Trends In Clinical Research Research Articles

Trends in research related to vaccine and cancer prevention from 1992 to 2022: A 30-years bibliometric analysis

ABSTRACT Vaccines may play an important role in cancer prevention. This bibliometric study in the field of vaccine and cancer prevention is designed to evaluate key research advances, identify existing deficiencies, and provide reference for future investigations. A total of 2916 original articles published in English from 1992 to 2022 were extracted from the Web of Science core collection. America (1,277) and the National Cancer Institute (82) were the most productive country and institution in this field, respectively. Vaccine was not only the most co-cited journal but also the most influential. Garland SM was the most prolific author, and Bosch FX was the most influential co-cited author. The keywords “cervical cancer” had the highest frequency. “Nanovaccines,” “vaccine acceptance” and “coverage” were the new research hotspots in this field. Currently, although an increasing number of publications involve vaccine and cancer prevention studies, most of them are related to cervical cancer, and few other cancers, suggesting the need to investigate other cancer prevention vaccines. The promising research hotspots, such as nanovaccines, vaccine acceptance, and vaccine coverage should be the focus of investigation. The study provides the current status and trends in clinical research on vaccine and cancer prevention, enabling researchers to identify hotspots and explore new study directions. In the future, vaccines are expected to play a key role in multiple cancer prevention.

Latest Trends in Non-Clinical and Clinical Research on Mesenchymal Stem Cell Therapy for Tendon Regeneration

Latest Trends in Non-Clinical and Clinical Research on Mesenchymal Stem Cell Therapy for Tendon Regeneration

Analysis of Clinical Research Trends for Thread Embedding Acupuncture of Cervical Radiculopathy

In this study, the evidence of thread embedding acupuncture (TEA) in treating cervical radiculopathy in randomized controlled trials was investigated. We searched 16 databases up to August 22, 2022. Of the 2,644 studies retrieved, 22 randomized controlled trials (2,483 participants) were selected. Quality assessments were performed using Cochrane’s risk-of-bias tool and RevMan 5.4 software. Outcome measures in the included studies typically showed TEA had a significant therapeutic effect compared with simple acupuncture and other remedies, and TEA was better than sham TEA. Catgut and polydioxanone had no difference in effectiveness, however, catgut was considered to be less safe. TEA was shown to be more therapeutic when inserted deeper into the skin. Ultrasound guided TEA was more effective and safer than conventional TEA, and using a flat blade needle was better than conventional needles for TEA. No serious adverse events were reported from using TEA, and only a few mild side effects were observed. However, the limited number and heterogeneity of the included studies, together with the unclear methodological quality, indicate that higher-quality studies need to be conducted to determine the effectiveness and safety of TEA for cervical radiculopathy.

Research Trends of Acupuncture Therapy on Polycystic Ovary Syndrome: A Bibliometric Analysis.

Background Acupuncture has been confirmed as a suitable therapy for treating polycystic ovary syndrome (PCOS). However, there is no bibliometric analysis of the global use of acupuncture for PCOS. Our study used CiteSpace (5.8.R3) to provide a profile of the current state and trends in this field. Methods Articles regarding acupuncture therapy for treating PCOS were retrieved from the Web of Science Core Collection. CiteSpace was used to analyze the number of publications, countries, institutions, journals, authors, cited references, and keywords by using standard bibliometric indicators. Results A total of 159 publications were considered for the final analysis. The number of publications has slowly increased with fluctuations between years, and the most active countries, institutions, journals, and authors concerning acupuncture therapy for PCOS were identified. Evidence-Based Complementary and Alternative Medicine was the most productive journal, and Fertil Steril was the most cited. China and Heilongjiang University of Chinese Medicine were considered the most prolific countries and institutions in this field, respectively. Elisabet Stener Victorin became the most influential author and most cited author. Jedel E. published the most cited article. “Polycystic ovary syndrome” was the most frequent keyword, and the top three frontiers mentioned were research method, intervention, and outcome. Conclusion The current status and trends in clinical research of acupuncture therapy on PCOS patients are revealed according to the results of this bibliometric study, which may facilitate researchers to identify hot topics and new directions for future study in this field.

