Abnormal Hair Research Articles

A Comprehensive Review on Herbal Hair Conditioners for Nourishment and Repair

The growing demand for natural and environmentally friendly hair care products has driven the creation of herbal hair conditioners, blending the advantages of traditional plant-based ingredients with contemporary hair care needs. These conditioners are made with plant extracts, essential oils, and other natural elements that nourish, hydrate, and protect the hair, all while avoiding the harsh chemicals commonly found in conventional products. Ingredients such as aloe vera, henna, argan oil, coconut oil, and chamomile are often included, known for their ability to support hair health, boost shine, minimize frizz, and improve scalp conditions. Herbal conditioners offer several advantages over synthetic alternatives, including their gentleness on the scalp and hair, compatibility with different hair types, and reduced risk of irritation or allergic reactions. These products are also typically free from parabens, sulfates, and artificial fragrances, catering to the increasing demand for clean and sustainable beauty solutions. This abstract underscores the rising significance of herbal hair conditioners in the beauty industry, highlighting their ability to deliver effective care while meeting consumer preferences for organic, cruelty-free, and eco-friendly products. Keywords- Hair Conditioner, Hair, Scalp

Menkes Kinky Hair Disease: Case Report and Review of Literature

Menkes Kinky Hair Disease: Case Report and Review of Literature

Validity and Advantages of Three-Dimensional High-Frequency Ultrasound in Dermatological Evaluation.

Background/Objectives: High-frequency ultrasound (HFUS) has been reported to be useful for the diagnosis of cutaneous diseases; however, its two-dimensional nature limits the value both in quantitative and qualitative evaluation. Three-dimensional (3D) visualization might help overcome the weakness of the currently existing HFUS. Methods: 3D-HFUS was newly developed and applied to various skin tumors and inflammatory hair diseases to assess its validity and advantages for dermatological use. Results: Three-dimensional images were successfully obtained from skin tumors, including basal cell carcinoma, subungual squamous cell carcinoma, Bowen's disease, and malignant melanoma, as well as inflammatory hair loss diseases including alopecia areata in different disease phases and lichen planopilaris. Vertical and horizontal images were generated from the original 3D image data and assessed in comparison with histopathological and/or dermoscopic images. By additionally obtaining horizontal data, lateral tumor margins at any depth were visualized in tumors. In inflammatory hair loss diseases, signs potentially associated with disease activity and pathology were detected. In addition, horizontal evaluation helped grasp hair cycle status and hair follicle densities. Conclusions: These findings suggested that this novel technology holds promise as a robust noninvasive tool to diagnose and evaluate various cutaneous diseases.

A Retrospective Review of Oral N-Acetylcysteine for Habit-Driven Cutaneous Disorders.

Oral N-acetylcysteine (NAC) has shown efficacy for debilitating habit-driven and neuropsychiatric disorders in small, mostly adult studies. We retrospectively evaluated the therapeutic use and safety of oral NAC in 93 children from the Children's Hospital of Philadelphia. This study supports the use of oral NAC for habit-driven skin, hair, and nail abnormalities in pediatric patients.

Exploring formulation, manufacture and characterisation techniques of lamellar gel networks in hair conditioners: A review

Exploring formulation, manufacture and characterisation techniques of lamellar gel networks in hair conditioners: A review

BcWRKY25-BcWRKY33A-BcLRP1/BcCOW1 module promotes root development for improved salt tolerance in Bok choy.

Root development is a complex process involving phytohormones and transcription factors. Our previous research has demonstrated that BcWRKY33A is significantly expressed in Bok choy roots under salt stress, and heterologous expression of BcWRKY33A increases salt tolerance and promotes root development in transgenic Arabidopsis. However, the precise molecular mechanisms by which BcWRKY33A governs root development remain elusive. Here, we investigated the role of BcWRKY33A in both root elongation and root hair formation in transgenic Bok choy roots. Our data indicated that overexpression of BcWRKY33A stimulated root growth and stabilized root hair morphology, while silencing BcWRKY33A prevented primary root elongation and resulted in abnormal root hairs morphology. Meanwhile, our research uncovered that BcWRKY33A directly binds to the promoters of BcLRP1 and BcCOW1, leading to an upregulation of their expression. In transgenic Bok choy roots, increased BcLRP1 and BcCOW1 transcript levels improved primary root elongation and root hair formation, respectively. Additionally, we pinpointed BcWRKY25 as a NaCl-responsive gene that directly stimulates the expression of BcWRKY33A in response to salt stress. All results shed light on the regulatory mechanisms governing root development by BcWRKY25-BcWRKY33A-BcLRP1/BcCOW1 module and propose potential strategies for improving salt tolerance in Bok choy.

