Simulations of the structural and microenvironments of cells and tissues have been driving development in biodegradable scaffolds. However, most scaffolds show poor attachment and proliferation. In this study, we developed a simple approach to promote the mechanical properties and biocompatibility associated with a biopolymer, polytrimethylene carbonate (PTMC), using oleic acid-modified tricalcium phosphate particles (OA-TCP), which osteoinductive the bone cells. The manipulating microsphere diameter can easily tune the mechanical properties and porosity of microsphere scaffold. In particular, we demonstrated that incorporating OA-TCP particles on PTMC/OA-TCP scaffolds increased the biocompatibility and mechanical properties (42 % porosity, compressive modulus of 217 MPa) compared with the PTMC/TCP scaffold control (42 % porosity, compressive modulus of 37 MPa). We also observed that increased weight loss and water absorption of PTMC/OA-TCP scaffold allowed better osteoblast proliferation. These data suggest that the modified strategy presented in this study is a promising alternative for potential multi-functional bone defects.