 0.05 were included in the final multivariable model. (Figure) Results: Among 25,299 patients with cirrhosis (median follow-up=4.1 years), the median PTUDS was 10.0% (interquartile range 0-29.9%). Variables found to have a statistically significant association with PTUDS are displayed in Table. Travel time, hepatic encephalopathy at baseline, and ascites at baseline were associated with increased PTUDS. Patients with alcohol-related liver disease, nonalcoholic steatohepatitis, and cryptogenic cirrhosis had lower PTUDS compared with patients with HCV. Conclusion: Travel time to the nearest radiology center is not associated with lower HCC surveillance rates while race, etiology of liver disease, and disease severity do appear to variably influence surveillance. By establishing factors associated with currently suboptimal surveillance rates, we can create targeted interventions to improve surveillance and, ultimately, patient outcomes.Figure 1.: Median PTUDS by County Table 1. - Multivariable Linear Regression Model of Factors Associated with HCC Surveillance Variable Beta Coefficient, 95% CI P-Value Travel Time 0.0016 (0.0012-0.0020) <0.001 Liver Disease Etiology Hepatitis C Virus Reference - Hepatitis B Virus 0.0246 (0.0019-0.0473) 0.034 Wilson's Disease 0.0137 (-0.571-0.0845) 0.704 Hemochromatosis 0.0067 (-0.0220-0.0354) 0.647 a1-Antitrypsin Deficiency 0.0673 (0.0200-0.1145) 0.005 Alcohol-Related Liver Disease -0.0720 (-0.0801- -0.0639) <0.001 Primary Biliary Cholangitis -0.0037 (-0.0261- 0.0186) 0.745 Autoimmune Hepatitis -0.0193 (-0.0406- 0.0019) 0.075 Primary Sclerosing Cholangitis 0.0123 (-0.0462- 0.0708) 0.680 Nonalcoholic Steatohepatitis -0.0835 (-0.0917- -0.0752) <0.001 Unknown/Cryptogenic -0.01566 (-0.1664- -0.1467) <0.001 Race White/Caucasian Reference - American Indian/Alaskan -0.0207 (-0.0871- 0.0457) 0.541 Asian 0.0531 (0.0258- 0.0805) <0.001 Black 0.0171 (0.0082- 0.0260) <0.001 Native Hawaiian/Pacific Islander -0.0075 (-0.1109- 0.0959) 0.887 Multiple Race -0.0474 (-0.0781- -0.0168) 0.002 Refuse to answer 0.0904 (0.0212- 0.1596) 0.010 No information 0.0575 (0.0283- 0.0866) <0.001 Other 0.0050 (-0.0048- 0.0148) 0.318 Unknown -0.0591 (-0.0837- -0.0346) <0.001 Disease Severity Hepatic Encephalopathy at Baseline 0.0431 (0.0328- 0.0534) <0.001 Ascites at Baseline 0.0638 (0.0551- 0.0724) <0.001

