Research Trends Research Articles

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders: Present trends and future directions

BACKGROUND Bipolar disorder (BD) is a severe mental illness characterized by significant mood swings. Effective drug treatment modalities are crucial for managing BD. AIM To analyze the current status and future trends of global research on BD drug treatment over the last decade. METHODS The Web of Science Core Collection database spanning from 2015 to 2024 was utilized to retrieve literature related to BD drug treatment. A total of 2624 articles were extracted. Data visualization and analysis were conducted using CiteSpace, VOSviewer, Pajek, Scimago Graphica, and R-studio bibliometrix to identify research hotspots, key contributors, and future trends. RESULTS The United States, China, and the United Kingdom have made the most significant contributions to research on BD drug treatment and formed notable research collaboration networks. The University of Pittsburgh, Massachusetts General Hospital, and the University of Michigan have been identified as the major research institutions in this field. The Journal of Affective Disorders is the most influential journal. A keyword analysis revealed research hotspots related to clinical symptoms, drug efficacy, and genetic mechanisms. A citation analysis identified the management guidelines published by Yatham et al in 2018 as the most cited paper. CONCLUSION This study provides a detailed overview of the field of BD drug treatment, highlighting key contributors, research hotspots, and future directions. The study findings can be employed as a reference for future research and policymaking, which may enable further development and optimization of BD pharmacotherapy.

A bibliometric analysis of reward-based crowdfunding related research: current trends and future prospect

Abstract The primary objective of this research pertains to conducting a bibliometric examination of articles accessible within the Web of Science database that pertain to reward-based crowdfunding. This research was conducted over a corpus of 261 publications spanning the timeframe of 2014 to 2023, from the WoS database. The results of the research revealed a notable trend of reward-based crowdfunding researchers. The research also sought to identify key authors, institutions, journals, and countries that hold paramount significance for future scholars delving into the study of reward-based crowdfunding, consequently delineating fundamental thematic underpinnings. The insights gleaned from these analyses are anticipated to offer valuable guidance to researchers engaging in explorations within this particular domain. The meticulous evaluation of publications and their interconnections sheds light on prevalent trends, influential contributors, and core topics, thereby furnishing a compass for prospective research endeavors.

Global research status and trends of somatic symptom disorder: A bibliometric study

BACKGROUND With the growing scholarly and clinical fascination with somatic symptom disorder (SSD), a bibliometric analysis is lacking. AIM To conduct a bibliometric analysis to investigate the current status and frontiers of SSD. METHODS The documents related to SSD are obtained from the web of science core collection database (WoSCC), and VOSviewer 1.6.16 from January 1, 2000 to December 31, 2023, and the WoSCC’s literature analysis wire were used to conduct the bibliometric analysis. RESULTS A total of 567 documents related to SSD were included, and 2325 authors across 947 institutions from 57 countries/regions have contributed to SSD research, published in 277 journals. The most productive author, institution, country and journal were Löwe B, University of Hamburg, Germany, and Journal of Psychosomatic Research respectively. The first high-cited document was published in the Journal of Psychosomatic Research in 2013 by Dimsdale JE and colleagues, which explored the rationale behind the SSD diagnosis introduction in diagnostic and statistical manual of mental disorders. CONCLUSION In conclusion, the main research hotspots and frontiers in the field of SSD are validity and reliability of the SSD criteria, functional impairment of SSD, and the treatment for SSD. More high-quality studies are needed to assess the diagnosis and treatment of SSD.

Review of sustainable temporary housing and reuse strategy for post-disaster architectures: current trends and strategic gaps

Sustainable temporary architecture after a disaster includes temporary buildings designed to meet the emergency housing needs of disaster victims. This approach minimizes the use of waste and natural resources, reduces the environmental impact, and assumes an important responsibility to maintain the long-term ecological balance. Within the scope of this research, comprehensive and systematic results are presented by analyzing disaster issues with the “reuse” strategy, which has started to be frequently encountered in the current literature. The studies were scanned in the Web of Science and Scopus databases under the heading “Title//Keywords,” and the data were analyzed in detail. The findings indicate research trends in the literature and gaps for future research. The results highlight the innovative approach for sustainable post-disaster temporary architecture in the context of reuse strategies and present the field’s challenges, limitations, and opportunities. This study is expected to help researchers, practitioners, experts, and politicians understand the evolutionary implications of disaster reuse strategies and develop other theoretical and practical initiatives that can be applied in this field.

