Trichophyton Research Articles

Keratinophilic Fungi Isolated from Soils of Long-Term Fold-Grazed, Degraded Pastures in National Parks of Slovakia

A total of 939 isolates of 11 genera representing 15 species of keratinophilic fungi were isolated and identified from the soils of three long-term fold-grazed pastures in national parks of Slovakia (Pod Ploskou, Strungový príslop, and Pod Kečkou) and one non-fold-grazed pasture in sierra Stolicke vrchy (Diel) using the hair-baiting technique. Keratinophilic fungi were present in all soil samples with a prevalence of Trichophyton ajelloi and Paecilomyces lilacinus. These fungi were more abundant in soil from fold-grazed pasture (Strungový príslop) compared to non-fold-grazed pasture (Diel). The occurrence of the other keratinophilic fungi was substantially lower, likely because of low pH in some soils.

Comparison of morphology, pathogenic ity and proteomics of granuloma- and tinea corporis-derived Trichophyton mentagrophytes

Objective To screen differentially expressed proteins between granuloma- and tinea corporis-derived Trichophyton mentagrophytes strains,and to explore the pathogenesis of T.mentagrophytes in deep and superficial infection.Methods Four T.mentagrophytes isolates from granuloma and 4 isolates from tinea corporis were cultured in agar plates and small steel rings at 27 ℃ and 37 ℃ respectively, followed by morphologic observation.Eight guinea pigs were immunocompromised by glucocorticoids,and superficially and subcutaneously inoculated with the same amount of fungal suspension to develop an animal model of tinea corporis and granuloma,respectively.Two weeks later,the infection of guinea pigs was confirmed by microscopy,fungal culture and histopathology.Proteins were extracted from a highly toxic granuloma-derived T.mentagrophytes strain and a lowly toxic tinea corporis-derived T.mentagrophytes strain,and subjected to twodimensional electrophoresis,mass spectrometry and identification by using the National Center for Biotechnology Information (NCBI) database.Results The granuloma-derived T.mentagrophytes isolates grew better at 37 ℃ than tinea corporis-derived T.mentagrophytes isolates did,while no significant difference was observed in the morphology of colonies between the two kinds of T.mentagrophytes isolates at 27 ℃.Tinea corporis models were successfully established in guinea pigs with the 8 T.mentagrophytes strains,and the granuloma-derived isolates induced a more intense inflammation than tinea corporis-derived isolates.Granuloma model was constructed only with 3 granuloma-derived strains,which was proved by microscopy,fungal culture and histopathology.A total of 463 ± 20 and 398 ± 17 protein spots were detected,with 62 and 21 upregulated proteins,from granuloma-derived and tinea corporis-derived T.mentagrophytes strains,respectively.Bioinformatics analysis revealed the following meaningful proteins from differentially expressed proteins in granuloma-derived T.mentagrophytes strains, including enolase, heat shock protein, serine/threonine protease, cellular signal transduction proteins,energy metabolism-related proteins,cytoskeleton proteins and some hypothetical proteins.Conclusions The granuloma-derived T.mentagrophytes strains are more heat-resistant with a higher potency to cause infection compared with tinea corporis-derived T.mentagrophytes strains.Differences exist in the expression of proteins between granuloma- and tinea corporis-derived T.mentagrophytes strains. Key words: Trichophyton; Proteomics; Virulence

Scutular tinea of the scrotum by Candida guilliermondii

ejd.2011.1613 Auteur(s) : Jiuhong Li1 lijiuhong2011@126.com, Zhenhai Yang1, Yilei Li1, Xiuhao Guan1, Bo Li1, Junping Lin1, Huachen Wei1,2 1 Department of Dermatology, No. 1 Hospital of China Medical University, 155N, Nanjing Street, 110001 Shenyang, China 2 Department of Dermatology, Mount Sinai Medical Center, New York, USA Scutula is the characteristic lesion of favus, appearing as a yellow saucer-shaped crust made up of hyphae and spores. Scutula is predominantly caused by Trichophyton schoenleinii, afflicting [...]

