Trends In Pharmacological Sciences Research Articles

Properties of large-conductance K+ channels in human myometrium during pregnancy and labour.

The conversion of the electrically silent pregnant uterus to highly excitable at term represents a dramatic physiological event which is poorly understood. Here we provide the first description, from single-channel recordings, of a large conductance (212 pS) calcium-activated potassium channel (BKCa) in human pregnant myometrium which, in labour tissue, is either absent or has been considerably altered in its physiological and pharmacological properties. In the latter, the K+ channels have an identical conductance (221 pS) and K+ selectivity to BKCa channels but exhibit no Ca2+ or voltage sensitivity. We have termed these BK channels. Furthermore, the activity of the BKCa channel from pregnant tissue is inhibited by internal application of Ba2+ but not tetraethylammonium (TEA), whereas the activity of the BK channel is sensitive to internal TEA but not Ba2+. The role of the BKCa channel may be to suppress myometrial activity during gestation whereas BK channel activity may be important in providing a Ca(2+)-independent K+ conductance which would allow cytoplasmic Ca2+ levels to rise without activating a counteracting Ca(2+)-dependent outward current, normally provided by the BKCa channels which, by its very nature, would tend to oppose depolarization. The findings suggest that K+ channels may have an important role in determining the functional activity of the myometrium.

Trends in Pharmacological Sciences

Trends in Pharmacological Sciences

Trends in Pharmacological sciences including Toxicological sciences

Trends in Pharmacological sciences including Toxicological sciences

Trends in Pharmacological Sciences including toxicological sciences: Angiotensin receptors are implicated in the mechanism of mas action

Trends in Pharmacological Sciences including toxicological sciences: Angiotensin receptors are implicated in the mechanism of mas action

Nature of Endothelium-Derived Relaxing Factor: Are There Two Relaxing Mediators?

Nature of Endothelium-Derived Relaxing Factor: Are There Two Relaxing Mediators?

Medicinal chemistry; a biochemical approach

'Should be welcomed by medicinal chemists, pharmacologists, biologists, and others for whom an interest in understanding drug action at the molecular level is of the first order.' Trends in Pharmacological Sciences

Trends in pharmacological sciences in 1784

Trends in pharmacological sciences in 1784

Problems of post-marketing surveillance.

British Journal of Clinical PharmacologyVolume 16, Issue 6 p. 581-585 Free Access Problems of post-marketing surveillance. WM Castle, WM CastleSearch for more papers by this authorJT Nicholls, JT NichollsSearch for more papers by this authorCC Downie, CC DownieSearch for more papers by this author WM Castle, WM CastleSearch for more papers by this authorJT Nicholls, JT NichollsSearch for more papers by this authorCC Downie, CC DownieSearch for more papers by this author First published: December 1983 https://doi.org/10.1111/j.1365-2125.1983.tb02225.xCitations: 7AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References CRAWFORD, M., BERNEKER, G-C. & PINTO DE, S. (1980). The pharmaceutical industry. The philosophy and practice of drug-surveillance within Ciba-Geigy. In Monitoring for Drug Safety, ed. W.H.W. Inman, pp. 165– 188. Lancaster, England: MTP Press Limited. IMS AMERICA LIMITED (1978). Final report—Task A—An experiment in early post-marketing surveillance of drugs. National Technical Information Service, p. 5. INMAN, W.H.W. (1980). Editor's introduction and commentary. In Monitoring for Drug Safety., pp. 3– 7. Lancaster, England: MTP Press Limited. INMAN, W.H.W. (1981). Postmarketing surveillance of adverse drug reactions in general practice II. Prescription-event monitoring at the University of Southampton. Br. med. J., 282, 1216– 1217. LEWIS, J. A. (1981). Post-marketing surveillance: how many patients Trends in Pharmacological Sciences, 2, 93– 94. SKEGG, D.C.G. (1978). Use of record linkage for drug surveillance 1978. In Computer aid to drug therapy and to drug monitoring, eds. P. Ducrot et al., pp. 77– 83. Amsterdam: Elsevier North-Holland Publishing Co. SKEGG, D.C.G. & DOLL, R. (1977). The case for recording events in clinical trials. Br. med. J., 2, 1523– 1524. STROM, B.L. & MELMON, K.L. (1979). Can postmarketing surveillance help to effect optimal drug therapy J. Am. med. Ass., 242, 2420– 2423. Citing Literature Volume16, Issue6December 1983Pages 581-585 ReferencesRelatedInformation

Clinical judgment and statistics.

