Trends In Clinical Research Research Articles

Trends in Clinical Research on Ultrasound-Guided Acupuncture: A Scoping Review

Acupuncture is widely used to reduce pain and improve function in various conditions. Despite ongoing research in ultrasound-guided acupuncture, evidence supporting efficacy remains inconclusive. This study aimed to examine Korean and international research trends, clinical efficacy, and safety of ultrasound-guided acupuncture by performing a scoping review of clinical research on ultrasound-guided acupuncture. Literature searches were conducted across 11 databases, including all clinical studies published before April 2024, without restrictions on condition/disease or type of study. Of the 2,644 identified articles, 25 studies were selected for review, mostly involving patients with musculoskeletal pain, and post-stroke sequelae. Interventions included ultrasound-guided acupuncture, warming acupuncture, dry needling, and electroacupuncture. The effectiveness of ultrasound-guided acupuncture was evaluated using pain, functional disability, and effective rate as outcome measures, and most studies reported significant improvements. This study is the first scoping review to report on trends, clinical efficacy, and safety of ultrasound-guided acupuncture. While it demonstrates potential for treating musculoskeletal disorders, post-stroke sequelae, spinal injuries, and other conditions/diseases, research on its application remains limited to specific conditions/diseases. Furthermore, substantial variations were observed in types of acupuncture, application areas, and treatment frequencies. Future research should focus on high-quality randomized controlled trials with standardized ultrasound frequencies for specific conditions/diseases.

The evolutionary paths of clinical psychology studies in the United States: A bibliometrics illustration of 69k publications.

We aim to uncover the hot topics and development trends in clinical psychology research in the United States. Utilizing bibliometric analysis, we examined clinical psychology papers published in the United States from 2010 to 2022 in the Web of Science database, employing citation analysis, content analysis, author analysis, and journal analysis. Our analysis revealed a significant increase in clinical psychology research, notably catalyzed by the 2019 COVID-19 pandemic. This surge was particularly evident in studies addressing mental disorders such as PTSD, anxiety, and suicidal behaviors, as well as psychological trauma related to issues like family conflict, elder abuse, and collective trauma. Furthermore, there was a distinct shift towards studying diverse populations, including gender and racial minorities, mothers, and adolescents. Therapeutic approaches, such as mindfulness-based practices and AI-assisted technologies, also gained prominence. This study represents the first large-scale bibliometric analysis in the field of clinical psychology in the United States. Our findings suggest that the COVID-19 pandemic highlights the importance of studying psychological issues linked to major events. Also, researchers are increasingly focusing on minority groups. This trend, along with the use of new technologies like big data and artificial intelligence, guides future research in clinical psychology. The works in this review suggest that the changing landscape of clinical psychology, especially post-COVID-19. The increased research post-pandemic emphasizes addressing psychological trauma arising from societal issues like family conflicts, elder abuse, and collective trauma. A positive shift towards inclusivity is evident in research, focusing on diverse groups like gender minorities, racial minorities, mothers, and adolescents. Additionally, the amplified focus on mental disorders like PTSD, anxiety, and suicidal behaviors during the pandemic stresses the need for tailored interventions and support systems. Exploring innovative methods such as mindfulness-based practices and AI-assisted technologies showcases the field's adaptability in mental health interventions.

A Review of Clinical Research on Gamchosasim-tang for Helicobacter Pylori Associated Gastric Ulcer

Objectives: The purpose of this study was to investigate clinical research trends regarding the efficacy of Gamchosasim-tang on Helicobacter pylori-associated gastric ulcer.Methods: Studies were searched on Pubmed, CNKI, and domestic databases (OASIS, ScienceON, RISS, KISS, and Kmbase) using keywords such as “helicobacter”, “h. pylori”, “ulcer”, and “Gancao Xiexin.” Data on the publication year, characteristics of patients, diagnosis methods, interventions, outcome measures, and results were extracted. The quality of each study was assessed using a risk-of-bias tool.Results: In total, eight studies were selected. All were randomized-controlled trials. Gamchosasim-tang and quadruple therapy were co-administered for the treatment group in most of the studies. A combination of Gamchosasim-tang and eradication therapy was effective in improving disease-associated symptoms and lowering recurrence rate. No obvious side effects were observed in any of the studies.Conclusion: Gamchosasim-tang can be a safe and effective treatment method for helicobacter pylori-associated gastric ulcer, so it can be used in clinical practice.