Species diversity of keratinophilic fungi in various soil types

Abstract Keratinophilic fungi are a highly specialized, keratin-degrading ecological group. They live in natural environments, mostly in the keratinrich remains of dead animal in the soil. We investigated species diversity in four types of soils with different physico-chemical properties. The strain material was identified based on morphological characters. Different representatives of Chrysosporium and geophilic dermatophytes dominated depending on soil pH. Geophilic dermatophytes were represented by one species, Trichophyton ajelloi, and the Chrysosporium group was represented by Chrysosporium keratinophilum. The frequency of Trichophyton ajelloi increased with an increase in pH, and it reached the maximum in strongly acidic soil (podzol), unlike the Chrysosporium group. The frequency of Chrysosporium keratinophilum was positively correlated with the content of humus, nitrogen, CaCO3 and phosphorus in the soils.

Contribution to knowledge Trichophytia by Cattle

Today's high-technology dairy cattle on large agglomerations caused a number of healthproblems. The aim of this paper is to indicate the presence of trichophytia, as a health problem, whichis present on all farms and herds of Holstein Friesian and Simmental breeding in the individualbreeding. Trichophytia is a health problem not only for animals but for the workers and veterinarianson farms. Trichophytia occurs mainly in calves and cows with poor body condition. Trichophytiacattle dermatomycosis caused by Trichophyton verucosum.The cause of this disease lives on the skin surface and its proteolitic and keratolytic enzymesand exotoxins cause parakeratosis and inflammatory changes. The predisposing factors for theoccurrence of trichophytia ranks higher percentage of humidity, overcrowding in the facilities, age ofanimals in the herd and the quality of food. The infection is transmitted by direct contact. For the onsetof winter weather favors the disease. However, in our previous studies diagnostic trichophytia ishighly pregnant heifers keeping related systems, in the fall (October-November) the number of cattlefarms holstein- friesian tied housing systems.

In vitro fungistatic effects of natural coniferous resin from Norway spruce (Picea abies)

Resins (rosin, pitch) are natural products of the coniferous trees and are antimicrobial against a wide range of microbes. The antifungal effectiveness of resin, purified from Norway spruce (Picea abies), was studied against human pathogenic fungi and yeasts with the agar plate diffusion tests and electron microscopy (EM). The fungistatic effect of these resin mixtures (resin salves) was tested against a set of Candida yeasts, dermatophytes, and opportunistic fungi. Transmission and scanning EM was done from samples of fungi (Trichophyton mentagrophytes). In agar diffusion tests, the resin was strongly antifungal against all dermatophytes tested, e.g., against all fungi of the genus Trichophyton, but it was not antifungal against the Candida yeasts or against the opportunistic fungi tested. According to EM, resin caused damages in the cell hyphae and cell wall structures. We conclude that, in the agar plate diffusion test, coniferous resins are strongly fungistatic against the dermatophytic fungi only.

Efficacy of the Trichophyton ajelloi and Lagenidium giganteum metabolites against mosquitoes after flash chromatography

Entomopathogens are significant natural enemies for mosquitoes. We have investigated the adulticidal efficacies of metabolites of Trichophyton ajelloi and Lagenidium giganteum against Culex quinquefasciatus and Aedes aegypti simultaneously. The T. ajelloi was grown on Sabouraud's dextrose broth medium at 25 ± 2°C and relative humidity at 75 ± 5% for 15 days. L. giganteum was grown in peptone yeast extract glucose broth at 25 ± 2°C and relative humidity 75 ± 5% for 15 days. The filtrations of metabolites have been made by using Whatman-1 filter paper then with the flash chromatograph. The bioassays were conducted as per the World Health Organization's methods and protocols (2006). In this significant investigations, the metabolites of T. ajelloi have been found highly susceptible against A. aegypti with LC(99)-7.24 ml after an exposure time of 24 h with a comparison, the LC(99)-66 ml was observed against C. quinquefasciatus after exposure of 24 h. Moreover, the L. giganteum metabolites have shown higher pathogenicity against C. quinquefasciatus with LC(99)-11.3 ml and A. aegypti with LC(99)-15.49 ml. Although, the efficacy in adults could be achieved with higher concentration can be significant also. Their adulticidal activities in different climatic zones are plausible with metabolites which have better LT values of T. ajelloi.