Trends in Domestic and International Clinical Research of Craniosacral Therapy: Scoping Review

Min-Jae Kwak, Yun-Hee Han, K.M.D., Ji-Hye Geum, K.M.D., Shin-Hyeok Park, K.M.D., Hyeon-Jun Woo, K.M.D., Won-Bae Ha, K.M.D., Jung-Han Lee, K.M.D.. J Korean Med Rehabi 2022;32:13-27. https://doi.org/10.18325/jkmr.2022.32.3.13

Knowledge Structure and Emerging Trends of Telerehabilitation in Recent 20 Years: A Bibliometric Analysis via CiteSpace.

PurposeTelerehabilitation, as an effective means of treatment, is not inferior to traditional rehabilitation, and solves the problem of many patients who do not have access to hospital-based training due to costs and distance. So far, the knowledge structure of the global use of telerehabilitation has not been formed. This study aimed to demonstrate the state of emerging trends and frontiers concerning the studies of telerehabilitation through bibliometric software.MethodsLiterature about telerehabilitation from 2000 to 2021 was retrieved from the Web of Science Core Collection. We used CiteSpace 5.8.R3 to analyze the publication years, journals/cited journals, countries, institutions, authors/cited authors, references, and keywords. Based on the analysis results, we plotted the co-citation map to more intuitively observe the research hotspots and knowledge structure.ResultsA total of 1,986 records were obtained. The number of annual publications gradually increased over the investigated period. The largest increase occurred between 2019 and 2020. J TELEMED TELECARE was the most prolific and the most cited journal. The United States was the most influential country, with the highest number of publications and centrality. The University of Queensland was the most productive institution. The author Tousignant M ranked the highest in the number of publications and Russell TG ranked the first in the cited authors. Respectively, the articles published by Cottrell MA and Russell TG ranked the first in the frequency and centrality of cited references. The four hot topics in telerehabilitation were “care”,“stroke”, “telemedicine” and “exercise”. The keyword “stroke” showed the strongest citation burst. The two frontier keywords were “physical therapy” and “participation”. The keywords were clustered to form 21 labels.ConclusionThis study uses visualization software CiteSpace to provide the current status and trends in clinical research of telerehabilitation over the past 20 years, which may help researchers identify new perspectives concerning potential collaborators and cooperative institutions, hot topics, and research frontiers in the research field. Bibliometric analysis of telerehabilitation supplements and improves the knowledge field of telemedicine from the concept of rehabilitation medicine and provides new insights into therapists during the COVID-19 pandemic.

Research Hotspots of the Rehabilitation Medicine Use of sEMG in Recent 12 Years: A Bibliometric Analysis

ObjectiveSurface electromyography (sEMG) has been widely applied to rehabilitation medicine. However, the bibliometric analysis of the rehabilitation medicine use of sEMG is vastly unknown. Therefore, this research aimed to investigate the current trends of the rehabilitation medicine use of sEMG in the recent 12 years by using CiteSpace (5.8).MethodsLiterature relating to rehabilitation medicine use of sEMG from 2010 to 2021 was retrieved from the Web of Science. CiteSpace analyzed country, institution, cited journals, authors, cited references and keywords. An analysis of counts and centrality was used to reveal publication outputs, countries, institutions, core journals, active authors, foundation references, hot topics and frontiers.ResultsA total of 1949 publications were retrieved from 2010 to 2021. The total number of publications continually increased over the past 12 years, and the most active countries, institutions, journals and authors in rehabilitation medicine use of sEMG were identified. The most productive country and institution in this field were America (484) and the University of Sao Paulo (36). Andersen LL (28) was the most prolific author, and Dario Farina ranked first among the cited authors. Besides, there were three main frontiers in keywords for sEMG research, including “activation”, “exercise”, and “strength”.ConclusionThe findings from this bibliometric study provide the current status and trends in clinical research of rehabilitation medicine use of sEMG over the past ten years, which may help researchers identify hot topics and explore new directions for future research in this field.

Research Trends and Most Influential Clinical Studies on Anti-PD1/PDL1 Immunotherapy for Cancers: A Bibliometric Analysis.