S2993 Extensive Hepatic Fibrosis Mimicking Primary Liver Malignancy

Introduction: Liver cirrhosis is a pathophysiological outcome of sustained liver inflammation. Sustained hepatic insults generate a process of fibrogenesis, in which an excessive extracellular matrix deposition replaces normal liver parenchyma. We present a patient with newly diagnosed liver cirrhosis who was found to have a liver mass suggestive of primary liver malignancy on imaging; however, multiple biopsies confirmed the mass to be fibrosis with mild hepatitis. Case Description/Methods: A 40-year-old male presented for the evaluation of new bilateral lower extremity edema. He reported a long history of alcohol use but otherwise denied prior medical history and no medication use. Laboratory work on admission was pertinent for a total bilirubin of 3.5, AST 162, ALT 57, alkaline phosphatase 176, albumin 3.0, and a non-reactive viral hepatitis panel. CT abdomen/pelvis revealed a heterogeneous liver suggestive of cirrhosis along with a 6.8 cm x 8.7 cm mass with irregular margins situated between the right and left lobes of the liver. On 3-phase MR imaging, the lesion demonstrated progressive enhancement in the portal venous phase and hepatic venous phase, with retention of contrast on 5-minute delayed images [Image 1a, b, c]. Overall, these findings suggested infiltrative cholangiocarcinoma. Additional imaging ruled out multifocal disease, and tumor markers CEA and AFP were unremarkable. Subsequently, a diagnostic laparotomy with liver biopsy was performed. The biopsy demonstrated fibrosis with atypical ductular proliferation, but the presence of low-grade infiltrative cholangiocarcinoma could not be ruled out. To rule out biopsy sampling error, two additional biopsies later that month concurred cirrhotic liver segments with areas of mild hepatitis. Tumor markers CK20 and CDX2 were negative, and no atypical cells were present. It was concluded that this liver lesion represented extensive hepatic fibrosis and mild hepatitis due to ongoing alcohol use, but no malignancy. Discussion: Liver cirrhosis is a major risk factor for the development of primary liver cancers such as hepatocellular carcinoma and cholangiocarcinoma. Triple-phase CT or MR imaging plays a key role in diagnosing these cancers; however, as demonstrated in our case, certain benign lesions such as liver fibrosis can mimic primary liver malignancy. Improved recognition of these benign lesions is necessary to avoid unnecessary and potentially harmful interventions.Figure 1.: 1a) Pre-contrast MR T2 weighted image showing a large central hepatic mass and lobular contour of liver consistent with cirrhosis. 1b) Post-gadolinium T1 fat-saturated MR image demonstrating enhancement of the liver lesion in the hepatic venous phase. The lesion showed high retention index of contrast on 5-minute delayed images (not included). 1c) Diffusion-weighted MR image showing the liver lesion with significantly restricted diffusion suggestive of infiltrative type of cholangiocarcinoma.

S3155 Recurrent Liver Abscess in a Non-Toxic Patient

Introduction: Liver abscesses are caused by direct spread from peritonitis, biliary tract infection or via hematogenous seeding from a distant source. Most are polymicrobial, however Escherichia coli and Klebsiella pneumoniae are the most common offending pathogens. Patients usually present with pain, fever, and clinical signs of infection. We describe a case of spontaneous liver abscess in a non-toxic patient that recurred 10 years after a previous abscess. Case Description/Methods: A 73-year-old-man with a history of type 2 diabetes mellitus, hypertension, CAD status post CABG and PCI 3 years ago, and abdominal aortic aneurysm status post endovascular aneurysm repair presented with 2 weeks of dark urine. After receiving his COVID-19 booster and influenza vaccinations, he developed flu-like symptoms with a self-resolving fever of 101.8°F. He had dark amber urine without dysuria or hematuria. Later, he experienced generalized weakness and decreased oral intake. Outpatient labs showed elevated liver function tests, and he was told to present to the ED. On arrival, he was afebrile with stable vitals. Physical exam was unremarkable. Laboratory evaluation showed a hemoglobin of 11.7 g/dL, sodium of 133 mEq/L, creatinine of 1.4 mg/dL, aspartate aminotransferase of 117 U/L, alanine aminotransferase of 212 U/L, alkaline phosphatase of 825 U/L, total bilirubin of 4.1 mg/dL, and direct bilirubin of 2.1 mg/dL. Triple-phase CT showed a 2.8 cm mass in the right liver lobe with linear enhancement. Ultrasound showed mixed echogenicity measuring 3.6 × 2.9 × 3.3 cm in segment 8 of the liver. On further evaluation, patient had an E. coli abscess diagnosed 10 years prior, managed with antibiotics and drainage. At that time, the abscess was within the right inferior liver lobe, similar to his current abscess. LFTs downtrended. Abscess was aspirated, with culture growing oxidase negative, gram-negative rods, likely E. coli. Patient started on ceftriaxone and metronidazole, to undergo colonoscopy as an outpatient and rule out colonic bacterial translocation. Discussion: Pyogenic liver abscess can result in significant morbidity and mortality because of worsening infection and sepsis. Abscesses occur because of spread from adjacent infection or after recent surgeries. Recurrence is very rare. Here, we describe a very unusual case of a pyogenic liver abscess growing E. coli in a non-toxic patient, with the same location and causative organism as an abscess managed 10 years prior.Figure 1.: Triple phase CT scan of the abdomen and pelvis in the transverse plane (a) demonstrating a 2.8 cm mass (arrow) in the right lobe of the liver with a small area of linear enhancement. Abdominal ultrasound demonstrating an area of mixed echogenicity (arrows) with areas of increased and decreased sonographic texture measuring 3.6 × 2.9 × 3.3 cm in segment 8 of the liver (b). CT, computed tomography.