Clinical and mycological analysis of 241 cases of tinea capitis in Guangzhou region

Objective To make a clinical and mycological analysis of tinea capitis in Guangzhou region. Methods A retrospective analysis was performed on 241 cases of tinea capitis collected from Feb, 1997 to Aug, 2010 in the Department of Dermatology, Sun Yet-sen Memorial Hospital. Results Among the 241 cases, 179 (74.27%) were tinea alba, 34 (14.11%) tinea kerion, 28 (11.62%) black dot ringworm, and no favus was observed. The dominant pathogenic fungi in decreasing order were Microsporum canis (182,80.89%), Trichophyton violaceum (25, 11.11%), Trichophyton mentagrophytes (10, 4.44%), Trichophyton tonsurans (3, 1.33%), Trichophyton rubrum (2, 0.89%), Microsporum gypseum (2, 0.89%) and Trichophyton verrucosum (1, 0.44%). Children were the main population (39.00%) suffering from tinea capitis. Conclusions In Guangzhou region, tinea alba is the most common type of tinea capitis, Microsporum canis is the main causative pathogen, and children are the predominate population affected by tinea capitis.

Analysis of extracellular enzymatic activity of fungi isolated from patients with onychomycosis

Objective To determine the extracellular enzymatic activity of common pathogens for onychomycosis, in the hope of finding virulence factors associated with the pathogenesis of onychomycosis. Methods Strains tested in this study included standard strains of common dermatophyte and non-dermatophyte fungi as well as clinical isolates of Trichophyton rubrum from patients with onychomycosis. All the tested strains were cultured in medium containing nail fragments at 25 ℃ for 10 to 21 days followed by the determination of the nail fragment-containing medium, a significant increase was observed in the activities of esterase, esterase lipase, N-acetyl-β-glucosaminidase and α-mannosidase in dermatophytes compared with non-dermatophytes (all P ＜ 0.05 ), as well as in the activity of N-acetyl-β-glucosaminidase in Trichophyton rubrum compared with the other tested species of fungi (all P ＜ 0.05). No significant difference was noted in the activity of extracellular enzymes, except for that of naphthol-AS-BI-phosphohydrolase, between the isolates of Trichophyton rubrum from patients with different ranges of scoring clinical index for onychomycosis (SCIO). Conclusions In specific conditions, the extracellular enzymatic activity of fungi isolated from patients with onychomycosis is associated with fungal species, and may have a certain influence on the manifestations of anychomycosis. Key words: Onychomycosis; Hydrolases; Virulence factors

Keratinophilic fungi in activated sludge of wastewater treatment plants with MBR in Berlin, Germany

Seventy-two samples of aerobic and anoxic activated sludge were collected from two wastewater treatment plants (36 from each) with membrane bioreactors (MBR) in Berlin (Germany) to determine the presence of cycloheximide-resistant, keratinophilic fungi using the hair-baiting technique. This is the first study on the occurrence of these fungi in MBR sludges. Forty-six fungal species belonging to 21 genera were isolated and identified (41 species and 21 genera versus 36 species and 19 genera from aerobic and anoxic sludge samples, respectively). Twelve species were dermatophytes or closely related fungi: Chrysosporium asperatum, C. georgii, C. indicum, C. keratinophilum, C. tropicum, C. pannorum, Microsporum cookei, M. ferrugineum, M. gypseum, Trichophyton ajelloi, T. mentagrophytes and T. terrestre. The other 32 species, included membe rs of Acremonium, Alternaria, Aspergillus, Candida, Chaetomium, Cladosporium, Fusarium, Geotrichum, Gliocladium, Gymnoascus, Mucor, Paecilomyces, Penicillium, Scopulariopsis, Sporothrix, Trichoderma, Verticillium and unidentified yeasts. The fungi isolated are pathogenic or potentially pathogenic to humans and animals, and their occurrence in activated sludge poses a health risk to wastewater treatment workers and the environment.

Case report: onychomycosis due to Trichophyton schoenleinii

Trichophyton schoenleinii is an antropophilic dermatophyte transmitted by contact between humans. This genus is an aetiological agent of mycosis of the scalp – tinea favosa. Infections with T. schoenleinii were the most frequent dermatomycoses in Poland before the Second World War. Improvements in living conditions and hygiene after the Second World War have led to considerable decrease of infection with this fungus. We describe a patient who had a toenails involvement due to T. schoenleinii.

