Tricresyl Phosphate Research Articles

Exposure assessment of aryl-organophosphate esters based on specific urinary biomarkers and their associations with reproductive hormone homeostasis disruption in women of childbearing age.

The effects of aryl-organophosphate esters (aryl-OPEs) on female reproduction health are still unclear owing to the lack of specific exposure biomarkers. Here, we analyzed the hydroxylated metabolites of three aryl-OPEs (phenyl diphenyl phosphate [TPhP], 2-ethylhexyl diphenyl phosphate [EHDPP], and tricresyl phosphate [TCrP]) and diphenyl phosphate (DPhP) in urine samples from 913 women of childbearing age, and explored the association between exposure to the aryl-OPEs and reproductive hormone levels. The detection frequencies of 2-ethyl-5-hydroxyhexyl diphenyl phosphate (5-OH-EHDPP), phenyl di-p-tolyl phosphate (4-OH-MDTP), and 4-hydroxyphenyl diphenyl phosphate (4-OH-TPhP) were 94.6%, 93.3%, and 84.2%, respectively. Multivariate linear regression analyses revealed that the quartiles of 4-OH-TPhP were positively associated with the progesterone (P4) level (p-trend=0.008), and the P level in the highest quartile of 5-OH-EHDPP was 7.2% (95% CI, 5.7% to 8.7%) higher than that in the lowest quartile. The 17β-estradiol levels in the highest quartiles of 4-OH-TPhP and 5-OH-EHDPP were 15.0% (95% CI, 13.7% to16.1%) and 5.9% (95% CI, 15.7% to 16.1%) lower than those in the lowest quartiles, respectively. The anti-Müllerian hormone level linearly increased across the quartiles of 4-OH-MDTP (p-trend=0.036), and the follicle-stimulating hormone exhibited the opposite trend (p-trend=0.0047). These results indicate that aryl-OPEs may disrupt hormone homeostasis using their specific biomarkers and may negatively affect female reproduction.

Synergistic effect of microcrystalline cellulose from oil palm empty fruit bunch waste and tricresyl phosphate on the properties of polylactide composites

Microcrystalline cellulose (MCC) was extracted from oil palm empty fruit bunch (OPEFB) waste by integrated chemical treatments of delignification, bleaching, and acidic hydrolysis. The obtained MCC (OPMC) and tricresyl phosphate (TCP) were used as additives for polylactide (PLA) composites. The influences of OPMC and TCP contents, separately and in combination, were evaluated on the properties of the composites. Characterization studies confirmed the successful extraction of OPMC from OPEFB waste. With regard to the properties of the PLA composite, the appropriate content of OPMC should be 5 phr. The good distribution of OPMC in the polymer matrix changed the failure behavior of the composite from brittle to ductile. All the PLA composites with TCP and OPMC showed flame inhibition and retarded ignition. The synergistic effect of TCP and OPMC resulted in outstanding improvement of impact strength and flame retardancy of composites. The impact toughness of PT10M5 increased to about 218.4 % and 72.3 % that of neat PLA and PT0M5, respectively. Moreover, PT10M5 achieved V-0 rating with high LOI (38.5 %). All these characteristics promise extended applications for PLA composite in bio, circular, and green (BCG) economies and electronics industries.

Characterization of the phosphotriesterase capable of hydrolyzing aryl-organophosphate flame retardants.