Characterization of a novel conditional knockout mouse model to assess efficacy of mRNA therapy in the context of severe OTC deficiency.

Ornithine transcarbamylase deficiency (OTCD) is the most common urea-cycle disorder, characterized by hyperammonemia and accompanied by a high unmet patient need. mRNA therapies have been shown to be efficacious in hypomorphic Sparse-fur abnormal skin and hair (Spf-ash) mice, a model of late-onset disease. However, studying the efficacy of ornithine transcarbamylase (OTC) mRNA therapy in traditional knockout mice, a model for severe early-onset OTCD, is hampered by the rapid lethality of the model and poor lipid nanoparticle (LNP) uptake into neonatal mouse liver. We developed a novel tamoxifen-inducible mouse to study the effect of mRNA therapy in the context of complete or near-complete OTC loss in adult animals. Characterization of the model showed that it is highly reproducible, 100% penetrant, and phenocopies hallmarks of human disease, with animals exhibiting decreased body weight, hyperammonemia, and brain edema. Delivery of OTC mRNA increased survival, maintained body weight, delayed the onset of hyperammonemia, and reduced brain edema. Therefore, this model provides a platform to study LNP-mediated mRNA therapies for the treatment of late-onset OTCD.

Review on Preparation and Evaluation of Herbal Hair Tonic

These days, people are interested in hair preparation and conditionar materials such as hair tonic, shampoos, hair gel, hair tonic spray, conditioners formulations containing herbal extracts. Hair tonic is a product used to style or fashion the hair. The objective of gift examine study involves preparation of herbal hair tonic with aid of the using coconut oil, hibiscus, aloe vera, amala, tulsi, reetha, jojoba oil, rosemary oil and its evaluation for antibacterial, antifungal and strengthness of activity. The final instruction of these ingredients is formulated in batches with alternate in concentration. Every formulation is tested right effects for antifungal, antibacterial and strengthness of hair activity. The formulation having different concentration were characterised for proximate analysis such as acid insoluble ash, good consistency properly spreadibility, Ph, water, soluble ash, insoluble ash, homogeneity, appearance. Hair is crown for the everyone because functions for hair providing protection, warmth, beauty and the support. Loss of hair is a universal most serious problem for everyone. That has been estimated to affected between 0.2 and 2% the world population. This study aimed involves preparation of herbal hair tonic from virgin coconut oil extract of a mix of nine herbs which is important or benifecial as herbal hair tonic

Mooew: Inovasi Hair Tonic Gel Eco-Friendly Berbasis Hydroxyproline Limbah Tulang Ikan Tenggiri dengan Ekstrak Chamomile Solusi Alopesia Kucing

This research aims to market business potential by implementing sales strategies that produce profitable and sustainable products. MOOEW Hair Tonic has a Return of Investment (ROI) of more than 100% which means that the profits obtained have exceeded the capital. This research uses qualitative exploration methods and economic feasibility studies, resulting in data that this product has a Return of Investment (ROI) of more than 100%, showing significant business sustainability potential. The results show that MOOEW Hair Tonic is able to answer the health care needs of cat fur effectively with a safe material composition and affordable price. This product is expected to encourage concern for the health of pets while supporting environment-based waste reduction. Conclusion, MOOEW Hair Tonic. MOOEW Hair Tonic offers simple, attractive and practical packaging so that it is easy to carry, easy to store and easy to apply. MOOEW Hair Tonic products are sold at affordable prices. However, the product prices we set do not reduce the quality of the raw materials we use.

A Scopic Review on Niosomes: Current Status of Approved Products and their Application in Cosmetics

Background: Niosomes have emerged as a promising vesicular drug delivery technol-ogy due to their applications in the pharmaceutical and cosmetics sectors. Their unique properties, including their amphiphilic characteristics and ability to self-assemble, make them highly adapta-ble for encapsulating both hydrophilic and lipophilic substances. Objective: The current study aims to provide a concise description of previously published data on the usage and applications of niosomes in cosmetics. It also seeks to conduct a thorough as-sessment of this data, focusing on their composition, production methods, and performance-related variables. Methods: This review examines the makeup and arrangement of niosomes, with particular atten-tion to their amphiphilic properties and self-assembly capabilities. The analysis includes various cosmetic applications of niosomes, exploring their role in delivering different cosmetic ingredi-ents such as antioxidants, vitamins, and peptides. Results: Niosomes have been effectively used in various cosmetic products, including skincare, haircare, and color cosmetics. They facilitate the delivery of active ingredients in anti-aging creams, moisturizers, sunscreen products, hair conditioners, and face washes. The ability of nio-somes to encapsulate diverse substances enhances the performance and efficacy of these cosmetic products. Conclusion: Niosomes represent a versatile and effective delivery system in the cosmetics indus-try. Their capacity to encapsulate both hydrophilic and lipophilic substances makes them suitable for a wide range of cosmetic applications, significantly improving the delivery and performance of cosmetic ingredients across different product categories.

