Injection Of Triamcinolone Acetonide For Treatment Research Articles

A Study on Intraocular Pressure Elevation after Intravitreal 4mg Triamcinolone Acetonide Injection in Treatment of Macular Edema among North India Population

A Study on Intraocular Pressure Elevation after Intravitreal 4mg Triamcinolone Acetonide Injection in Treatment of Macular Edema among North India Population

Local triamcinolone acetonide injection for treatment of nasal tip cysts

Local triamcinolone acetonide injection for treatment of nasal tip cysts

Comparison of high- and low-dose intra-articular triamcinolone acetonide injection for treatment of primary shoulder stiffness: a prospective randomized trial

Intra-articular corticosteroid injection has a proven effect for shoulder stiffness, yet the optimal dose is still controversial. The purpose of the study was to compare the outcomes of intra-articular triamcinolone acetonide injection at 2 different doses in patients with shoulder stiffness. Intra-articular injection of 40 mg (group I, n = 76) or 20 mg (group II, n = 71) of triamcinolone acetonide was performed in patients with shoulder stiffness. The outcome measures including range of motion (ROM), American Shoulder and Elbow Surgeons score, visual analog scale for pain score, and Simple Shoulder Test score were evaluated at 3 weeks, 6 weeks, 12 weeks, 6 months, 12 months, and the last follow-up. Among the patients with controlled diabetes, the levels of blood glucose, fructosamine, and HbA1c were measured to evaluate systemic serologic changes induced by injection. There were significant improvements in ROM and functional scores in both groups at the last follow-up. However, there was no significant difference between the groups in any of the parameters at each time point. None of the diabetic patients in either group had a significant increase in blood glucose, fructosamine, and HbA1c levels compared with levels before injection. However, those in group I showed significantly higher blood glucose levels at 6 weeks after injection compared with those in group II (P = .01). Intra-articular injection of triamcinolone is an effective method for improving ROM and clinical function in patients with shoulder stiffness. However, there was no significant difference in regard to different doses. In diabetic patients, a lower dose is recommended as short-term glucose levels may increase with a high dose of corticosteroid.

Intravitreal versus posterior subtenon injection of triamcinolone acetonide in diabetic macular edema

Objectives: In this study, intravitreal injection of triamcinolone acetonide (TA) was compared with posterior subtenon injection of TA for treatment of diabetic macular edema (DME). Materials and Methods: In this prospective, open, randomized, parallel group, comparative study, 60 patients of diabetic macular oedema visiting the Department of Ophthalmology, Govt. Medical College, Patiala were included. The patients fulfilling the inclusion criteria and having none of the exclusion criteria were enrolled in the study after obtaining written informed consent. Patients were then randomized into two groups (group I, II) and received intravitreal and posterior subtenon injection of triamcinolone acetonide, respectively. The comparison was based on change in best corrected visual acuity and macular thickness using optical coherence tomography (OCT). The results were subjected to statistical analysis and observations thus made in both groups were compared. Results: With intravitreal TA, the mean pre-treatment CMT, mean post-treatment CMT and mean reduction in CMT were 395.53 ± 15.31 ?m, 221.2 ± 10.71 ?m and 174.33 ?m (44.08 %) while the mean pre-treatment VA, mean post-treatment VA and mean improvement in VA were 0.79 ± 0.16, 0.51 ± 0.15 and 0.28 (36.11 %) logMAR units. With posterior subtenon TA, the mean pre-treatment CMT, mean post-treatment CMT and mean reduction in CMT were 394.43 ± 15.03 ?m, 247.3 ± 11.82 ?m and 147.13 ?m (37.3 %) while the mean pre-treatment VA, mean post-treatment VA and mean improvement in VA were 0.81 ± 0.15, 0.58 ± 0.14 and 0.23 (28.24 %) logMAR units. The mean pre-treatment IOP, mean post-treatment IOP and mean rise in IOP with intravitreal TA were 16.67 ± 1.92 mm Hg, 18.87 ± 1.81 mm Hg and 2.2 mm Hg (13.19 %), whereas with posterior subtenon TA were 16.87 ± 1.85 mm Hg, 17.4 ± 1.59 mm Hg and 0.53 (3.14 %). Conclusions: When used in diabetic macular edema, intravitreal triamcinolone acetonide is more effective than posterior subtenon