HomeCirculationVol. 63, No. 1Clinical judgment and statistics. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBClinical judgment and statistics. K M Detre, P Peduzzi and Y K Chan K M DetreK M Detre Search for more papers by this author , P PeduzziP Peduzzi Search for more papers by this author and Y K ChanY K Chan Search for more papers by this author Originally published1 Jan 1981https://doi.org/10.1161/01.CIR.63.1.239Circulation. 1981;63:239–241"Clinical judgment and statistics.." Circulation, 63(1), pp. 239–241 Previous Back to top Next FiguresReferencesRelatedDetailsCited By Welsh B, Podolsky S and Zane S (2021) Richard Cabot, pair-matched random allocation, and the attempt to compare like with like in the social sciences and medicine. Part 1: the context of the social sciences, Journal of the Royal Society of Medicine, 10.1177/01410768211003771, 114:4, (212-217), Online publication date: 1-Apr-2021. Concato J and Hartigan J (2016) P values: from suggestion to superstition, Journal of Investigative Medicine, 10.1136/jim-2016-000206, 64:7, (1166-1171), Online publication date: 1-Oct-2016. Chan Y, Archibald D and Peduzzi P (1983) Management of a multicenter clinical trial, Trends in Pharmacological Sciences, 10.1016/0165-6147(83)90269-9, 4, (21-24), Online publication date: 1-Jan-1983. Spodick D (1982) The randomized controlled clinical trial, The American Journal of Medicine, 10.1016/0002-9343(82)90746-X, 73:3, (420-425), Online publication date: 1-Sep-1982. Takaro T, Peduzzi P, Detre K, Hultgren H, Murphy M, van der Bel-Kahn J, Thomsen J and Meadows W (1982) Survival in subgroups of patients with left main coronary artery disease. Veterans Administration Cooperative Study of Surgery for Coronary Arterial Occlusive Disease., Circulation, 10.1161/01.CIR.66.1.14, 66:1, (14-22), Online publication date: 1-Jul-1982. January 1, 1981Vol 63, Issue 1 Advertisement Article InformationMetrics Copyright © 1981 by American Heart Associationhttps://doi.org/10.1161/01.CIR.63.1.239 Originally publishedJanuary 1, 1981 PDF download Advertisement

China invents male birth control pill.

The American Journal of Chinese MedicineVol. 08, No. 01n02, pp. 195-197 (1980) NEWS & VIEWSNo AccessChina Invents Male Birth Control PillWei WenWei WenChina Feature P.O. Box 522, Beijing, China Search for more papers by this author https://doi.org/10.1142/S0192415X80000165Cited by:8 Previous AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail Remember to check out the Most Cited Articles! Check out our Chinese Medicine Titles today. Includes titles by Nobel Winner, Tu You You and more! FiguresReferencesRelatedDetailsCited By 8Anti-inflammatory Effects of Gossypol on Human Lymphocytic Jurkat Cells via Regulation of MAPK Signaling and Cell CycleChien-Wei Chen, Sindy Hu, Ke-Hung Tsui, Guey-Shyang Hwang and Szu-Tah Chen et al.22 August 2018 | Inflammation, Vol. 41, No. 6“Put It in Your Shoe It Will Make You Limp”: British Men’s Online Responses to a Male PillAmanda D. Wilson3 April 2018 | The Journal of Men’s Studies, Vol. 26, No. 3CottonLori Hinze and Russell Kohel24 August 2011The effect of gossypol on fast axonal transport and microtubule assemblyMartin Kanje, Per Ekström, Johanna Deinum and Margareta Wallin1 Apr 1986 | Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 856, No. 3Toxicological effects of gossypolA. A. Nomeir and M. B. Abou-donia1 Jan 1985Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro.M Nordenskjold and B Lambert1 Apr 1984 | Journal of Medical Genetics, Vol. 21, No. 2Training toxicologists: the move from learning to understandingB. Max1 Jan 1984 | Trends in Pharmacological Sciences, Vol. 5The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics.Y C Tsui, M R Creasy and M A Hulten1 Apr 1983 | Journal of Medical Genetics, Vol. 20, No. 2 Recommended Vol. 08, No. 01n02 Metrics History Received 27 March 1979 PDF download

Myogenic tone in isolated perfused resistance vessels from rats.

Myogenic tone in isolated perfused resistance vessels from rats.