Review of Herbal Hair Oil

Herbal formulations always have activity and comparatively lesser or no side Effects with synthetic. The growth activity in a concentration range for 1-10% separately.Excellent results of hair growth were seen in formulation prepared by boiling method of oil preparation technique. Natural remedies AR acceptable in the belief that they are safer with fewer side effects than synthetic one. Herbal hair oil is one of the most well recognized for hair treatment. Herbal oil not only moisturizes scalp but also reserves dry scalp and dry hair condition. It provides various essential nutrients required to maintain function of sebaceous glands and promotes natural hair growth. Were subjected to test of sensitivity, pH, odour, colour etc. In Ayurveda medicine, herbs are used as an integral part of health care system. Besides healthcare, herbs are also used for beautification of the body and for preparation of various cosmetics and colors .The aim of present study involve spreparation of poly herbal hair oil using fresh leaves of various plants. The prepared herbal oils were subjected to photochemical screening,. The aim of present study involves preparation of poly herbal hair oil. Using the leaves in neem. The concept of beauty and cosmetics is as ancient as mankind and civilization. So, they use various beauty products that have herbs to look charming and young. Herbal cosmetics are now-a-days widely used by the common people because of concept of f ewer side effect sand with abettersa wetland security profiles

Cinnamic Acid Derivatives as Potential Multifunctional Agents in Cosmetic Formulations Used for Supporting the Treatment of Selected Dermatoses.

Cinnamic acid and its natural derivatives were primarily used in cosmetics as fragrance materials as well as skin and hair conditioners. Nowadays, not only natural but also synthetic cinnamic acid derivatives are used as active ingredients of cosmetic formulations. They still serve as fragrance ingredients but also as active ingredients supporting the treatment of selected dermatoses such as acne vulgaris, atopic dermatitis, and hyperpigmentation. They are also commonly used in anti-aging cosmetic formulations. On the other hand, several cinnamic acid derivatives used as fragrances in cosmetic products are classified as potential allergens which can cause contact dermatitis. The main mechanisms of action proved for various cinnamic acid derivatives include antioxidant, antimicrobial, anti-inflammatory, and antimelanogenic properties. Most commonly used cinnamic acid derivatives in cosmetics products are hydroxy acids such as ferulic acid, caffeic acid, p-coumaric acid, and sinapic acid. Chemical synthesis led to several modified acids, esters, and amides, which also showed the potential to be used in cosmetic formulations.

Exploring Pediatric Dermatology in Skin of Color: Focus on Dermoscopy.

This literature review aims to comprehensively evaluate the clinical and dermoscopic presentations of common pediatric diseases among children with skin of color (SoC) while also addressing potential variations based on racial backgrounds. This review encompasses various conditions, such as nevi subtypes, viral infections, infestations, and inflammatory dermatoses, as well as hair diseases and abnormal vascular formations, occurring in pediatric populations. Overall, we identified 7 studies on nevi subtypes, 24 studies on skin infections, 6 on inflammatory dermatoses, 10 on hair diseases and disorders, and 14 on miscellaneous disorders that also satisfied our SoC- and race-specific criteria. In case of no results, we assumed that dermoscopic findings are similar between SoC adults and children, confirming the hypothesis with our cases of dark-skinned Indian child patients. Inflammatory dermatoses such as psoriasis, eczema, and cutaneous mastocytosis, as well as skin infections like cutaneous leishmaniasis, appear with brownish backgrounds or exhibit dark structures more frequently than the respective dermoscopy images of Caucasian populations. Dermoscopy traits such as erythema in tinea capitis are uncommon or even absent on a dark-colored scalp, while a dark skin tone often obscures many characteristic features, such as dark and yellow dots in alopecia areata and even parts of an intradermal parasite in the case of scabies. Race-specific traits were also observed, such as corkscrew hair in tinea capitis, primarily seen in patients of African origin. Many dermoscopic images are consistent between SoC and non-SoC in various skin lesions, including vascular anomalies, juvenile xanthogranuloma, mastocytoma, and viral skin lesions like molluscum contagiosum, as well as in various hair disorders such as trichotillomania, while tinea capitis displays the most diverse reported dermoscopic features across SoC- and race-specific studies.

