Global warming, caused by the burning of fossil fuels and deforestation, is triggering significant changes in the Earth's environment. Phenomena like El Niño and La Niña, analyzed through modeling techniques, reveal complex patterns affecting various time scales. In regions with fragile soils, the trend is rapid progression towards scenarios of desertification and abandonment in the coming years. The migration of rural populations from these areas to urban centers, abandoning subsistence economies, may increase poverty in cities, a movement comparable to the Industrial Revolution's exodus, already visible in economic and social data. This article theoretically reviews topics related to desertification resulting from climate change, aiming to identify the social and economic consequences of this phenomenon in the region. Additionally, it explores possible actions to mitigate problems caused by global warming. In conclusion, a solution based on the Triple Helix Theory, which promotes interaction between government, universities, and businesses, will be presented. This approach could be crucial in mitigating the impacts of desertification, fostering sustainable development and innovation in the affected region.