A related group of phosphotriesters known as organophosphate flame retardants (OPFRs) has become emerging contaminants due to its worldwide use. The lack of an easily hydrolysable bond renders OPFRs inert to the well-known phosphotriesterases capable of hydrolyzing the neurotoxic organophosphates. An OPFRs phosphotriesterase gene stpte was cloned from plasmid pStJH of strain Sphingopyxis terrae subsp. terrae YC-JH3 and was heterologously expressed in Escherichia coli. The recombinant protein St-PTE was purified and analyzed.St-PTE showed the highest catalytic activity at pH 8.5 and 35°C.The optimal substrate for St-PTE is triphenyl phosphate, with kcat/Km of 5.03 × 106M-1s-1, two orders of magnitude higher than those of tricresyl phosphate (4.17 × 104M-1s-1), 2-ethylhexyl diphenyl phosphate (2.03 × 104M-1s-1) and resorcinol bis(diphenyl phosphate) (6.30 × 104M-1s-1).St-PTE could break the P-O bond of tri-esters and convert aryl-OPFRs into their corresponding di-ester metabolites, including polymers of resorcinol bis(diphenyl phosphate). Mediated by transposase, the gene of OPFRs phosphotriesterase could be transferred horizontally among closely related strains of Sphingomonas, Sphingobium and Sphingopyxis. KEY POINTS: • St-PTE from Sphingopyxis terrae subsp. terrae YC-JH3 could hydrolyze aryl-OPFRs. • Metabolites of RBDPP hydrolyzed by phosphotriesterase were identified. • St-PTE could hydrolyze the P-O cleavage of dimer and trimer of RBDPP. • Phosphotriesterase genes transfer among Sphingomonadaceae mediated by transposase.

Potential Application of Carbon‐based Electrical Sensor for the Highly Sensitive Diltiazem HCl Quantification in its Pharmaceutical Products and Biological Samples

AbstractDiltiazem (DTZ) hydrochloride, a calcium channel blocker compound, is a very well‐known drug used by many clinicians to treat important diseases playing a role in increased morbidity and mortality among adults worldwide, namely hypertension, cardiac arrhythmia, and ischemic heart disease (angina pectoris). These diseases are a common public health concern, implying that the construction of a specific, accurate, and simple sensor for DTZ determination is needed. Herein, an innovative, portable, and sensitive modified carbon paste electrode (MCPE) was seamlessly developed based on the affordable green compound N‐bromosuccinimide (NBS) as a sensing material and tricresyl phosphate as a solvent mediator for the voltammetric determination of DTZ. The proposed NBS‐MCPE exhibited an excellent electrocatalytic activity towards the oxidation of DTZ molecules in a phosphate buffer solution of pH 5.0 in presence of 20 μM sodium dodecyl sulfate to improve the developed sensor performance. The sensor was found to respond linearly to the DTZ drug over a wide concentration ranging from 1 μM to 300 μM with a low limit of detection. LSV and EIS measurements were also used to scrutinize our sensor, in addition to using scanning electron microscopy and energy dispersive X‐ray analysis techniques for its surface morphology inspection before and after soaking in the drug‐containing solution. The applicability of the proposed sensor for the rapid, sensitive, and selective determination of DTZ in pharmaceutical preparation and human urine samples was assessed and the obtained results were compared with that of the reported HPLC analytical method.

Suspect and nontarget screening of known and unknown organophosphate esters (OPEs) in soil samples

Ninety-five soil samples (n = 95) were analyzed using an integrated suspect and non-target organophosphate ester (OPE) screening strategy. This suspect and non-target screening strategy allowed us to fully or tentatively identify 26 OPEs or OPE-like substances. Among these 26 newly identified contaminants, bisphenol A bis(diphenylphosphate) (BPABDP) exhibited the highest detection frequency of 83.2 %, with a concentration range of ND - 385 ng/g dry weight (dw). We also observed that BPABDP was significantly correlated with all other OPEs (p < 0.001 in all pairs), suggesting that BPABDP is widely used as a plasticizer and flame retardant in various commercial products. Another interesting finding was the discovery of four novel OPE structures with tentatively proposed chemical structures. Among these four non-target OPEs, (tert-butyl) phenyl bis(2,4-di-tert-butylphenyl) phosphate (TBPBDTBPP) shared a backbone structure very similar to that of the well-known OPE, tris(2,4-di-tert-butylphenyl) phosphate (TDTBPP). Detection frequency of this newly discovered OPE was high, up to 69.5 %, and it was significantly correlated with isodecyl diphenyl phosphate (IDDP), BPABDP, diphenyl 2-isopropylphenyl phosphate (2IPPDPP), and tricresyl phosphate (TCrP, p < 0.05 in all pairs), respectively. This study reported the most comprehensive suite of OPEs in soil samples, and 16 out of them were recognized in soil for the first time.