A Kinematic Deviation Index (KDI) for Evaluation of Forelimb Function in Rodents.

Rodent models are widely used to study neurological conditions and assess forelimb movement to measure function performance, deficit, recovery and treatment effectiveness. Traditional assessment methods based on endpoints such as whether the task is accomplished, while easy to implement, provide limited information on movement patterns important to assess different functional strategies. On the other side, detailed kinematic analysis provides granular information on the movement patterns but is difficult to compare across laboratories, and may not translate to clinical metrics of upper limb function. To address these limitations, we developed and validated a kinematic deviation index (KDI) for rodents that mimics current trends in clinical research. The KDI is a unitless summary score that quantifies the difference between an animal movement during a task and its optimal performance derived from spatiotemporal marker sequences without pre-specifying movements. We demonstrate the utility of KDI in assessing reaching and grasping in mice and validate its discrimination between trial endpoints in healthy animals. Furthermore, we show KDI sensitivity to interventions, including acute and chronic spinal cord injury and optogenetic disruption of sensorimotor circuits. The KDI provides a comprehensive measure of motor function that bridges the gap between detailed kinematic analysis and simple success/failure metrics, offering a valuable tool for assessing recovery and compensation in rodent models of neurological disorders.

Comparison of clinical research trends and hotspots in allergic rhinitis and asthma from 2013 to 2023 based on bibliometric analysis

PurposeTo analyze and compare clinical research trends and hot topics in allergic rhinitis (AR) and asthma and provide valuable theoretical data and references for future research. MethodsClinical studies focusing on AR or asthma published from 2013 to 2023 were retrieved from the Web of Science Core Collection. Eligible articles were screened and analyzed using bibliometrics from multiple indicators. ResultsA total of 261 eligible articles on AR and 991 qualified articles on asthma were screened. The following bibliometric analyses identified the Journal of Allergy and Clinical Immunology as the most influential publication on AR and asthma and proved the significant contributions of Harvard University in clinical studies on AR and asthma. The analyses also revealed that the top ten prolific authors for AR were from China, the United Kingdom, Japan, and Germany, whereas the top ten productive authors for asthma were mainly from the USA. Collaborations among countries for AR were relatively concentrated in the Occident, whereas international cooperation on asthma was mainly achieved by the Occident and certain Eastern countries. ConclusionsThis study compared and analyzed the current status and evolution of AR and asthma-related clinical research using bibliometric analysis. Additionally, the study comprehensively summarized the impactful authors, institutions, and countries, and revealed the replacement and evolution of hotspots.

Trends in Domestic and International Clinical Research on Korean Medicine Treatments for Triangular Fibrocartilage Complex Injury

Trends in Domestic and International Clinical Research on Korean Medicine Treatments for Triangular Fibrocartilage Complex Injury

Trends in Current Clinical Research on Herbal Medicines and Gut Microbiota

Trends in Current Clinical Research on Herbal Medicines and Gut Microbiota

Assessing the current utilization status of wearable devices in clinical research.