Genotyping of Trichophyton violaceum isolated from children with tinea capitis in Xinjiang Uygur Autonomous Region by PCR-RFLP analysis

Objective To analyze the genotypic characteristics of T. violaceum, and offer evidence for molecular epidemiological study of causative agents of pediatric tinea capitis, in Xinjiang Uygur Autonomous Region. Methods The PCR-restriction fragment length polymorphisim (RFLP) of the nontranscribed spacer region of ribosomal DNA (rDNA-NTS) was assessed by using 5 restriction enzymes, including HaeⅢ, Bgl Ⅰ,MspⅠ, DdeⅠ and MboⅠ, for 30 clinical isolates of T. violaceum from children with tinea capitis in Xinjiang Uygur Autonomous Region. Nine strains of T. violaceum from Beijing and 2 strains from Taiwan served as the control.Results All the 41 strains of T. violaceum were classified into 12 genotypes with the restriction enzyme Ddel.Ten genotypes were revealed in the 30 strains from Xinjiang; among them, 17 strains showed 7 different genotypes (D, F, G, H, I, J and K) with a high intraspecies diversity in comparison with the Beijing and Taiwan isolates; the remaining 13 strains from Xinjiang showed 3 genotypes, which were shared by the Beijing and Taiwan isolates. Conclusions The T. violaceum isolates from children with tinea capitis in Xinjiang Uygur Autonomous Region have unique genotypes, but also show genetic homogeneity with the strains from Beijing and Taiwan, hinting the genetic diversity of T. violaceum. Key words: Tinea capitis; Trichophyton violaceum; DNA fingerprinting

Tinea capitis: still an unsolved problem?

Tinea capitis is a fungal infection specifically involving the scalp and hair. It is the most common dermatophyte infection in children under 12 years of age, with a predominance in those of sub-Saharan African descent. Common signs include hair loss, scaling, erythema and impetigo-like plaques. Adults may also be affected, but to a lesser degree. The causative species are from the Microsporum and Trichophyton genera. Limited treatment options and diverse modes of transmission complicate the clinician's ability to address this disease adequately. Although dermatophytes are ubiquitous in our environment and tinea capitis is common, therapeutic options can be utilised to reduce morbidity.

The Sensitivity of Dermatophytes to the Antimicrobial Activity of Manuka Honey and Other Honey

Honey has been reported to have antifungal activity and so was tested against clinical isolates of the common dermatophyte species which cause tineas in man. A honey with an average level of hydrogen peroxide, and a manuka (Leptospermum scoparium J. R. and G. Forst, family Myrtaceae) honey with an average level of non-peroxide antibacterial activity were used. An agar well diffusion assay was used, the contents of the wells being replaced with freshly prepared honey solutions at 24-h intervals over the 3–4 days of incubation. The lowest concentrations (% v/v, in steps of 5%) of manuka honey with catalase added to remove hydrogen peroxide, and of the other honey (without catalase) showed that inhibition of growth around the wells were, respectively, Epidermophyton floccosum 25%, 10%; Microsporum canis 25%, 15%; Microsporum gypseum 55%, 20%; Trichophyton mentagrophytes var. interdigitale 45%, 15%; Trichophyton mentagrophytes var. mentagrophytes 25%, 15%; Trichophyton rubrum 20%, 5% and Trichophyton tonsurans 25%, 20%. No inhibitory activity was detected with the other honey at 50% (v/v) with catalase added. The results of this investigation show that the common dermatophytes are sensitive to the antimicrobial activity of honey, indicating that clinical evaluation of honey in the treatment of tineas is warranted. This would determine whether the hydrogen peroxide or the non-peroxide antifungal agent diffuses better into the skin.

Phytochemical properties and in-vitro antifungal activity of Senna alata Linn. crude stem bark extract