Identification and characterization of alopecia areata subgroups regarding quality of life impairment based on demographic, clinical, psychological, and social factors

ABSTRACT The benign dermatological hair condition Alopecia Areata (AA) is known to impair Quality of Life (QoL), especially mental and social health, due to the accompanying visible appearance changes. Previous studies have identified demographic, clinical, social, and psychological variables related to QoL. Yet, the novelty of this study lies in examining how QoL differences in AA relate to (combinations of) these variables. The aim of the current study is to identify and characterize subgroups of AA persons with less or more QoL impairment by means of (combinations of) demographic, clinical, psychological, and social factors, including both potential risk (perceived stigmatization, avoidant coping, physical identity definition) and protective factors (disclosure, social support, emotion-focused coping and non-physical identity definition). An online questionnaire was filled out by 322 persons with AA, including the Dermatology Life Quality Index (DLQI) as QoL measure, Perceived Stigmatization Questionnaire (FSQ), brief COPE, Social Support Survey, a newly developed identity-definition measure, clinical characteristics, and demographics. Classification and Regression Tree (CART) analysis identified subgroups based on QoL outcome. Lowest QoL impairment was found in persons with low feelings of being flawed combined with low secretiveness. Low QoL impairment was also found in persons feeling flawed combined with low avoidant coping, low sensitivity to others’ opinions and older age. QoL impairment was intermediate in persons perceiving more social support in those with a younger age, and defining identity less on physical appearance in those sensitive to others’ opinions. Highest QoL impairment was characterized by feeling flawed combined with an avoidant coping style. Current findings provide indications for the identification of risk and protective profiles for QoL impairment and which factors to address in interventions to improve QoL in AA.

An integrated approach to address the biodegradability of cosmetic formulations as part of a corporate sustainability strategy

AbstractObjectiveThe biodegradability of organic chemicals with usual down‐the‐drain disposal in their end‐of‐life is a key parameter to be considered by industries pursuing sustainability in their new product developments. It is a property that, once improved in any formulated product portfolio, will allow for a significant reduction in the presence of its ingredients in the natural environment, with a potential reduction in the pollution‐related environmental impact after consumption. This article aimed to propose an intelligent strategy for addressing biodegradability in the cosmetics sector, with the potential to support both product claims and corporate sustainability initiatives.MethodsThe framework for achieving a portfolio biodegradability indicator is composed of three levels of assessment, the first being an ingredient level assessment, the second being an individual product biodegradability calculation (PBI—Product Biodegradability Index), and finally a third level to calculate an emission‐based, company‐wide biodegradability indicator (GBI—Global Biodegradability Index). A case study is presented and discussed in detail, as a proof of applicability of the whole framework to support new developments for an improved environmental performance. Important insights in terms of ingredients assessment criteria are also presented.ResultsA fictitious portfolio composed of two soaps (a bar and a liquid), two hair care products (shampoo and hair conditioner) and one bath oil resulted in a GBI of 92.8%. The bar soap was the main contributor for this global index, with a PBI of 98.8% and a relatively high consumption volume of 1 ton/year, which accounts for approximately 66% of the total portfolio consumption. Other products, like hair care, presented lower PBIs, but their lower mass consumption representativeness within the portfolio prevented a significant negative impact on the global index. The main strategic directions derived from the case study, to ensure a stable and high biodegradability of the consumed organic mass, were properly discussed.ConclusionThe output of this framework provided an intelligent management strategy for innovation, where reformulation efforts can be targeted at products and ingredients with the highest potential to improve the biodegradability profile of the total organic mass released to the environment from a given portfolio.

Mexican Mint (Coleus amboinicus) Emulgel: Natural Solution for Antidandruff Hair Care

Today, the world is developing more and more in all sectors at a faster pace. But with all these developments, people are more prone to falling ill due to factors such as pollution, unhealthy lifestyles, busy work schedules, etc. Nowadays, even children suffer from the issue of dandruff and scalp infections which in later teenage years leads to unhealthy scalp and hair fall problems. Dandruff is a common scalp condition that affects individuals of all ages. It not only causes discomfort but also undermines hair health and aesthetics. Although scalp disorders are not among those that cause severe physical illness or morbidity yet are of great social concern. Scalp and hair conditions have more of a psychological impact on societies. Even minor changes in hair like graying of hair, affects the self-confidence and self-esteem of an individual. There are many types of medications and formulations to treat hair dandruff issues, one of which includes a novel drug delivery system such as “Emulgel” in the form of a mask. The anti-dandruff hair mask offers multiple benefits, including reduction in scalp inflammation and effective management of hair dandruff problems. Furthermore, it rejuvenates the scalp and nourishes hair follicles due to its natural vitamins and nutrient content. Keywords: Dandruff, Pityriasis capitis, Seborrheic dermatitis, Mexican mint, Herbal hair mask, Hair mask

Mesenchymal Stem Cell Exosomes Therapy for Acquired Trichorrhexis Nodosa: A Case Series.