In this study, a bibliometric analysis was carried out to identify the most influential clinical studies and research trends on anti-programmed cell death 1/programmed cell death 1 ligand 1 (anti-PD1/PDL1) immunotherapy. On January 1, 2022, we used Web of Science to identify the 100 most frequently cited papers on clinical studies investigating anti-PD1/PDL1 immunotherapy, and extracted the following data: publication year, source title, country/region, institution, and the total number of citations. The research design and area were classified independently by the authors. Subsequently, we carried out a bibliometric analysis to determine the trends and identify the major journals on anti-PD1/PDL1 immunotherapy. The authors analyzed the current research hotspots based on papers published in major journals from 2020 to 2021. These 100 papers were cited a total of 138,840 times, and the median number of citations was 899.5 (range: 341–7,983). “Safety, activity, and immune correlates of anti-PD-1 antibody in cancer” by Topalian et al. had the highest number of citations (7,983 times). New England Journal of Medicine had the highest number of top-cited papers (40 papers), average citations per paper (1,558.3 citations), and rate of top-cited papers (65.6%). Authors from the USA contributed most of the papers (76 papers). Lung cancer (30 papers, 46,422 citations) and melanoma (20 papers, 30,881 citations) were the most cited research areas. In summary, anti-PD1/PDL1 has become standard treatment for various cancer, while adjuvant anti-PD1/PDL1 therapy is currently a research hotspot. New England Journal of Medicine was identified as the most influential journal in this area. Non-small cell lung cancer and melanoma are the most well-studied cancers, while nivolumab and pembrolizumab are the most commonly investigated anti-PD1/PDL1 antibodies. Further studies are warranted to identify effective predictive biomarkers or models, clarify the molecular mechanism of combined therapy, and establish optimal therapeutic strategies. This study may assist researchers in obtaining a comprehensive impression of the landscape and current trends in anti-PD1/PDL1 immunotherapy and gain inspiration to conduct further studies.

Forewords.

Developmental Medicine & Child NeurologyVolume 64, Issue S2 p. 4-4 FOREWORDSFree Access Forewords First published: 25 February 2022 https://doi.org/10.1111/dmcn.15157AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat It is a great pleasure to publish and archive the abstracts of the 2022 combined 11th Australasian Academy of Cerebral Palsy and Developmental Medicine (AusACPDM) and 3rd International Alliance of Academies of Childhood Disabilities (IAACD) Conference. The meeting is organized in Melbourne but it effectively involves participants online wherever they are. The conference is defiantly entitled ‘Better Together’. In a very creative way making the most of virtual technology, this is precisely what it is designed to make us all experience. The abstracts are presented by many teams worldwide, and many result from multicentric interdisciplinary collaboration. They reflect important trends in clinical research in childhood-onset disability as well as a clear ethical drive. A number of them describe new findings relating to multiple aspects of participation1 in life situations, and about quality of life. Some present novel findings with respect to recognition and control of emotion in various neurodevelopmental disorders. Mental health is also a prominent topic. Several research projects champion equity in inspiring ways with potentially wide application. Important epidemiological findings shed light on specificities within communities, including studies conducted in collaboration with indigenous peoples. Several teams present new takes on orthopaedic issues. Other very promising results rely on technological applications, from wearable sensors and virtual reality to telerehabilitation. These are but a few of topics of a most interesting meeting that combines the excellence and human touch so typical of the AusACPDM, and marks the beginning of an exciting new era for the IAACD.2 The published abstracts will hopefully serve as reference for reflection and discussion, and as testimony to the current evolution of the field. Though they were selected carefully by the scientific committee for the conference, readers must keep in mind that the work they summarize for presentation at the meeting did not go through the review and editorial process that is required for publication of a full research article. Rather, the dynamic discussions to which they will give rise will be part of a constructive exchange of ideas between peers that will likely contribute to enhance the quality and relevance of that work. I hope those discussions can result in submission of full papers in Developmental Medicine & Child Neurology and elsewhere to improve the lives of disabled people. I will be present online (as well as on Twitter: @ProfBernardDan) throughout the meeting, and so will a number of members of the editorial team. We will be happy to discuss any issues relating to the field, the journal, teaching courses, and our book programme – both during the ‘Ask the editor’ session (one of the ‘Ask me anything’ interactive events) that is scheduled on Friday 4 March at 7:00–8:00am Melbourne time, and at any other time we make common. We look forward to working with you, because we are indeed better together. With best wishes, Bernard Dan, Editor in Chief of DMCN REFERENCES 1 C Imms, D Green, editors. Participation: optimising outcomes in childhood-onset neurodisability. London: Mac Keith Press; 2020. Google Scholar 2Forssberg H, Damiano D, Armstrong R. ‘Better Together’: achieving a global professional network for childhood disability. Dev Med Child Neurol. 2022; 64: 277– 278. Wiley Online LibraryPubMedGoogle Scholar Volume64, IssueS2Special Issue: Australasian Academy of Cerebral Palsy and Developmental Medicine and the International Alliance of Academies of Childhood Disability, Abstracts for the Conference, 1–5 March 2022, Melbourne, AustraliaMarch 2022Pages 4-4 ReferencesRelatedInformation

Mapping of global research output in congenital cataracts from 1903 to 2021.