The global trends in digital citizenship research: A bibliometric analysis with R program and VosviewerA

The global trends in digital citizenship research: A bibliometric analysis with R program and VosviewerA

A place in the shade? Shaded spaces as a domain of geographical research: a literature review (1990–2024)

The study of shade and shaded spaces has attracted growing interest in a number of disciplines. Although geographic studies specifically focused on this subject are relatively rare, there is a substantial body of interdisciplinary research that addresses the theme of shade in relation to ecological, urban, medical and social research interests. There have recently been calls to further analyze these spaces, especially if we consider their importance in relation to climate change. In response to this, this paper aims to examine shade as a field of geographical research through a literature review. Ninety-four articles published in international journals between 1990 and 2024 were identified. The articles were analyzed with particular reference to the distribution in time of the publications, the geographic location of the case studies, interdisciplinary connections, research interests, and the methodologies used. The study reveals the interdisciplinary nature of shade studies and their growth in recent years. The literature analysis enables us to identify dominant research trends and at the same time highlight certain gaps. The study also emphasizes the value of shade as a resource, its many benefits, and its environmental and social significance as a geographical factor at various levels. In conclusion, this paper seeks to bring the topic of shade to the forefront of research, encouraging further empirical studies with a particular focus on the right to shade and climate change mitigation.

A systematic review of plastic recycling: technology, environmental impact and economic evaluation.

In this systematic review, advancements in plastic recycling technologies, including mechanical, thermolysis, chemical and biological methods, are examined. Comparisons among recycling technologies have identified current research trends, including a focus on pretreatment technologies for waste materials and the development of new organic chemistry or biological techniques that enable recycling with minimal energy consumption. Existing environmental and economic studies are also compared. The findings highlight differences in the environmental characteristics of various recycling methods, including their ability to recover plastic resins, carbon footprint, electricity consumption and gas emissions. The comparisons also reveal the challenges associated with these methods: mechanical recycling often encounters economic barriers due to contamination and inefficiencies in sorting and cleaning processes; thermolysis is constrained by high energy demands and operational costs, whereas chemical and biological recycling faces limitations related to scalability and material costs. Additionally, current challenges, emerging research areas and future directions in plastic recycling are discussed. For example, the role of innovative techniques, such as artificial intelligence, in refining recycling processes is emphasized. The importance of incorporating circular economy principles in the integrated sustainable analysis of recycling processes is also highlighted. The innovative contribution of this review is to address both technological developments and their environmental and economic implications. The focus is placed on literature from the past 10 years to ensure coverage of the most recent advancements. Overall, the insights of this review article aim to guide researchers, policymakers and industry stakeholders in improving sustainable management practices for plastic waste.

Global research progress and trends in traditional Chinese medicine for chronic kidney disease since the 21st century: a bibliometric analysis

ObjectiveThis study analyzed literature on traditional Chinese medicine (TCM) in treating chronic kidney disease (CKD) to identify research trends and provide guidance for future studies and clinical practice.MethodsThe study used data from Web of Science from 2000 to 2024 to analyze English-language literature on CKD and TCM. Bibliometric analysis was done using R software and the bibliometric package, with scientific mapping and visualization analysis conducted using tools like Citespace, VOSviewer, and ScimagoGraphica to explore research trends and connections.ResultsThis study revealed that a total of 1,153 relevant documents were retrieved, and the number of published articles showed an increasing trend, reaching a peak in 2022. In terms of article publication, China ranked first with 760 articles, closely followed by the United States with 132 articles. Guangzhou University of Traditional Chinese Medicine published 60 papers, the most among academic institutions, followed by Shanghai University of Traditional Chinese Medicine with 54 papers. In terms of individual authors, Liu Xinhui holds the record for the highest number of published articles, totaling 17, followed by Li Ping and Li Shunmin. The prevalent keywords include “chronic kidney disease,” “TCM,” and “oxidative stress.” Currently, the prominent areas of research interest include network pharmacology, gut microbiota, oxidative stress, and related topics. The current research trend in this field is towards the adoption of novel methodologies such as network pharmacology and the emphasis on exploring the relationship between gut microbiota and CKD.ConclusionGlobal research on TCM in the treatment of CKD is showing a positive development trend, but further research on safety, efficacy evaluation, and international cooperation is still needed. The development trend is to adopt new scientific research methods and focus on exploring the mechanism of TCM in treating CKD.

