Trends of climate variables were studied for the latest 41 years (1973-2013) and their effects on the quantity and quality of the grape production for Feteasca regala variety, clone 21 Bl, grafted on Kober 5 BB, in the plantation of the University of Agricultural Sciences and Veterinary Medicine, Bucharest, for the latest 16 years (1998-2013). Following the trend of main climate variables, there was a highly significant heating, especially in the summer. Some significant correlations were established between climate variables and production, sugar accumulation in the berries and titratable acidity in the must. Significant results were obtained with bioclimatic indices Huglin and Winkler. It also increased the number of hot days (with maximum temperature above 30°C) and very hot days (with maximum temperature above 35°C), which adversely affects the metabolism of vines, producing unbalanced wines. Since it is expected that this trend of temperature rising continues in the future and that the ripening period of the grapes takes place in warmer conditions, there are necessary adjustments of viticulture development strategies under the new conditions.