Application study on vitrectomy combined with triamcinolone acetonide injection in treatment for posterior segment eye trauma

Objective To observe the curative effects of vitrectomy combined with triamcinolone acetonide (TA) injection in treatment for posterior segment eye trauma.Methods Retrospective analysis was carried out to 60 patients in our hospital from June 2010 to June 2012 in ophthalmology hospital line of vitreoretinal operation of ocular trauma,they were randomly divided into treatment group given intravitreal operation combined with TA injection and vitreoretinal operation treatment observation group,comparative observation of the curative effect of two groups were analyzed.Results Among the two groups, the posterior segment of the eye injury of vitreous hemorrhage,retinal hemorrhage,foreign body removal,net off,showed no significant difference (P＞ 0.05 ); the postoperative visual acuity in the treatment group improved in 25 eyes by 78.13％,5 eyes remained unchanged accounting 15.63％,decreased in 1 eye (3.13％),the postoperative visual acuity of the observation group improved in 20 eyes accounting 58.82％,remained unchanged in 10 eyes by 29.41％,decreased in 4 eyes (11.76％),there was significant difference between two groups (P＜ 0.05 ); postoperative complications of anterior chamber reaction 2+,net off of two groups had significant difference (P＜ 0.05 ),high intraocular pressure,cataract patients in the two groups had no significant difference(P＞ 0.05).Conclusion Vitreous operation combined with TA injection in the treatment of posterior segment ocular trauma has significant effect,which is worth of popularizing. Key words: Vitreous operation; Triamcinolone acetonide (TA); Posterior segment ocular trauma

Arteriovenous crossing sheathotomy versus intravitreal triamcinolone acetonide injection for treatment of macular edema associated with branch retinal vein occlusion

To compare the functional and anatomical outcomes of arteriovenous (AV) sheathotomy and intravitreal triamcinolone acetonide (IVTA) injection in the treatment of macular edema associated with branch retinal vein occlusion (BRVO). Forty eyes of 40 patients with macular edema secondary to BRVO were randomized into two treatment groups. A total of 20 patients received AV sheathotomy (sheathotomy group), and the second group of 20 patients was treated with IVTA (IVTA group). Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity (VA) score, total macular volume measured, and foveal thickness by 3rd generation optical coherence tomography (OCT3) were evaluated as main outcome measurements. The average changes in ETDRS scores, total macular volumes, and foveal thicknesses compared to baseline values, were significant 3 months and 6 months after treatment in both groups (P < 0.05, paired t-test), but only the IVTA group showed significant improvements 1 month after treatment. The between-group differences in average ETDRS score, total macular volume, and foveal thickness changes were significantly better at 1 month after treatment in the ITVA group (P = 0.026, P < 0.001, P = 0.001, respectively, Student's t-test), at which time IVTA patients had better vision and anatomical outcomes than did those in the sheathotomy group. After either AV sheathotomy or IVTA treatment, patients with macular edema secondary to BRVO showed similar functional and anatomical outcomes 6 months later. When the cost and the risks of vitreoretinal surgery are considered, IVTA treatment may be a better treatment option, as the drug yields better short-term outcomes.

Noninfectious Hypopion after Intravitreal Triamcinolone Acetonide Injection for Central Retinal Vein Occlusion: A Case Report

Although it is rare, infectious endophthalmitis is a severe ocular complication resulting from intravitreal injection of triamcinolone acetonide (TA). Therefore, care must be taken by ophthalmologists to differentiate between what is infectious and noninfectious endophthalmitis. We report on a 62-year-old woman who received an intravitreal injection of TA for treatment of central retinal vein occlusion. One day after the injection, a hypopion (a white-yellowish deposit) was noted in the inferior anterior chamber. The patient complained that her vision had deteriorated, but there was no pain, eyelid edema, increased conjunctival injection or corneal edema. The hypopion gradually diminished and by the fifth postoperative day, resolved completely without the administration of intravitreal or systemic antibiotic therapy.