The Trends of Peace Education Research in Indonesia: A Bibliometric Analysis Aligned with Quality of Education

Introduction: This bibliometric analysis examines the trends and development of peace education research in Indonesian universities from 2014 to 2024. Utilizing data from reputable databases such as Web of Science and Scopus, the study identifies key characteristics of published works, including authorship, subject areas, and trends in scientific production. The findings reveal a growing interest in peace education, with a significant increase in publications over the years. The research primarily focuses on the religious and philosophical foundations of peace education in Indonesia, emphasizing the influence of cultural values on this field. The analysis also identifies prominent authors, influential journals, and collaborative networks within the field. Finally, the study concludes by highlighting key themes and trends in Indonesian peace education research, emphasizing the importance of character education, diversity, religious moderation, conflict resolution, and youth engagement. These findings contribute to a more nuanced understanding of the evolving landscape of peace education research in Indonesian universities and offer insights that will inform future research and practice. Objective: This study conducts a bibliometric analysis to explore trends and developments in peace education research at Indonesian University from 2014 to 2014. Theoretical Framework: The stuudy is grounded in key theories and models relevant to peace education, focusing on religious, philosophical, and cultural influences that shape this field in Indonesia. Method: The study utilizes a bibliometric approach, analyzing data from databases such as Web of Science and Scopus. It examines authorship, subject areas, and trends in scientific production through a comprehensive review of published works from 2014 to 2024. Results and Discussion: Findings show a significant increase in peace education publications over the decade, highlighting key themes like character education, diversity, religious moderation, conflict resolution, and youth engagement. The discussion contextualizes these findings within the theoretical framework, identifying implications and limitations. Research Implications: The study offers practical and theoretical insights, particularly on how cultural values inluence peace education in Indonesia. It provides valuable guidance for future research and educational practices. Originality/Value: The research contributes to the literature mapping out the evolving landscape of peace education in Indonesia, identifying influential authors, journals, and collaborative networks. It underscores the growing importance of peace education themes in Indonesia academic discourse.

Research hotspots and trends of acupoint and pain based on PubMed: a bibliometric analysis

Research hotspots and trends of acupoint and pain based on PubMed: a bibliometric analysis

Advancements and Prospects in Nanorobotic Applications for Ophthalmic Therapy.

This study provides a bibliometric and bibliographic review of emerging applications of micro- and nanotechnology in treating ocular diseases, with a primary focus on glaucoma. We aim to identify key research trends and analyze advancements in devices and drug delivery systems for ocular treatments. The methodology involved analyzing 385 documents indexed on the Web of Science using tools such as VOSviewer and Bibliometrix. The results show a marked increase in scientific output, highlighting prominent authors and institutions, with England leading in the field. Key findings suggest that nanotechnology holds the potential to address the limitations of conventional treatments, including low ocular bioavailability and adverse side effects. Nanoparticles, nanovesicles, and polymer-based systems appear promising for prolonged and controlled drug release, potentially offering enhanced therapeutic efficacy. In conclusion, micro- and nanotechnology could transform ocular disease treatment, although challenges remain concerning the biocompatibility and scalability of these devices. Further clinical studies are necessary to establish these innovations within the therapeutic context of ophthalmology.