Background and aim:Globally, congenital cataract remains one of the main causes of visual loss in children. This study was designed to plot the overall research output and evaluate some key bibliometric indicators in congenital cataracts research.Methods:Publications on congenital cataracts were retrieved from the Web of Science Core Collection database. The published literature was searched using the keywords “congenital cataract” OR “congenital cataracts” in the title filed with document types and language restrictions. The data were exported into HistCite to analyze; publication year, top authors, countries, institutions, journals, keywords, and most cited studies. VOSviewer software was used to construct network visualization mapping.Results:A total of 1427 publications (1903–2021) published in English language were included in this study. Over the past few decades, the total number of publications in congenital cataracts was found to be increased. The most productive year was 2016 (n = 72), while the most cited year was 1941 (1268 citations). The Investigative Ophthalmology & Visual Science (Impact Factor: 4.799) was the most attractive journal with 161 publications, and the Molecular Vision (Impact Factor : 2.367) was the most cited journal with 1915 citations and 161.723 citations per year. The most productive country was the United States of America (USA) (n = 325), while the most active institute was Sun Yat-sen University, China (n = 36). The most prolific author was Yao K (n = 27). The most studied Web of Science category was ophthalmology (n = 852). The most widely used keyword was congenital (n = 1427). The most cited paper in congenital cataracts was “Congenital cataract following German measles in the mother, cited 1268 times. The USA and author keyword congenital cataract had the highest total link strength.Conclusion:These findings provide useful insights, current status, and trends in clinical research in congenital cataracts. This study can be used to identify future research areas and standard bibliography references for better diagnosis and disease control.

Analysis of Clinical Research Trends for Acupotomy Treatment of Peripheral Facial Palsy

The purpose of this review was to investigate acupotomy treatment for peripheral facial palsy. By reviewing recent clinical trends, this may contribute to standardizing acupotomy treatment methods. There were 7 randomized controlled trials and 6 case series using acupotomy treatment for peripheral facial palsy published between January 01, 2014 and April 05, 2021, which were retrieved from 9 online databases. The number and characteristics of participants, main treatment sites, combination treatments, size of acupotomy needle, frequency and total period of treatment, evaluation indices, efficacy, and adverse events were analyzed. “Tender point or induration,” “infraorbical foramen,” and “buccal mucosa” were the most used treatment sites. The sizes of acupotomy needles varied from 20 mm to 80 mm in length, and 0.35 mm to 1.0 mm in diameter. One treatment cycle was performed every 3 to 5-7 days, and the number of treatments per treatment session ranged from 3 to 5-9 cycles. The results were evaluated using 1 to 4 evaluation indices and 9 different evaluation indices were used overall. The efficacy rate was the most used index, followed by the House-Brackmann grade, and electrocardiography. The “Risk of Bias 2,” categorized most studies as having “some concerns.” There were few adverse events reported.

Scoping Review of Prospective Clinical Studies, Projects, and Clinical Study Protocol for Korean Medicine Treatment on Dementia

Objectives: The aim of this study is to review and analyze the trends in prospective clinical research (PCR), project, clinical study protocol of Korean medicine (KM) for dementia. Methods: We searched PCRs of KM on dementia in six electronical databases, up to January 28, 2021. Moreover, the clinical research protocol and projects of KM for dementia were searched. Results: Total eight PCRs, nine projects, and three clinical study protocols were included. In the PCRs, there were one randomized controlled trial, five before and after study, and two comparative group before-after studies. Four of them used herbal medicine, two used acupuncture, one study used both herbal medicine and acupuncture, and the other one used moxibustion. <i>Jowiseungchung-tang</i> was the most frequently used herbal medicine. BL62, KI6 were used in electro-acupuncture, auricular-<i>Shenmen</i> in auricular acupuncture, and GV20 in moxibustion. The most frequent outcome was Korean-Dementia Rating Scale (K-DRS). One reported significant increase in K-DRS score, one reported 60% improvement, and the other studies mostly reported no significant difference. In the projects including 20 clinical studies of dementia, herbal medicine, integrative medicine and acupuncture were mainly used. In the protocols, herbal medicine, complex KM intervention, and integrative medicine were used. Conclusions: Currently, the number of PCRs of KM for dementia is very scarce. Therefore, the researcher's interest in this field and national research support should be made more, and the quality of clinical research in the future can be further improved by supplementing the limitations of previously published clinical research.