Tri-ortho-cresyl phosphate induces axonal degeneration in chicken DRG neurons by the NAD+ pathway

Wallerian degeneration (WD) is a well-known process by which degenerating axons and myelin are cleared after nerve injury. Although organophosphate-induced delayed neuropathy (OPIDN) is characterized by Wallerian-like degeneration of long axons in human and sensitive animals, the precise pathological mechanism remains unclear. In this study, we cultured embryonic chicken dorsal root ganglia (DRG) neurons, the model of OPIDN in vitro, to investigate the underlying mechanism of axon degeneration induced by tri-ortho-cresyl phosphate (TOCP), an OPIDN inducer. The results showed that TOCP exposure time- and concentration-dependently induced a serious degeneration and fragmentation of the axons from the DRG neurons. A collapse of mitochondrial membrane potential and a dramatic depletion of ATP levels were found in the DRG neurons after TOCP treatment. In addition, nicotinamide nucleotide adenylyl transferase 2 (NMNAT2) expression and nicotinamide adenine dinucleotide (NAD+) level was also found to be decreased in the DRG neurons exposed to TOCP. However, the TOCP-induced Wallerian degeneration in the DRG neurons could be inhibited by ATP supplementation. And exogenous NAD+ or NAD+ processor nicotinamide riboside can rescue TOCP-induced ATP deficiency and prevent TOCP-induced axon degeneration of the DRG neurons. These findings may shed light on the pathophysiological mechanism of TOCP-induced axonal damages, and implicate the potential application of NAD+ to treat OPIDN.

Occurrence, distribution and risk assessment of organophosphate esters (OPEs) in water sources from Northeast to Southeast China

With the wide utilization of organophosphate esters (OPEs) in recent years, OPEs have been detected more frequently in the aquatic environment. However, the distribution of OPEs in drinking source water has rarely been investigated across a large region. In this study, the occurrence and distribution of 13 OPEs were investigated in 23 source water sites from Northeast to Southeast (spacing greater than 3320 km) with a direct injection ultra-performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS) method. Total OPEs ranged from 218.8 to 636.6 ng/L, with a mean of 380.8 ng/L. The average detected concentration of OPEs in southern cities was higher than that in northern cities. Chlorinated OPEs accounted for 64.74% of the total concentration. Triethyl phosphate (TEP), tri (2-chloroethyl) phosphate (TCEP), and tri (chloropropyl) phosphate (TCPP) were detected in all water samples. Rainfall is a significant factor that affects the OPE concentration (less rainfall, higher concentration). China's OPE concentrations have rapidly reached a median level when compared to those of other countries. Ecological risk assessment showed that most OPEs have no or low risk to organisms (fish, crustacea, algae), except tricresyl phosphate (TCP), which is medium risk. The risk of OPEs in less-rain regions needs to be of greater concern, especially TCP.

Remodeling on adipocytic physiology of organophosphorus esters in mature adipocytes

The emerging endocrine disruption chemicals organophosphate esters (OPEs) pose high risk of metabolic disruption. However, limited information is available on physiological disturbance of OPEs on adipose, a major endocrine and metabolic organ. In this study, physiological change was investigated after exposing 3T3-L1fully differentiated adipocytes to six OPEs at non-cytotoxic concentrations. We found two chlorinated-OPEs (tris-(2-chloro-1-(chloromethyl) ethyl) phosphate (TDCPP) and tris(2-chloroisopropyl) phosphate (TCPP)) and two alkyl-OPEs (tributyl phosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP)) induced inflammation-like adipokines (chemoattractant protein 1 and interleukin-6), respectively. Increment of insulin-resistance-related hormones (resistin and leptin) were observed under TDCPP, TCPP, and TBP exposure. Functional and mechanistic investigation revealed that all of the compounds inhibited lipolysis at basal level through dephosphorylated HSLser563, the rate limiting enzyme of lipolysis. Triphenyl phosphate (TPhP), tricresyl phosphate (TCP), TDCPP, TBP and TBEP enhanced glucose uptake at both basal and insulin-stimulated status. We evidenced that impact was independent of the classical pIRSser639/pAKTser473 nor the insulin-independent AMPK pathway. The elevated mRNA of slc2a4 and its transcriptional factor LXRα may, at least partially, explain for the increase of glucose uptake. Given the focus within the endocrine disruption on glands, it would be prudent not to ignore endocrinal impact on adipocytes.