Recent trends in scientific research in chest radiology: What to do or not to do? That is the critical question in research.

Hereby inviting young rising stars in chest radiology in Japan for contributing what they are working currently, we would like to show the potentials and directions of the near future research trends in the research field. I will provide a reflection on my own research topics. At the end, we also would like to discuss on how to choose the themes and topics of research: What to do or not to do? We strongly believe it will stimulate and help investigators in the field.

Insights into anesthesia administration for elderly individuals undergoing painless gastroenteroscopy: A bibliometric study

BACKGROUND Administering anesthesia to elderly patients undergoing gastroenteroscopy necessitates careful attention due to age-related physiological changes and an increased risk of complications. AIM To analyze the research trends in anesthesia management for elderly patients undergoing gastroenteroscopy. METHODS We performed a literature search using the Web of Science database to identify articles published between 2004 and 2023. Bibliometric and visual analyses were conducted using CiteSpace, R, and VOSviewer to explore the current research landscape of anesthesia administration in painless gastroenteroscopy for elderly patients and to identify future research directions by examining trends and emerging hotspots in this domain. RESULTS A total of 800 articles were examined, revealing a rising trend in annual publication counts. The United States led with 181 articles, followed by China with 112, collectively contributing over 35% of the studies among the top ten countries. The majority of publications appeared in the United States journals, with the top three being Gastrointestinal Endoscopy [impact factor (IF) = 7.7, H-index = 26], Digestive Diseases and Sciences (IF = 3.1), and Endoscopy (IF = 9.3). Six primary research clusters were identified: Obstructive sleep apnea and airway management, surveillance and risk factors, colorectal cancer examination and treatment, sedation and safety of propofol and midazolam, patient satisfaction, and mortality and complications. These findings underscore the pivotal focus areas in anesthesia for elderly patients undergoing gastroenteroscopy. CONCLUSION A comprehensive understanding of current research trends and hotspots will aid anesthesiologists in developing more evidence-based practices, thereby improving the safety and outcomes for elderly patients undergoing gastroenteroscopy.

Research trends in digital marketing and data-driven marketing: A bibliometric analysis

The accelerated development of digital technologies and the Internet stimulates the transition from the traditional to the digital model of marketing. The study presents a bibliometric analysis to examine international publications in the field of digital marketing (DM) and data-driven marketing (DDM) with a holistic approach, determine the current level of research interest in the topic under review and identify key development trends. The fundamental principles of bibliometrics and scientometric management constitute the methodological framework of the paper. Among the research methods applied are statistical and scientometric analyses. The data used in the study were retrieved from the Web of Science. Bibliometric analysis was carried out with 1,541 and 58 articles on digital and data-driven marketing, respectively. The data set covers the period of 2006–2024, when the first study on digital marketing emerged, and the period of 2003–2024 for data-driven marketing. The obtained data were processed using the R Project. The findings indicate a constantly growing research interest in the concepts under consideration. We have identified journals with most publications on digital marketing (Sustainability) and data-driven marketing (Journal of Business Research); established the countries publishing most studies on DM (USA) and DDM (China); and revealed the most frequently used keywords in DM (‘impact’) and DDM (‘management’). The results of keywords’ occurrence analysis were utilized to create thematic maps for visualizing motor, niche, basic and emerging/declining research areas in the field of digital and data driven marketing.

Exploring the Known and Mapping Future Directions in Biopesticides Research: A Bibliometric Analysis

Numerous concerns associated with the use of synthetic pesticides have led to important initiatives aimed at ensuring eco-friendly practices in pest and disease control. Third-generation pesticides, biopesticides, have become a key factor in those efforts, capturing the attention of researchers worldwide. To evaluate trends in biopesticide research over the past three decades, a bibliometric analysis was performed on bibliographic data sourced from the Web of Science database. This analysis included metrics such as publication dynamics, types of documents, and assessments of research fields and categories. Co-authorship, citation, and co-occurrence networks were visualized using VOSviewer software to identify collaboration patterns, influential publications, emerging topics, and interdisciplinary connections. A total of 5054 publications on the topic of ‘biopesticide’ were found (1994–2024), nearly half of which were published in the last five years. Out of 136 contributing countries, researchers from the USA, People’s Republic of China, and India produced the most publications, while a total of 19,676 authors contributed to at least one paper throughout the entire examined period. The identification of the most frequently used keywords highlighted significant topics within biopesticide-related publications, from the earliest to the most recent, aiding in our understanding of the developmental trajectory and opportunities for future exploration.