Korean Domestic Trends in Clinical Research on Rheumatoid Arthritis since 2008

Yun-Hee Han, K.M.D., Hyeon-Jun Woo, K.M.D., Soo-Yeon Park, R.N., Chang-Hoon Lee, M.D., Chong-Hyuk Chung, M.D., Myeung-Su Lee, M.D., Jung-Han Lee, K.M.D.. J Korean Med Rehabi 2021;31:18-29. https://doi.org/10.18325/jkmr.2021.31.3.19

Stromal Vascular Fraction: Biology and Application Outlook

Stromal vascular fraction (SVF) is a heterogeneous cell extract obtained with enzymatic dissociation of adipose tissue followed by centrifugation. This population includes many different cell types, i.a. adipose tissue stem cells (ATSCs), vascular endothelial and smooth muscle cells and their precursors, pericytes, fibroblasts, macrophages, T-lymphocytes, etc., excluding mature adipocytes. The main SVF component is ATSCs capable of self-renewal and multipotent differentiation. Since early research on SVF, an extensive effort has been aimed at understanding its clinical applications promoting a significant progress in the SVF use for treatment of various diseases and injuries. The past decade has witnessed an upward publication trend in basic and clinical research into the SVF therapeutic value. Manifold methods and devices for the SVF isolation from human liposuction lipoaspirate have been developed, continuously contributing to preclinical and clinical trials of its safety and efficacy. This review discusses the main properties and functions of the SVF cell population, its efficacy and safety for human therapy.

Current and future trends in periodontal tissue engineering and bone regeneration.

Periodontal tissue engineering involves a multi-disciplinary approach towards the regeneration of periodontal ligament, cementum and alveolar bone surrounding teeth, whereas bone regeneration specifically applies to ridge reconstruction in preparation for future implant placement, sinus floor augmentation and regeneration of peri-implant osseous defects. Successful periodontal regeneration is based on verifiable cementogenesis on the root surface, oblique insertion of periodontal ligament fibers and formation of new and vital supporting bone. Ultimately, regenerated periodontal and peri-implant support must be able to interface with surrounding host tissues in an integrated manner, withstand biomechanical forces resulting from mastication, and restore normal function and structure. Current regenerative approaches utilized in everyday clinical practice are mainly guided tissue/bone regeneration-based. Although these approaches have shown positive outcomes for small and medium-sized defects, predictability of clinical outcomes is heavily dependent on the defect morphology and clinical case selection. In many cases, it is still challenging to achieve predictable regenerative outcomes utilizing current approaches. Periodontal tissue engineering and bone regeneration (PTEBR) aims to improve the state of patient care by promoting reconstitution of damaged and lost tissues through the use of growth factors and signaling molecules, scaffolds, cells and gene therapy. The present narrative review discusses key advancements in PTEBR including current and future trends in preclinical and clinical research, as well as the potential for clinical translatability.

Recent Trends in Clinical Research on Herbal Medicine Based on Pinellia Ternata for Treatment of Gastroesophageal Reflux Disease

Recent Trends in Clinical Research on Herbal Medicine Based on Pinellia Ternata for Treatment of Gastroesophageal Reflux Disease

Cold atmospheric pressure (physical) plasma in dermatology: where are we today?

Cold atmospheric pressure plasma is physical plasma (essentially ionized gas) created at room temperature and atmospheric pressure, and it has complex effects on cells, tissues, and living organisms. These effects are studied extensively for medical and dermatological use. This article reviews current achievements and new trends in clinical dermatological cold plasma research, discusses the basics of plasma physics and plasma engineering, and describes the most important areas of laboratory plasma research to provide a well-rounded understanding of the nature, present applications, and future promise of this exciting, emerging technology.

Trends in Clinical Information Systems Research in 2019.