This study reports on the phytochemical properties and in-vitro antifungal activity of Senna alata Linn. crude stem bark extract on clinical test dermatophytes. The studies on the antifungal activities of crude extracts of Senna alata L. stem bark were carried out. The test was conducted on dermatophytes, which included clinical dermatophytes of the genera Trichophyton, Microsporum and Epidemophyton. These fungi are the causative agents of various types of dermotophytosis that attack various parts of the body and tend to the following conditions, Tinea capilis, Tinea cruris, Tinea corporis and Tinea pedis. The results obtained showed that the crude extract of the stem bark of Senna alata L. exhibited marked antifungal effects on Microsporum canslaslomyces, Trichophyton verrucosum,Trichophyton mentagrophytes, and Epidermophyton floccosum. The crude extract showed the highest inhibition on T. verrucosum and E. floccosum with 21.00 and 20.05 mm zones of inhibition respectively. The Minimum Inhibitory Concentration (MIC) was also performed and the result showed that the MIC of Senna alata L. crude stem bark extract on all the tested dermatophytes was 5.0 mg/mL. The result showed that the crude extract ofS. alata L stem bark was fungicidal for all tested dermatophytes at concentration of 10.00 and 5.00 mg/mL except E. floccosum which was only fungicidal at concentration of 10.00 mg/mL. The crude extract of S. alata L. stem bark screening showed vary degree of activities against all the tested dermatophytes. Phytochemical analysis revealed the presence of important secondary metabolites (tannins, steroids, alkaloids, anthraquinones, terpenes, carbohydrates and saponins) in the plant thus indicating the therapeutic potentials of the plant. It is concluded that S. alata L. stem bark could be a potential source of active antimicrobial agents, and a detailed assessment of its in vivo potencies and toxicological profile is therefore advocated. Key words: Antifungal activity, crude extract, dermatophytes, phytochemicals, Senna alataL., stem bark, MIC.

Fungal infections among diabetic foot ulcer- patients attending diabetic clinic in Kenyatta National Hospital, Kenya.

To isolate and identify fungal pathogens associated with dermatophytoses in diabetic patients and identify the spectrum of yeasts colonising diabetic foot ulcers at Kenyatta National Hospital. A cross sectional Laboratory based study. The Kenyatta National Hospital diabetic clinic. Sixty one patients with diabetic foot ulcers from August to November 2009. The five most occurring pathogens were Biopolaris hawaiiensis (5.5%), Trichophyton schoenleinii (3.7%), Aspergillus niger (3.0%), Trichophyton rubrum (3.0%), Fusarium oxysporum (3.0%). Other moulds accounted forless than 3.0%. One suspected case (0.6%) of Penicilium marneffei was isolated although it couldnotbe ascertained due to its high containment requirement. Among the dermatophytes, the most occurring mould was Trichophyton schoenleinii (3.7%) while innon-dermatophyte was Biopolaris hawaiiensis (5.5%). Eight pathogenic yeasts were identified with C. parapsilosis (6.1%) being the most common followed by C. famata (3.0%). Fungal infestation was highest in callus formation (78.6%). Fungal aetiological agents are significant cause of diabetic woundinfection and may require antifungal intervention for successful management of diabetic foot ulcers.

Studies on Fungal Cultural Filtrates against Adult Culex quinquefasciatus (Diptera: Culicidae) a Vector of Filariasis.

Entomopathogenic fungi have significant potential to control mosquito population. The culture filtrates of Fusarium oxysporum, Lagenidium giganteum, Trichophyton ajelloi, and Culicinomyces clavisporus were evaluated against adults of Cx. quinquefasciatus. The culture filtrates were obtained by filtering the broth through Whatman-1 filter paper. These culture filtrates of C. clavisporus have been found significantly pathogenic with LC50-2.5, LC90-7.24, and LC99-8.7 ML, respectively, after exposure of 24 h. However, the culture filtrates when were combined, in ratios 1 : 1 : 1 of Fusarium oxysporum, Lagenidium giganteum, Trichophyton ajelloi the mortalities were significantly increased. The LC50-3.71, LC90-8.12, and LC99-11.48 were significantly recorded after exposure of 10 hrs. Similarly, the culture filtrates of T. ajelloi, Culicinomyces clavisporus, and L. giganteum have been combined in ratios 1 : 1 : 1. Similarly the LC50-1.94, LC90-4, and LC99-6.16 ML Were recorded after exposure of 10 hrs. The results of present study show promise for the use of selected fungal metabolites for control of Cx. quinquefasciatus in the Laboratory.