Emerging Trends in Secondary Metabolite Research in Caryophyllales: Betalains and Their Roles in Plant Adaptation and Defense Mechanisms.

Betalains, a distinctive group of nitrogen-containing pigments exclusive to the Caryophyllales order, possess diverse biological activities such as antioxidant, anti-inflammatory, and antimicrobial properties, making them highly valuable for applications in food, nutraceutical, and pharmaceutical industries. This Review provides a comprehensive analysis of betalain biosynthesis, structural diversity, and ecological significance, highlighting their roles in enhancing stress resilience, adaptation mechanisms, and plant evolutionary strategies. The evolutionary development of betalains is explored, revealing their emergence through gene duplication events and providing insights into their mutual exclusivity with anthocyanins. This study utilizes comparative genetics and advanced molecular tools to uncover the intricate regulatory networks involving transcription factors such as MYB, bHLH, WRKY, and SPL, which govern betalain biosynthesis. Furthermore, the Review discusses innovative transgenic studies that introduce betalains into non-native species, demonstrating their potential to enhance stress tolerance and boost agricultural productivity. While significant progress has been made in understanding betalain biosynthesis pathways, the evolutionary relationships with anthocyanins and the specific ecological functions of betalains in plants remain areas of ongoing exploration. Future research directions include integrating chemotaxonomic studies, molecular phylogenetics, and multiomics approaches to unravel the full spectrum of betalain functions and regulatory mechanisms. Such studies are essential to deepening our understanding of these vibrant pigments and their evolutionary implications, offering new opportunities for biotechnological innovations and sustainable agricultural practices. This Review stands out by combining genetic, ecological, and evolutionary perspectives, providing novel insights into the multifunctionality of betalains and their potential to drive future advancements in plant science and biotechnology.

Global trends and hotspots of type 2 diabetes in children and adolescents: A bibliometric study and visualization analysis.

Epidemiological surveys indicate an increasing incidence of type 2 diabetes mellitus (T2DM) among children and adolescents worldwide. Due to rapid disease progression, severe long-term cardiorenal complications, a lack of effective treatment strategies, and substantial socioeconomic burdens, it has become an urgent public health issue that requires management and resolution. Adolescent T2DM differs from adult T2DM. Despite a significant increase in our understanding of youth-onset T2DM over the past two decades, the related review and evidence-based content remain limited. To visualize the hotspots and trends in pediatric and adolescent T2DM research and to forecast their future research themes. This study utilized the terms "children", "adolescents", and "type 2 diabetes", retrieving relevant articles published between 1983 and 2023 from three citation databases within the Web of Science Core Collection (SCI, SSCI, ESCI). Utilizing CiteSpace and VoSviewer software, we analyze and visually represent the annual output of literature, countries involved, and participating institutions. This allows us to predict trends in this research field. Our analysis encompasses co-cited authors, journal overlays, citation overlays, time-zone views, keyword analysis, and reference analysis, etc. A total of 9210 articles were included, and the annual publication volume in this field showed a steady growth trend. The United States had the highest number of publications and the highest H-index. The United States also had the most research institutions and the strongest research capacity. The global hot journals were primarily diabetes professional journals but also included journals related to nutrition, endocrinology, and metabolism. Keyword analysis showed that research related to endothelial dysfunction, exposure risk, cardiac metabolic risk, changes in gut microbiota, the impact on comorbidities and outcomes, etc., were emerging keywords. They have maintained their popularity in this field, suggesting that these areas have garnered significant research interest in recent years. Pediatric and adolescent T2DM is increasingly drawing global attention, with genes, behaviors, environmental factors, and multisystemic interventions potentially emerging as future research hot spots.

