Abstract Background: Essential tremor (ET) is a neurological movement disorder that manifest a tremor in different body parts, but mainly the hands, leading to movement disability and social withdrawal. It is the most prevalent movement disorder with more than half of the patients not achieving satisfactory tremor reduction using medication. Thus, deep brain stimulation (DBS) becomes a standard treatment. However, DBS is highly invasive with stimulation electrodes being implanted in deep brain regions. To overcome that, the motor and the cerebellar cortex have been suggested as an alternative, more superficial, targets for stimulation. While results from an epidural cortical stimulation study were promising, this technique remains highly invasive requiring a craniotomy to implant the electrodes. Recently, we proposed a novel minimally invasive neuromodulation technique, epicranial current stimulation (ECS), that can deliver strong cortical current through subcutaneous electrodes. Here, we used Harmaline ET model in rats to test the ability of direct current epicranial current stimulation (DC-ECT) in reducing tremor. Methods: Rats were implanted with discrete epicranial electrodes placed over the motor cortices, the cerebellum and the frontal cortex. After surgery recovery, the rats were injected with Harmaline (15 mg/kg) to induce tremor which was measured using an accelerometer. Then DC-ECT was applied and different electrodes configurations were used to test the effects of stimulation on tremor suppression. Results: Our results show that DC-ECT suppresses Harmaline tremor in rats. Cerebellar stimulation showed a significant decrease in tremor compared to no stimulation. This effect was polarity dependent with anodal stimulation showing tremor reduction but not cathodal one. Conclusion: DC-ECT is a very promising neuromodulation technique that can suppress harmaline induced tremor in rats. Given its minimally invasive nature, it could be an alternative to DBS for ET patients. Keywords: epicranial stimulation, Essential tremor, Harmaline, Direct current stimulation