Summary Objective : To give an overview of recent research and to propose a selection of best papers published in 2019 in the field of Clinical Information Systems (CIS). Method : Each year, we apply a systematic process to retrieve articles for the CIS section of the IMIA Yearbook of Medical Informatics. For six years now, we use the same query to find relevant publications in the CIS field. Each year we retrieve more than 2,000 papers. As CIS section editors, we categorize the retrieved articles in a multi-pass review to distill a pre-selection of 15 candidate best papers. Then, Yearbook editors and external reviewers assess the selected candidate best papers. Based on the review results, the IMIA Yearbook Editorial Committee chooses the best papers during the selection meeting. We used text mining, and term co-occurrence mapping techniques to get an overview of the content of the retrieved articles. Results : We carried out the query in mid-January 2020 and retrieved a de-duplicated result set of 2,407 articles from 1,023 different journals. This year, we nominated 14 papers as candidate best papers, and three of them were finally selected as best papers in the CIS section. As in previous years, the content analysis of the articles revealed the broad spectrum of topics covered by CIS research. Conclusions : We could observe ongoing trends, as seen in the last years. Patient benefit research is in the focus of many research activities, and trans-institutional aggregation of data remains a relevant field of work. Powerful machine-learning-based approaches, that use readily available data now often outperform human-based procedures. However, the ethical perspective of this development often comes too short in the considerations. We thus assume that ethical aspects will and should deliver much food for thought for future CIS research.

Trends in Clinical Practice Research in ASHA Journals: 2008-2018.

Purpose Despite the American Speech-Language-Hearing Association's (ASHA's) endorsement of evidence-based practice (EBP) and speech-language pathologists' (SLPs') agreement on the importance of EBP, practicing clinicians report barriers to implementing EBP. The purpose of this study was to examine trends in clinical practice research published in ASHA journals over the past 11 years (2008-2018). Method A total of 2,483 articles from the American Journal of Speech-Language Pathology; Language, Speech, and Hearing Services in Schools; and Journal of Speech, Language, and Hearing Research were extracted for coding. Coders were licensed SLPs who were trained to 80% reliability on classifying the type of research in each article. Clinical practice research articles were further classified as studies on assessment, studies on intervention, and studies that explore the implementation of EBP. Results Clinical practice research comprised the minority of literature published in ASHA journals in the field of speech-language pathology (25%). These articles were composed of assessment (10%), intervention (15%), and implementation (< 1%). These articles were distributed across a variety of primary content areas, with an absence of implementation science for the majority of clinical areas. Conclusions The lack of clinical practice research readily available to practicing SLPs is a barrier to EBP. The results of this study underscore the need for increased clinical practice research. Future work should investigate EBP in the context of clinician-researcher partnerships and increasing the capacity of clinicians to conduct clinical practice research. Supplemental Material https://doi.org/10.23641/asha.12550928.

Research Trends of Acupuncture Therapy on Knee Osteoarthritis from 2010 to 2019: A Bibliometric Analysis.

BackgroundAcupuncture has been widely applied to relieve knee osteoarthritis (KOA) in many countries. However, the bibliometric analysis of the global use of acupuncture on KOA is largely unknown. Therefore, this study aimed to explore the current status and trends of the global use of acupuncture on KOA in recent 10 years by using CiteSpace (5.6.R3).MethodsPublications regarding acupuncture therapy for treating KOA between 2010 and 2019 were extracted from the Web of Science database. CiteSpace was used to analyze the number of publications, countries, institutions, journals, authors, cited references and keywords by using standard bibliometric indicators.ResultsA total of 343 publications were retrieved from 2010 to 2019. The total number of publications continually increased over the past four years, and the most active journals, countries, institutions and authors in the field of acupuncture therapy on patients with KOA were identified. The Evid Based Complement Alternat Med (28) was the most prolific journal, and the Ann Intern Med (202) was the most cited journal. The most productive country and institution in this field was China (115) and University of York (18), respectively. Hugh Macpherson (18) was the most prolific author and Witt C ranked the first in the cited authors. In the ranking of frequency in cited reference, the first article was published by Scharf HP (54). The keyword of ‘randomized controlled trial’ ranked first for research developments with the highest citation burst (3.9486). Besides, there were three main frontiers in keywords for KOA research, including ‘research method, ‘age’ and ‘measure of intervention’.ConclusionThe findings from this bibliometric study provide current status and trends in clinical research of acupuncture therapy on patients with KOA over the past ten years, which may help researchers identify hot topics and explore new directions for future research in this field.