Biodegradation of tricresyl phosphates isomers by a novel microbial consortium and the toxicity evaluation of its major products

A novel microbial consortium ZY1 capable of degrading tricresyl phosphates (TCPs) was isolated, it could quickly degrade 100% of 1 mg/L tri-o-cresyl phosphate (ToCP), tri-p-cresyl phosphate (TpCP) and tri-m-cresyl phosphate (TmCP) within 36, 24 and 12 h separately and intracellular enzymes occupied the dominated role in TCPs biodegradation. Additionally, triphenyl phosphate (TPHP), 2-ethylhexyl diphenyl phosphate (EHDPP), bisphenol-A bis (diphenyl phosphate) (BDP), tris (2-chloroethyl) phosphate (TCEP) and tris (1-chloro-2-propyl) phosphate (TCPP) could also be degraded by ZY1 and the aryl-phosphates was easier to be degraded. The TCPs reduction observed in freshwater and seawater indicated that high salinity might weak the degradability of ZY1. The detected degradation products suggested that TCPs was mainly metabolized though the hydrolysis and hydroxylation. Sequencing analysis presented that the degradation of TCPs relied on the cooperation between sphingobacterium, variovorax and flavobacterium. The cytochrome P450/NADPH-cytochrome P450 reductase and phosphatase were speculated might involve in TCPs degradation. Finally, toxicity evaluation study found that the toxicity of the diesters products was lower than their parent compound based on the generation of the intracellular reactive oxygen (ROS) and the apoptosis rate of A549 cell. Taken together, this research provided a new insight for the bioremediation of TCPs in actual environment.

A QuEChERS-based UPLC-MS/MS method for rapid determination of organophosphate flame retardants and their metabolites in human urine

Organophosphate flame retardants (OPFRs) have been widely used in consumer products to prevent fire spread. However, once released into the atmospheric environment, they may accumulate in humans and undergo metabolic transformation and excretion by urine. In order to clarify the human exposure to OPFRs, a quick, easy, cheap, effective, rugged, and safe method for the simultaneous determination of urinary OPFRs and their metabolites by ultra-performance liquid chromatography-tandem triple quadrupole mass spectrometry was developed. After the optimization by a single-factor or orthogonal experiment, the satisfactory recovery (87.8–119%), matrix effect (−8.88–9.29%), method quantitation limit (3.66–159 ng/L), and inter-day repeatability (1.24 − 10.6%) of most analytes were achieved in artificial urine samples. Based on a monitoring test by the developed method, we propose that urinary bis(1-chloro-2-propyl) phosphate and di-p-cresyl phosphate could be used to trace human exposure to tris(1-chloro-2-propyl) phosphate and tricresyl phosphate, respectively. Most importantly, this is the first study to reveal that 4-hydroxyphenyl diphenyl phosphate (4-OH-TPHP) was dominantly presented in its conjugated form rather than its free form in urine (p = 0.037). Overall, the obtained results contribute a relatively rapid method to help conduct large-scale urine monitoring for revealing the human exposure and risk of OPFRs.