Information regarding the use of wearable devices in clinical research, including disease areas, intervention techniques, trends in device types, and sample size targets, remains elusive. Therefore, we conducted a comprehensive review of clinical research trends related to wristband wearable devices in research planning and examined their applications in clinical investigations. As this study identified trends in the adoption of wearable devices during the planning phase of clinical research, including specific disease areas and targeted number of intervention cases, we searched ClinicalTrials.gov-a prominent platform for registering and disseminating clinical research. Since wrist-worn devices represent a large share of the market, we focused on wrist-worn devices and selected the most representative models among them. The main analysis focused on major wearable devices to facilitate data analysis and interpretation, but other wearables were also surveyed for reference. We searched ClinicalTrials.gov with the keywords "ActiGraph,""Apple Watch,""Empatica,""Fitbit,""Garmin," and "wearable devices" to obtain studies published up to 21 August 2022. This initial search yielded 3214 studies. After excluding duplicate National Clinical Trial studies (the overlap was permissible among different device types except for wearable devices), our analysis focused on 2930 studies, including simple, time-series, and type-specific assessments of various variables. Overall, an increasing number of clinical studies have incorporated wearable devices since 2012. While ActiGraph and Fitbit initially dominated this landscape, the use of other devices has steadily increased, constituting approximately 10% of the total after 2015. Observational studies outnumbered intervention studies, with behavioral and device-based interventions being particularly prevalent. Regarding disease types, cancer and cardiovascular diseases accounted for approximately 20% of the total. Notably, 114 studies adopted multiple devices simultaneously within the context of their clinical investigations. Our findings revealed that the utilization of wearable devices for data collection and behavioral interventions in various disease areas has been increasing over time since 2012. The increase in the number of studies over the past 3 years has been particularly significant, suggesting that this trend will continue to accelerate in the future. Devices and their evaluation methods that have undergone thorough validation, confirmed their accuracy, and adhered to established legal regulations will likely assume a pivotal role in evaluations, allowing for remote clinical trials. Moreover, behavioral intervention therapy utilizing apps is becoming more extensive, and we expect to see more examples that will lead to their approval as programmed medical devices in the future.

Recent Domestic and International Clinical Research Trends in Gua Sha Therapy: A Scoping Review

Recent Domestic and International Clinical Research Trends in Gua Sha Therapy: A Scoping Review

An Analysis of Domestic and International Clinical Research Trends on Korean Medicine Treatments for Iliopsoas Muscle

An Analysis of Domestic and International Clinical Research Trends on Korean Medicine Treatments for Iliopsoas Muscle

Bibliometric analysis of publications on kinesiophobia in orthopedics between 1970 - 2023

Aims: This bibliometric study aimed to examine the hotspots and frontiers of kinesiophobia research in orthopedics and to assess the overall scientific output of the field. Methods: The Web of Science Core Collection was mined for articles on kinesiophobia that were published between 1970 and September 2023. Using common bibliometric indicators, Vosviewer was used to examine the number of publications, countries, institutions, journals, authors, cited references, and keywords. Results: The results of a bibliometric analysis focused on the body of knowledge on kinesiophobia. The study analyzed 2,035 articles from 75 different countries and identified important trends and groundbreaking research. In particular, there has been a steady increase in recent years, with publications increasing significantly between 2001 and 2012. The highest contribution came from the United States and the most cited articles addressed clinical recommendations for low back pain. Both the Florida State University System and the University of Florida made significant contributions. With a total of 51,443 citations, this study provides a comprehensive overview to help guide future research in orthopaedics and related fields. Conclusion: The results of this bibliometric study give an overview of the state and trends in clinical research on kinesiophobia and may be used by researchers to pinpoint hot themes and consider fresh lines of inquiry.

골절의 약침치료에 대한 임상 연구 동향

골절의 약침치료에 대한 임상 연구 동향

Molecular Eye: A System for Precise Diagnosis and Treatment of Major Clinical Diseases Based on Molecular Probe Technology.