Current applications and research trends of ultrasound examination in acute kidney injury assessment: a bibliometric analysis.

Acute kidney injury (AKI) is a significant clinical condition, and ultrasound examination has emerged as a crucial non-invasive imaging method for assessing kidney status, especially in its diagnosis and management. This study aims to perform a bibliometric analysis to clarify current research trends in ultrasound assessment of AKI. We conducted a literature search in the Web of Science database using keywords related to ultrasound examinations of acute kidney injury, up to November 15, 2023. The results were analyzed using the bibliometric software package in R. Relevant literature information was analyzed. A total of 1109 articles were included in the study. Research papers published between 2019 and 2024 demonstrated a significant upward trend. The United States, China, and Italy ranked as the top three countries in terms of publication volume. Among the top 10 research institutions with the highest number of publications, 6 are in the United States, with Université de Montréal being the institution with the most publications. Keyword trends focused on: resistive index, risk factors, therapy, glomerular filtration rate, survival, etc. CONCLUSION: This bibliometric study highlights the advancements in ultrasound examination for AKI and underscores the importance of such analyses in determining research trends. Future research should emphasize the integration of various imaging techniques to improve diagnostic accuracy and clinical management of AKI.

The Health Impact of Cocoa from Cultivation to the Formation of Biogenic Amines: An Updated Review

Cocoa and chocolate are known for their health benefits, which depend on factors like cocoa variety, post-harvest practices, and manufacturing processes, including fermentation, drying, roasting, grinding, and refining. These processing methods can influence the concentration and bioavailability of bioactive compounds, such as polyphenols that are linked to cardiovascular health and antioxidant effects. Recent scientific research has led to the development of cocoa-based products marketed as functional foods. However, despite the growing interest in the functional potential of cocoa, the literature lacks crucial information about the properties of different varieties of cocoa and their possible implications for human health. Moreover, climate change is affecting global cocoa production, potentially altering product composition and health-related characteristics. In addition to polyphenols, other compounds of interest are biogenic amines, due to their role and potential toxic effects on human health. Based on toxicological data and recent research on the complex relationship between biogenic amines and cocoa fermentation, setting limits or standards for biogenic amines in cocoa and chocolate could help ensure product safety. Finally, new trends in research on biogenic amines in chocolate suggest that these compounds might also be used as quality markers, and that product formulation and process conditions could change content and diversity of the different amines.

Bibliometric insights into astrocytic roles in depression and treatment

ObjectiveDepression is a mental disorder that significantly impairs both physical and mental health. Recent studies have shown that reactive astrogliosis have gained significant attention for their involvement in the pathophysiology of depression. However, there is no bibliometric analysis in this research field. This study aims to provide a comprehensive overview of the knowledge structure and research hotspots regarding the role of astrocytes in the mechanisms and treatment of depression through bibliometric analysis. The scope of the literature review encompasses both basic and clinical research.MethodsPublications related to astrocytes in depression and treatment from 2014 to 2023 were searched in the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, and the R package “bibliometrix” were used to conduct this bibliometric analysis.ResultsFrom 2014 to 2023, a total of 1,502 documents from 78 countries on astrocytes in depression and treatment were analyzed from 169 journals, with the most co-cited journals being the Journal of Neuroscience and PNAS. China Medical University was the most productive institution. The analysis identified key authors like Verkhratsky Alexei and Baoman Li, and major co-cited references by Rajkowska and Liddelow. Keywords such as “synaptic plasticity,” “astrocytes,” and “neuroinflammation” revealed research trends focusing on molecular mechanisms, gut microbiota, and inflammation.ConclusionThis is the first bibliometric study to comprehensively summarize the research trends and advancements regarding astrocytes in depression and its treatment. Through this bibliometric analysis, we aim to enhance the understanding of the significance of astrocytes in depression research and provide new perspectives and insights for future investigations. We hope that this study will facilitate a broader integration of basic and clinical research, offering novel approaches for the treatment of depression.