Interaction of anti‐wear additiveTCPwith advanced bearing steels

AbstractThe quest for high‐performance energy efficient aircraft turbine engines has led to the development of a number of high‐performance rolling element bearing materials and engine lubricants with the aim of providing superior mechanical component durability. The heat treatments/surface treatments used to achieve the desired physical and mechanical properties for these newer alloys can result in altered surface chemistry from currently used materials. Surface chemistry plays an important role during lubricant‐bearing material interactions and the formation of beneficial tribological films during component operation. The objective of this study was to analyse the tribo‐films formed on bearing surfaces and investigate the interaction of lubricant additives, specifically the phosphorus‐based anti‐wear additive tricresyl phosphate (TCP), with different bearing materials under relevant bearing operating conditions. Bearing tests were conducted on 208‐size (40 mm bore) angular contact bearings at 127°C and 154°C using gas turbine engine lubricants conforming to MIL‐PRF‐23699G at maximum Hertzian contact stresses of 3.1 GPa and 3.55 GPa. Bearing materials evaluated included AISI M50, M50NiL, nitrided M50NiL (N) and three variants of Pyrowear 675 with silicon nitride rolling elements. Tribo‐films were analysed using Energy dispersive X‐ray spectroscopy and Auger Electron spectroscopy. Results indicate that phosphorus‐rich anti‐wear tribo‐films form on all of the bearing materials studied. The applied thrust load and heat treatment had a significant effect on tribo‐film thickness. The study also suggests that current gas turbine engine lubricants formulated with TCP should form beneficial tribo‐films that enhance bearing fatigue life and performance.

Characterisation of carbon paste electrodes bulk-modified with surfactants for measurements in nonaqueous media

This article deals with carbon paste electrodes bulk-modified with surfactants for measurements in pure organic solvents where common carbon paste-based mixtures undergo disintegration. The electrodes of interest were prepared by mixing of selected carbon materials (namely: two types of graphite powder, glassy carbon powder, raw shungite powder, and multi-wall carbon nanotubes, with various binders (mineral oil, silicone oil, paraffin wax, vaseline, atactic polypropylene, and tricresyl phosphate), together with surfactants of choice (sodium dodecyl sulfate, cetylpyridinium chloride, benzethonium chloride, cetyltrimethylammonium bromide, didodecyldimethylammonium bromide, Triton X-100, and 1,3‒didecyl‒2‒methylimidazolium chloride). The corresponding studies were focused on the optimal composition of the individual pastes and their characterisation in organic solvents, when using cyclic voltammetry with model redox pairs (ferrocenium/ferrocene and quinone/hydroquinone). The results obtained suggest one that amount of the individual components depends predominantly on the type of carbon used. Key factors for selection of the proper surfactant are its polarity, chemical inertness, and electrochemical inactivity. For comparison, glassy carbon disc electrode was also used.

Implications of estrogen receptor alpha (ERa) with the intersection of organophosphate flame retardants and diet-induced obesity in adult mice

ABSTRACT Previously, organophosphate flame retardants (OPFRs) were found to produce intersecting disruptions of energy homeostasis using an adult mouse model of diet-induced obesity. Using the same mixture consisting of 1 mg/kg/day of each triphenyl phosphate, tricresyl phosphate, and tris(1,3-dichloro-2-propyl)phosphate, the current study aimed to identify the role of estrogen receptor alpha (ERα) in OPFR-induced disruption, utilizing ERα knockout (ERαKO) mice fed either a low-fat diet (LFD) or high-fat diet (HFD). Body weight and composition, food intake patterns, glucose and insulin tolerance, circulating peptide hormones, and expression of hypothalamic genes associated with energy homeostasis were measured. When fed HFD, no marked direct effects of OPFR were observed in mice lacking ERα, suggesting a role for ERα in generating previously reported wildtype (WT) findings. Male ERαKO mice fed LFD experienced decreased feeding efficiency and altered insulin tolerance, whereas their female counterparts displayed less fat mass and circulating ghrelin when exposed to OPFRs. These effects were not noted in the previous WT study, indicating that loss of ERα may sensitize animals fed LFD to alternate pathways of endocrine disruption by OFPRs. Collectively, these data demonstrate both direct and indirect actions of OPFRs on ERα-mediated pathways governing energy homeostasis and support a growing body of evidence urging concern for risk of human exposure.