S2858 Post-ERCP Subcapsular Hepatic Hematoma

Introduction: Endoscopic retrograde cholangiopancreatography (ERCP) is both a diagnostic and therapeutic procedure used for management of biliary pathology. Rates of even the most common complications, including biliary perforation and pancreatitis, are low, however other complications can be life-threatening and must be kept in mind when evaluating a patient post-ERCP. Here, we describe a case of post-ERCP subcapsular hepatic hematoma (SHH). Case Description/Methods: A 39-year-old man with a history of hypertension, type II diabetes mellitus and alcohol use disorder complicated by chronic pancreatitis with multiple episodes of common bile duct (CBD) stricture status post multiple ERCPs presents with epigastric pain and right upper quadrant pain. He was admitted two weeks prior for epigastric pain, where he was found to have CBD stricture, and underwent ERCP with stent placement. Pain did not completely resolve after his last hospitalization and escalated to a 10/10. On arrival, he was afebrile with stable vitals. Physical exam demonstrated epigastric tenderness to palpation with voluntary guarding, but a soft abdomen without rebound tenderness. Labs significant for WBC count of 10.8 x 10^9/L, alkaline phosphatase of 117 U/L, and hemoglobin 11.7 g/dL. Abdominal ultrasound showed a 7.3 x 3.9 cm area of mixed echogenicity in the right liver lobe. Triple phase CT of the abdomen and pelvis showed a 9 x 6.5 x 2.5 cm heterogeneous subcapsular liver collection. He was given Zosyn, and WBCs downtrended. On day 3, liver function tests (LFTs) rose: aspartate aminotransferase was 397 U/L, alanine aminotransferase was 206 U/L, alkaline phosphatase was 571 U/L, and total bilirubin was 5.0 mg/dL. Repeat CT showed expected hematoma resolution with correct biliary stent placement. Antibiotics were re-started. LFTs and symptoms improved. He was discharged on a 14-day course of Levofloxacin and Metronidazole. (Figure) Discussion: SHH is a rare but known complication of ERCP. Hematomas can expand, resulting in significant anemia and LFT elevation, or become infected with resultant sepsis. Patients with SHH must be carefully monitored in the post-ERCP setting. This patient exhibited an elevated WBC count with delayed elevation in LFTs, concerning for potential infection of the hematoma, yet without overt signs of infection, including lack of fever. He was managed with antibiotics without hematoma drainage, demonstrating the efficacy of conservative management for such a potentially deadly complication of ERCP.Figure 1.: Triple phase computed tomography scan of the abdomen and pelvis demonstrating a right-sided subcapsular hematoma in segment 6 of the liver in the coronal (a) and transverse (b) planes (arrow).

Is four years enough? An audit of post-hepatectomy surveillance for liver metastases.

Optimal timing and modality of surveillance post hepatectomy for colorectal cancer liver metastases (CLM) has not been established. Recommendations vary between countries and surgical units. Individual clinicians do not always adhere to guidelines. Using a prospectively collected database of consecutive hepatectomy patients at The Queen Elizabeth Hospital in Adelaide, Australia, CLM patients were reviewed for evidence of recurrent disease (20 February 1996-30 June 2018). Timing and modality of disease detection was analysed. Follow up was until 30 June 2020 or death. 244 patients underwent hepatectomy for CLM during the study period. 139 patients (57%) experienced recurrence post initial hepatectomy (mean time 13.2 months; range 0.6-84.7). For all hepatic recurrences (n=172), majority of disease was detected in the first seven months post hepatectomy (55%) and by four years, 97.7% of recurrent disease was detected. 51 patients underwent curative repeat hepatectomy after recurrence was detected. Nearly all disease was detected via surveillance CT (160/172; 93%); 12 patients presented with clinical symptoms. Hepatectomy patients are likely to experience recurrent disease and clinicians must ensure a robust surveillance plan is in place. We recommend a triple-phase CT at 6, 12, 18, 24, 36 and 48 months.

TRIPLE PHASE CT SCAN IMPROVES DETECTION AND CHARACTERISATION OF LIVER LESIONS.