With the flourishing development of precision medicine, theranostics, generally recognized as the integration of diagnosis and treatment, has emerged as a prominent trend in clinical research. However, theranostics primarily emphasizes the end result of integration, without providing sufficient details on how precise diagnosis and synergetic individualized treatment could be achieved and what clinical challenges could be effectively addressed in clinical practice. Molecular probe technology provides a robust method to bridge the gap between theory and practice. Through meticulous design of the chemical structure, imaging labels or drugs were conjugated to tumor-targeting peptides, antibodies, or inducers to form molecular probes, which allow a seamless switch between targeted intervention and targeted imaging with consistency in time, space, and biodistribution. Thus, this review proposes a concept called "molecular eye", which refers to a comprehensive system for precise diagnosis and treatment of major clinical diseases based on molecular probe technology. This medical system emphasizes the chemical basis of probe development and optimization, which can provide precise actionable information for clinical decision making, allow molecular-targeted therapy, expand the indications of old therapy, and accelerate the regulatory approval of molecular drugs. "Molecular eye" resembles the piercing eye of the Monkey King, which can detect previously "invisible" diseases and facilitate disease diagnosis, treatment, real-time evaluation, and pathology research, guiding drug development. The emergence of the "molecular eyes" will provide opportunities and challenges in the fields of clinical practice and medical research and propel the progression of contemporary medicine toward precision medicine.

Domestic Clinical Research Trends of Shinbaro Pharmacopuncture: Scoping Review

Domestic Clinical Research Trends of Shinbaro Pharmacopuncture: Scoping Review

Domestic Clinical Research Trends of Pharmacopuncture Treatment for Nerve Entrapment Syndroeme: A Scoping Review

Domestic Clinical Research Trends of Pharmacopuncture Treatment for Nerve Entrapment Syndroeme: A Scoping Review

Trends in Clinical Research of Catgut Embedding for Obesity Treatment

Trends in Clinical Research of Catgut Embedding for Obesity Treatment

Bibliometric and Visual Analysis in the Field of Dry Needling for Myofascial Pain Syndrome from 2000 to 2022.

Evidence has shown that dry needling (DN) is effective for myofascial pain syndrome (MPS). However, bibliometrics has rarely been used to analyze the literature related to DN for MPS. The purpose of this study is to provide a systematic overview of global frontiers and research hotspots of DN in the treatment of MPS from 2000 to 2022. A search was conducted on Web of Science Core Collection (WoS CC) for literature on DN for MPS from 2000 to 2022. Based on the basic information provided by WoS CC, CiteSpace software was used to conduct bibliometric analysis of the countries, institutions, categories, journals, authors, references and keywords involved in this topic. A total of 458 papers were obtained, with the number of publications increasing over time. Journal of Bodywork and Movement Therapies (31) was the most productive journal based on the number of publications, while Arch Phys Med Rehab (329) was the most co-cited journal. The most productive countries and institutions were USA (112) and Universidad Rey Juan Carlos (39), respectively. Fernandez-de-las-penas, Cesar has the highest number of publications (24) and Simons DG, who was an author with the highest number of citations (250). The article published by Gattie et al (co-citations: 65), and Mejuto-Vazquez et al (centrality: 0.36) were the most representative and symbolic. Based on the co-cited literature and keywords, myofascial trigger point, research methods, and acupuncture were the hot research topics and trends in the field. The current status and trends in clinical research of DN for MPS are revealed according to the results of this bibliometric study, which may facilitate researchers to identify hot topics and new directions for future research.

Study on the mechanism of Lily in the treatment of viral pneumonia based on network pharmacology analysis