Shear activation of ZDDP reaction films in the presence and absence of nanodiamonds

We explore the impact of shear stress and nanodiamond (ND) additives on the formation temperatures of thermal- and tribo- reaction films of steel samples immersed in basestock oils containing zinc dialkyl dithio-phosphate (ZDDP) additives. The measurements were performed in-situ using a quartz crystal microbalance (QCM) immersed in oil, oil plus ZDDP, and oil plus ZDDP-ND blends over the temperature range 25 200 °C. ZDDP reaction film formation temperatures were observed to decrease with contact stress and be similar in value to ZDDP-ND blends. ND were observed to be embedded in the reaction films, consistent with prior observations for Tricresyl phosphate (TCP) ND blends, and also consistent with the presence of both primary and secondary reaction products in the films. In addition, the ZDDP+ND reaction tribofilms were observed to be thicker, rougher and more adhesive than those formed with only ZDDP.

Tricresyl phosphate inhibits fertilization in Japanese medaka (Oryzias latipes): Emphasizing metabolic toxicity

As tricresyl phosphate (TCrP) is commonly found in global water sources, its potential reproductive toxicity to fish is of increasing concern. Japanese medaka larvae were exposed to TCrP at 657.9, 1,511, and 4042 ng/L for 100 days. We identified significant fertilization inhibition (6.9%–12.8%) in all exposure groups. Intersex was significantly induced at 4042 ng/L, with an incidence of 22.0%. TCrP exposure also caused dilation of the efferent duct in the testes with maximum duct widths of 83.3, 93.2, and 149.7 μm in the 657.9, 1,511, and 4042 ng/L exposure groups, respectively. These widths were all significantly larger than that observed in the control group (37.7 μm) and likely contributed substantially to fertilization inhibition. The TCrP metabolites 4-OH-MDTP and 3-OH-MDTP, were detected at high concentrations in the liver and elicited 5.8-fold and 5.3-fold greater androgen receptor antagonistic activity than that elicited by TCrP (39.8 μM), which may explain the intersex observed in low exposure groups. 4-OH-MDTP and 3-OH-MDTP elicited anti-estrogenic activities by blocking the estrogen receptor, and the concentrations at which its responses were equal to the IC20 of tamoxifen were 16.1 μM and 18.9 μM, respectively, as detected using the yeast two-hybrid assay. Such anti-estrogenic activities were likely the main driver of dilation of the efferent duct. Observed adverse outcomes after exposure to TCrP all occurred under environmentally relevant concentrations, suggesting considerable ecological risk to wild fish.

Implications of peroxisome proliferator-activated receptor gamma (PPARY) with the intersection of organophosphate flame retardants and diet-induced obesity in adult mice

ABSTRACT Previously, organophosphate flame retardants (OPFRs) were demonstrated to dysregulate homeostatic parameters of energy regulation within an adult mouse model of diet-induced obesity. Using the same OPFR mixture consisting of 1 mg/kg/day of each triphenyl phosphate, tricresyl phosphate, and tris(1,3-dichloro-2-propyl)phosphate, the current study examined the role of peroxisome proliferator-activated receptor gamma (PPARγ) in OPFR-induced disruption by utilizing mice with brain-specific deletion of PPARγ (PPARγKO) fed either a low-fat diet (LFD) or high-fat diet (HFD). Body weight and composition, feeding behavior, glucose and insulin tolerance, circulating peptide hormones, and expression of hypothalamic genes associated with energy homeostasis were recorded. When fed HFD, the effects of OPFR on body weight and feeding behavior observed in the previous wild-type (WT) study were absent in mice lacking neuronal PPARγ. This posits PPARγ as an important target for eliciting OPFR disruption in a diet-induced obesity model. Interestingly, female PPARγKO mice, but not males, experienced many novel OPFR effects not noted in WT mice, including decreased fat mass, altered feeding behavior and efficiency, improved insulin sensitivity, elevated plasma ghrelin and hypothalamic expression of its receptor. Taken together, these data suggest both direct roles for PPARγ in OPFR disruption of obese mice and indirect sensitization of pathways alternative to PPARγ when neuronal expression is deleted.