Characterization of various focal liver lesions based on patterns of enhancement, morphology and size is critical for narrowing the diagnosis and determining the treatment options. The differential diagnosis (malignant and non malignant lesions) of focal liver lesions is broad and many benign focal liver lesions such as Cysts, abscesses, hemangiomas, and focal nodular hyperplasia etc. are commonly encountered. It is essential to detect and characterize these lesions for reduction in treatment cost and to avoid unnecessary interventions. In this study we assessed the various imaging features of focal liver lesions. Triple phase CT scan has revolutionised evaluation of liver lesions, minimising the need for biopsy and also surgery in benign lesions. Understanding the various patterns of enhancement of these lesions is crucial to management of these patients.

Factors influencing enhancement timing in a triple-phase abdominal CT angiography protocol in dogs.

To evaluate the enhancement accuracy of a triple-phase abdominal CT angiography (CTA) protocol in dogs and explore the patient, scan, and contrast parameters associated with accuracy of enhancement. 233 client-owned dogs that underwent routine abdominal CTA. During each CTA study, the subjective timing accuracy (early, ideal, late) of the 3 obtained vascular phases (arterial, venous, delayed) was scored by consensus (2 reviewers) at 4 target organs (liver, pancreas, left kidney, and spleen). These scores were evaluated for statistical associations with 21 study variables (patient, scan, and contrast medium). The objective enhancement (HU) for each target organ was also compared statistically with subjective timing accuracy scores and the study variables. The study protocol performed best for the pancreas, moderately for the liver, and worse for the spleen and left kidney. Measurements of scan length and time were associated positively with phase lateness for most target organs and phases. Increased heart rate was the most significant patient factor associated positively with phase lateness within the liver (all phases), pancreas (arterial and venous phases), and kidney (arterial phase). Contrast medium variables were less associated with timing accuracy in this protocol. Objective enhancement (HU) correlated poorly with subjective phase timing accuracy and study variables. Scan time, scan length, and heart rate were the predominant variables contributing to lateness in this canine abdominal CTA protocol. The findings of this exploratory study may aid in protocol adjustment and choice of included anatomy for dogs undergoing routine abdominal CTA.

Abstract No. 539 Retrospective review of pancreatic venous anatomy

To map the pancreatic venous anatomy as seen on triple-phase CT of the abdomen in preparation for Pancreatic Retrograde Venous Infusion (PRVI) Pressure Enabled Drug Delivery (PEDD) trials for locally advanced pancreatic ductal adenocarcinoma

Panorama of multidetector-row computed tomography findings of carcinoma gall bladder - A retrospective observational study.

Carcinoma of the gall bladder (Ca GB) has marked ethnic and geographical variations with a broad spectrum of imaging findings on multidetector-row computed tomography (MDCT). We aim to study the spectrum of the imaging findings of Ca GB on MDCT in an Eastern Indian hospital as these imaging findings help in accurate diagnosis and staging of this lethal disease. The MDCT images of 100 biopsy-proven cases of adenocarcinoma of GB performed from January 1, 2017, to December 31, 2018, in our hospital were retrospectively reviewed by two experienced radiologists blinded to the diagnosis. The CT protocol was a plain scan followed by triple-phase contrast-enhanced CT. Reconstructed images in the form of maximum intensity projection, volume-rendered technology, and minimum intensity projection images were also assessed. Descriptive statistics were used for data analysis. Ca GB showed a female predominance (female:male -1.9:1). The mean age of presentation was 54.7 years (females) and 58 years (males). The morphological patterns were a mass replacing the GB (46%), focal or diffuse wall thickening (26%), and an intraluminal polypoidal mass (28%). Direct extension was to liver (76%), duodenum (32%), colon (19%), pancreas (9%), and abdominal wall (1%). Biliary dilatation (53%), vascular invasion (14%), omental involvement (23%), ascites (22%), N1 (40%), and retroperitoneal lymphadenopathy (33%) were common. Distant metastasis comprised of hepatic (42%), pulmonary (7%), Krukenberg's tumor (6%), and osseous (1%) lesions. The stages at diagnosis were I or II (3%), IIIA (4%), IIIB (16%), IVA (10%), and IVB (67%). Ca GB has a broad spectrum of findings on MDCT and it mostly presents at an advanced stage. MDCT with reconstructions is beneficial in the assessment of locoregional and distant spread and cancer staging which has a direct implication on patient management, survival, and mortality.