Incidence of dermatophytes and other keratinophilic fungi in the schools and college playground soils of Jaipur, India

A total of 50 soil samples collected from school and college playgrounds soil of Jaipur, India were examined for the prevalence of keratinophilic fungi and related dermatophytes. Two keratinous fragments, human hair and nails were used for the growth of fungi by hair-baiting technique. A total number of 25 species belonging to 16 genera were recovered, 8 of which were common to both the school and college playgrounds soil. Dermatophytes and closely related species were represented by 25 species; of which the following were the most commonly found species in soil:Chrysosporium tropicum (26%), Chrysosporium indicum (22%), Trichophyton mentagrophytes (16%), Microsporum gypseum (14%), etc. Some of the isolates of these related and dermatophytes like Trichophyton verrucosum, Trichophytontonsurans, Cladosporium sp., Paecilomyces sp., Aspergillus nidulans, Aspergillusversicolar, Alternaria sp., Fusarium moniliforme, etc, were first isolated from playgrounds soil of Jaipur. The selection of certain keratinolytic isolates could become useful in managing polluted soil of playgrounds by students and people. To our knowledge, This appears to be the first report concerning the isolation of T. tonsurans, A. versicolar, Cladosporium sp., Trichophyton verrucosum, Alternaria sp.,Paecilomyces sp., F. moniliforme and A. nidulans as keratinolytic fungi from soil samples of Jaipur (India). Key words: Playgrounds soil, keratinophilic fungi, dermatophytes, Jaipur.

Antifungal activity of Peganum harmala seeds extract in vitro

Peganum harmala (Zygophyllaceae) is an intriguing herb with a long history of medicinal use. Antifungal activity of P. harmala seed extract against certain fungal species was investigated in vitro. Antifungal activity of the extract of P. harmala seeds was investigated against several fungal species using in vitro agar dilution technique. The fungal species included: Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum, Trichophyton tonsurans and Fonsecaea pedrosoi. P. harmala extract, diluted 2.5:1000, produced complete inhibition against microsporum and trichophyton species. The extract had a considerable antifungal activity. Further purification and extraction of the active principles (alkaloids) of P. harmala seeds might show a true antifungal activity comparable to standard antifungal drugs.

Erratum

International Journal of DermatologyVolume 49, Issue 10 p. 1223-1223 Free Access Erratum This article corrects the following: Tinea capitis in adults in Tunisia Amel Mebazaa MD, Kamel E.L. Oumari MD, Moncef Ben Said MD, Najet Ghariani MD, Mohamed Denguezli MD, Akila Fathallah Mili MD, Nesrine Kenani MD, Colandane Belajouza MD, Rafiaa Nouira MD, Volume 49Issue 5International Journal of Dermatology pages: 513-516 First Published online: April 26, 2010 First published: 28 September 2010 https://doi.org/10.1111/j.1365-4632.2010.04794.xAboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In (1), the following editorial errors occurred. • The authors should be listed in the following order: Amel Mebazaa1, md, Kamel EL Oumari1, md, Najet Ghariani1, md, Akila Fathallah Mili2, md, Colandane Belajouza1, md, Rafiaa Nouira1, md, Mohamed Denguezli1, md, and Moncef Ben Said2, md 1Department of Dermatology, and 2Department of Mycology, Farhat Hached Hospital, Sousse, Tunisia • Changes were made to the abstract and should read as follows: Abstract Objective To determine the pattern of infectious agents causing tinea capitis (TC) in adult patients in the center of Tunisia. Methods From January 1990 to December 2005, we have retrospectively collected all cases of adult TC, confirmed by the mycological examination. Results Sixty patients (18 male, 42 female) with a mean age of 34.5 years were diagnosed as having adult TC among a total number of 1137 cases of TC (5.27%). Clinical features were polymorphic and diagnosis was made on mycological examination. Culture identified Trichophyton violaceum in 36 cases (60%), Microsporum canis in 12 cases (20%), Trichophyton schoenleini in 7 cases (12%), Trichophyton verrucosum in two cases (3.5%), and Trichophyton mentagrophytes and Trichophyton rubrum in one case (each 1.77%). Culture was negative in one case (1.77%). Treatment consisted of administration of Griseofulvin (20–25 mg/kg/d) during 6–8 weeks associated with antifungal topics. A complete recovery was noted in 55 cases (92%) and a relapse occurred in two patients (3.5%). A scary alopecia was observed in one patient (1.77%) and two patients were lost to follow-up. Conclusion Trichophyton violaceum remains the most common etiological agent of adult TC in Tunisia. Microsporum canis is rising rapidly most notably due to the high frequency of asymptomatic carriage by domestic animals. We apologize for the errors. References 1 Mebazaa A, Oumari KE, Ghariani N, et al. Tinea capitis in adults in Tunisia. Int J Dermatol 2010; 49: 513– 516. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume49, Issue10October 2010Pages 1223-1223 ReferencesRelatedInformation