Occurrence and in vitro toxicity of organic compounds in urban background PM2.5

This study describes the chemical composition and in vitro toxicity of the organic fraction of fine particulate matter (PM2.5) at an urban background site, which receives emissions either from Frankfurt international airport or the city centre, respectively. We analysed the chemical composition of filter extracts (PM2.5) using ultrahigh-performance liquid chromatography coupled to a high-resolution mass spectrometer, followed by a non-target analysis. In parallel, we applied the bulk of the filter extracts to a Microtox and acetylcholinesterase-inhibition assay for in vitro toxicity testing. We find that both the chemical composition and toxicity depend on the prevailing wind directions, and the airport operating condition, respectively. The occurrence of the airport marker compounds tricresyl phosphate and pentaerythritol esters depends on the time of the day, reflecting the night flight ban as well as an airport strike event during November 2019. We compared the organic aerosol composition and toxicity from the airport wind-sector against the city centre wind-sector. We find that urban background aerosol shows a higher baseline toxicity and acetylcholinesterase inhibition compared to rural PM2.5 that is advected over the airport. Our results indicate that the concentration and individual composition of PM2.5 influence the toxicity. Suspected drivers of the acetylcholinesterase inhibition are i.e. organophosphorus esters like triphenyl phosphate and cresyldiphenyl phosphate, and the non-ionic surfactant 4-tert-octylphenol ethoxylate. However, further research is necessary to unambiguously identify harmful organic air pollutants and their sources and quantify concentration levels at which adverse effects in humans and the environment can occur.

Validation of the basic friction equation on Real contact surface based on macro and nano properties of Tribo-film

The formation of tribofilm by lubricant additives plays an important role in improving the performance of boundary lubrication. In previous studies, it has been discussed that the frictional force due to adhesion can be expressed as a product of the real contact area and the shear strength of the contact junction. Therefore, to evaluate the friction mechanism dominated by the tribofilm in detail, it is important to divide and identify the effects of the shear strength and real contact area. However, there are few studies that have verified the relationship between shear strength and macro friction coefficient with experimental data. In this study, nanofrictional property and real contact area of tribofilm was investigated using nanoindentation equipment and contact analysis. The results show that the shear strength of base material and tribofilms are correlated with the macro friction coefficients. In addition, the friction coefficients are calculated by applying the shear strength to the basic friction equation. The result shows that the friction coefficients calculated from the basic friction equation coincide with those measured by the macro friction test at a certain contact ratio of tribofilms formed in Tricresyl phosphate and over based calcium sulfonate.

Modeling the formulation of the PVC cable composition

Increasing the fire-retardant characteristics of polymeric cable materials has attracted the close attention of experts all over the world for many years, since fires are often associated with the ignition of cable products, followed by the spread of fire through cable communications. In this regard, the development of new modern formulations of fireproof compositions with improved performance properties is especially relevant for the production of PVC cable composites. The article describes the production of a new phosphorus-containing flame retardant phenyldixylol phosphate and investigated its physicochemical properties. The new flame retardant was tested in an industrial formulation of a PVC cable composition using dibutoxyethyl adipate as a plasticizer. Using the methods of correlation-regression analysis and optimization, the optimal ratio of the resulting additive and tricresyl phosphate was selected, which provides the best technological and operational parameters of the PVC composite.

Fluorescence Turn-Off Sensing Strategy Based on Al-Based Mof for Selective Detection of Tricresyl Phosphate

Fluorescence Turn-Off Sensing Strategy Based on Al-Based Mof for Selective Detection of Tricresyl Phosphate