Background: Viral pneumonia poses an increasing threat to human life and health, and the treatment of viral pneumonia with single traditional Chinese medicine is a frontier trend in clinical research at present. Objective: Based on network pharmacology, this study aimed at exploring the potential targets and mechanisms of Lilium brownii in treating viral pneumonia. Methods: Traditional Chinese Medicine Systems Pharmacology (TCMSP) (https://tcmspw.com/index.php), the database and analysis platform of traditional Chinese medicine, was employed to retrieve and convert the active components and component targets of Lily. Then, the targets identified in the TCMSP database, were translated into the specific list of UniProt database (https://www.uniprot.org/). Meanwhile, GeneCards database was utilized to obtain the targets associated with viral pneumonia, (https://www.genecards.org). Subsequently, we employed the Venny2.1 database (https://bioinfogp.cnb.csic.es/tools/venny/) for the construction of network and the analysis of active ingredients as well as key targets. Results: Six active components, 447 action targets, 3,473 disease targets and 4 drug cross targets were obtained. The top 10 GO biological processes, 10 GO cell components, 10 GO molecular functions and the top 10 KEGG signal pathways, as well as key molecules were identified. Of these, Lily may act on three key targets, including the apoptosis regulator BCL2, Caspase-3 (CASP3), Caspase-8 (CASP8), and p53 signal pathway. Conclusions: Lily may play a regulatory role in the manifestation of viral pneumonia, as it modulates apoptosis processes across diverse species and influences the p53 signaling pathway. These discoveries establish a foundation for prospective experimental validation.

Bibliometric Analysis of Research Trends on Tuina Manipulation for Neck Pain Treatment Over the Past 10 Years.

Tuina is an effective treatment for neck pain (NP). However, there has been no bibliometric analysis of the global application and emerging trends of tuina performed for NP. Therefore, this study aimed to provide an overview of the current state and future trends in the field. Articles about tuina for NP, published from January 1, 2013, to January 1, 2023, were searched in the Web of Science Core Collection database. CiteSpace (6.1.R6) and VOSviewer (1.6.18) software were used to analyze annual trends in literature posts, countries, institutions, authors, cited references, and knowledge graphs of keyword co-occurrence, clustering, and burst using standard bibliometric indicators. The final analysis comprised 505 valid documents. The results demonstrate that the number of articles in the field of tuina therapy for NP has gradually increased over the years, showing the most active countries, institutions, journals, and authors. There were 323 keywords in the field, 322 research authors, and 292 research institutions, with the USA having the most publications (n = 140). The most published institution is Vrije University Amsterdam, and the most published journal is the Cochrane Database of Systematic Reviews. Peter R Blanpied is the most influential and most-cited author. Interventions (dry needling, massage therapy, and muscle energy techniques), common treatment sites for NP (upper trapezius), and complications (cervicogenic headache) are the top three frontiers mentioned in the field of tuina research for NP. The bibliometric study showed the current status and trends in clinical research on treating patients with NP using tuina, which may help researchers identify topics of interest and scope for future research in this field.

Research advances and trends in the surgical treatment of carpal tunnel syndrome from 2003 to 2022: A CiteSpace-based bibliometric analysis.

Carpal Tunnel Syndrome (CTS) is one of the most common peripheral neuropathies. The typical symptoms are tingling and numbness in the median nerve distribution of the hand. Current treatment for CTS includes general conservative treatment and surgical treatment. Surgical treatment plays a crucial role in the management of CTS, but little bibliometric analysis has been conducted on it. Therefore, this study aimed to map the literature co-citation network using CiteSpace (6.1 R4) software. Research frontiers and trends were identified by retrieving subject headings with significant changing word frequency trends, which can be used to predict future research advances in the surgical treatment of CTS. Publications on the surgical treatment of CTS in the Web of Science database were collected between 2003 and 2022. CiteSpace software was applied to visualize and analyze publications, countries, institutions, journals, authors, references, and keywords. A total of 336 articles were collected, with the USA being the major publishing power in all countries/regions. JOURNAL OF HAND SURGERY AMERICAN VOLUME was the journal with the most published and co-cited articles. Based on keyword and reference co-citation analysis, keywords such as CTS, surgery, release, median nerve, and diagnosis were the focus of the study. The results of this bibliometric study provide clinical research advances and trends in the surgical treatment of patients with CTS over the past 20 years, which may help researchers to identify hot topics and explore new directions for future research in the field.