Recent preclinical studies have demonstrated the potential efficacy of stem cell exosomes in the treatment of hair loss. However, there is a paucity of clinical studies investigating the application of exosomes for this purpose. This case series presents three patients treated with exosomes for acquired trichorrhexis nodosa (ATN), a condition characterized by hair shaft abnormalities and breakage. This study aims to evaluate the effectiveness and safety of utilizing mesenchymal stem cell (MSC) exosomes as a novel therapeutic approach for the management of ATN. A standardized process was employed to prepare 0.1 mL of exosomes, which were subsequently injected into bilateral regions of the patients' scalps at 0.5-1 cm intervals on a monthly basis. Each injection comprised a total volume of 5 mL, and all three patients underwent a minimum of four treatment sessions. The comparative efficacy of the treatment was evaluated using clinical photographs, dermatoscopy, and scanning electron microscopy (SEM) for all three patients post-intervention. The hair condition of the three patients demonstrated significant improvement, characterized by increased length and density, enhanced pigmentation with a reduced presence of dusty white dots, and the disappearance of dermoscopic black dots and broken hairs. SEM analysis revealed a remarkable recovery in the hair cuticle layers. At the 1-year follow-up, hair growth essentially remained normal. Exosomes derived from mesenchymal stem cells demonstrate efficacy in treating ATN, presenting a novel therapeutic approach for this condition.

Актуальні проблеми цифрової обробки трихологічних зображень

This article explores modern methods of digital processing of trichological images for hair condition diagnosis. Special attention is paid to modules that employ computer vision techniques and machine learning algorithms to enhance diagnostic accuracy. Proposed automated image analysis solutions effectively detect hair structure anomalies and simplify the diagnostic process. The article discusses the advantages and limitations of existing approaches and prospects for their further development to improve medical procedures. Applications of these technologies in clinical practice are also examined.

Formation and Preparation of Herbal Hair Tonic

Today, people are keenly interested in hair preparations and conditioner materials that includes shampoos, hair tonic, and conditioner formulation with herbal extracts. Hair tonic is the product which is used in styling hair. The objective of the present study involved the preparation of herbal hair tonic through the use of jojoba, tulsi, and coconut oil and its evaluation for antifungal and antibacterial activity. The final preparation of these ingredients is formulated in batches with change in concentration. Each formulation is tested for antibacterial and antifungal activity. The formulation of different concentrations was characterized for proximate analysis including moisture content, total ash, acid insoluble ash, water soluble ash, water insoluble ash, sulphated ash. It means for antifungal and antibacterial activity the formulation gives good results, the formulation having good consistency, good spread ability, homogeneity, appearance, and pH.

Placental Extracts, Proteins, and Hydrolyzed Proteins as Active Ingredients in Cosmetic Preparations for Hair Loss: A Systematic Review of Available Clinical Evidence

Placentae and their derivatives have been used in both traditional and modern medicine, as well as in cosmetic sciences. Although hair loss is frequently mentioned among problems for which the placenta is supposed to be a remedy, the evidence seems rather scarce. The aim of this study was to highlight the clinical evidence for the efficacy of placenta products against baldness and hair loss. Methods: This systematic review was performed according to PRISMA and PICO guidelines. Database searches were conducted in PubMed, Google Scholar and Scopus. Results: Among the 2922 articles retrieved by the query, only 3 previously published clinical trials on placental products were identified. One study was a randomized controlled trial, in which the efficacy of a bovine placenta hair tonic was found to be comparable to that of minoxidil 2% in women with androgenic alopecia. Another controlled study showed that a porcine placenta extract significantly accelerated the regrowth of shaved hair in healthy people. The third study was an uncontrolled trial of a hair shampoo and tonic containing equine placental growth factor in women with postpartum telogen effluvium with unclear and difficult-to-interpret results. Due to the design and methodology of these studies, the level of evidence as assessed with the GRADE method was low for the first study and very low for the other two. Conclusions: The very limited scientific evidence available to date appears, overall, to indicate the efficacy of placental products in both inhibiting hair loss and stimulating hair growth. Unfortunately, the number of clinical studies published to date is very limited. Further, carefully designed, randomized controlled trials of well-defined placental products are needed to definitively address the question of the value of the placenta and its derivatives in hair loss.