The influence of global change on vegetation cover and processes has drawn increasing attention in the past few decades. In this study, we used remotely sensed rainfall and land surface temperature to investigate the spatiotemporal pattern and trend in vegetation condition using NDVI as proxy from 2001 to 2017 in a humid and dry tropical region. We also determined the partial correlation coefficient of temperature and rainfall with NDVI and the response of NDVI to changes in landcover categories due to human activities. We found that the mean annual maximum NDVI was 0.42, decreasing at a rate of 0.06 per decade. About 27.4% of the area was found to have experienced a significant negative trend in vegetation cover, while only 0.34% exhibited significant increasing vegetation vigour. Land surface temperature increased at a mean rate of 0.75°C/decade, with higher rates in agriculture, savanna, settlements, woodlands, and riparian vegetation than in forest and mangrove vegetations. Precipitation also reduced at a mean rate of 58.69 mm/decade, with higher rates in agriculture savanna and riparian vegetation than in sahelian grasslands, mangrove, forest, and woodlands. NDVI was negatively correlated with temperature in savanna, settlements, degraded forest, and sahelian grasslands providing confirmation of ongoing land degradation. It was concluded that vegetation vigour will continue to decline under rainfall and increasing temperature conditions especially in dryer regions. The use of land surface temperature in this study is particularly valuable in highlighting areas where changes in NDVI occurred as a result of synergistic action between climate and human-induced landcover changes. Our findings underscore the importance of landuse policies that account for spatial variation in synergistic relationships between the nexus of climate and land conversion processes that influence vegetation cover change in different landcover types in tropical regions.