Construction of a rapid surface and processing is an effective way to improve the manufacturing efficiency, this paper linked the 3D scanning, fast surface construction and NC closely, described the whole process of surface data acquisition and processing, surface construction and the process of NC machining. The outer surface of the mouse was scanned from multiple angles by using 3D CaMega scanner, a plurality of point cloud was obtained, the point cloud processing, triangle face processing construct refinement of the model surface and grid lines were all processed in Geomagic Studio software, through adjustments, NURBS surface was generated. Also the mould surface of the mouse was constructed in the UG NX software. This paper wrote the machining process, Programmed NC Milling in UG NX software, generated the trajectory of rough and finishes machining as well as the programs of machining tool. Also CNC milling was processed CNC machining center.